Database Query Results : Radiotherapy/Radiation, ,

Rad, Radiotherapy/Radiation: Click to Expand ⟱

Features:

Treatment of disease with radiation, especially by selective irradiation with x-rays or other ionizing radiation and by ingestion of radioisotopes.

Radiosensitizer
Atorvaqone, (mitochondria inhibitor) decrease O2 consumption making more O2 available as a radiosensitizer.

Scientific Papers found: Click to Expand⟱

1337-

2DG,

Rad,

2-deoxy-D-glucose causes cytotoxicity, oxidative stress, and radiosensitization in pancreatic cancer

in-vivo,

NA,

mice

"highlight2" >ChemoSen↑, "highlight2" >GlucoseCon↓, "highlight2" >ROS↑,

5282-

3BP,

Rad,

3-Bromopyruvate-mediated MCT1-dependent metabolic perturbation sensitizes triple negative breast cancer cells to ionizing radiation

in-vitro,

BC,

MDA-MB-231

in-vitro,

BC,

MDA-MB-468

"highlight2" >Glycolysis↓, "highlight2" >RadioS↑, "highlight2" >eff↑, "highlight2" >GAPDH↓, "highlight2" >PPP↑, "highlight2" >GSH↓, "highlight2" >ECAR↓,

5279-

3BP,

Rad,

Abstract 5243: 3-Bromopyruvate in combination with radiation inhibits pancreatic cancer growth by dismantling mitochondria and ATP generation in a preclinical mouse model

in-vivo,

PC,

"highlight2" >ATP↓, "highlight2" >HK2↓, "highlight2" >RadioS↑,

328-

AgNPs,

Rad,

Silver nanoparticles outperform gold nanoparticles in radiosensitizing U251 cells in vitro and in an intracranial mouse model of glioma

vitro+vivo,

GBM,

U251

 75.9 μg/mL

"highlight2" >Apoptosis↑, "highlight2" >TumAuto↑,

4358-

AgNPs,

HPT,

Rad,

Silver nanocrystals mediated combination therapy of radiation with magnetic hyperthermia on glioma cells

in-vitro,

GBM,

U251

10 nm silver nanoparticles (AgNPs) on human glioma U251 c

"highlight2" >RadioS↑, "highlight2" >eff↑, "highlight2" >TumCD↑,

4400-

AgNPs,

Rad,

Differential cytotoxic and radiosensitizing effects of silver nanoparticles on triple-negative breast cancer and non-triple-negative breast cells

in-vitro,

BC,

MCF-7

in-vitro,

Nor,

MCF10

in-vitro,

BC,

MDA-MB-231

in-vitro,

BC,

BT549

in-vivo,

BC,

MDA-MB-231

right hind flanks of the mice

"highlight2" >ROS↑, "highlight2" >DNAdam↑, "highlight2" >selectivity↑, "highlight2" >TumCG↓, "highlight2" >RadioS↑, "highlight2" >Dose↝, "highlight2" >selectivity↑, "highlight2" >other↝, "highlight2" >eff↓, "highlight2" >eff↑, "highlight2" >γH2AX↑, "highlight2" >Dose↓, "highlight2" >eff↑,

4401-

AgNPs,

Rad,

Metformin-loaded chitosan nanoparticles augment silver nanoparticle-induced radiosensitization in breast cancer cells during radiation therapy

in-vitro,

BC,

 Met NPs and AgNPs had average diameters of 51.5 ± 9.4 nm and 3.02 ± 0.03 nm,

"highlight2" >RadioS↑, "highlight2" >DNAdam↑,

4404-

AgNPs,

Rad,

Main Approaches to Enhance Radiosensitization in Cancer Cells by Nanoparticles: A Systematic Review

Review,

Var,

"highlight2" >eff↑, "highlight2" >ROS↑,

4563-

AgNPs,

Rad,

Silver nanoparticles enhance neutron radiation sensitivity in cancer cells: An in vitro study

in-vitro,

BC,

MCF-7

in-vitro,

Ovarian,

SKOV3

in-vitro,

GBM,

U87MG

in-vitro,

Melanoma,

A431

"highlight2" >RadioS↑, "highlight2" >ROS↑, "highlight2" >TumCCA↑, "highlight2" >Apoptosis↑, "highlight2" >ER Stress↑,

