Features: |
Vitamin K2 (menaquinone) Menaquinone-4 (MK-4), a subtype of vitamin K2 Helps blood clot, calcium metabolise and heart health. Bone health: Vitamin K2 helps to regulate calcium levels in the body, which can help to prevent conditions such as osteoporosis and fractures. Vitamin K2 has been studied for its potential role in cancer prevention and treatment. Some of the key findings include: -Shown to inhibit the growth of cancer cells, including those found in leukemia, lung cancer, and prostate cancer. -Shown to induce apoptosis (cell death) in cancer cells, which can help to prevent the spread of cancer. -Shown to have anti-angiogenic effects, which means it can help to prevent the formation of new blood vessels that feed cancer cells. -Synergistic effects with other nutrients, such as vitamin D and calcium, to enhance its anti-cancer effects. Vitamin K2 exists in several forms known as menaquinones, with MK-4 and MK-7 being the most studied. MK-4 is often used in Japan for therapeutic purposes, whereas MK-7 (derived from bacterial fermentation) is widely available as a supplement in Western countries. For bone and cardiovascular health—and by extension, exploring potential anticancer benefits—doses for MK-7 commonly range from 90 to 200 micrograms per day. |
652- | EGCG,  | VitK2,  | CUR,  |   | Case Report of Unexpectedly Long Survival of Patient With Chronic Lymphocytic Leukemia: Why Integrative Methods Matter |
- | Case Report, | CLL, | NA |
1211- | VitK2,  |   | Mechanisms of PKC-Mediated Enhancement of HIF-1α Activity and its Inhibition by Vitamin K2 in Hepatocellular Carcinoma Cells |
- | in-vitro, | HCC, | HUH7 |
2285- | VitK2,  |   | New insights into vitamin K biology with relevance to cancer |
- | Review, | Var, | NA |
2284- | VitK2,  |   | Menadione-induced DNA damage in a human tumor cell line |
- | in-vitro, | BC, | MCF-7 |
2283- | VitK2,  |   | Vitamin K Contribution to DNA Damage—Advantage or Disadvantage? A Human Health Response |
- | Review, | Var, | NA |
2282- | VitK2,  |   | Vitamin K prevents oxidative cell death by inhibiting activation of 12-lipoxygenase in developing oligodendrocytes |
- | in-vitro, | Nor, | NA |
2281- | VitK2,  |   | The biological responses of vitamin K2: A comprehensive review |
- | Review, | Var, | NA |
2280- | VitK2,  |   | Vitamin K2 induces non-apoptotic cell death along with autophagosome formation in breast cancer cell lines |
- | in-vitro, | BC, | MDA-MB-231 | - | in-vitro, | BC, | MDA-MB-468 | - | in-vitro, | AML, | HL-60 |
2279- | VitK2,  |   | Vitamin K2 Induces Mitochondria-Related Apoptosis in Human Bladder Cancer Cells via ROS and JNK/p38 MAPK Signal Pathways |
- | in-vitro, | Bladder, | T24 | - | in-vitro, | Bladder, | J82 | - | in-vitro, | Nor, | HEK293 | - | in-vitro, | Nor, | L02 | - | in-vivo, | NA, | NA |
2278- | VitK2,  | VitK3,  | VitC,  |   | Vitamin K: Redox-modulation, prevention of mitochondrial dysfunction and anticancer effect |
- | Review, | Var, | NA |
2277- | VitK2,  |   | Vitamin K2 suppresses rotenone-induced microglial activation in vitro |
- | in-vitro, | Nor, | BV2 | - | NA, | AD, | NA | - | NA, | Park, | NA |
2276- | VitK2,  |   | Vitamin K2 (MK-7) Intercepts Keap-1/Nrf-2/HO-1 Pathway and Hinders Inflammatory/Apoptotic Signaling and Liver Aging in Naturally Aging Rat |
- | in-vivo, | Nor, | NA |
2275- | VitK2,  |   | Delivery of the reduced form of vitamin K2(20) to NIH/3T3 cells partially protects against rotenone induced cell death |
- | in-vitro, | Nor, | NIH-3T3 |
2274- | VitK2,  |   | Vitamin K2 Modulates Mitochondrial Dysfunction Induced by 6-Hydroxydopamine in SH-SY5Y Cells via Mitochondrial Quality-Control Loop |
- | in-vitro, | Nor, | SH-SY5Y |
1840- | VitK2,  |   | The mechanisms of vitamin K2-induced apoptosis of myeloma cells |
- | in-vitro, | Melanoma, | NA |
1833- | VitK2,  |   | Divergent effects of vitamins K1 and K2 on triple negative breast cancer cells |
- | in-vitro, | BC, | HS587T | - | in-vitro, | BC, | MDA-MB-231 | - | in-vitro, | BC, | SUM159 |
1830- | VitK2,  |   | Vitamin K Intake and Risk of Lung Cancer: The Japan Collaborative Cohort Study |
- | Study, | Lung, | NA |
1829- | VitK2,  |   | Vitamin K: New insights related to senescence and cancer metastasis |
- | Review, | Var, | NA |
1825- | VitK2,  |   | Vitamin K intake and prostate cancer risk in the Prostate, Lung, Colorectal, and Ovarian Cancer (PLCO) Screening Trial |
- | Analysis, | Pca, | NA |
1824- | VitK2,  |   | Vitamin K and its analogs: Potential avenues for prostate cancer management |
- | Review, | Pca, | NA |
1823- | VitK2,  | VitK3,  |   | Vitamins K2, K3 and K5 exert antitumor effects on established colorectal cancer in mice by inducing apoptotic death of tumor cells |
- | in-vitro, | CRC, | NA | - | in-vivo, | NA, | NA |
1822- | VitK2,  |   | Vitamin K: A novel cancer chemosensitizer |
- | Review, | Var, | NA |
1818- | VitK2,  |   | New insights on vitamin K biology with relevance to cancer |
- | Review, | Var, | NA |
1817- | VitK2,  |   | Research progress on the anticancer effects of vitamin K2 |
- | Review, | Var, | NA |
1816- | VitK2,  |   | Role of Vitamin K in Selected Malignant Neoplasms in Women |
- | Review, | Var, | NA |
1214- | VitK2,  |   | Vitamin K2 promotes PI3K/AKT/HIF-1α-mediated glycolysis that leads to AMPK-dependent autophagic cell death in bladder cancer cells |
- | in-vitro, | Bladder, | T24 | - | in-vitro, | Bladder, | J82 |
1213- | VitK2,  |   | Vitamin K2 Inhibits Hepatocellular Carcinoma Cell Proliferation by Binding to 17β-Hydroxysteroid Dehydrogenase 4 |
- | in-vitro, | HCC, | HepG2 |
1212- | VitK2,  |   | Vitamin K2 stimulates osteoblastogenesis and suppresses osteoclastogenesis by suppressing NF-κB activation |
- | in-vitro, | ostP, | NA |
1831- | VitK3,  | VitK2,  |   | The anticancer effects of vitamin K |
- | Review, | Var, | NA |
1815- | VitK3,  | VitK2,  |   | Vitamin K |
- | Review, | Nor, | NA |
Filter Conditions: Pro/AntiFlg:% IllCat:% CanType:% Cells:% prod#:168 Target#:% State#:% Dir#:%
wNotes=0 sortOrder:rid,rpid