Database Query Results : Photodynamic Therapy, ,

PDT, Photodynamic Therapy: Click to Expand ⟱
Features: Therapy
Photodynamic therapy is a form of phototherapy involving light and a photosensitizing chemical substance used in conjunction with molecular oxygen to elicit cell death.


Scientific Papers found: Click to Expand⟱
1374- BBR,  PDT,    Berberine associated photodynamic therapy promotes autophagy and apoptosis via ROS generation in renal carcinoma cells
- in-vitro, RCC, 786-O - in-vitro, RCC, HK-2
"highlight2" >ROS↑, "highlight2" >TumAuto↑, "highlight2" >Apoptosis↑, "highlight2" >Casp3↑, "highlight2" >eff↑,
2681- BBR,  PDT,    Berberine-photodynamic induced apoptosis by activating endoplasmic reticulum stress-autophagy pathway involving CHOP in human malignant melanoma cells
- in-vitro, Melanoma, NA
"highlight2" >Apoptosis↑, "highlight2" >cl‑Casp3↑, "highlight2" >LC3s↑, "highlight2" >ER Stress↑, "highlight2" >ROS↑, "highlight2" >CHOP↑,
2680- BBR,  PDT,    Photodynamic therapy-triggered nuclear translocation of berberine from mitochondria leads to liver cancer cell death
- in-vitro, Liver, HUH7
"highlight2" >TumCD↑, "highlight2" >ROS↑, "highlight2" >TumCCA↑, "highlight2" >ER Stress↑,
482- CUR,  PDT,    The Antitumor Effect of Curcumin in Urothelial Cancer Cells Is Enhanced by Light Exposure In Vitro
- in-vitro, Bladder, RT112 - in-vitro, Bladder, UMUC3
"highlight2" >Apoptosis↑, "highlight2" >TumCG↓, "highlight2" >TumCP↓,
483- CUR,  PDT,    Visible light and/or UVA offer a strong amplification of the anti-tumor effect of curcumin
- in-vivo, NA, A431
"highlight2" >TumVol↓, "highlight2" >TumCP↓, "highlight2" >Apoptosis↑,
484- CUR,  PDT,    Low concentrations of curcumin induce growth arrest and apoptosis in skin keratinocytes only in combination with UVA or visible light
- in-vitro, Melanoma, NA
"highlight2" >Cyt‑c↑, "highlight2" >Casp9↑, "highlight2" >Casp8↑, "highlight2" >NF-kB↓, "highlight2" >EGFR↓,
485- CUR,  PDT,    Red Light Combined with Blue Light Irradiation Regulates Proliferation and Apoptosis in Skin Keratinocytes in Combination with Low Concentrations of Curcumin
- in-vitro, Melanoma, NA
"highlight2" >NF-kB↓, "highlight2" >Casp8↑, "highlight2" >Casp9↑, "highlight2" >p‑Akt↓, "highlight2" >p‑ERK↓,
1175- IVM,  PDT,    Drug induced mitochondria dysfunction to enhance photodynamic therapy of hypoxic tumors
- in-vitro, Var, NA
"highlight2" >Hypoxia↓, "highlight2" >mitResp↓, "highlight2" >ROS↑,
2532- M-Blu,  PDT,    Methylene blue in anticancer photodynamic therapy: systematic review of preclinical studies
- Review, Var, NA
"highlight2" >AntiCan↑,
2533- M-Blu,  PDT,    Methylene blue-mediated photodynamic therapy enhances apoptosis in lung cancer cells
- in-vitro, Lung, A549
"highlight2" >MMP↓, "highlight2" >p‑MAPK↑, "highlight2" >ROS↑, "highlight2" >cl‑PARP↑, "highlight2" >Bcl-2↓, "highlight2" >Mcl-1↓, "highlight2" >eff↓,
2534- M-Blu,  doxoR,  PDT,    Methylene Blue-Mediated Photodynamic Therapy in Combination With Doxorubicin: A Novel Approach in the Treatment of HT-29 Colon Cancer Cells
- in-vitro, CRC, HT-29
"highlight2" >LDH↑, "highlight2" >ROS↑,
1476- SFN,  PDT,    Enhancement of cytotoxic effect on human head and neck cancer cells by combination of photodynamic therapy and sulforaphane
- in-vitro, HNSCC, NA
"highlight2" >eff↑, "highlight2" >tumCV↓, "highlight2" >ROS↑, "highlight2" >eff↓, "highlight2" >Casp↑,
4564- SNP,  GoldNP,  Cu,  Chemo,  PDT  Cytotoxicity and targeted drug delivery of green synthesized metallic nanoparticles against oral Cancer: A review
- Review, Var, NA
"highlight2" >ROS↑, "highlight2" >DNAdam↑, "highlight2" >TumCCA↑, "highlight2" >eff↑, "highlight2" >Apoptosis↑, "highlight2" >eff↓, "highlight2" >ChemoSen↑,
335- SNP,  PDT,    Biogenic Silver Nanoparticles for Targeted Cancer Therapy and Enhancing Photodynamic Therapy
- Review, NA, NA
"highlight2" >ROS↑, "highlight2" >GSH↓, "highlight2" >GPx↑, "highlight2" >Catalase↓, "highlight2" >SOD↓, "highlight2" >p38↑, "highlight2" >BAX↑, "highlight2" >Bcl-2↓,
336- SNP,  PDT,    Photodynamic ability of silver nanoparticles in inducing cytotoxic effects in breast and lung cancer cell lines
- in-vitro, BC, MCF-7
"highlight2" >Apoptosis↑,
1838- VitK3,  PDT,    Photodynamic Effects of Vitamin K3 on Cervical Carcinoma Cells Activating Mitochondrial Apoptosis Pathways
- in-vitro, Cerv, NA
"highlight2" >eff↑, "highlight2" >ROS↑, "highlight2" >tumCV↓, "highlight2" >TumCG↓, "highlight2" >Apoptosis↑, "highlight2" >cl‑Casp3↑, "highlight2" >cl‑Casp9↑, "highlight2" >Bcl-xL↑, "highlight2" >Cyt‑c↑, "highlight2" >Bcl-2↓,
1834- VitK3,  PDT,    Effects of Vitamin K3 Combined with UVB on the Proliferation and Apoptosis of Cutaneous Squamous Cell Carcinoma A431 Cells
- in-vitro, Melanoma, A431
"highlight2" >eff↑, "highlight2" >TumCG↓, "highlight2" >TumCP↓, "highlight2" >ROS↑, "highlight2" >MMP↓,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 17

