Database Query Results : Silver-NanoParticles, ,

AgNPs, Silver-NanoParticles: Click to Expand ⟱

Features:

Silver NanoParticles (AgNPs)
Summary:
1.Smaller sizes are generally more bioactive due to increased surface area and enhanced tumor accumulation via the enhanced permeability and retention (EPR) effect.
2.Two relevant forms: particulate silver (AgNPs) and ionic silver (Ag⁺). There is debate regarding oral use, as Ag⁺ can precipitate as AgCl in gastric acid, reducing bioavailability; AgNPs may partially avoid this via particulate uptake and intracellular Ag⁺ release. Gastric pH may influence this equilibrium.
3. Dose example 80kg person: 1.12-2mg/day, which can be calculated based on ppm and volume taken (see below) target < 10ppm and 120mL per day (30ppm and 1L per day caused argyria 30mg/day ) (Case Report: 9‐15 ppm@120mL, i.e. 1.1mg/L to 1.8mg/L per day)
Likely 10ppm --> 10mg/L, hence if take 100mL, then 1mg/day? (for Cancer)
The current Rfd for oral silver exposure is 5 ug/kg/d with a critical dose estimated at 14 ug/kg/d for the average person.
Seems like the Cancer target range is 14ug/kg/day to 25ug/kg/day. 80Kg example: 1.12mg to 2mg “1.4µg/kg body weight. If I would have 70kg, I would want to use 100µg/day. However, for fighting active disease, I would tend to explore higher daily dose, as I think this may be too low.”
These values reflect experimental or anecdotal contexts and are not established safe or therapeutic doses.
4. Antioxidants such as NAC can counteract AgNP cytotoxicity by restoring glutathione pools and suppressing ROS-mediated mitochondrial damage.
5. In vitro studies commonly show ROS elevation in both cancer and normal cells; however, in vivo, superior antioxidant, NRF2, and repair capacity in normal tissues may confer selectivity.
6. Pathways/mechanisms of action/:
-” intracellular ROS was increased...reduction in levels of glutathione (GSH)”
- Normal-cell selectivity is partly mediated by NRF2-dependent antioxidant and detoxification responses.
- AgNPs impair mitochondrial electron transport, increasing electron leak and amplifying ROS upstream of ΔΨm collapse.
-AgNPs inhibit VEGF-driven endothelial signaling and permeability (anti-angiogenic effect)
-”upregulation of proapoptotic genes (p53, p21, Bax, and caspases) and downregulation of antiapoptotic genes (Bcl-2)”
-” upregulation of AMPK and downregulation of mTOR, MMP-9, BCL-2, and α-SMA”
-”p53 is a key player...proapoptotic genes p53 and Bax were significantly increased... noticeable reduction in Bcl-2 transcript levels”
-” p53 participates directly in the intrinsic apoptosis pathway by regulating the mitochondrial outer membrane permeabilization”
- “Proapoptotic markers (BAX/BCL-XL, cleaved poly(ADP-ribose) polymerase, p53, p21, and caspases 3, 8 and 9) increased.”
-”The antiapoptotic markers, AKT and NF-kB, decreased in AgNP-treated cells.”

Chronic accumulation and long-term systemic effects remain insufficiently characterized.

Silver NanoParticles and Magnetic Fields
Summary:
1. “exposure to PMF increased the ability of AgNPs uptake”
2. 6x improvement from AgNPs alone

could glucose capping of SilverNPs work as trojan horse?

Sodium selenite might protect against toxicity of AgNPs in normal cells.

-uncoated AgNPs can degrade the gut microbiome. PVP, citrate, green-synthesized, chitosan coating, may reduce the effect.
Similar oxidative considerations may apply to selenium compounds, though mechanisms differ.
co-ingestion with food (higher pH) favors reduction and lower Ag+ levels.
-action mechanisms of AgNPs: the release of silver ions (Ag+), generation of reactive oxygen species (ROS), destruction of membrane structure.

AgNP anticancer effects come from three overlapping mechanisms:
-Nanoparticle–cell interaction (uptake, membrane effects)
-Intracellular ROS generation
-Controlled Ag⁺ release inside cancer cells

Comparison adding Citrate Capping
| Property              | Uncapped AgNPs | Citrate-capped AgNPs |
| --------------------- | -------------- | -------------------- |
| Stability             | Poor           | Excellent            |
| Free Ag⁺              | High           | Low                  |
| Normal cell toxicity  | Higher         | Lower                |
| Cancer selectivity    | Lower          | **Higher**           |
| Mechanism specificity | Crude          | **Targeted**         |
| Storage behavior      | Degrades       | Stable               |

