Database Query Results : Exercise, ,

Ex, Exercise: Click to Expand ⟱
Features: Therapy
Regular physical activity has been shown to influence cancer risk, progression, and survivorship. While exercise is not a cure for cancer, extensive research indicates that it can help reduce the risk of developing certain types of cancer and improve outcomes and quality of life for those diagnosed.

-Lowering the levels of hormones levels.
-Preventing high blood levels of insulin.
-Regular physical activity leads to decreased levels of inflammatory markers (such as C-reactive protein and interleukin-6).
-Improving immune system function (enhancing the circulation of immune cells, including natural killer cells, T lymphocytes, and macrophages)
-Reducing the time it takes for food to travel through the digestive system.
-Helping to prevent obesity, which is a risk factor for many cancers.
-Exercise promotes the upregulation of antioxidant defenses.
Scientific Papers found: Click to Expand⟱
3876- Carno,  Ex,    Swimming exercise versus L-carnosine supplementation for Alzheimer’s dementia in rats: implication of circulating and hippocampal FNDC5/irisin
- in-vivo, AD, NA
*cognitive↑, carnosine is equivalent to exercise in reversing cognitive decline and Alzheimer’s biomarkers.
*neuroP↑, enhancement of hippocampal FNDC5/irisin and insulin signalling may be involved in mediating these neuroprotective effects.

2154- dietP,  Ex,    American Cancer Society (ACS) Nutrition and Physical Activity Guidelines after colon cancer diagnosis and disease-free (DFS), recurrence-free (RFS), and overall survival (OS) in CALGB 89803 (Alliance)
- Trial, Colon, NA
OS↑, Colon cancer patients with a healthy body weight who engaged in physical activity, ate a diet high in whole grains, vegetables, and fruits and low in red/processed meats, and drank moderate alcohol had longer DFS and OS than patients who did not

2143- Ex,    The association between physical activity and bladder cancer: systematic review and meta-analysis
- Review, Bladder, NA
Risk↓, Physical activity is associated with decreased risk of bladder cancer.
Dose↝, Comparing the highest with the lowest physical activity level, the combined bladder cancer risk estimate was 0.85

4174- Ex,    Exercise-Mediated Neurogenesis in the Hippocampus via BDNF
- Review, NA, NA
*neuroP↑, Exercise is known to have numerous neuroprotective and cognitive benefits, especially pertaining to memory and learning related processes.
*cognitive↑,
*memory↑,
*BDNF↑, relationship between exercise and hippocampal neurogenesis, and identifies a key molecule mediating this process, brain-derived neurotrophic factor (BDNF).
*neuroG↑, brain-derived neurotrophic factor (BDNF), that has been shown to modulate neurogenesis and how exercise influences BDNF levels

4155- Ex,    Prior regular exercise reverses the decreased effects of sleep deprivation on brain-derived neurotrophic factor levels in the hippocampus of ovariectomized female rats
- in-vivo, AD, NA
*BDNF↑, Furthermore, sleep deprived OVX rats under exercise conditions had a significant (p<0.05) up-regulation of the BDNF protein and mRNA in the hippocampus.

4145- Ex,    Effects of different physical activities on brain-derived neurotrophic factor: A systematic review and bayesian network meta-analysis
- Review, AD, NA
*BDNF↑, The Bayesian network meta-analysis ranked the effect of exercise on BDNF level improvement in healthy and non-healthy subjects as follows: RT > HIIT > CT > AT+RT > AT > CG.
*eff↑, resistance training (RT) at moderate intensity is recommended for children and older adults in the case of exercise tolerance and is effective in maintaining or modulating BDNF levels for promoting brain health.

4144- Ex,    Exploring the impact of exercise-induced BDNF on neuroplasticity in neurodegenerative and neuropsychiatric conditions
- Review, AD, NA
*BDNF↑, Regular physical activity not only elevates BDNF levels but also fosters memory and learning, offering important implications for the prevention and treatment of neuropsychiatric and neurodegenerative conditions.
*memory↑,
*neuroP↑,
*cognitive↑, exercise interventions for improved cognitive outcomes.

