Radiotherapy/Radiation / antiOx Cancer Research Results

Rad, Radiotherapy/Radiation: Click to Expand ⟱
Features:
Treatment of disease with radiation, especially by selective irradiation with x-rays or other ionizing radiation and by ingestion of radioisotopes.

Radiosensitizer
Atorvaqone, (mitochondria inhibitor) decrease O2 consumption making more O2 available as a radiosensitizer.
-Hypoxia (low oxygen levels) within tumors is a major cause of resistance to radiotherapy


antiOx, anti-oxidant activities: Click to Expand ⟱
Source:
Type:
Various antioxidants such as Nrf2, SODs, catalase, GPxs, PRDXs, and GSTs are altered in different cancers and have been linked to prognosis. Their overexpression can correlate with aggressive tumor behavior and resistance to treatment in many contexts.
Scientific Papers found: Click to Expand⟱
3445- ALA,  Rad,    The radioprotective effects of alpha-lipoic acid on radiotherapy-induced toxicities: A systematic review
- Review, Var, NA
*radioP↑, *antiOx↑, *Inflam↓,
6906- FIS,  Rad,    Combining fisetin and ionizing radiation suppresses the growth of mammalian colorectal cancers in xenograft tumor models
- in-vivo, CRC, CT26 - in-vivo, CRC, HCT116
antiOx↑, Inflam↓, angioG↓, TumCI↓, TumCP↓, TumCG↓, RadioS↑,
1775- MEL,  Chemo,  Rad,    A Systematic Review of the Chemo/Radioprotective Effects of Melatonin against Ototoxic Adverse Effects Induced by Chemotherapy and Radiotherapy
- Review, Var, NA
chemoP↑, radioP↑, antiOx↑, Inflam↑,
4615- Se,  Rad,    Selenium as an adjuvant for modification of radiation response
- Review, Nor, NA
*antiOx↑, *radioP↑, *GSH↑, *GPx↑, *Dose↝, selectivity↑, RadioS↑,
4611- SeNPs,  Rad,    Radioprotective Effect of Selenium Nanoparticles: A Mini Review
- Review, Var, NA
*antiOx↑, *Inflam↓, *radioP↑, *ROCK1↓, *DNAdam↓, *Apoptosis↓, *RadioS↑, *Dose↝,
4612- SeNPs,  Rad,    Histopathological Evaluation of Radioprotective Effects: Selenium Nanoparticles Protect Lung Tissue from Radiation Damage
- in-vivo, Nor, NA
*radioP↑, *Inflam↓, *antiOx↑, *Dose↝, *DNAdam↓, *ROS↓, *SOD↑, *GPx↑, *Dose↝, *eff↑,
4610- SSE,  Rad,    Protection during radiotherapy: selenium
- Review, Var, NA
*radioP↑, *antiOx↑, *Inflam↓, *DNAdam↓, *lipid-P↓, *selenoP↑, *GPx1↑, *BUN↓,

Showing Research Papers: 1 to 7 of 7

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 7

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 2,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

TumCG↓, 1,  

Migration(tgid=13) ⓘ

TumCI↓, 1,   TumCP↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

Inflam↓, 1,   Inflam↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

RadioS↑, 2,   selectivity↑, 1,  

Functional Outcomes(tgid=23) ⓘ

chemoP↑, 1,   radioP↑, 1,  
Total Targets: 11

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 5,   GPx↑, 2,   GPx1↑, 1,   GSH↑, 1,   lipid-P↓, 1,   ROS↓, 1,   selenoP↑, 1,   SOD↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

BUN↓, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↓, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 3,  

Migration(tgid=13) ⓘ

ROCK1↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

Inflam↓, 4,  

Drug Metabolism & Resistance(tgid=21) ⓘ

Dose↝, 4,   eff↑, 1,   RadioS↑, 1,  

Functional Outcomes(tgid=23) ⓘ

radioP↑, 5,  
Total Targets: 17

Scientific Paper Hit Count for: antiOx, anti-oxidant activities
7 Radiotherapy/Radiation
2 Selenium NanoParticles
1 Alpha-Lipoic-Acid
1 Fisetin
1 Melatonin
1 Chemotherapy
1 Selenium
1 Selenite (Sodium)
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:201  Target#:1103  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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