332-

AgNPs,

Rad,

Enhancement of Radiosensitization by Silver Nanoparticles Functionalized with Polyethylene Glycol and Aptamer As1411 for Glioma Irradiation Therapy

in-vivo,

GBM,

 mice

"highlight2" >OS↑,

331-

AgNPs,

Rad,

Silver nanoparticles: a novel radiation sensitizer for glioma?

vitro+vivo,

GBM,

 rats

"highlight2" >OS↑,

330-

AgNPs,

Rad,

Reactive oxygen species acts as executor in radiation enhancement and autophagy inducing by AgNPs

in-vitro,

GBM,

U251

"highlight2" >TumAuto↑, "highlight2" >ROS↑,

329-

AgNPs,

Rad,

Enhancement of radiotherapy efficacy by silver nanoparticles in hypoxic glioma cells

in-vitro,

GBM,

U251

"highlight2" >Apoptosis↑, "highlight2" >TumAuto↑,

2669-

AL,

Rad,

Inhibition of ICAM-1 expression by garlic component, allicin, in gamma-irradiated human vascular endothelial cells via downregulation of the JNK signaling pathway

in-vitro,

Nor,

HUVECs

"highlight2" >*ICAM-1↓, "highlight2" >*AP-1↓, "highlight2" >*p‑cJun↓, "highlight2" >*radioP↑, "highlight2" >JNK↓,

2668-

AL,

Rad,

Allicin enhances the radiosensitivity of colorectal cancer cells via inhibition of NF-κB signaling pathway

in-vitro,

CRC,

HCT116

"highlight2" >RadioS↑, "highlight2" >NF-kB↓,

298-

ALA,

Rad,

Synergistic Tumoricidal Effects of Alpha-Lipoic Acid and Radiotherapy on Human Breast Cancer Cells via HMGB1

in-vitro,

BC,

MDA-MB-231

"highlight2" >Apoptosis↑, "highlight2" >P53↑, "highlight2" >p38↑, "highlight2" >NF-kB↑, "highlight2" >TumCCA↑,

3445-

ALA,

Rad,

The radioprotective effects of alpha-lipoic acid on radiotherapy-induced toxicities: A systematic review

Review,

Var,

"highlight2" >*radioP↑, "highlight2" >*antiOx↑, "highlight2" >*Inflam↓,

2583-

Api,

Rad,

The influence of apigenin on cellular responses to radiation: From protection to sensitization

Review,

Var,

"highlight2" >radioP↑, "highlight2" >RadioS↑, "highlight2" >*COX2↓, "highlight2" >*ROS↓, "highlight2" >VEGF↓, "highlight2" >MMP2↓, "highlight2" >STAT3↓, "highlight2" >AMPK↑, "highlight2" >Apoptosis↑, "highlight2" >MMP9↓, "highlight2" >glucose↓,

3163-

Ash,

Rad,

Withaferin A, a steroidal lactone, selectively protects normal lymphocytes against ionizing radiation induced apoptosis and genotoxicity via activation of ERK/Nrf-2/HO-1 axis

"highlight2" >*radioP↑, "highlight2" >selectivity↑, "highlight2" >*Casp3↓, "highlight2" >*DNAdam↓, "highlight2" >*ROS↓, "highlight2" >*GSH↓, "highlight2" >*NRF2↑, "highlight2" >*HO-1↑, "highlight2" >*Catalase↑, "highlight2" >*SOD↑, "highlight2" >*Prx↑, "highlight2" >*ERK↑,

4824-

ASTX,

Rad,

Astaxanthin protects the radiation-induced lung injury in C57BL/6 female mice

in-vivo,

Nor,

 mice model of RILI

"highlight2" >*radioP↑, "highlight2" >Inflam↓,

4822-

ASTX,

Rad,

Astaxanthin Synergizes with Ionizing Radiation (IR) in Oral Squamous Cell Carcinoma (OSCC)

"highlight2" >tumCV↓, "highlight2" >selectivity↑, "highlight2" >RadioS↑, "highlight2" >GPx4↓, "highlight2" >Ferroptosis↑,

4979-

ATV,

Rad,

Short‐Term Statin Treatment Reduces, and Long‐Term Statin Treatment Abolishes, Chronic Vascular Injury by Radiation Therapy

in-vivo,

Nor,

C57Bl/6 mice were pretreated with pravastatin for 72 hours and then exposed to 12 Gy X‐ray head‐and‐neck irradiation