Rank	Pathway / Target Axis	Cancer Cells	Normal Cells	Primary Effect	Notes / Cancer Relevance	Ref
1	Oxidative stress / ROS generation	↑ ROS (sustained)	↑ transient ROS → ↓ net ROS after adaptation	Upstream cytotoxic trigger	AgNP exposure commonly elevates ROS in cancer cells, initiating downstream stress-death programs	(ref)
2	Thiol buffering (GSH pool)	↓ GSH (depletion)	↔ or transient ↓ with recovery	Loss of redox buffering	Colon cancer model: AgNPs induce oxidative cell damage through inhibition/depletion of reduced glutathione with downstream mitochondrial apoptosis	(ref)
3	Mitochondrial ETC / respiration	↓ ETC efficiency; ↑ electron leak	↔ mild inhibition with recovery	Bioenergetic destabilization	ETC impairment amplifies ROS, precedes ΔΨm loss, and contributes to ATP collapse in cancer cells
4	Mitochondrial integrity (ΔΨm / MMP)	↓ ΔΨm	↔ largely preserved	Mitochondrial dysfunction	Breast cancer model: AgNP exposure dissipates mitochondrial membrane potential during cytotoxic progression	(ref)
5	Intrinsic apoptosis (caspase cascade)	↑ caspase-dependent apoptosis	↔ minimal activation	Programmed cell death	Colon cancer model: “silver-based nanoparticles” induce apoptosis mediated through p53 (apoptosis direction shown)	(ref)
6	Genotoxic stress / DNA damage	↑ DNA damage	↑ damage at high dose with efficient repair	Checkpoint/death signaling	Study documents AgNP-mediated DNA damage; susceptibility increases with impaired DNA repair capacity	(ref)
7	ER stress / UPR (CHOP-dependent)	↑ ER stress → apoptosis	↑ adaptive UPR (no CHOP)	Proteotoxic stress signaling	Breast cancer cells: AgNPs induce “irremediable” ER stress leading to UPR-dependent apoptosis	(ref)
8	Autophagy program	↑ autophagy (protective)	↑ adaptive autophagy	Stress adaptation	AgNPs induce autophagy in cancer cells; inhibiting autophagy enhances AgNP anticancer killing	(ref)
9	Autophagic flux / lysosomal function	↓ flux (lysosomal defect)	↔ preserved flux	Autophagic failure	AgNP-induced lysosomal dysfunction drives autophagic flux defects (LC3-II accumulation)	(ref)
10	NRF2 antioxidant response	↔ insufficient activation	↑ NRF2 activation	Adaptive redox defense	NRF2 activation in normal cells restores GSH and antioxidant enzymes, limiting toxicity
11	Stress MAPK (p38) / checkpoint signaling	↑ p38 → arrest/apoptosis	↑ transient p38 → recovery	Stress signaling	Jurkat T-cell model shows p38 MAPK activation with DNA damage and apoptosis	(ref)
12	Angiogenesis / invasion (VEGF, NF-κB-linked)	↓ angiogenesis / ↓ invasion	↔ minimal effect	Anti-angiogenic / anti-invasive	AgNPs inhibit VEGF-induced permeability and invasion in tumor models	(ref)

Scientific Papers found: Click to Expand⟱

4562-

AgNPs,

VitC,

Eco-friendly Synthesis of Silver Nanoparticles using Ascorbic Acid and its Optical Characterization

Study,

NA,

"highlight2" >*other↑, "highlight2" >*other↝,

4584-

AgNPs,

Silver Nanoparticles Synthesized Using Carica papaya Leaf Extract (AgNPs-PLE) Causes Cell Cycle Arrest and Apoptosis in Human Prostate (DU145) Cancer Cells

in-vitro,

Pca,

DU145

"highlight2" >selectivity↑, "highlight2" >ROS↑, "highlight2" >BAX↑, "highlight2" >cl‑Casp3↑, "highlight2" >p‑PARP↑, "highlight2" >TumCCA↑, "highlight2" >cycD1/CCND1↓, "highlight2" >p27↑, "highlight2" >P21↑, "highlight2" >AntiCan↑,

4583-

AgNPs,

Metal-Based Nanoparticles for Cardiovascular Diseases

Review,

NA,

"highlight2" >RadioS↑, "highlight2" >*ROS↑, "highlight2" >*BBB↝,

4582-

AgNPs,

Silver CASRN 7440-22-4 | DTXSID4024305

"highlight2" >*Dose↝,

4581-

AgNPs,

Antimicrobial, anticoagulant and antiplatelet activities of green synthesized silver nanoparticles using Selaginella (Sanjeevini) plant extract

"highlight2" >*Bacteria↓, "highlight2" >*AntiAg↑, "highlight2" >*toxicity↓,

4580-

AgNPs,

Biogenic Synthesis of Antibacterial, Hemocompatible, and Antiplatelets Lysozyme Functionalized Silver Nanoparticles through the One-Step Process for Therapeutic Applications

in-vitro,

NA,

"highlight2" >*AntiAg↑,

4579-

AgNPs,

Response of platelets to silver nanoparticles designed with different surface functionalization

"highlight2" >*AntiAg↑, "highlight2" >*AntiThr↑, "highlight2" >*Dose↝,

4578-

AgNPs,

Green synthesized novel silver nanoparticles and their application as anticoagulant and thrombolytic agents: A perspective

Review,

NA,

"highlight2" >*AntiThr↑,

4577-

AgNPs,

Characterization of Antiplatelet Properties of Silver Nanoparticles

vitro+vivo,

Stroke,

"highlight2" >*AntiAg↑, "highlight2" >*Bacteria↓, "highlight2" >*Dose↝, "highlight2" >*Dose↝, "highlight2" >*Dose↝, "highlight2" >*toxicity↝,

4576-

AgNPs,

Nanosilver, Next-Generation Antithrombotic Agent

Study,

NA,

"highlight2" >*AntiAg↑, "highlight2" >*Bacteria↓,

4574-

AgNPs,

Advances in nano silver-based biomaterials and their biomedical applications

Review,

NA,

"highlight2" >*Wound Healing↑, "highlight2" >*AntiThr↑, "highlight2" >*AntiAg↑, "highlight2" >eff↑,

4573-

AgNPs,

Bioactive silver nanoparticles derived from Carica papaya floral extract and its dual-functioning biomedical application

in-vitro,

Var,

MCF-7

21.25 ± 1.14 µg/mL

NA,

HEK293

169.96 ± 2.3 µg/mL

"highlight2" >toxicity↓, "highlight2" >Bacteria↓, "highlight2" >selectivity↑,

4564-

AgNPs,

GoldNP,

Cu,

Chemo,

PDT

Cytotoxicity and targeted drug delivery of green synthesized metallic nanoparticles against oral Cancer: A review

