Radiotherapy/Radiation / NADPH Cancer Research Results

Rad, Radiotherapy/Radiation: Click to Expand ⟱
Features:
Treatment of disease with radiation, especially by selective irradiation with x-rays or other ionizing radiation and by ingestion of radioisotopes.

Radiosensitizer
Atorvaqone, (mitochondria inhibitor) decrease O2 consumption making more O2 available as a radiosensitizer.
-Hypoxia (low oxygen levels) within tumors is a major cause of resistance to radiotherapy


NADPH, Nicotinamide adenine dinucleotide phosphate: Click to Expand ⟱
Source:
Type:
NADPH (Nicotinamide adenine dinucleotide phosphate) is a crucial molecule in cellular metabolism, playing a key role in various biological processes, including energy production, antioxidant defenses, and biosynthesis.
NADPH is essential for the proper functioning of the pentose phosphate pathway, which generates NADPH and ribose-5-phosphate. Cancer cells may exploit this pathway to support their high energy demands.
Many types of cancer, including breast, lung, and colon cancer, exhibit increased NADPH levels compared to normal tissues. This increase is often associated with enhanced glucose-6-phosphate dehydrogenase (G6PD) activity, a key enzyme in the pentose phosphate pathway that generates NADPH.
Scientific Papers found: Click to Expand⟱
1485- CUR,  Chemo,  Rad,    Curcumin, the golden spice from Indian saffron, is a chemosensitizer and radiosensitizer for tumors and chemoprotector and radioprotector for normal organs
- Review, Var, NA
ChemoSen↑, NF-kB↓, *STAT3↓, *COX2↓, *Akt↓, *NRF2↑, *HO-1↑, *GPx↑, *NADPH↑, *GSH↑, *ROS↓, *p300↓, radioP↑, chemoP↑, RadioS↑,
1987- PTL,  Rad,    A NADPH oxidase dependent redox signaling pathway mediates the selective radiosensitization effect of parthenolide in prostate cancer cells
- in-vitro, Pca, PC3 - in-vitro, Nor, PrEC
selectivity↑, RadioS↑, ROS↑, *ROS∅, NADPH↑, Trx↓, PI3K↑, Akt↑, p‑FOXO3↓, SOD2↓, Catalase↓, radioP↑, *NADPH∅, *GSH↑, *GSH/GSSG↑, *NRF2↑,

Showing Research Papers: 1 to 2 of 2

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

Catalase↓, 1,   ROS↑, 1,   SOD2↓, 1,   Trx↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

NADPH↑, 1,  

Cell Death(tgid=5) ⓘ

Akt↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

p‑FOXO3↓, 1,   PI3K↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

NF-kB↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ChemoSen↑, 1,   RadioS↑, 2,   selectivity↑, 1,  

Functional Outcomes(tgid=23) ⓘ

chemoP↑, 1,   radioP↑, 2,  
Total Targets: 14

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

GPx↑, 1,   GSH↑, 2,   GSH/GSSG↑, 1,   HO-1↑, 1,   NRF2↑, 2,   ROS↓, 1,   ROS∅, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

NADPH↑, 1,   NADPH∅, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

p300↓, 1,   STAT3↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2↓, 1,  
Total Targets: 13

Scientific Paper Hit Count for: NADPH, Nicotinamide adenine dinucleotide phosphate
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:201  Target#:624  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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