"highlight2" >radioP↑, "highlight2" >radioP↑,

4978-

ATV,

Rad,

Atorvastatin Sensitizes Breast and Lung Cancer Cells to Ionizing Radiation

in-vitro,

BC,

A549

"highlight2" >Apoptosis↑, "highlight2" >RadioS↑, "highlight2" >TumCP↓, "highlight2" >ROS↑,

5367-

AV,

Rad,

Aloe vera for prevention of radiation-induced dermatitis: a self-controlled clinical trial

Trial,

Var,

60 patients

"highlight2" >radioP↑, "highlight2" >Dose↝, "highlight2" >eff↑,

2769-

Ba,

Rad,

Baicalein ameliorates ionizing radiation-induced injuries by rebalancing gut microbiota and inhibiting apoptosis

in-vivo,

Nor,

MICE

"highlight2" >*radioP↑, "highlight2" >GutMicro↑, "highlight2" >*P53↓, "highlight2" >*Apoptosis↑, "highlight2" >*DR4↓,

2289-

Ba,

Rad,

Baicalein Inhibits the Progression and Promotes Radiosensitivity of Esophageal Squamous Cell Carcinoma by Targeting HIF-1A

in-vitro,

ESCC,

KYSE150

20uM

"highlight2" >TumCP↓, "highlight2" >TumCMig↓, "highlight2" >Glycolysis↓, "highlight2" >cycD1/CCND1↓, "highlight2" >CDK4↓, "highlight2" >ECAR↓, "highlight2" >TumCCA↑, "highlight2" >HK1↓, "highlight2" >ALDH↓, "highlight2" >ALDOA↓, "highlight2" >PKM2↓, "highlight2" >Hif1a↓,

2481-

Ba,

Rad,

Radiotherapy Increases 12-LOX and CCL5 Levels in Esophageal Cancer Cells and Promotes Cancer Metastasis via THP-1-Derived Macrophages

in-vitro,

ESCC,

Eca109

0, 20, 40, or 80 µmol/L

in-vitro,

ESCC,

KYSE150

"highlight2" >12LOX↓, "highlight2" >RadioS↑, "highlight2" >Dose↝, "highlight2" >RANTES↓, "highlight2" >MCP1↓,

2622-

Ba,

Cisplatin,

Rad,

Natural Baicalein-Rich Fraction as Radiosensitizer in Combination with Bismuth Oxide Nanoparticles and Cisplatin for Clinical Radiotherapy

in-vitro,

BC,

MDA-MB-231

in-vitro,

BC,

MCF-7

"highlight2" >RadioS↑,

1381-

BBR,

Rad,

Berberine enhances the sensitivity of radiotherapy in ovarian cancer cell line (SKOV-3)

in-vitro,

Ovarian,

SKOV3

5 µM

"highlight2" >RadioS↑, "highlight2" >ROS↑, "highlight2" >GSH↓, "highlight2" >Apoptosis↑,

2022-

BBR,

GoldNP,

Rad,

Berberine-loaded Janus gold mesoporous silica nanocarriers for chemo/radio/photothermal therapy of liver cancer and radiation-induced injury inhibition

in-vitro,

Liver,

SMMC-7721 cell

in-vitro,

Nor,

HL7702

"highlight2" >*toxicity↓, "highlight2" >radioP↑, "highlight2" >BioAv↑, "highlight2" >AntiTum↑, "highlight2" >selectivity↑, "highlight2" >eff↑, "highlight2" >chemoP↑,

1390-

BBR,

Rad,

Berberine Inhibited Radioresistant Effects and Enhanced Anti-Tumor Effects in the Irradiated-Human Prostate Cancer Cells

in-vitro,

Pca,

PC3

"highlight2" >RadioS↑, "highlight2" >Apoptosis↑, "highlight2" >ROS↑, "highlight2" >eff↑, "highlight2" >BAX↑, "highlight2" >Casp3↑, "highlight2" >P53↑, "highlight2" >p38↑, "highlight2" >JNK↑, "highlight2" >Bcl-2↓, "highlight2" >ERK↓, "highlight2" >HO-1↓,

1399-

BBR,

Rad,

Radiotherapy Enhancing and Radioprotective Properties of Berberine: A Systematic Review

Review,

NA,

"highlight2" >*ROS↓, "highlight2" >*MDA↓, "highlight2" >*TNF-α↓, "highlight2" >*TGF-β↓, "highlight2" >*IL10↑, "highlight2" >ROS↑, "highlight2" >DNAdam↑, "highlight2" >mtDam↑, "highlight2" >MMP↓, "highlight2" >Apoptosis↑, "highlight2" >TumCCA↑, "highlight2" >Hif1a↓, "highlight2" >VEGF↓, "highlight2" >RadioS↑,