Review,

Var,

"highlight2" >ROS↑, "highlight2" >DNAdam↑, "highlight2" >TumCCA↑, "highlight2" >eff↑, "highlight2" >Apoptosis↑, "highlight2" >eff↓, "highlight2" >ChemoSen↑,

4563-

AgNPs,

Rad,

Silver nanoparticles enhance neutron radiation sensitivity in cancer cells: An in vitro study

in-vitro,

BC,

MCF-7

in-vitro,

Ovarian,

SKOV3

in-vitro,

GBM,

U87MG

in-vitro,

Melanoma,

A431

"highlight2" >RadioS↑, "highlight2" >ROS↑, "highlight2" >TumCCA↑, "highlight2" >Apoptosis↑, "highlight2" >ER Stress↑,

4585-

AgNPs,

Tyndall-effect-based colorimetric assay with colloidal silver nanoparticles for quantitative point-of-care detection of creatinine using a laser pointer pen and a smartphone

"highlight2" >*other↝,

4561-

AgNPs,

VitC,

Cellular Effects Nanosilver on Cancer and Non-cancer Cells: Potential Environmental and Human Health Impacts

in-vitro,

CRC,

HCT116

in-vitro,

Nor,

HEK293

"highlight2" >NRF2↑, "highlight2" >TumCCA↑, "highlight2" >ROS↑, "highlight2" >selectivity↑, "highlight2" >*AntiViral↑, "highlight2" >*toxicity↝, "highlight2" >ETC↓, "highlight2" >MMP↓, "highlight2" >DNAdam↑, "highlight2" >Apoptosis↑, "highlight2" >lipid-P↑, "highlight2" >other↝, "highlight2" >UPR↑, "highlight2" >*GRP78/BiP↑, "highlight2" >*p‑PERK↑, "highlight2" >*cl‑eIF2α↑, "highlight2" >*CHOP↑, "highlight2" >*JNK↑, "highlight2" >Hif1a↓, "highlight2" >AntiCan↑, "highlight2" >*toxicity↓, "highlight2" >eff↑,

4560-

AgNPs,

Exploiting antidiabetic activity of silver nanoparticles synthesized using Punica granatum leaves and anticancer potential against human liver cancer cells (HepG2)

in-vitro,

Liver,

HepG2

in-vitro,

Diabetic,

"highlight2" >AntiCan↑, "highlight2" >Dose↝, "highlight2" >*antiOx↑, "highlight2" >*AntiDiabetic↑, "highlight2" >*Bacteria↓,

4559-

AgNPs,

Anticancer activity of biogenerated silver nanoparticles: an integrated proteomic investigation

in-vitro,

BC,

SkBr3

IC50 value of 5 μg/ml

in-vitro,

CRC,

HT-29

in-vitro,

CRC,

HCT116

in-vitro,

Colon,

Caco-2

"highlight2" >MMP2↓, "highlight2" >MMP9↓, "highlight2" >ROS↑, "highlight2" >TumAuto↑, "highlight2" >Apoptosis↑, "highlight2" >ER Stress↑,

4558-

AgNPs,

Role of Oxidative and Nitro-Oxidative Damage in Silver Nanoparticles Cytotoxic Effect against Human Pancreatic Ductal Adenocarcinoma Cells

in-vitro,

PC,

PANC1

3.19 ug/mL

"highlight2" >ROS↑, "highlight2" >selectivity↑, "highlight2" >NO↑, "highlight2" >SOD↓, "highlight2" >GPx4↓, "highlight2" >Catalase↓, "highlight2" >TumCCA↑, "highlight2" >MMP↓,

4557-

AgNPs,

The apoptotic effect of nanosilver is mediated by a ROS- and JNK-dependent mechanism involving the mitochondrial pathway in NIH3T3 cells

in-vitro,

NA,

NIH-3T3

in-vitro,

CRC,

HCT116

"highlight2" >Cyt‑c↑, "highlight2" >ROS↑, "highlight2" >JNK↑,

4556-

AgNPs,

Biofilm Impeding AgNPs Target Skin Carcinoma by Inducing Mitochondrial Membrane Depolarization Mediated through ROS Production

in-vitro,

Melanoma,

A431

"highlight2" >MMP↓, "highlight2" >ROS↑, "highlight2" >*toxicity↓, "highlight2" >Bacteria↓,

4555-

AgNPs,

Silver nanoparticles from Dendropanax morbifera Léveille inhibit cell migration, induce apoptosis, and increase generation of reactive oxygen species in A549 lung cancer cells

in-vitro,

Lung,

A549

in-vitro,

Liver,

HepG2

"highlight2" >*Bacteria↓, "highlight2" >tumCV↓, "highlight2" >selectivity↑, "highlight2" >ROS↑, "highlight2" >Apoptosis↑, "highlight2" >TumCMig↓, "highlight2" >AntiCan↑,

4554-

AgNPs,

Involvement of telomerase activity inhibition and telomere dysfunction in silver nanoparticles anticancer effects

in-vitro,

Cerv,

HeLa

"highlight2" >Telomerase↓, "highlight2" >eff↝,

4553-

AgNPs,

Cytotoxicity induced by engineered silver nanocrystallites is dependent on surface coatings and cell types

in-vitro,

Nor,

RAW264.7

"highlight2" >*Wound Healing↑, "highlight2" >*eff↝, "highlight2" >*toxicity↝,

4552-

AgNPs,

ART/DHA,

Green synthesis of silver nanoparticles using Artemisia turcomanica leaf extract and the study of anti-cancer effect and apoptosis induction on gastric cancer cell line (AGS)

in-vitro,

GC,

AGS

"highlight2" >AntiCan↑, "highlight2" >Apoptosis↑, "highlight2" >eff↑,

4397-

AgNPs,

Synthesis and Characterization of Silver Nanoparticles from Rhizophora apiculata and Studies on Their Wound Healing, Antioxidant, Anti-Inflammatory, and Cytotoxic Activity

NA,

Wounds,

 99 nm, with a zeta potential of −6 mV

"highlight2" >selectivity↑, "highlight2" >tumCV↓, "highlight2" >antiOx↑, "highlight2" >Inflam↓,

4550-

AgNPs,

The Effect of Charge at the Surface of Silver Nanoparticles on Antimicrobial Activity against Gram-Positive and Gram-Negative Bacteria: A Preliminary Study

Study,

Nor,

"highlight2" >*Bacteria↓,

4599-

AgNPs,

ProBio,

Impacts of dietary silver nanoparticles and probiotic administration on the microbiota of an in-vitro gut model

in-vivo,

Nor,

"highlight2" >*GutMicro∅, "highlight2" >*chemoPv↑,

5239-

AgNPs,

NOX4- and Nrf2-mediated oxidative stress induced by silver nanoparticles in vascular endothelial cells

in-vitro,

Nor,

HUVECs

"highlight2" >*ROS↑, "highlight2" >*Apoptosis↑, "highlight2" >*NRF2↝,

5238-

AgNPs,

β-Sitosterol-assisted silver nanoparticles activates Nrf2 and triggers mitochondrial apoptosis via oxidative stress in human hepatocellular cancer cell line

in-vitro,

HCC,

HepG2

"highlight2" >TumCP↓, "highlight2" >ROS↑, "highlight2" >NRF2↑, "highlight2" >BAX↑, "highlight2" >P53↑, "highlight2" >Cyt‑c↑, "highlight2" >Casp9↑, "highlight2" >Casp3↑, "highlight2" >Bcl-2↓,

5237-

AgNPs,

Nrf2 Activation Mitigates Silver Nanoparticle-Induced Ferroptosis in Hepatocytes

in-vitro,

Liver,

HepG2

"highlight2" >Ferroptosis↑, "highlight2" >p62↑, "highlight2" >NRF2↝, "highlight2" >eff↓,

5236-

AgNPs,

Adaptive regulations of Nrf2 alleviates silver nanoparticles-induced oxidative stress-related liver cells injury

in-vitro,

Liver,

HepG2

in-vitro,

Nor,

L02

"highlight2" >tumCV↓, "highlight2" >ROS↑, "highlight2" >*ROS↑, "highlight2" >DNAdam↑, "highlight2" >*DNAdam↑, "highlight2" >eff↓, "highlight2" >selectivity↑,

5147-

AgNPs,

Size dependent anti-invasiveness of silver nanoparticles in lung cancer cells

in-vitro,

Lung,

A549

"highlight2" >TumCMig↓, "highlight2" >TumCI↓, "highlight2" >ROS↑, "highlight2" >p‑NF-kB↑, "highlight2" >selectivity↑, "highlight2" >eff↝,

5146-

AgNPs,

Silver Nanoparticle-Induced Autophagic-Lysosomal Disruption and NLRP3-Inflammasome Activation in HepG2 Cells Is Size-Dependent

in-vitro,

Liver,

HepG2

"highlight2" >TumAuto↑, "highlight2" >EPR↑, "highlight2" >LC3B↑, "highlight2" >CHOP↑, "highlight2" >ER Stress↑, "highlight2" >NLRP3↑, "highlight2" >Casp1↓,

5145-

AgNPs,

Silver nanoparticles induce irremediable endoplasmic reticulum stress leading to unfolded protein response dependent apoptosis in breast cancer cells

in-vitro,

BC,

MCF-7

in-vitro,

BC,

T47D

"highlight2" >Bacteria↓, "highlight2" >Apoptosis↑, "highlight2" >ER Stress↑, "highlight2" >UPR↑, "highlight2" >PERK↑, "highlight2" >IRE1↑, "highlight2" >ATF6↑, "highlight2" >ATF4↑, "highlight2" >CHOP↑, "highlight2" >Casp9↑, "highlight2" >Casp7↑, "highlight2" >Mcl-1↓, "highlight2" >XIAP↓, "highlight2" >PARP↝, "highlight2" >selectivity↑,

5144-

AgNPs,

Differential effects of silver nanoparticles on DNA damage and DNA repair gene expression in Ogg1-deficient and wild type mice

in-vivo,

Nor,

orally to 4 mg/kg of citrate-coated AgNPs over a period of 7 d.

wild type mice

"highlight2" >*DNAdam↑, "highlight2" >*toxicity↝, "highlight2" >eff↝,

5143-

AgNPs,

Thermal Co-reduction engineered silver nanoparticles induce oxidative cell damage in human colon cancer cells through inhibition of reduced glutathione and induction of mitochondria-involved apoptosis

in-vitro,

CRC,

HCT116

28.11 μg/ml.

