Siegesbeckia glabrescens Cancer Research Results

GSL, Siegesbeckia glabrescens: Click to Expand ⟱
Features:
Germacranolide sesquiterpene lactone (GSL) was isolated from Siegesbeckia glabrescens as an inhibitor of Gli.


Scientific Papers found: Click to Expand⟱
108- GSL,    A sesquiterpene lactone from Siegesbeckia glabrescens suppresses Hedgehog/Gli-mediated transcription in pancreatic cancer cells
- in-vitro, PC, PANC1 - in-vitro, PC, AsPC-1 - in-vitro, PC, C3H10T1/2
HH↓, Gli1↓, cycD1/CCND1↓, TumCP↓,
7111- GSL,    In vitro antiinflammatory activity of a new sesquiterpene lactone isolated from Siegesbeckia glabrescens
- NA, Nor, NA
*NO↓, *PGE2↓, *iNOS↓, *COX2↓, *NF-kB↓, *Inflam↓,

Showing Research Papers: 1 to 2 of 2

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


Cell Cycle & Senescence(tgid=11) ⓘ

cycD1/CCND1↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

Gli1↓, 1,   HH↓, 1,  

Migration(tgid=13) ⓘ

TumCP↓, 1,  
Total Targets: 4

Pathway results for Effect on Normal Cells:


Cell Death(tgid=5) ⓘ

iNOS↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

NO↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2↓, 1,   Inflam↓, 1,   NF-kB↓, 1,   PGE2↓, 1,  
Total Targets: 6

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:151  Target#:%  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

Home Page