2715-

BBR,

Rad,

Berberine Can Amplify Cytotoxic Effect of Radiotherapy by Targeting Cancer Stem Cells

in-vitro,

BC,

MCF-7

"highlight2" >tumCV↓, "highlight2" >OCT4↓, "highlight2" >SOX2↓, "highlight2" >RadioS↑, "highlight2" >CSCs↓,

702-

Bor,

GEN,

SeMet,

Rad,

Evaluation of ecological and in vitro effects of boron on prostate cancer risk (United States)

Analysis,

NA,

"highlight2" >Risk↓, "highlight2" >TumCMig↓, "highlight2" >Bcl-2↓,

2804-

CHr,

Rad,

Gamma-Irradiated Chrysin Improves Anticancer Activity in HT-29 Colon Cancer Cells Through Mitochondria-Related Pathway

in-vitro,

CRC,

HT29

"highlight2" >RadioS↑, "highlight2" >ROS↑, "highlight2" >MMP↓, "highlight2" >Casp3↑, "highlight2" >Casp9↑, "highlight2" >cl‑PARP↑,

1980-

CUR,

Rad,

Thioredoxin reductase-1 (TxnRd1) mediates curcumin-induced radiosensitization of squamous carcinoma cells

in-vitro,

Cerv,

HeLa

10 µM

in-vitro,

Laryn,

FaDu

10 µM

"highlight2" >selectivity↑, "highlight2" >RadioS↑, "highlight2" >TrxR↓, "highlight2" >ROS↑, "highlight2" >ERK↑, "highlight2" >Dose∅, "highlight2" >cl‑PARP↑,

1485-

CUR,

Chemo,

Rad,

Curcumin, the golden spice from Indian saffron, is a chemosensitizer and radiosensitizer for tumors and chemoprotector and radioprotector for normal organs

Review,

Var,

"highlight2" >ChemoSen↑, "highlight2" >NF-kB↓, "highlight2" >*STAT3↓, "highlight2" >*COX2↓, "highlight2" >*Akt↓, "highlight2" >*NRF2↑, "highlight2" >*HO-1↑, "highlight2" >*GPx↑, "highlight2" >*NADPH↑, "highlight2" >*GSH↑, "highlight2" >*ROS↓, "highlight2" >*p300↓, "highlight2" >radioP↑, "highlight2" >chemoP↑, "highlight2" >RadioS↑,

1979-

CUR,

Rad,

Dimethoxycurcumin, a metabolically stable analogue of curcumin enhances the radiosensitivity of cancer cells: Possible involvement of ROS and thioredoxin reductase

in-vitro,

Lung,

A549

"highlight2" >eff↑, "highlight2" >ROS↑, "highlight2" >GSH/GSSG↓, "highlight2" >TrxR↓, "highlight2" >selectivity↑,

1870-

DCA,

Rad,

Dichloroacetate (DCA) sensitizes both wild-type and over expressing Bcl-2 prostate cancer cells in vitro to radiation

in-vitro,

Pca,

PC3

"highlight2" >TumCCA↑, "highlight2" >Apoptosis↑, "highlight2" >MMP↓, "highlight2" >eff↑, "highlight2" >RadioS↑,

5195-

DCA,

Rad,

Dichloroacetate Radiosensitizes Hypoxic Breast Cancer Cells

in-vitro,

BC,

4T1

in-vitro,

BC,

EMT6

"highlight2" >PDKs↑, "highlight2" >ROS↑, "highlight2" >p‑PDH↓, "highlight2" >ECAR↓, "highlight2" >lactateProd↓, "highlight2" >selectivity↓, "highlight2" >RadioS↑,

5193-

dietMet,

Rad,

A Phase I Trial of a Methionine Restricted Diet with Concurrent Radiation Therapy

Trial,

Var,

"highlight2" >toxicity↝, "highlight2" >other↝,

5010-

DSF,

Cu,

Rad,

Disulfiram/Copper Combined with Irradiation Induces Immunogenic Cell Death in Melanoma

in-vivo,

Melanoma,

B16-F10

"highlight2" >Apoptosis↑, "highlight2" >ICD↑, "highlight2" >HMGB1↑, "highlight2" >ATP↓, "highlight2" >TumCG↓,

