Siegesbeckia glabrescens / iNOS Cancer Research Results

GSL, Siegesbeckia glabrescens: Click to Expand ⟱

Features:

Germacranolide sesquiterpene lactone (GSL) was isolated from Siegesbeckia glabrescens as an inhibitor of Gli.

iNOS, Inducible nitric oxide synthase: Click to Expand ⟱

Source: HalifaxProj(block)

Type:

An enzyme that produces nitric oxide (NO) in response to inflammatory stimuli.
iNOS can promote tumor growth by enhancing blood flow and nutrient supply to tumors through vasodilation. It may also help cancer cells evade apoptosis (programmed cell death).
Immune Activation: In some contexts, NO produced by iNOS can enhance the immune response against tumors, promoting the activation of immune cells that can target and destroy cancer cells.
Inhibition of Tumor Growth: High levels of NO can induce cytotoxic effects on tumor cells, leading to reduced proliferation and increased apoptosis.

Scientific Papers found: Click to Expand⟱

7111-

GSL,

In vitro antiinflammatory activity of a new sesquiterpene lactone isolated from Siegesbeckia glabrescens

NA,

Nor,

*NO↓, *PGE2↓, *iNOS↓, *COX2↓, *NF-kB↓, *Inflam↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:

Total Targets: 0

Pathway results for Effect on Normal Cells:

Cell Death(tgid=5) ⓘ

iNOS↓, 1,

Angiogenesis & Vasculature(tgid=14) ⓘ

NO↓, 1,

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2↓, 1, Inflam↓, 1, NF-kB↓, 1, PGE2↓, 1,
Total Targets: 6

Scientific Paper Hit Count for: iNOS, Inducible nitric oxide synthase

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells