Database Query Results : Vitamin B12, ,

VitB12, Vitamin B12: Click to Expand ⟱
Features:
Helps make red blood cells, metabolize food and prevent nerve damage.
Scientific Papers found: Click to Expand⟱
3941- 5HT,  dietMed,  VitB12,  FA,  VitC  Nutrition strategies that improve cognitive function
- Review, AD, NA
*other↑, *other↓, *cognitive↑, *eff↑, *eff↑,
4061- betaCar,  VitB12,  VitB6,  FA,  VitB3  Revisiting the Role of Vitamins and Minerals in Alzheimer’s Disease
- Review, AD, NA
*cognitive↑, *cognitive↑, *Inflam↓, *homoC↓, *TNF-α↓, *other↝, *memory↑,
2175- Chemo,  VitB12,  FA,    Systemic Chemotherapy Interferes in Homocysteine Metabolism in Breast Cancer Patients
- Study, BC, NA
other↓, other↝, homoC↓, eff↝, other↝,
4261- Chol,  VitB12,  FA,  VitB2,    B-Vitamin and Choline Supplementation Changes the Ischemic Brain
- Study, Stroke, NA
*BDNF↑, *homoC↓,
2174- FA,  VitB12,   
- Analysis, Var, NA
homoC↓, eff↑, eff↑, eff↑, eff↝, homoC↝, other?,
4064- FA,  VitB6,  VitB12,    High-dose B vitamin supplementation and cognitive decline in Alzheimer disease: a randomized controlled trial
- Trial, AD, NA
*homoC↓, *cognitive∅,
4074- FA,  VitB12,    Associations between Alzheimer's disease and blood homocysteine, vitamin B12, and folate: a case-control study
- Trial, AD, NA
*cognitive↑, *homoC↓, *other↝, *other↝,
2173- FA,  VitB12,    Elevated serum homocysteine levels associated with poor recurrence-free and overall survival in patients with colorectal cancer
- Study, CRC, NA
Risk↓, eff↝, eff↝, homoC↓,
2176- FA,  VitB12,    Hyperhomocysteinemia and Cancer: The Role of Natural Products and Nutritional Interventions
- Review, Var, NA
homoC↓, eff↝,
4063- Flav,  VitB12,  VitB6,    Homocysteine and Dementia: An International Consensus Statement
- Review, AD, NA
*homoC↓, *cognitive↑,
3939- SAMe,  VitB12,  ALC,    Efficacy of a Vitamin/Nutriceutical Formulation for Moderate-stage to Later-stage Alzheimer's disease: A Placebo-controlled Pilot Study
- Trial, NA, NA
*cognitive↑, *Mood↑,
4067- VitB12,  VitB6,  VitD3,    Plants, Plants, and More Plants: Plant-Derived Nutrients and Their Protective Roles in Cognitive Function, Alzheimer's Disease, and Other Dementias
- Review, AD, NA
*cognitive↑,
4066- VitB12,  VitB6,  FA,    Vitamin B6, B12, and Folate’s Influence on Neural Networks in the UK Biobank Cohort
- Study, AD, NA
*other↓, *other↑, *other↑,
4318- VitB12,    Unraveling the molecular mechanisms of vitamin deficiency in Alzheimer's disease pathophysiology
- Review, AD, NA
*homoC↓, *cognitive↑,
4058- VitB12,  VitB6,  FA,    The preventive efficacy of vitamin B supplements on the cognitive decline of elderly adults: a systematic review and meta-analysis
- Review, AD, NA
*homoC↓, *cognitive↑,
4056- VitB12,  VitB6,  FA,    Vitamin B12, B6, or Folate and Cognitive Function in Community-Dwelling Older Adults: A Systematic Review and Meta-Analysis
- Review, AD, NA