1620-

EA,

Rad,

Radiosensitizing effect of ellagic acid on growth of Hepatocellular carcinoma cells: an in vitro study

in-vitro,

Liver,

HepG2

"highlight2" >ROS↑, "highlight2" >P53↑, "highlight2" >TumCCA↑, "highlight2" >IL6↓, "highlight2" >COX2↓, "highlight2" >TNF-α↓, "highlight2" >MMP↓, "highlight2" >angioG↓, "highlight2" >MMP9↓, "highlight2" >BAX↑, "highlight2" >Casp3↑, "highlight2" >Apoptosis↑, "highlight2" >RadioS↑, "highlight2" >TBARS↑, "highlight2" >GSH↓, "highlight2" >Bax:Bcl2↑, "highlight2" >p‑NF-kB↓, "highlight2" >p‑STAT3↓,

3234-

EGCG,

Rad,

EGCG, a tea polyphenol, as a potential mitigator of hematopoietic radiation injury in mice

in-vivo,

Nor,

"highlight2" >*DNMTs↓, "highlight2" >*radioP↑, "highlight2" >*HDAC↑,

3213-

EGCG,

Rad,

Epigallocatechin-3-gallate Enhances Radiation Sensitivity in Colorectal Cancer Cells Through Nrf2 Activation and Autophagy

in-vitro,

CRC,

HCT116

12.5 μM EGCG

"highlight2" >RadioS↑, "highlight2" >TumCP↓, "highlight2" >NRF2↑,

1914-

Fer,

VitC,

TMZ,

Rad,

Pharmacologic Ascorbate and Ferumoxytol Combined with Temozolomide and Radiation Therapy for the Treatment of Newly Diagnosed Glioblastoma

Trial,

GBM,

"highlight2" >eff↑,

832-

GAR,

Rad,

Garcinol, a Histone Acetyltransferase Inhibitor, Radiosensitizes Cancer Cells by Inhibiting Non-Homologous End Joining

in-vitro,

Lung,

A549

in-vitro,

NA,

HeLa

"highlight2" >HATs↓, "highlight2" >other↑,

3526-

GoldNP,

Rad,

Advances in nanoparticle-based radiotherapy for cancer treatment

Review,

Var,

"highlight2" >RadioS↑, "highlight2" >EPR↑, "highlight2" >ROS↑, "highlight2" >TumCCA↑,

4420-

GoldNP,

Rad,

Computational modeling and experimental synthesis of BSA-coated bimetallic theranostic MnO₂-Au@curcumin nanoplatform for synergistic radiochemotherapy of breast cancer

in-vitro,

BC,

4T1

"highlight2" >RadioS↑,

1901-

GoldNP,

Rad,

The role of thioredoxin reductase in gold nanoparticle radiosensitization effects

in-vitro,

Lung,

A549

10nm, 50 ug Au/ml

"highlight2" >MMP↓, "highlight2" >ROS↑, "highlight2" >RadioS↑, "highlight2" >TrxR↓,

941-

Gos,

Rad,

The Lactate Dehydrogenase Inhibitor Gossypol Inhibits Radiation-Induced Pulmonary Fibrosis

in-vivo,

NA,

mice, injection to mice starting at week 4 postirradiation at a dose of 5 mg/kg in 30 μl volume

"highlight2" >lactateProd↓, "highlight2" >other↓, "highlight2" >TGF-β↓,

3152-

H2,

VitC,

Rad,

Hydrogen and Vitamin C Combination Therapy: A Novel Method of Radioprotection

in-vitro,

Nor,

HUVECs

in-vivo,

NA,

"highlight2" >AntiTum↑, "highlight2" >OS↑, "highlight2" >QoL↑, "highlight2" >TumVol↓, "highlight2" >radioP↑, "highlight2" >Dose↑, "highlight2" >Dose↝, "highlight2" >eff↑,

2902-

HNK,

Rad,

Honokiol Mitigates Ionizing Radiation-Induced Injury by Maintaining the Redox Balance of the TrxR/Trx System

in-vitro,

Nor,

BEAS-2B

"highlight2" >*TrxR1↑, "highlight2" >*Trx↑, "highlight2" >*radioP↑, "highlight2" >*ROS↓,