4143- Ex,    Brain-Derived Neurotrophic Factor: A Connecting Link Between Nutrition, Lifestyle, and Alzheimer’s Disease
- Review, AD, NA
*BDNF↑, a healthy lifestyle, exercise, and dietary modifications are shown to positively influence insulin regulation in the brain, reduce inflammation, and up-regulate the levels of BDNF, and are thus expected to have roles in AD
*eff↑, Donepezil and galantamine (Acetylcholinesterase inhibitor) treated animal and human patients have shown to have higher levels of BDNF
*other↓, decline in BDNF levels is linked to increasing age, and it is more noticeable in females, the elderly, and those with higher body weights (Komulainen et al., 2008; Lee et al., 2009). The decline correlates with memory loss and hippocampal atrophy
*eff↑, A single aerobic exercise session done consistently was associated with a higher increase in BDNF levels compared to if done acutely

4142- Ex,    Mechanisms of the Beneficial Effects of Exercise on Brain-Derived Neurotrophic Factor Expression in Alzheimer’s Disease
- Review, AD, NA
*BDNF↑, Physical exercise, on the other hand, protects synaptic and neuronal structure and function, with increased BDNF as a major mediator of exercise-induced enhancements in cognitive function.
*cognitive↑, fundamental mechanisms of how exercise impacts BDNF and cognition are not yet fully understood but are a prerequisite to developing new biomarkers and therapies to delay or prevent cognitive decline.

4141- Ex,    Effects of exercise on brain-derived neurotrophic factor in Alzheimer's disease models: A systematic review and meta-analysis
- Review, AD, NA
*BDNF↑, There was a significant effect of exercise on increasing BDNF levels in AD models [standardized mean differences (SMD) = 0.98, P < 0.00001].
*other↑, In addition, exercise significantly increased BDNF levels in the hippocampus
*eff↑, treadmill exercise, swimming, and voluntary running, significantly increased BDNF levels in hippocampus and cortex of AD models, with swimming being the most effective intervention type.

4140- Ex,    Experimental and clinical evidence of physical exercise on BDNF and cognitive function: A comprehensive review from molecular basis to therapy
- Review, AD, NA
*BDNF↑, physical exercise (PE) can influence brain function, especially cognition, through the modulatory effects of brain-derived neurotrophic factor (BDNF) has been extensively studied over the past few decades.
*cognitive↑, Furthermore, the beneficial effect of voluntary physical activity on cognitive performance through modulating neurotrophic factors has been reported.

4139- Ex,    Impact of physical exercise on the regulation of brain-derived neurotrophic factor in people with neurodegenerative diseases
- Review, AD, NA
*BDNF↑, recent studies are analyzed that indicate an increase in BDNF levels following physical activity, particularly in young adults.
*eff↑, with the most significant effects seen in aerobic and high-intensity exercises.
*eff↑, Both acute and prolonged exercise increase BDNF, but the effect is more sustained with regular, long-term regimens.
*cognitive↑, Prolonged aerobic exercise increases BDNF and improves vascular and cognitive functions, with positive effects observed in older adults.
*memory↑, In animal models, forced and voluntary exercise increased hippocampal BDNF, improving spatial memory and synaptic function.
*BrainVol↑,
*TrkB↑, The interaction of BDNF with its receptor TrkB is involved in the processes that lead to enhancements in learning and memory associated with exercise
*GABA↑, BDNF increases the expression of markers associated with GABAergic neurotransmission, such as GABA, GAD65, and GAD67

4138- Ex,    Relationship Between Exercise and Alzheimer’s Disease: A Narrative Literature Review
- Review, AD, NA
*other↑, Patients with AD who presented with long-term exercise interventions appeared to have improved blood flow, increased hippocampal volume, and improved neurogenesis.
*Risk↓, studies have proven that physical inactivity is one of the most common preventable risk factors for developing AD
*cognitive↑, Physical exercise seems to be effective in improving several neuropsychiatric symptoms of AD, notably cognitive function.