*Risk∅, *cognitive↑, *cognitive∅,
4054- VitB12,  VitB6,  FA,    Role of B vitamins in modulating homocysteine and metabolic pathways linked to brain atrophy: Metabolomics insights from the VITACOG trial
- Study, AD, NA
*homoC↓, *neuroP↑, *cognitive↑,
4053- VitB12,  VitB6,  FA,    Vitamins in Alzheimer’s Disease—Review of the Latest Reports
- Review, AD, NA
*cognitive↑, *homoC↓, *SAM-e↓,
4050- VitB12,  VitD3,  VitE,    Nutrient intake, nutritional status, and cognitive function with aging
- Review, AD, NA
neuroP↑,
4048- VitB12,    Plasma Homocysteine and Serum Folate and Vitamin B12 Levels in Mild Cognitive Impairment and Alzheimer’s Disease: A Case-Control Study
- Study, AD, NA
*homoC↓, *other↝, *other↝,
4047- VitB12,    Cognitive impairment and vitamin B12: a review
- Review, AD, NA
*cognitive↝,
4046- VitB12,    Plasma Vitamin B-12 Levels and Risk of Alzheimer’s Disease: A Case-Control Study
- Study, AD, NA
*cognitive↑,
4045- VitB12,  FA,    Cognitive and clinical outcomes of homocysteine-lowering B-vitamin treatment in mild cognitive impairment: a randomized controlled trial
- Trial, AD, NA
*homoC↓, *cognitive↑, *memory↑, *other↑,
4043- VitB12,  FA,    Preventing Alzheimer's disease-related gray matter atrophy by B-vitamin treatment
- Trial, AD, NA
*other↑, *other↑, *eff↝, *homoC↓, *cognitive↑,
4042- VitB12,    Genetic determinants of low vitamin B12 levels in Alzheimer's disease risk
- Review, AD, NA
*cognitive∅,
4041- VitB12,    Thoughts on B-vitamins and dementia
- Review, AD, NA
*cognitive↑, *other↝,
4040- VitB12,  FA,    Role of vitamin B12 and folic acid in treatment of Alzheimer’s disease: a meta-analysis of randomized control trials
- Review, AD, NA
*memory↑, *neuroP↑, *cognitive↑, *QoL∅,
4038- VitB12,    Vitamin B12 and Age-Related Cognitive Decline—Dementia and “Alzheimer’s Disease”
- Review, AD, NA
*cognitive↑,
4037- VitB12,  FA,    Mechanistic Link between Vitamin B12 and Alzheimer’s Disease
- Review, AD, NA
*antiOx↑, *ROS↓, *GSH↑, *Inflam↓, *IL6↓, *TNF-α↓, *other↑, *other↑, *other↑, *Aβ↓, *memory↑, *p‑tau↓, *APP↓, *BACE↓, *ATP↑, *neuroP↑,
4057- VitB6,  VitB12,  FA,    Folate, Vitamin B6 and Vitamin B12 Intake and Mild Cognitive Impairment and Probable Dementia in the Women’s Health Initiative Memory Study
- Study, AD, NA
*Risk↓, *Risk∅,
4062- VitB6,  FA,  VitB12,    Vitamin B6, B9, and B12 Intakes and Cognitive Performance in Elders: National Health and Nutrition Examination Survey, 2011–2014
- Study, AD, NA
*Risk↓, *Risk↓, *Risk↓, *cognitive↑,
4065- VitB6,  VitB12,  FA,    Vitamin B6, B12, and Folic Acid Supplementation and Cognitive Function
- Review, AD, NA
*cognitive∅, *cognitive↑,
4077- VitB6,  FA,  VitB12,  VitD3,  VitE  Vitamin Supplementation as an Adjuvant Treatment for Alzheimer’s Disease
- Review, AD, NA
*antiOx↑, *cognitive↑, *homoC↓, *Risk↓, *Risk↓, *Risk↓, *other↝, *Dose↝, *Risk↓, *Risk↓,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 33

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 2,   GSH↑, 1,   ROS↓, 1,   SAM-e↓, 1,  

Mitochondria & Bioenergetics ATP production, membrane potential, mitochondrial signaling, and dynamics (fission, fusion, mitophagy). It includes mitochondrial contributions to apoptosis, metabolism, and redox signaling. Mitochondrial dysfunction is a core driver of cancer metabolism, neurodegeneration, and age-related decline." style="cursor:help;color:#555;font-weight:normal;">ⓘ

ATP↑, 1,  

Core Metabolism/Glycolysis ⓘ

homoC↓, 13,  

Transcription & Epigenetics ⓘ

other↓, 2,   other↑, 9,   other↝, 7,  

Migration ⓘ

APP↓, 1,  

Immune & Inflammatory Signaling Inflammation group includes innate and adaptive immune pathways, cytokines, chemokines, pattern-recognition receptors, complement, and inflammasomes. It regulates host defense, tumor immunity, neuroinflammation, and chronic inflammatory disease processes." style="cursor:help;color:#555;font-weight:normal;">ⓘ

IL6↓, 1,   Inflam↓, 2,   TNF-α↓, 2,  

Synaptic & Neurotransmission memory, and neuronal survival, and is especially relevant to Alzheimer’s and other neurodegenerative diseases." style="cursor:help;color:#555;font-weight:normal;">ⓘ

BDNF↑, 1,   p‑tau↓, 1,  

Protein Aggregation tau biology, proteolytic processing, and aggregate toxicity. It captures molecular features specific to neurodegenerative pathology but remains extensible to other aggregation disorders." style="cursor:help;color:#555;font-weight:normal;">ⓘ

Aβ↓, 1,   BACE↓, 1,  

Drug Metabolism & Resistance ⓘ

Dose↝, 1,   eff↑, 2,   eff↝, 1,  

Clinical Biomarkers Inflammation state | Microenvironment | Research-stage | | 28 | XIST | Epigenetic instability | Aggressiveness | Not yet clinical | | 29 | FOXM1 | High-risk biology | Aggressiveness | No routine testing | | 30 | TRIB3 | Stress adaptation | Aggressiveness | Mechanistic, not clinical | Core Liver & Systemic Biomarkers in Oncology | Marker | What It Reflects | Main Use in Cancer | Decision Impact | | --------- | ----------------------------------- | ----------------------------------------- | ----------- | | ALT | Hepatocellular injury | Baseline eligibility, toxicity monitoring | High | | AST | Liver + systemic injury | Detect liver injury, muscle involvement | High | | ALP | Cholestasis, bone turnover | Liver mets vs bone mets | High | | bilirubin | Hepatic clearance | Chemotherapy dosing | Critical | | albumin | Synthetic liver function, nutrition | Prognosis, frailty | High | | LDH | Tumor burden, hypoxia | Aggressiveness, prognosis | High | | INR | Liver synthetic failure | Treatment safety | High | Key Inflammatory / Host-Response Biomarkers Used in Oncology | Biomarker | What It Reflects | Main Use in Cancer | Clinical Decision Impact | | ------------------ | -------------------------------- | ---------------------------- | -------------------- | | C-reactive protein | Systemic inflammation | Prognosis, therapy tolerance | High | | ESR | Chronic inflammation | Disease activity trend | Moderate | | ferritin | Inflammation + iron status | Cachexia, cytokine load | High | | IL-6 | Cytokine signaling | Aggressiveness, cachexia | High (specialty use) | | LDH | Tumor burden + hypoxia | Risk stratification | Very high | | albumin | Nutritional & inflammatory state | Frailty, survival | Very high | </pre> " style="cursor:help;color:#555;font-weight:normal;">ⓘ

IL6↓, 1,  

Functional Outcomes cognitive performance, toxicity, and organism-level effects. It is intentionally mechanism-agnostic and anchors molecular data to real-world biological impact." style="cursor:help;color:#555;font-weight:normal;">ⓘ

cognitive↑, 21,   cognitive↝, 1,   cognitive∅, 4,   memory↑, 4,   Mood↑, 1,   neuroP↑, 3,   QoL∅, 1,   Risk↓, 9,   Risk∅, 2,  
Total Targets: 30

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:165  Target#:%  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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