5053-

HPT,

Rad,

Chemo,

Association of elevated reactive oxygen species and hyperthermia induced radiosensitivity in cancer stem-like cells

in-vitro,

Var,

"highlight2" >CSCs↓, "highlight2" >TumCP↓, "highlight2" >ROS↑, "highlight2" >RadioS↑,

2917-

LT,

Rad,

Luteolin acts as a radiosensitizer in non‑small cell lung cancer cells by enhancing apoptotic cell death through activation of a p38/ROS/caspase cascade

in-vitro,

Lung,

"highlight2" >Bcl-2↓, "highlight2" >Casp3↑, "highlight2" >Casp8↑, "highlight2" >Casp9↑, "highlight2" >p‑p38↑, "highlight2" >ROS↑, "highlight2" >RadioS↑,

1775-

MEL,

Chemo,

Rad,

A Systematic Review of the Chemo/Radioprotective Effects of Melatonin against Ototoxic Adverse Effects Induced by Chemotherapy and Radiotherapy

Review,

Var,

"highlight2" >chemoP↑, "highlight2" >radioP↑, "highlight2" >antiOx↑, "highlight2" >Inflam↑,

517-

MF,

Rad,

Therapeutic Electromagnetic Field (TEMF) and gamma irradiation on human breast cancer xenograft growth, angiogenesis and metastasis

in-vivo,

NA,

MDA-MB-231

15mT, 120 pulse/s

in mice

"highlight2" >TumMeta↓, "highlight2" >TumCG↓,

2251-

MF,

Rad,

BEMER Electromagnetic Field Therapy Reduces Cancer Cell Radioresistance by Enhanced ROS Formation and Induced DNA Damage

in-vitro,

Lung,

A549

 0 μT to 35 μT and a mattress applicator

in-vitro,

HNSCC,

UTSCC15

in-vitro,

CRC,

DLD1

in-vitro,

PC,

MIA PaCa-2

"highlight2" >RadioS↑, "highlight2" >DNAdam↑, "highlight2" >ROS↑, "highlight2" >ChemoSen∅, "highlight2" >Pyruv↓, "highlight2" >ADP:ATP↓, "highlight2" >ROS↑,

3487-

MF,

Rad,

High-specificity protection against radiation-induced bone loss by a pulsed electromagnetic field

Review,

Var,

"highlight2" >radioP↑, "highlight2" >*Ca+2↑, "highlight2" >RAS↑, "highlight2" >MAPK↓,

5245-

MFrot,

Rad,

The hemoprotective effects of a rotary magnetic field in mice exposed to γ irradiation

in-vivo,

Nor,

132 male BALB/c mice

"highlight2" >*OS↑, "highlight2" >*radioP↑,

2939-

NAD,

Rad,

NMN ameliorated radiation induced damage in NRF2-deficient cell and mice via regulating SIRT6 and SIRT7

in-vitro,

Nor,

"highlight2" >*SIRT6↑, "highlight2" >*DNAdam↓, "highlight2" >*radioP↑, "highlight2" >*ROS↓,

1311-

NarG,

Rad,

Naringenin sensitizes lung cancer NCI-H23 cells to radiation by downregulation of akt expression and metastasis while promoting apoptosis

in-vitro,

Lung,

H23

"highlight2" >tumCV↓, "highlight2" >ROS↑, "highlight2" >Casp3↑, "highlight2" >p‑Akt↓, "highlight2" >Akt↓, "highlight2" >MMP2↓, "highlight2" >P21↓,

1270-

NCL,

Rad,

Niclosamide enhances the antitumor effects of radiation by inhibiting the hypoxia-inducible factor-1α/vascular endothelial growth factor signaling pathway in human lung cancer cells

in-vivo,

Lung,

"highlight2" >Hif1a↓, "highlight2" >VEGF↓,

2066-

PB,

Rad,

Butyric acid prodrugs are histone deacetylase inhibitors that show antineoplastic activity and radiosensitizing capacity in the treatment of malignant gliomas

in-vitro,

GBM,

U251

"highlight2" >RadioS↑,

2063-

PB,

Rad,

Phenylbutyrate sensitizes human glioblastoma cells lacking wild-type p53 function to ionizing radiation

in-vitro,

GBM,

U87MG

2 mM

NA,

U251

"highlight2" >RadioS↑, "highlight2" >eff↝, "highlight2" >P53↝,

2064-

PB,

Rad,

Phenylbutyrate Attenuates the Expression of Bcl-XL, DNA-PK, Caveolin-1, and VEGF in Prostate Cancer Cells

in-vitro,

Pca,

PC3

2 or 5 mM PB

in-vitro,

Pca,

DU145

in-vitro,

Pca,

LNCaP

"highlight2" >Bcl-xL↓, "highlight2" >Cav1↓, "highlight2" >VEGF↓, "highlight2" >RadioS↑, "highlight2" >chemoP↑, "highlight2" >HDAC↓, "highlight2" >*toxicity↓, "highlight2" >Diff↑, "highlight2" >Prot↓,

