Ex, Exercise: Click to Expand ⟱
Features: Therapy
Regular physical activity has been shown to influence cancer risk, progression, and survivorship. While exercise is not a cure for cancer, extensive research indicates that it can help reduce the risk of developing certain types of cancer and improve outcomes and quality of life for those diagnosed.

-Lowering the levels of hormones levels.
-Preventing high blood levels of insulin.
-Regular physical activity leads to decreased levels of inflammatory markers (such as C-reactive protein and interleukin-6).
-Improving immune system function (enhancing the circulation of immune cells, including natural killer cells, T lymphocytes, and macrophages)
-Reducing the time it takes for food to travel through the digestive system.
-Helping to prevent obesity, which is a risk factor for many cancers.
-Exercise promotes the upregulation of antioxidant defenses.
Scientific Papers found: Click to Expand⟱
2154- dietP,  Ex,    American Cancer Society (ACS) Nutrition and Physical Activity Guidelines after colon cancer diagnosis and disease-free (DFS), recurrence-free (RFS), and overall survival (OS) in CALGB 89803 (Alliance)
- Trial, Colon, NA
OS↑, Colon cancer patients with a healthy body weight who engaged in physical activity, ate a diet high in whole grains, vegetables, and fruits and low in red/processed meats, and drank moderate alcohol had longer DFS and OS than patients who did not

2143- Ex,    The association between physical activity and bladder cancer: systematic review and meta-analysis
- Review, Bladder, NA
Risk↓, Physical activity is associated with decreased risk of bladder cancer.
Dose↝, Comparing the highest with the lowest physical activity level, the combined bladder cancer risk estimate was 0.85

2144- Ex,    Physical activity, hormone replacement therapy and breast cancer risk: A meta-analysis of prospective studies
- Analysis, NA, NA
Risk↓, Increasing physical activity is associated with meaningful reductions in the risk of breast cancer,
Dose?, Compared to the lowest level of physical activity, the highest level was associated with a summary relative risk (SRR) of 0.88 for all breast cancer, 0.89 for ER+/PR+ breast cancer and 0.8 for ER-/PR- breast cancer.
eff↑, Findings indicate that a physically inactive women engaging in at least 150 min per week of vigorous physical activity would reduce their lifetime risk of breast cancer by 9%

2145- Ex,    Leisure time physical activity and cancer risk: evaluation of the WHO's recommendation based on 126 high-quality epidemiological studies
- Analysis, Var, NA
Risk↓, Overall, the total cancer risk was reduced by 10% in people who undertook the most LTPA as compared with those who did the least
Dose↝, Moreover, the protective role of LTPA against cancer becomes saturated at 20 metabolic equivalents of energy hours per week, with a relative risk of 0.91
eff↑, Our meta-analysis indicates that the current WHO recommendation of physical activity can result in a 7% reduction in cancer risk, which is mainly attributed to its protective role against breast cancer and colorectal cancer.

2146- Ex,    A systematic review and meta-analysis of physical activity and endometrial cancer risk
- Review, Endo, NA
Risk↓, High versus low physical activity was related to reduced endometrial cancer risk [relative risk (RR) = 0.80
eff↑, recreational physical activity, occupational physical activity, and walking/biking for transportation are related to decreased endometrial cancer risk. Inverse associations are evident for physical activity of light, moderate to vigorous

2147- Ex,    The association between physical activity and gastroesophageal cancer: systematic review and meta-analysis
- Review, GC, NA
Risk↓, When we compared high versus low physical activity levels and summarized associations according to anatomic site and tumor histology, risk reductions were evident for esophageal adenocarcinoma [relative risk (RR) = 0.79

2148- Ex,    Effects of Exercise on Cancer Treatment Efficacy: A Systematic Review of Preclinical and Clinical Studies
- Review, Var, NA
ChemoSen↑, Exercise significantly enhanced the efficacy of chemotherapy and tamoxifen in seven of eight rodent models in either an additive, sensitizing, or synergistic manner.

2149- Ex,    Physical activity and exercise training in cancer patients
- Analysis, Var, NA
eff↑, Most guidelines for cancer survivors suggest that physical activity and exercise should be an integral and continuous part of care for all cancer survivors
Dose↑, Strong evidence supports the promotion of physical activity and exercise for adult cancer patients before, during, and after cancer treatment, across all cancer types, and including patients with advanced disease

2150- Ex,    Roles and molecular mechanisms of physical exercise in cancer prevention and treatment
- Review, Var, NA
eff↓, Physical exercise should be considered an important intervention to prevent and treat cancer and its complications.
Dose↝, Sensitivity to physical exercise varies in different cancers; we provide evidence for the exercise type and strength in various cancers and in differing stages.
TumCP↓, nhibiting cancer cell proliferation and inducing apoptosis and regulating metabolism and the immune environment are the main mechanisms of the benefits of physical exercise in cancer prevention and treatment.
Apoptosis↓,
ChemoSen↑, Graphic Abstract
chemoP↑, Graphic Abstract

2151- Ex,    The effects of physical activity on overall survival among advanced cancer patients: a systematic review and meta-analysis
- Review, Var, NA
eff↑, a higher level of physical activity in non-randomised trials was significantly associated with reduced mortality risk
eff↝, Nevertheless, it might be too late for advanced cancer patients to start exercising for survival improvements, based on findings from randomised controlled trials.

2153- Ex,    The Impact of Exercise on Cancer Mortality, Recurrence, and Treatment-Related Adverse Effects
- Review, Var, NA
eff↑, The findings of this review support the view that exercise is an important adjunct therapy in the management of cancer
BMD↑, Finally, thrice weekly resistance training during 6 months of radiotherapy for metastases to the spine resulted in significantly improved spine bone density compared with passive physical therapy
cognitive↑, Two of the 5 observed significant improve- ments in cognitive function
OS↑, 28-44% reduced risk of cancer-specific mortality
Remission↑, 21%-35% lower risk of cancer recurrence
eff↑, exercise may elicit positive changes in inflammation, immunity, and oxidative stress, as well as in metabolic and sex hormones, all of which are factors believed to contribute to cancer progression

1753- WBV,  Ex,    Physical Exercise with or without Whole-Body Vibration in Breast Cancer Patients Suffering from Aromatase Inhibitor—Induced Musculoskeletal Symptoms: A Pilot Randomized Clinical Study
- Trial, BC, NA
Pain↓, The WBV group (mean age: 51.73 ± 10.73 years; body mass index (BMI): 25.56 ± 5.17 kg/m2) showed a statistically significant pain reduction
Strength↑, Concurrently, muscle strength, physical performance, and quality of life significantly improved in both groups, without significant differences between groups
QoL↑,
Dose∅, with a frequency of 30 Hz, peak-to-peak amplitude of 1.15 mm. in squatting position (110° knee flexion)


* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 12

Results for Effect on Cancer/Diseased Cells:
Apoptosis↓,1,   BMD↑,1,   chemoP↑,1,   ChemoSen↑,2,   cognitive↑,1,   Dose?,1,   Dose↑,1,   Dose↝,3,   Dose∅,1,   eff↓,1,   eff↑,7,   eff↝,1,   OS↑,2,   Pain↓,1,   QoL↑,1,   Remission↑,1,   Risk↓,5,   Strength↑,1,   TumCP↓,1,  
Total Targets: 19

Results for Effect on Normal Cells:

Total Targets: 0

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:171  Target#:%  State#:%  Dir#:%
  wNotes=on  sortOrder:rid,rpid

 

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