Propyl gallate / TumCCA Cancer Research Results

PG, Propyl gallate: Click to Expand ⟱
Features:
An ester formed by the condensation of gallic acid and propanol.
Propyl gallate (PG), chemically known as propyl-3,4,5-trihydroxybenzoate, is widely present in processed food and cosmetics, hair products, and lubricants.
PG alone demonstrated antioxidative and cytoprotective properties against cellular damage and gained a pro-oxidative property in combination with copper (II). It was reported that PG was one of the most active compounds capable of generating H2O2 in DMEM media
Main cancer-relevant pathways modulated by propyl gallate
A. Redox imbalance & oxidative stress (dominant)
-↑ Intracellular ROS (context- and dose-dependent)
  -Pro-oxidant in cancer cells with high basal ROS
  -Mitochondrial superoxide accumulation
  -Thiol depletion (↓ GSH, ↓ Trx buffering capacity)
Importance: ★★★★★  (Primary mechanism)

B. Mitochondrial dysfunction & intrinsic apoptosis
-↑ MOMP → caspase cascade
  -Loss of mitochondrial membrane potential (ΔΨm)
  -Cytochrome-c release
  -Caspase-9 → caspase-3 activation
  -↑ Bax / ↓ Bcl-2 ratio
Importance: ★★★★☆

C. ER stress & unfolded protein response (UPR)
-↑ PERK–eIF2α–ATF4–CHOP
  -ROS-linked protein misfolding
  -Pro-apoptotic UPR signaling dominates over adaptive UPR
Importance: ★★★☆☆

D. Cell cycle disruption
-G1 or G2/M arrest (cell-type dependent)
  -↓ Cyclin D1, Cyclin B1
  -↑ p21, p27
Importance: ★★☆☆☆

E. MAPK stress signaling
-↑ JNK / p38
  -Stress-activated apoptosis signaling
  -Often precedes mitochondrial failure
Importance: ★★☆☆☆

F. Inflammation & survival pathways (secondary)
-↓ NF-κB, ↓ STAT3 (indirect)
  -Suppression is largely ROS-mediated, not direct inhibition
  -Reduced anti-apoptotic gene transcription
Importance: ★★☆☆☆

G. NRF2–ARE signaling (dual role)
-Low dose: NRF2 activation → cytoprotection
  -High dose / cancer cells: NRF2 overwhelmed → apoptosis
Importance: ★★☆☆☆
(Highly context dependent; double-edged)
Rank Pathway / Target Axis Direction Primary Effect Notes / Cancer Relevance Ref
1 Glutathione (GSH) redox buffering ↓ GSH (depletion) Upstream redox vulnerability Leukemia and HeLa models report GSH depletion as an early, causal event in PG-induced cytotoxicity (ref)
2 Nrf2 antioxidant-response axis ↓ Nrf2 nuclear translocation → ↓ γ-GCS Impaired antioxidant capacity PG inhibits Nrf2 nuclear translocation and downstream glutathione-synthesis control, linking to GSH depletion and apoptosis in leukemia cells (ref)
3 Reactive oxygen species (ROS) balance (context-dependent) ↑ ROS (tumor models) / ↓ ROS (TMZ-combo migration model) Oxidative-stress modulation PG increases ROS in hepatocellular carcinoma (HCC) with autophagy/apoptosis; in TMZ-treated glioma, PG inhibits TMZ-induced ROS linked to reduced migration (ref)
4 MAPK stress signaling (ERK/JNK/p38) ↑ MAPK activation Stress-to-death signaling PG activates MAPKs; authors position MAPKs/Nrf2-mediated GSH depletion as an early driver of apoptosis (ref)
5 Autophagy program (LC3 conversion) ↑ autophagy Stress response contributing to growth inhibition HCC study: PG induces ROS and activates autophagy (LC3-I→LC3-II), with associated apoptosis markers (ref)
6 Apoptosis (caspase cascade; intrinsic/extrinsic components) ↑ caspase activation / ↑ apoptosis Programmed cell death Leukemia: caspases-3/8/9 activation with p53/Bax/Fas/FasL changes; lung cancer: caspase-dependent apoptosis with PARP cleavage (ref)
7 Cell-cycle regulation ↑ G1 arrest (e.g., ↑ p27) Proliferation blockade HeLa and lung cancer models report PG-induced G1 phase arrest with cell-cycle regulator changes (ref)
8 Lung cancer growth suppression ↓ proliferation / ↓ viability Anti-growth effect PG reduces growth of Calu-6 and A549 lung cancer cells with G1 arrest and caspase-dependent apoptosis (ref)
9 Migration / invasion phenotype (TMZ-combination glioma model) ↓ migration (via ↓ TMZ-induced ROS; NF-κB pathway implicated in full paper title) Anti-migratory effect (combination context) TMZ + PG enhances inhibition of U87MG glioma migration; abstract states PG inhibits TMZ-induced ROS and implicates mitochondrial complex III / NADPH oxidase as ROS sources (ref)
10 In vivo anti-tumor effect (HCC; zebrafish model) ↓ tumor growth / ↓ proliferation Demonstrated in vivo activity HCC study includes in vivo suppression (zebrafish) alongside ROS increase and autophagy activation (ref)


TumCCA, Tumor cell cycle arrest: Click to Expand ⟱
Source:
Type:
Tumor cell cycle arrest refers to the process by which cancer cells stop progressing through the cell cycle, which is the series of phases that a cell goes through to divide and replicate. This arrest can occur at various checkpoints in the cell cycle, including the G1, S, G2, and M phases. S, G1, G2, and M are the four phases of mitosis.
Scientific Papers found: Click to Expand⟱
1766- PG,    Propyl gallate induces human pulmonary fibroblast cell death through the regulation of Bax and caspase-3
- in-vitro, Nor, NA
TumCCA↑, MMP↓,
1768- PG,    Propyl gallate reduces the growth of lung cancer cells through caspase‑dependent apoptosis and G1 phase arrest of the cell cycle
- in-vitro, Lung, Calu-6 - in-vitro, Lung, A549
TumCG↓, TumCCA↑, Dose∅, Bcl-2↓, cl‑PARP↑, MMP↓, Casp3↑, Casp8↑,
5219- PG,    Propyl gallate inhibits the growth of HeLa cells via caspase-dependent apoptosis as well as a G1 phase arrest of the cell cycle
- in-vitro, Cerv, HeLa
TumCG↓, TumCCA↑, p27↑, Apoptosis↑, MMP↓, Casp3↑, Casp8↑, cl‑PARP↑,

Showing Research Papers: 1 to 3 of 3

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 3

Pathway results for Effect on Cancer / Diseased Cells:


Mitochondria & Bioenergetics ⓘ

MMP↓, 3,  

Cell Death ⓘ

Apoptosis↑, 1,   Bcl-2↓, 1,   Casp3↑, 2,   Casp8↑, 2,   p27↑, 1,  

DNA Damage & Repair ⓘ

cl‑PARP↑, 2,  

Cell Cycle & Senescence ⓘ

TumCCA↑, 3,  

Proliferation, Differentiation & Cell State ⓘ

TumCG↓, 2,  

Drug Metabolism & Resistance ⓘ

Dose∅, 1,  
Total Targets: 10

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: TumCCA, Tumor cell cycle arrest
3 Propyl gallate
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:138  Target#:322  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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