1683-

PBG,

Rad,

Protective effect of propolis in protecting against radiation-induced oxidative stress in the liver as a distant organ

in-vivo,

Nor,

rats

"highlight2" >GPx↑, "highlight2" >SOD↓, "highlight2" >RadioS↑,

1987-

PTL,

Rad,

A NADPH oxidase dependent redox signaling pathway mediates the selective radiosensitization effect of parthenolide in prostate cancer cells

in-vitro,

Pca,

PC3

in-vitro,

Nor,

PrEC

"highlight2" >selectivity↑, "highlight2" >RadioS↑, "highlight2" >ROS↑, "highlight2" >*ROS∅, "highlight2" >NADPH↑, "highlight2" >Trx↓, "highlight2" >PI3K↑, "highlight2" >Akt↑, "highlight2" >p‑FOXO3↓, "highlight2" >SOD2↓, "highlight2" >Catalase↓, "highlight2" >radioP↑, "highlight2" >*NADPH∅, "highlight2" >*GSH↑, "highlight2" >*GSH/GSSG↑, "highlight2" >*NRF2↑,

3075-

RES,

Rad,

The Protection Effect of Resveratrol Against Radiation-Induced Inflammatory Bowel Disease via NLRP-3 Inflammasome Repression in Mice

in-vivo,

Nor,

100 mg/kg

Male C57/6 mice

"highlight2" >*SIRT1↑, "highlight2" >*radioP↑, "highlight2" >*NLRP3↓, "highlight2" >*Weight↑, "highlight2" >*IL1β↓,

3015-

RosA,

Rad,

Rosmarinic Acid Prevents Radiation-Induced Pulmonary Fibrosis Through Attenuation of ROS/MYPT1/TGFβ1 Signaling Via miR-19b-3p

in-vivo,

Nor,

IMR90

(60 mg/kg

rats

"highlight2" >*radioP↑, "highlight2" >*Inflam↓, "highlight2" >*ROS↓, "highlight2" >*NF-kB↓, "highlight2" >*Rho↓, "highlight2" >*ROCK1↓, "highlight2" >*other↓,

3012-

RosA,

Rad,

Rosmarinic Acid Prevents Radiation-Induced Pulmonary Fibrosis Through Attenuation of ROSMYPT1TGFβ1 Signaling Via miR-19b-3p

in-vitro,

Nor,

IMR90

"highlight2" >*Inflam↓, "highlight2" >*ROS↓, "highlight2" >*p‑NF-kB↓, "highlight2" >*Rho↓, "highlight2" >*ROCK1↓, "highlight2" >*radioP↑, "highlight2" >*MCP1↓, "highlight2" >*RANTES↓, "highlight2" >*ICAM-1↓, "highlight2" >*PGC1A↑, "highlight2" >*NOX4↓, "highlight2" >*Dose↝,

4994-

Sal,

Rad,

Salinomycin overcomes radioresistance in nasopharyngeal carcinoma cells by inhibiting Nrf2 level and promoting ROS generation

"highlight2" >AntiCan↑, "highlight2" >RadioS↓, "highlight2" >Apoptosis↑, "highlight2" >NRF2↓, "highlight2" >ROS↑, "highlight2" >DNAdam↑,

5038-

SAS,

Rad,

Sulfasalazine, an inhibitor of the cystine-glutamate antiporter, reduces DNA damage repair and enhances radiosensitivity in murine B16F10 melanoma

in-vivo,

Melanoma,

B16-F10

"highlight2" >xCT↓, "highlight2" >ROS↑, "highlight2" >RadioS↓, "highlight2" >GSH↓, "highlight2" >selectivity↑, "highlight2" >DNArepair↓, "highlight2" >TumCCA↑, "highlight2" >H2O2↑, "highlight2" >Dose↝,

