Radiotherapy/Radiation / Mst1 Cancer Research Results

Rad, Radiotherapy/Radiation: Click to Expand ⟱
Features:
Treatment of disease with radiation, especially by selective irradiation with x-rays or other ionizing radiation and by ingestion of radioisotopes.

Radiosensitizer
Atorvaqone, (mitochondria inhibitor) decrease O2 consumption making more O2 available as a radiosensitizer.
-Hypoxia (low oxygen levels) within tumors is a major cause of resistance to radiotherapy


Mst1, Mammalian Ste20-like kinase 1: Click to Expand ⟱
Source:
Type:
MST1 (Mammalian Ste20-like kinase 1), also known as STK4, is a key component of the Hippo signaling pathway and has been implicated in regulating cell proliferation, apoptosis, and tissue homeostasis.

Several studies have suggested that MST1 expression may be reduced in aggressive breast cancer subtypes.

• Prognosis: Lower MST1 levels have been associated with enhanced tumor growth and metastasis, suggesting a potential tumor suppressor role. Some reports correlate low MST1 with poorer disease-free and overall survival.
Scientific Papers found: Click to Expand⟱
7279- GGB,  Rad,    Radioprotective effect of Ginkgolide B on brain: the mediating role of DCC/MST1 signaling
- in-vivo, Nor, NA
*cognitive↑, *radioP↑, *ROS↓, *p‑Akt↑, *Bcl-2↑, *Mst1↓, *p‑p38↓, *JNK↓, *cl‑Casp3↓, *BAX↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Total Targets: 0

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

ROS↓, 1,  

Cell Death(tgid=5) ⓘ

p‑Akt↑, 1,   BAX↓, 1,   Bcl-2↑, 1,   cl‑Casp3↓, 1,   JNK↓, 1,   p‑p38↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

Mst1↓, 1,  

Functional Outcomes(tgid=23) ⓘ

cognitive↑, 1,   radioP↑, 1,  
Total Targets: 10

Scientific Paper Hit Count for: Mst1, Mammalian Ste20-like kinase 1
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:201  Target#:1266  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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