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

Catalase↓, 1,   GPx↑, 1,   GSH↓, 1,   ROS↑, 11,   SOD↓, 1,  

Mitochondria & Bioenergetics ⓘ

mitResp↓, 1,   MMP↓, 2,  

Core Metabolism/Glycolysis ⓘ

LDH↑, 1,  

Cell Death ⓘ

p‑Akt↓, 1,   Apoptosis↑, 7,   BAX↑, 1,   Bcl-2↓, 3,   Bcl-xL↑, 1,   Casp↑, 1,   Casp3↑, 1,   cl‑Casp3↑, 2,   Casp8↑, 2,   Casp9↑, 2,   cl‑Casp9↑, 1,   Cyt‑c↑, 2,   p‑MAPK↑, 1,   Mcl-1↓, 1,   p38↑, 1,   TumCD↑, 1,  

Transcription & Epigenetics ⓘ

tumCV↓, 2,  

Protein Folding & ER Stress ⓘ

CHOP↑, 1,   ER Stress↑, 2,  

Autophagy & Lysosomes ⓘ

LC3s↑, 1,   TumAuto↑, 1,  

DNA Damage & Repair ⓘ

DNAdam↑, 1,   cl‑PARP↑, 1,  

Cell Cycle & Senescence ⓘ

TumCCA↑, 2,  

Proliferation, Differentiation & Cell State ⓘ

p‑ERK↓, 1,   TumCG↓, 3,  

Migration ⓘ

TumCP↓, 3,  

Angiogenesis & Vasculature ⓘ

EGFR↓, 1,   Hypoxia↓, 1,  

Immune & Inflammatory Signaling ⓘ

NF-kB↓, 2,  

Drug Metabolism & Resistance ⓘ

ChemoSen↑, 1,   eff↓, 3,   eff↑, 5,  

Clinical Biomarkers ⓘ

EGFR↓, 1,   LDH↑, 1,  

Functional Outcomes ⓘ

AntiCan↑, 1,   TumVol↓, 1,  
Total Targets: 45

Pathway results for Effect on Normal Cells:


Total Targets: 0

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:175  Target#:%  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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