4137- Ex,    The impact of exercise on patients with dementia
- Trial, AD, NA
*Strength↑, All the patients of the exercise group had significantly better left upper body strength, higher aerobic endurance, and left and right balance maintenance time than those of the no-exercise group
*QoL↑, Moreover, the exercise group had significantly lesser unexpected hospitalization than the no-exercise group in the patients with mild dementia
*cognitive∅, However, in the mild and moderate dementia subgroups, age, sex, education years, and MMSE showed no significant differences between the groups

3985- Ex,    The combined effect of physical activity and fruit and vegetable intake on decreasing cognitive decline in older Taiwanese adults
- Study, AD, NA
*cognitive↑, The risk of cognitive decline decreased by 63% when high physical activity and high fruit and vegetable intake were combined

2153- Ex,    The Impact of Exercise on Cancer Mortality, Recurrence, and Treatment-Related Adverse Effects
- Review, Var, NA
eff↑, The findings of this review support the view that exercise is an important adjunct therapy in the management of cancer
BMD↑, Finally, thrice weekly resistance training during 6 months of radiotherapy for metastases to the spine resulted in significantly improved spine bone density compared with passive physical therapy
cognitive↑, Two of the 5 observed significant improve- ments in cognitive function
OS↑, 28-44% reduced risk of cancer-specific mortality
Remission↑, 21%-35% lower risk of cancer recurrence
eff↑, exercise may elicit positive changes in inflammation, immunity, and oxidative stress, as well as in metabolic and sex hormones, all of which are factors believed to contribute to cancer progression

2151- Ex,    The effects of physical activity on overall survival among advanced cancer patients: a systematic review and meta-analysis
- Review, Var, NA
eff↑, a higher level of physical activity in non-randomised trials was significantly associated with reduced mortality risk
eff↝, Nevertheless, it might be too late for advanced cancer patients to start exercising for survival improvements, based on findings from randomised controlled trials.

2150- Ex,    Roles and molecular mechanisms of physical exercise in cancer prevention and treatment
- Review, Var, NA
eff↓, Physical exercise should be considered an important intervention to prevent and treat cancer and its complications.
Dose↝, Sensitivity to physical exercise varies in different cancers; we provide evidence for the exercise type and strength in various cancers and in differing stages.
TumCP↓, nhibiting cancer cell proliferation and inducing apoptosis and regulating metabolism and the immune environment are the main mechanisms of the benefits of physical exercise in cancer prevention and treatment.
Apoptosis↓,
ChemoSen↑, Graphic Abstract
chemoP↑, Graphic Abstract

2149- Ex,    Physical activity and exercise training in cancer patients
- Analysis, Var, NA
eff↑, Most guidelines for cancer survivors suggest that physical activity and exercise should be an integral and continuous part of care for all cancer survivors
Dose↑, Strong evidence supports the promotion of physical activity and exercise for adult cancer patients before, during, and after cancer treatment, across all cancer types, and including patients with advanced disease

2148- Ex,    Effects of Exercise on Cancer Treatment Efficacy: A Systematic Review of Preclinical and Clinical Studies
- Review, Var, NA
ChemoSen↑, Exercise significantly enhanced the efficacy of chemotherapy and tamoxifen in seven of eight rodent models in either an additive, sensitizing, or synergistic manner.

2147- Ex,    The association between physical activity and gastroesophageal cancer: systematic review and meta-analysis
- Review, GC, NA
Risk↓, When we compared high versus low physical activity levels and summarized associations according to anatomic site and tumor histology, risk reductions were evident for esophageal adenocarcinoma [relative risk (RR) = 0.79

2146- Ex,    A systematic review and meta-analysis of physical activity and endometrial cancer risk
- Review, Endo, NA
Risk↓, High versus low physical activity was related to reduced endometrial cancer risk [relative risk (RR) = 0.80
eff↑, recreational physical activity, occupational physical activity, and walking/biking for transportation are related to decreased endometrial cancer risk. Inverse associations are evident for physical activity of light, moderate to vigorous

2145- Ex,    Leisure time physical activity and cancer risk: evaluation of the WHO's recommendation based on 126 high-quality epidemiological studies
- Analysis, Var, NA
Risk↓, Overall, the total cancer risk was reduced by 10% in people who undertook the most LTPA as compared with those who did the least
Dose↝, Moreover, the protective role of LTPA against cancer becomes saturated at 20 metabolic equivalents of energy hours per week, with a relative risk of 0.91
eff↑, Our meta-analysis indicates that the current WHO recommendation of physical activity can result in a 7% reduction in cancer risk, which is mainly attributed to its protective role against breast cancer and colorectal cancer.