"highlight2" >ROS↑, "highlight2" >lipid-P↑, "highlight2" >GSH↓, "highlight2" >MMP↓, "highlight2" >Casp3↑, "highlight2" >Apoptosis↑, "highlight2" >TumCCA↑,

5142-

AgNPs,

Biosynthesized Protein-Capped Silver Nanoparticles Induce ROS-Dependent Proapoptotic Signals and Prosurvival Autophagy in Cancer Cells

in-vitro,

CRC,

HUH7

220 and 249 nm

"highlight2" >ROS↑, "highlight2" >Apoptosis↑, "highlight2" >eff↑, "highlight2" >ChemoSen↑, "highlight2" >EPR↑, "highlight2" >Casp↑, "highlight2" >MAPK↑,

4661-

AgNPs,

Silver nanoparticles induces apoptosis of cancer stem cells in head and neck cancer

in-vitro,

HNSCC,

"highlight2" >TumCD↑, "highlight2" >CSCs↝,

4600-

AgNPs,

Effects of particle size and coating on toxicologic parameters, fecal elimination kinetics and tissue distribution of acutely ingested silver nanoparticles in a mouse model

in-vivo,

Nor,

Mice

"highlight2" >*Half-Life↝, "highlight2" >*toxicity↓, "highlight2" >*Dose↑, "highlight2" >*other↝, "highlight2" >*eff↝, "highlight2" >*BioAv↓,

4551-

AgNPs,

Fenb,

Ångstrom-Scale Silver Particles as a Promising Agent for Low-Toxicity Broad-Spectrum Potent Anticancer Therapy

in-vivo,

Lung,

mice

"highlight2" >eff↑, "highlight2" >eff↑, "highlight2" >Apoptosis↑, "highlight2" >selectivity↓, "highlight2" >TumCG↓,

4598-

AgNPs,

In vivo human time-exposure study of orally dosed commercial silver nanoparticles

in-vivo,

Nor,

62 Human voluneers

"highlight2" >*toxicity∅, "highlight2" >*Dose↝, "highlight2" >*Dose↝, "highlight2" >*BioAv↝, "highlight2" >*BioAv↝, "highlight2" >*H2O2∅, "highlight2" >*IL8∅, "highlight2" >*IL1α∅, "highlight2" >*IL1β∅, "highlight2" >*MCP1∅, "highlight2" >*NQO1∅, "highlight2" >*BioAv↓,

4596-

AgNPs,

Oral administration of silver nanomaterials affects the gut microbiota and metabolic profile altering the secretion of 5-HT in mice

in-vivo,

NA,

Mice

"highlight2" >*GutMicro↝, "highlight2" >*5HT↑,

4595-

AgNPs,

ORAL DELIVERY OF SILVER NANOPARTICLES – A REVIEW

Review,

NA,

"highlight2" >*BioAv↝,

4594-

AgNPs,

Citrate,

Bioavailability and Toxicokinetics of citrate-coated silver nanoparticles in rats

in-vivo,

Nor,

rats

"highlight2" >*BioAv↓,

4593-

AgNPs,

Chit,

Chitosan-coated silver nanoparticles promoted antibacterial, antibiofilm, wound-healing of murine macrophages and antiproliferation of human breast cancer MCF 7 cells

in-vitro,

BC,

MCF-7

"highlight2" >*Bacteria↓, "highlight2" >*Wound Healing↑, "highlight2" >TumCG↓,

4592-

AgNPs,

Chit,

Chitosan conjugated silver nanoparticles: the versatile antibacterial agents

in-vitro,

NA,

"highlight2" >*Bacteria↓,

4591-

AgNPs,

Chit,

Synthesis and Characterization of Multifunctional Chitosan–Silver Nanoparticles: An In-Vitro Approach for Biomedical Applications

in-vitro,

NA,

"highlight2" >*Bacteria↓, "highlight2" >*Wound Healing↑,

4590-

AgNPs,

Chit,

Silver nanochitosan: a sustainable approach for enhanced antimicrobial, antioxidant, and anticancer applications

in-vitro,

NA,

"highlight2" >*Bacteria↓, "highlight2" >*Wound Healing↑,

4589-

AgNPs,

Chit,

Synthesis and Characterization of Chitosan–Silver Nanocomposite Film: Antibacterial and Cytotoxicity Study

in-vitro,

NA,

"highlight2" >*Bacteria↓,

4588-

AgNPs,

Chit,

Solid-state tailored silver nanocomposites from chitosan: Synthesis, antimicrobial evaluation and molecular docking

in-vitro,

NA,

"highlight2" >*Bacteria↓,

4587-

AgNPs,

Chit,

Multifunctional Silver Nanoparticles Based on Chitosan: Antibacterial, Antibiofilm, Antifungal, Antioxidant, and Wound-Healing Activities

in-vitro,

NA,

"highlight2" >*Bacteria↓, "highlight2" >*Wound Healing↑,

4586-

AgNPs,

Tyndall-effect-enhanced supersensitive naked-eye determination of mercury (II) ions with silver nanoparticles

"highlight2" >*other↝, "highlight2" >*other↝,

4410-

AgNPs,

Green-synthesized silver nanoparticles: a sustainable nanoplatform for targeted colon cancer therapy

Review,

Colon,

"highlight2" >AntiCan↑, "highlight2" >ROS↑, "highlight2" >mtDam↑, "highlight2" >tumCV↓, "highlight2" >selectivity↑,

