Database Query Results : Propyl gallate, ,

PG, Propyl gallate: Click to Expand ⟱
Features:
An ester formed by the condensation of gallic acid and propanol.
Propyl gallate (PG), chemically known as propyl-3,4,5-trihydroxybenzoate, is widely present in processed food and cosmetics, hair products, and lubricants.
PG alone demonstrated antioxidative and cytoprotective properties against cellular damage and gained a pro-oxidative property in combination with copper (II). It was reported that PG was one of the most active compounds capable of generating H2O2 in DMEM media
Main cancer-relevant pathways modulated by propyl gallate
A. Redox imbalance & oxidative stress (dominant)
-↑ Intracellular ROS (context- and dose-dependent)
  -Pro-oxidant in cancer cells with high basal ROS
  -Mitochondrial superoxide accumulation
  -Thiol depletion (↓ GSH, ↓ Trx buffering capacity)
Importance: ★★★★★  (Primary mechanism)

B. Mitochondrial dysfunction & intrinsic apoptosis
-↑ MOMP → caspase cascade
  -Loss of mitochondrial membrane potential (ΔΨm)
  -Cytochrome-c release
  -Caspase-9 → caspase-3 activation
  -↑ Bax / ↓ Bcl-2 ratio
Importance: ★★★★☆

C. ER stress & unfolded protein response (UPR)
-↑ PERK–eIF2α–ATF4–CHOP
  -ROS-linked protein misfolding
  -Pro-apoptotic UPR signaling dominates over adaptive UPR
Importance: ★★★☆☆

D. Cell cycle disruption
-G1 or G2/M arrest (cell-type dependent)
  -↓ Cyclin D1, Cyclin B1
  -↑ p21, p27
Importance: ★★☆☆☆

E. MAPK stress signaling
-↑ JNK / p38
  -Stress-activated apoptosis signaling
  -Often precedes mitochondrial failure
Importance: ★★☆☆☆

F. Inflammation & survival pathways (secondary)
-↓ NF-κB, ↓ STAT3 (indirect)
  -Suppression is largely ROS-mediated, not direct inhibition
  -Reduced anti-apoptotic gene transcription
Importance: ★★☆☆☆

G. NRF2–ARE signaling (dual role)
-Low dose: NRF2 activation → cytoprotection
  -High dose / cancer cells: NRF2 overwhelmed → apoptosis
Importance: ★★☆☆☆
(Highly context dependent; double-edged)
Rank Pathway / Target Axis Direction Primary Effect Notes / Cancer Relevance Ref
1 Glutathione (GSH) redox buffering ↓ GSH (depletion) Upstream redox vulnerability Leukemia and HeLa models report GSH depletion as an early, causal event in PG-induced cytotoxicity (ref)
2 Nrf2 antioxidant-response axis ↓ Nrf2 nuclear translocation → ↓ γ-GCS Impaired antioxidant capacity PG inhibits Nrf2 nuclear translocation and downstream glutathione-synthesis control, linking to GSH depletion and apoptosis in leukemia cells (ref)
3 Reactive oxygen species (ROS) balance (context-dependent) ↑ ROS (tumor models) / ↓ ROS (TMZ-combo migration model) Oxidative-stress modulation PG increases ROS in hepatocellular carcinoma (HCC) with autophagy/apoptosis; in TMZ-treated glioma, PG inhibits TMZ-induced ROS linked to reduced migration (ref)
4 MAPK stress signaling (ERK/JNK/p38) ↑ MAPK activation Stress-to-death signaling PG activates MAPKs; authors position MAPKs/Nrf2-mediated GSH depletion as an early driver of apoptosis (ref)
5 Autophagy program (LC3 conversion) ↑ autophagy Stress response contributing to growth inhibition HCC study: PG induces ROS and activates autophagy (LC3-I→LC3-II), with associated apoptosis markers (ref)
6 Apoptosis (caspase cascade; intrinsic/extrinsic components) ↑ caspase activation / ↑ apoptosis Programmed cell death Leukemia: caspases-3/8/9 activation with p53/Bax/Fas/FasL changes; lung cancer: caspase-dependent apoptosis with PARP cleavage (ref)
7 Cell-cycle regulation ↑ G1 arrest (e.g., ↑ p27) Proliferation blockade HeLa and lung cancer models report PG-induced G1 phase arrest with cell-cycle regulator changes (ref)
8 Lung cancer growth suppression ↓ proliferation / ↓ viability Anti-growth effect PG reduces growth of Calu-6 and A549 lung cancer cells with G1 arrest and caspase-dependent apoptosis (ref)
9 Migration / invasion phenotype (TMZ-combination glioma model) ↓ migration (via ↓ TMZ-induced ROS; NF-κB pathway implicated in full paper title) Anti-migratory effect (combination context) TMZ + PG enhances inhibition of U87MG glioma migration; abstract states PG inhibits TMZ-induced ROS and implicates mitochondrial complex III / NADPH oxidase as ROS sources (ref)
10 In vivo anti-tumor effect (HCC; zebrafish model) ↓ tumor growth / ↓ proliferation Demonstrated in vivo activity HCC study includes in vivo suppression (zebrafish) alongside ROS increase and autophagy activation (ref)


Scientific Papers found: Click to Expand⟱
1763- PG,    Generation of Hydrogen Peroxide in Cancer Cells: Advancing Therapeutic Approaches for Cancer Treatment
- Review, NA, NA
"highlight2" >*antiOx↑, "highlight2" >*ROS↓, "highlight2" >*ROS↑,
1764- PG,  Cu,    DNA strand break induction and enhanced cytotoxicity of propyl gallate in the presence of copper(II)
- in-vitro, Nor, GM05757
"highlight2" >*DNAdam↑, "highlight2" >*ROS↑, "highlight2" >*Dose∅, "highlight2" >*DNAdam∅,
1765- PG,    Enhanced cell death effects of MAP kinase inhibitors in propyl gallate-treated lung cancer cells are related to increased ROS levels and GSH depletion
- in-vitro, Lung, A549 - in-vitro, Lung, Calu-6
"highlight2" >TumCD↑, "highlight2" >MMP↓, "highlight2" >ROS↑, "highlight2" >GSH↓, "highlight2" >Dose∅, "highlight2" >eff↑,
1766- PG,    Propyl gallate induces human pulmonary fibroblast cell death through the regulation of Bax and caspase-3
- in-vitro, Nor, NA
"highlight2" >TumCCA↑, "highlight2" >MMP↓,
1767- PG,    Propyl gallate induces cell death in human pulmonary fibroblast through increasing reactive oxygen species levels and depleting glutathione
- in-vitro, Nor, NA
"highlight2" >*ROS↑, "highlight2" >*GSH↓, "highlight2" >*SOD↓, "highlight2" >*Catalase↓, "highlight2" >eff↓,
1768- PG,    Propyl gallate reduces the growth of lung cancer cells through caspase‑dependent apoptosis and G1 phase arrest of the cell cycle
- in-vitro, Lung, Calu-6 - in-vitro, Lung, A549
"highlight2" >TumCG↓, "highlight2" >TumCCA↑, "highlight2" >Dose∅, "highlight2" >Bcl-2↓, "highlight2" >cl‑PARP↑, "highlight2" >MMP↓, "highlight2" >Casp3↑, "highlight2" >Casp8↑,
1769- PG,    The Anti-Apoptotic Effects of Caspase Inhibitors in Propyl Gallate-Treated Lung Cancer Cells Are Related to Changes in Reactive Oxygen Species and Glutathione Levels
- in-vitro, Lung, Calu-6 - in-vitro, Lung, A549
"highlight2" >TumCP↓, "highlight2" >eff↑, "highlight2" >ROS↑, "highlight2" >GSH↓,
1770- PG,    Propyl gallate sensitizes human lung cancer cells to cisplatin-induced apoptosis by targeting heme oxygenase-1 for TRC8-mediated degradation
- in-vitro, Lung, NA
"highlight2" >antiOx↑, "highlight2" >Inflam↓, "highlight2" >HO-1↓, "highlight2" >eff↑, "highlight2" >ChemoSen↑,
1771- PG,    Pharmacokinetic and toxicological overview of propyl gallate food additive
- Human, Nor, NA
"highlight2" >*toxicity∅,
1772- PG,    Propyl gallate decreases the proliferation of Calu-6 and A549 lung cancer cells via affecting reactive oxygen species and glutathione levels
- in-vitro, Lung, Calu-6 - in-vitro, Lung, A549
"highlight2" >ROS⇅, "highlight2" >TumCP↓, "highlight2" >GSH↓,
1774- PG,    Geno- and cytotoxicity of propyl gallate food additive
- in-vitro, Lung, A549
"highlight2" >TumCG↓, "highlight2" >Dose∅, "highlight2" >DNAdam↑,
5217- PG,    Role of redox signaling regulation in propyl gallate-induced apoptosis of human leukemia cells
- in-vitro, AML, THP1 - in-vitro, AML, Jurkat - in-vitro, AML, HL-60
"highlight2" >tumCV↓, "highlight2" >Casp3↑, "highlight2" >Casp8↑, "highlight2" >Casp9↑, "highlight2" >P53↑, "highlight2" >BAX↑, "highlight2" >Fas↑, "highlight2" >FasL↑, "highlight2" >MAPK↑, "highlight2" >NRF2↓, "highlight2" >GSH↓,
5218- PG,    Propyl gallate inhibits hepatocellular carcinoma cell growth through the induction of ROS and the activation of autophagy
- in-vitro, HCC, Hep3B
"highlight2" >TumCP↓, "highlight2" >Apoptosis↑, "highlight2" >ROS↑, "highlight2" >TumAuto↑, "highlight2" >cl‑Casp3↑, "highlight2" >cl‑PARP↑, "highlight2" >BAX↑, "highlight2" >BAD↑, "highlight2" >Bcl-2↓, "highlight2" >toxicity↓, "highlight2" >hepatoP↑, "highlight2" >GSH↓,
5219- PG,    Propyl gallate inhibits the growth of HeLa cells via caspase-dependent apoptosis as well as a G1 phase arrest of the cell cycle
- in-vitro, Cerv, HeLa
"highlight2" >TumCG↓, "highlight2" >TumCCA↑, "highlight2" >p27↑, "highlight2" >Apoptosis↑, "highlight2" >MMP↓, "highlight2" >Casp3↑, "highlight2" >Casp8↑, "highlight2" >cl‑PARP↑,
5220- PG,  TMZ,    Propyl Gallate Exerts an Antimigration Effect on Temozolomide-Treated Malignant Glioma Cells through Inhibition of ROS and the NF- κ B Pathway
- in-vitro, GBM, U87MG
"highlight2" >TumCMig↓, "highlight2" >MMP2↓, "highlight2" >MMP9↓, "highlight2" >NF-kB↓, "highlight2" >ROS↑, "highlight2" >selectivity↑,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 15