5138-

SAS,

Rad,

Drug repurposing: sulfasalazine sensitizes gliomas to gamma knife radiosurgery by blocking cystine uptake through system Xc-, leading to glutathione depletion

vitro+vivo,

GBM,

"highlight2" >cystine↓, "highlight2" >GSH↓, "highlight2" >ROS↑, "highlight2" >RadioS↑, "highlight2" >eff↓, "highlight2" >DNAdam↑, "highlight2" >OS↑,

4613-

Se,

Rad,

Effect of Selenium and Selenoproteins on Radiation Resistance

Review,

Nor,

"highlight2" >*selenoP↑, "highlight2" >*GPx1↑, "highlight2" >*GPx4↑, "highlight2" >*lipid-P↓, "highlight2" >*DNAdam↓, "highlight2" >*ROS↓,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 92

Pathway results for Effect on Cancer / Diseased Cells:

Pathway results for Effect on Normal Cells:

Redox & Oxidative Stress ⓘ

antiOx↑, 5, Catalase↑, 1, GPx↑, 3, GPx1↑, 2, GPx4↑, 1, GSH↓, 1, GSH↑, 3, GSH/GSSG↑, 1, HO-1↑, 2, lipid-P↓, 2, MDA↓, 1, NOX4↓, 1, NRF2↑, 4, Prx↑, 1, ROS↓, 15, ROS∅, 1, selenoP↑, 4, SOD↑, 2, Trx↑, 1, TrxR1↑, 1,

Core Metabolism/Glycolysis ⓘ

BUN↓, 1, NADPH↑, 1, NADPH∅, 1, PGC1A↑, 1, SIRT1↑, 1,

Cell Death ⓘ

Akt↓, 1, Apoptosis↓, 1, Apoptosis↑, 1, Casp3↓, 1, DR4↓, 1,

Transcription & Epigenetics ⓘ

p‑cJun↓, 1, other↓, 1,

DNA Damage & Repair ⓘ

DNAdam↓, 7, DNMTs↓, 1, P53↓, 1, SIRT6↑, 1,

Proliferation, Differentiation & Cell State ⓘ

ERK↑, 1, HDAC↑, 1, p300↓, 1, STAT3↓, 1,

Migration ⓘ

AP-1↓, 1, Ca+2↑, 1, Rho↓, 2, ROCK1↓, 3, TGF-β↓, 1,

Angiogenesis & Vasculature ⓘ

VEGF↓, 1,

Immune & Inflammatory Signaling ⓘ

COX2↓, 2, ICAM-1↓, 2, IL10↑, 1, IL1β↓, 1, Inflam↓, 7, MCP1↓, 1, NF-kB↓, 1, p‑NF-kB↓, 1, RANTES↓, 1, TNF-α↓, 1,

Protein Aggregation ⓘ

NLRP3↓, 1,

Drug Metabolism & Resistance ⓘ

Dose↝, 6, eff↑, 1, RadioS↑, 1,

Functional Outcomes ⓘ

OS↑, 1, QoL↑, 1, radioP↑, 20, toxicity↓, 2, toxicity∅, 1, Weight↑, 1,
Total Targets: 66

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:201  Target#:%  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

Database Query Results : Radiotherapy/Radiation, ,

Pathway results for Effect on Cancer / Diseased Cells:

Redox & Oxidative Stress ⓘ

Mitochondria & Bioenergetics ⓘ

Core Metabolism/Glycolysis ⓘ

Cell Death ⓘ

Transcription & Epigenetics ⓘ

Protein Folding & ER Stress ⓘ

Autophagy & Lysosomes ⓘ

DNA Damage & Repair ⓘ

Cell Cycle & Senescence ⓘ

Proliferation, Differentiation & Cell State ⓘ

Migration ⓘ

Angiogenesis & Vasculature ⓘ

Immune & Inflammatory Signaling ⓘ

Hormonal & Nuclear Receptors ⓘ

Drug Metabolism & Resistance ⓘ

Clinical Biomarkers ⓘ

Functional Outcomes ⓘ

Pathway results for Effect on Normal Cells:

Redox & Oxidative Stress ⓘ

Core Metabolism/Glycolysis ⓘ

Cell Death ⓘ

Transcription & Epigenetics ⓘ

DNA Damage & Repair ⓘ

Proliferation, Differentiation & Cell State ⓘ

Migration ⓘ

Angiogenesis & Vasculature ⓘ

Immune & Inflammatory Signaling ⓘ

Protein Aggregation ⓘ

Drug Metabolism & Resistance ⓘ

Functional Outcomes ⓘ

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