Trichostatin A / H3K9 Cancer Research Results

TSA, Trichostatin A: Click to Expand ⟱
Features:
Trichostatin A (TSA) is a naturally occurring compound that belongs to the class of histone deacetylase inhibitors (HDACis).
TSA has been shown to induce apoptosis (programmed cell death) in various cancer cell lines, including leukemia, breast, and lung cancer cells.
H3K9, histone H3 lysine 9: Click to Expand ⟱
Source:
Type:

H3K9 (histone H3 lysine 9) is a major regulatory residue on histone H3 that can undergo methylation or acetylation to alter chromatin structure and gene expression. Methylated H3K9, particularly H3K9me2 and H3K9me3, is generally associated with transcriptional repression and heterochromatin formation, whereas H3K9ac is associated with more transcriptionally active chromatin. In cancer, abnormal regulation of H3K9 modifications can contribute to silencing of tumour-suppressor genes, altered differentiation, stemness and treatment resistance. H3K9 should therefore be treated as an umbrella epigenetic target, with specific marks such as H3K9me3



Scientific Papers found: Click to Expand⟱
7186- CHA,  TSA,    Improved Therapeutic Effect against Leukemia by a Combination of the Histone Methyltransferase Inhibitor Chaetocin and the Histone Deacetylase Inhibitor Trichostatin A
- in-vitro, AML, NA
SUV39H↓, H3K9↓, eff↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

H3K9↓, 1,   SUV39H↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

eff↑, 1,  
Total Targets: 3

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: H3K9, histone H3 lysine 9
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:205  Target#:1593  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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