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 1,   GSH↓, 5,   HO-1↓, 1,   NRF2↓, 1,   ROS↑, 4,   ROS⇅, 1,  

Mitochondria & Bioenergetics ⓘ

MMP↓, 4,  

Cell Death ⓘ

Apoptosis↑, 2,   BAD↑, 1,   BAX↑, 2,   Bcl-2↓, 2,   Casp3↑, 3,   cl‑Casp3↑, 1,   Casp8↑, 3,   Casp9↑, 1,   Fas↑, 1,   FasL↑, 1,   MAPK↑, 1,   p27↑, 1,   TumCD↑, 1,  

Transcription & Epigenetics ⓘ

tumCV↓, 1,  

Autophagy & Lysosomes ⓘ

TumAuto↑, 1,  

DNA Damage & Repair ⓘ

DNAdam↑, 1,   P53↑, 1,   cl‑PARP↑, 3,  

Cell Cycle & Senescence ⓘ

TumCCA↑, 3,  

Proliferation, Differentiation & Cell State ⓘ

TumCG↓, 3,  

Migration ⓘ

MMP2↓, 1,   MMP9↓, 1,   TumCMig↓, 1,   TumCP↓, 3,  

Immune & Inflammatory Signaling ⓘ

Inflam↓, 1,   NF-kB↓, 1,  

Drug Metabolism & Resistance ⓘ

ChemoSen↑, 1,   Dose∅, 3,   eff↓, 1,   eff↑, 3,   selectivity↑, 1,  

Functional Outcomes ⓘ

hepatoP↑, 1,   toxicity↓, 1,  
Total Targets: 40

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 1,   Catalase↓, 1,   GSH↓, 1,   ROS↓, 1,   ROS↑, 3,   SOD↓, 1,  

DNA Damage & Repair ⓘ

DNAdam↑, 1,   DNAdam∅, 1,  

Drug Metabolism & Resistance ⓘ

Dose∅, 1,  

Functional Outcomes ⓘ

toxicity∅, 1,  
Total Targets: 10

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:138  Target#:%  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

Home Page