4424-

AgNPs,

Understanding the prospective of nano-formulations towards the treatment of psoriasis

in-vivo,

PSA,

"highlight2" >*eff↑,

4549-

AgNPs,

Silver nanoparticles: Synthesis, medical applications and biosafety

Review,

Var,

Review,

Diabetic,

"highlight2" >ROS↑, "highlight2" >eff↑, "highlight2" >other↝, "highlight2" >DNAdam↑, "highlight2" >EPR↑, "highlight2" >eff↑, "highlight2" >eff↑, "highlight2" >TumMeta↓, "highlight2" >angioG↓, "highlight2" >*Bacteria↓, "highlight2" >*eff↑, "highlight2" >*AntiViral↑, "highlight2" >*AntiFungal↑, "highlight2" >eff↑, "highlight2" >eff↑, "highlight2" >TumCP↓, "highlight2" >tumCV↓, "highlight2" >P53↝, "highlight2" >HIF-1↓, "highlight2" >TumCCA↑, "highlight2" >lipid-P↑, "highlight2" >ATP↓, "highlight2" >Cyt‑c↑, "highlight2" >MMPs↓, "highlight2" >PI3K↓, "highlight2" >Akt↓, "highlight2" >*Wound Healing↑, "highlight2" >*Inflam↓, "highlight2" >*Bone Healing↑, "highlight2" >*glucose↓, "highlight2" >*AntiDiabetic↑, "highlight2" >*BBB↑,

4422-

AgNPs,

Bioengineering of Piper longum L. extract mediated silver nanoparticles and their potential biomedical applications

in-vitro,

Cerv,

HeLa

"highlight2" >AntiCan↑, "highlight2" >selectivity↑,

4421-

AgNPs,

Effect of Biologically Synthesized Silver Nanoparticles on Human Cancer Cells

in-vitro,

Cerv,

"highlight2" >selectivity↑, "highlight2" >eff↝, "highlight2" >other↝,

4419-

AgNPs,

Tackling the various classes of nano-therapeutics employed in topical therapy of psoriasis

NA,

PSA,

"highlight2" >IL1α↓, "highlight2" >other↝,

4418-

AgNPs,

Nanocarriers for the topical treatment of psoriasis - pathophysiology, conventional treatments, nanotechnology, regulatory and toxicology

Human,

PSA,

"highlight2" >*Inflam↓, "highlight2" >*EPR↑,

4417-

AgNPs,

Caffeine-boosted silver nanoparticles target breast cancer cells by triggering oxidative stress, inflammation, and apoptotic pathways

in-vitro,

BC,

MDA-MB-231

"highlight2" >ROS↑, "highlight2" >MDA↑, "highlight2" >COX2↑, "highlight2" >IL1β↑, "highlight2" >TNF-α↑, "highlight2" >GSH↓, "highlight2" >Cyt‑c↑, "highlight2" >Casp3↑, "highlight2" >BAX↑, "highlight2" >Bcl-2↓, "highlight2" >LDH↓, "highlight2" >cycD1/CCND1↓, "highlight2" >CDK2↓, "highlight2" >TumCCA↑, "highlight2" >mt-Apoptosis↑,

4416-

AgNPs,

Efficacy of curcumin-synthesized silver nanoparticles on MCF-7 breast cancer cells

in-vitro,

BC,

MCF-7

"highlight2" >TumCMig↓, "highlight2" >Apoptosis↑, "highlight2" >BAX↑, "highlight2" >P53↑, "highlight2" >Bcl-2↓,

4415-

AgNPs,

SDT,

CUR,

Examining the Impact of Sonodynamic Therapy With Ultrasound Wave in the Presence of Curcumin-Coated Silver Nanoparticles on the Apoptosis of MCF7 Breast Cancer Cells

in-vitro,

BC,

MCF-7

29.3 ± 5.6 nm

 48.23 µg/ml

SDT was performed using an US frequency of 1 MHz, intensity of 2 W/cm2, and a distance of 2 cm.

"highlight2" >tumCV↓, "highlight2" >BAX↑, "highlight2" >Casp3↑, "highlight2" >Bcl-2↓, "highlight2" >eff↑, "highlight2" >ROS↑, "highlight2" >sonoS↑, "highlight2" >eff↑, "highlight2" >MMP↓, "highlight2" >Cyt‑c↑,

4414-

AgNPs,

Silver nanoparticles: Forging a new frontline in lung cancer therapy

Review,

Lung,

"highlight2" >tumCV↑, "highlight2" >ROS↑, "highlight2" >MMP↓, "highlight2" >TumCCA↑, "highlight2" >Apoptosis↑, "highlight2" >angioG↓,

4413-

AgNPs,

Anzaroot,

Green synthesis of silver nanoparticles from plant Astragalus fasciculifolius Bioss and evaluating cytotoxic effects on MCF7 human breast cancer cells

in-vitro,

BC,

MCF-7

12.35 μg/mL

The IC50 value for root extract-mediated SNPs was found to be 21.73 μg/mL

"highlight2" >chemoP↑, "highlight2" >TumCG↓, "highlight2" >eff↑, "highlight2" >CellMemb↑, "highlight2" >selectivity↑, "highlight2" >ROS↑, "highlight2" >P53↑,

4412-

AgNPs,

Biosynthesis and characterization of silver nanoparticles from Asplenium dalhousiae and their potential biological properties

in-vitro,

CRC,

HCT116

in-vitro,

Melanoma,

A2780S

"highlight2" >Bacteria↓, "highlight2" >antiOx↑, "highlight2" >AntiCan↑, "highlight2" >eff↑,

4411-

AgNPs,

Eco-friendly synthesis of silver nanoparticles using Anemone coronaria bulb extract and their potent anticancer and antibacterial activities

in-vitro,

Lung,

A549

in-vitro,

PC,

MIA PaCa-2

in-vitro,

Pca,

PC3

in-vitro,

Nor,

HEK293

"highlight2" >AntiCan↑, "highlight2" >selectivity↑, "highlight2" >Apoptosis↑, "highlight2" >TumCCA↑, "highlight2" >Bacteria↓, "highlight2" >tumCV↓, "highlight2" >selectivity↑, "highlight2" >Apoptosis↑, "highlight2" >TumCCA↑,