2144- Ex,    Physical activity, hormone replacement therapy and breast cancer risk: A meta-analysis of prospective studies
- Analysis, NA, NA
Risk↓, Increasing physical activity is associated with meaningful reductions in the risk of breast cancer,
Dose?, Compared to the lowest level of physical activity, the highest level was associated with a summary relative risk (SRR) of 0.88 for all breast cancer, 0.89 for ER+/PR+ breast cancer and 0.8 for ER-/PR- breast cancer.
eff↑, Findings indicate that a physically inactive women engaging in at least 150 min per week of vigorous physical activity would reduce their lifetime risk of breast cancer by 9%

4107- FLS,  Ex,    Combined effects of aerobic exercise and 40-Hz light flicker exposure on early cognitive impairments in Alzheimer's disease of 3×Tg mice
- in-vivo, AD, NA
*Aβ↓, Aβ and tau proteins levels were significantly reduced in the early stage of AD, resulting in protection against cognitive decline by reducing neuroinflammation and proinflammatory cytokines.
*cognitive↑,
*Inflam↓,
*eff↑, exercise with 40-Hz light flickering was significantly more effective than exercise or 40-Hz light flickering alone

3789- UA,  Ex,    Combined Ursolic Acid and Resistance/Endurance Training Improve Type 3 Diabetes Biomarkers-Related Memory Deficits in Hippocampus of Aged Male Wistar Rats
- in-vivo, AD, NA
*BDNF↑, supplement effect showed that BDNF/B‑actin significantly increased in ursolic acid condition

4183- VitD3,  Ex,    Combined Exercise and Vitamin D on Brain-Derived Neurotrophic Factor
- Review, NA, NA
*BDNF↑, Certain types of physical exercise have been shown to markedly (threefold) increase BDNF synthesis in the human brain, a phenomenon that is partly responsible for exercise-induced neurogenesis and improvements in cognitive function [42].
*Inflam↓, In addition to its effects on gene expression, vitamin D may also modulate BDNF levels through its anti-inflammatory properties
*other↝, , research has suggested that vitamin D may interact with other molecules implicated in BDNF regulation, such as serotonin and dopamine.

1753- WBV,  Ex,    Physical Exercise with or without Whole-Body Vibration in Breast Cancer Patients Suffering from Aromatase Inhibitor—Induced Musculoskeletal Symptoms: A Pilot Randomized Clinical Study
- Trial, BC, NA
Pain↓, The WBV group (mean age: 51.73 ± 10.73 years; body mass index (BMI): 25.56 ± 5.17 kg/m2) showed a statistically significant pain reduction
Strength↑, Concurrently, muscle strength, physical performance, and quality of life significantly improved in both groups, without significant differences between groups
QoL↑,
Dose∅, with a frequency of 30 Hz, peak-to-peak amplitude of 1.15 mm. in squatting position (110° knee flexion)


* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 28

Results for Effect on Cancer/Diseased Cells:
Apoptosis↓,1,   BMD↑,1,   chemoP↑,1,   ChemoSen↑,2,   cognitive↑,1,   Dose?,1,   Dose↑,1,   Dose↝,3,   Dose∅,1,   eff↓,1,   eff↑,7,   eff↝,1,   OS↑,2,   Pain↓,1,   QoL↑,1,   Remission↑,1,   Risk↓,5,   Strength↑,1,   TumCP↓,1,  
Total Targets: 19

Results for Effect on Normal Cells:
Aβ↓,1,   BDNF↑,11,   BrainVol↑,1,   cognitive↑,9,   cognitive∅,1,   eff↑,7,   GABA↑,1,   Inflam↓,2,   memory↑,3,   neuroG↑,1,   neuroP↑,3,   other↓,1,   other↑,2,   other↝,1,   QoL↑,1,   Risk↓,1,   Strength↑,1,   TrkB↑,1,  
Total Targets: 18

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