4423-

AgNPs,

Pongamia pinnata seed extract-mediated green synthesis of silver nanoparticle loaded nanogel for estimation of their antipsoriatic properties

in-vivo,

PSA,

 116 nm

"highlight2" >*eff↑, "highlight2" >*other↑,

4409-

AgNPs,

Plant-based synthesis of gold and silver nanoparticles using Artocarpus heterophyllus aqueous leaf extract and its anticancer activities

in-vitro,

BC,

MCF-7

12.75 nm

54.981 µg/mL

"highlight2" >tumCV↓, "highlight2" >TumCCA↑, "highlight2" >cycD1/CCND1↓, "highlight2" >COX2↓, "highlight2" >HER2/EBBR2↓,

4408-

AgNPs,

Chitosan-coated silver nanoparticles synthesized using Moringa oleifera flower extract: A potential therapeutic approach against triple-negative breast cancer

in-vitro,

BC,

MDA-MB-231

 27 ± 0.5 μg/mL

"highlight2" >tumCV↓,

4407-

AgNPs,

Green Synthesis and Characterization of Silver Nanoparticles from Eclipta alba and Its Activity Against Triple-Negative Breast Cancer Cell Line (MDA-MB-231)

in-vitro,

BC,

MDA-MB-231

 40-60 nm

"highlight2" >antiOx↑, "highlight2" >TumCG↓,

4406-

AgNPs,

Silver nanoparticles achieve cytotoxicity against breast cancer by regulating long-chain noncoding RNA XLOC_006390-mediated pathway

in-vitro,

BC,

MCF-7

63.1 ± 8.3 nm

tissues from 64 patients

in-vitro,

BC,

T47D

in-vitro,

BC,

MDA-MB-231

"highlight2" >TumCD↑, "highlight2" >other↓, "highlight2" >P53↑, "highlight2" >TumCCA↑, "highlight2" >Apoptosis↑, "highlight2" >ChemoSen↑, "highlight2" >tumCV↓, "highlight2" >γH2AX↑, "highlight2" >SOX4↓,

4405-

AgNPs,

Silver nanoparticles defeat p53-positive and p53-negative osteosarcoma cells by triggering mitochondrial stress and apoptosis

in-vitro,

OS,

"highlight2" >Apoptosis↑, "highlight2" >other↑, "highlight2" >ROS↑, "highlight2" >eff↑, "highlight2" >P53↝, "highlight2" >Apoptosis↑, "highlight2" >cl‑Casp3↑, "highlight2" >survivin↓, "highlight2" >MMP↓, "highlight2" >Cyt‑c↑,

4404-

AgNPs,

Rad,

Main Approaches to Enhance Radiosensitization in Cancer Cells by Nanoparticles: A Systematic Review

Review,

Var,

"highlight2" >eff↑, "highlight2" >ROS↑,

4403-

AgNPs,

Silver Nanoparticles Decorated UiO-66-NH2 Metal-Organic Framework for Combination Therapy in Cancer Treatment

in-vitro,

GBM,

U251

in-vitro,

GBM,

U87MG

in-vitro,

GBM,

GL26

in-vitro,

Cerv,

HeLa

in-vitro,

CRC,

RKO

"highlight2" >AntiCan↑, "highlight2" >eff↑, "highlight2" >EPR↑, "highlight2" >selectivity↑, "highlight2" >ROS↑, "highlight2" >Casp↑, "highlight2" >Apoptosis↑, "highlight2" >DNAdam↑, "highlight2" >tumCV↓, "highlight2" >eff↑,

4402-

AgNPs,

Enhancement of Triple-Negative Breast Cancer-Specific Induction of Cell Death by Silver Nanoparticles by Combined Treatment with Proteotoxic Stress Response Inhibitors

in-vitro,

BC,

BT549

in-vitro,

BC,

MDA-MB-231

in-vitro,

Nor,

MCF10

"highlight2" >TumCD↑, "highlight2" >selectivity↑, "highlight2" >*toxicity↝, "highlight2" >Dose↝, "highlight2" >OS↑,

4401-

AgNPs,

Rad,

Metformin-loaded chitosan nanoparticles augment silver nanoparticle-induced radiosensitization in breast cancer cells during radiation therapy

in-vitro,

BC,

 Met NPs and AgNPs had average diameters of 51.5 ± 9.4 nm and 3.02 ± 0.03 nm,

"highlight2" >RadioS↑, "highlight2" >DNAdam↑,

4400-

AgNPs,

Rad,

Differential cytotoxic and radiosensitizing effects of silver nanoparticles on triple-negative breast cancer and non-triple-negative breast cells

in-vitro,

BC,

MCF-7

in-vitro,

Nor,

MCF10

in-vitro,

BC,

MDA-MB-231

in-vitro,

BC,

BT549

in-vivo,

BC,

MDA-MB-231

right hind flanks of the mice

"highlight2" >ROS↑, "highlight2" >DNAdam↑, "highlight2" >selectivity↑, "highlight2" >TumCG↓, "highlight2" >RadioS↑, "highlight2" >Dose↝, "highlight2" >selectivity↑, "highlight2" >other↝, "highlight2" >eff↓, "highlight2" >eff↑, "highlight2" >γH2AX↑, "highlight2" >Dose↓, "highlight2" >eff↑,

"highlight2" >DNAdam↑,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 272

Pathway results for Effect on Cancer / Diseased Cells:

Infection & Microbiome ⓘ

Bacteria↓, 9, CD8+↑, 1,
Total Targets: 230

Pathway results for Effect on Normal Cells:

Redox & Oxidative Stress ⓘ

antiOx↑, 9, Catalase↑, 5, GPx↑, 3, GSH↓, 2, GSH↑, 5, GSTA1↑, 1, GSTs↑, 1, H2O2∅, 1, HO-1↑, 1, lipid-P↓, 1, MDA↓, 4, MDA↑, 1, MPO↓, 1, NQO1∅, 1, NRF2↑, 1, NRF2↝, 1, ROS↓, 6, ROS↑, 7, ROS∅, 1, mt-ROS↑, 1, SOD↑, 6, TAC↑, 1, TrxR↓, 1,

Metal & Cofactor Biology ⓘ

IronCh↑, 1,

Mitochondria & Bioenergetics ⓘ

ATP↓, 1, MMP↓, 1,

Core Metabolism/Glycolysis ⓘ

ALAT↓, 3, glucose↓, 1, LDH↓, 1, SIRT1↑, 1,

Cell Death ⓘ

Apoptosis↑, 1, BAX↑, 1, Bcl-2↓, 1, Casp3↑, 1, JNK↑, 1,

Transcription & Epigenetics ⓘ

AntiThr↑, 4, other↑, 2, other↝, 11,

Protein Folding & ER Stress ⓘ

CHOP↑, 1, cl‑eIF2α↑, 1, GRP78/BiP↑, 1, p‑PERK↑, 1,

Autophagy & Lysosomes ⓘ

LC3II↑, 1, p62↑, 1,

DNA Damage & Repair ⓘ

DNAdam↑, 2,

Proliferation, Differentiation & Cell State ⓘ

Diff↑, 1,

Migration ⓘ

AntiAg↑, 7, MMP11↑, 1, MMP3↑, 1, MMP9↓, 1, TGF-β↑, 1, TumCP↓, 1,

Angiogenesis & Vasculature ⓘ

EPR↑, 1, NO↓, 2, NO↑, 1, VEGF↓, 2,

Barriers & Transport ⓘ

BBB↑, 2, BBB↝, 1,

Immune & Inflammatory Signaling ⓘ

COX2↓, 1, CRP↓, 1, IL1↓, 2, IL10↑, 1, IL1α∅, 1, IL1β↓, 1, IL1β∅, 1, IL4↑, 1, IL5↑, 1, IL6↓, 2, IL8∅, 1, Inflam↓, 11, MCP1∅, 1, NF-kB↓, 3, TNF-α↓, 2, TNF-α↑, 1,

Synaptic & Neurotransmission ⓘ

5HT↑, 1,

Protein Aggregation ⓘ

NLRP3↓, 1,

Drug Metabolism & Resistance ⓘ

BioAv↓, 3, BioAv↑, 2, BioAv↝, 3, Dose↑, 1, Dose↝, 12, eff?, 1, eff↓, 1, eff↑, 20, eff↝, 2, Half-Life↝, 1, selectivity↑, 1,

Clinical Biomarkers ⓘ

ALAT↓, 3, AST↓, 3, BMD↑, 1, CRP↓, 1, GutMicro↝, 2, GutMicro∅, 1, IL6↓, 2, LDH↓, 1,

Functional Outcomes ⓘ

AntiDiabetic↑, 2, Bone Healing↑, 1, chemoPv↑, 1, hepatoP↑, 6, neuroP↑, 1, RenoP↑, 3, toxicity↓, 14, toxicity↝, 9, toxicity∅, 1, Wound Healing↑, 7,

Infection & Microbiome ⓘ

AntiFungal↑, 1, AntiViral↑, 2, Bacteria↓, 22, Inf↓, 1, Sepsis↓, 1,
Total Targets: 110

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:153  Target#:%  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

Database Query Results : Silver-NanoParticles, ,

Pathway results for Effect on Cancer / Diseased Cells:

Redox & Oxidative Stress ⓘ

Mitochondria & Bioenergetics ⓘ

Core Metabolism/Glycolysis ⓘ

Cell Death ⓘ

Kinase & Signal Transduction ⓘ

Transcription & Epigenetics ⓘ

Protein Folding & ER Stress ⓘ

Autophagy & Lysosomes ⓘ

DNA Damage & Repair ⓘ

Cell Cycle & Senescence ⓘ

Proliferation, Differentiation & Cell State ⓘ

Migration ⓘ

Angiogenesis & Vasculature ⓘ

Barriers & Transport ⓘ

Immune & Inflammatory Signaling ⓘ

Cellular Microenvironment ⓘ

Protein Aggregation ⓘ

Drug Metabolism & Resistance ⓘ

Clinical Biomarkers ⓘ

Functional Outcomes ⓘ

Infection & Microbiome ⓘ

Pathway results for Effect on Normal Cells:

Redox & Oxidative Stress ⓘ

Metal & Cofactor Biology ⓘ

Mitochondria & Bioenergetics ⓘ

Core Metabolism/Glycolysis ⓘ

Cell Death ⓘ

Transcription & Epigenetics ⓘ

Protein Folding & ER Stress ⓘ

Autophagy & Lysosomes ⓘ

DNA Damage & Repair ⓘ

Proliferation, Differentiation & Cell State ⓘ

Migration ⓘ

Angiogenesis & Vasculature ⓘ

Barriers & Transport ⓘ

Immune & Inflammatory Signaling ⓘ

Synaptic & Neurotransmission ⓘ

Protein Aggregation ⓘ

Drug Metabolism & Resistance ⓘ

Clinical Biomarkers ⓘ

Functional Outcomes ⓘ

Infection & Microbiome ⓘ

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