Database Query Results : VitK3,menadione, ,

VitK3, VitK3,menadione: Click to Expand ⟱
Features:
Menadione (2-methyl-1,4-naphthoquinone, also termed vitamin K3)
Menadione-induced ROS generation is concentration-dependent and high concentrations trigger cell death.
Clinical trials conducted on patients with prostate cancer showed that ascorbic acid-menadione produced an immediate drop in tumor cell numbers through a mechanism named autoschizis.
Scientific Papers found: Click to Expand⟱
4713- Se,  VitC,  VitK3,    Selenium supplementation protects cancer cells from the oxidative stress and cytotoxicity induced by the combination of ascorbate and menadione sodium bisulfite
- in-vitro, GBM, NA
"highlight2" >eff↓,
2187- SK,  VitK3,    Shikonin, vitamin K3 and vitamin K5 inhibit multiple glycolytic enzymes in MCF-7 cells
- in-vitro, BC, MCF-7
"highlight2" >Glycolysis↓, "highlight2" >PKM2↓,
609- VitC,  ALA,  VitK3,  Se,    Vitamin C and Cancer: Is There A Use For Oral Vitamin C?
"highlight2" >OS↑,
1836- VitC,  VitK3,  Chemo,    Vitamins C and K3: A Powerful Redox System for Sensitizing Leukemia Lymphocytes to Everolimus and Barasertib
- in-vitro, AML, NA
"highlight2" >tumCV↓, "highlight2" >selectivity↑, "highlight2" >Apoptosis↑, "highlight2" >eff↑, "highlight2" >ChemoSen↑,
1819- VitC,  VitK3,    The association of vitamins C and K3 kills cancer cells mainly by autoschizis, a novel form of cell death. Basis for their potential use as coadjuvants in anticancer therapy
- Review, Var, NA
"highlight2" >Dose?, "highlight2" >TumCD↑, "highlight2" >selectivity↑, "highlight2" >H2O2↑, "highlight2" >ROS↑, "highlight2" >DNAdam↑,
600- VitC,  VitK3,    Serum markers variation consistent with autoschizis induced by ascorbic acid-menadione in patients with prostate cancer
- in-vitro, NA, NA
"highlight2" >autoS↑, "highlight2" >TumCD↑,
612- VitC,  VitK3,    Effects of sodium ascorbate (vitamin C) and 2-methyl-1,4-naphthoquinone (vitamin K3) treatment on human tumor cell growth in vitro. I. Synergism of combined vitamin C and K3 action
"highlight2" >H2O2↑,
635- VitC,  VitK3,    The combination of ascorbate and menadione causes cancer cell death by oxidative stress and replicative stress
- in-vitro, NA, NA
"highlight2" >RNR↓, "highlight2" >GSH↓, "highlight2" >Trx1↓, "highlight2" >GPx↓, "highlight2" >lipid-P↑, "highlight2" >AIF↑, "highlight2" >ROS↑,
1823- VitK2,  VitK3,    Vitamins K2, K3 and K5 exert antitumor effects on established colorectal cancer in mice by inducing apoptotic death of tumor cells
- in-vitro, CRC, NA - in-vivo, NA, NA
"highlight2" >TumCP↓, "highlight2" >TumCCA↑, "highlight2" >Casp3↑,
2278- VitK2,  VitK3,  VitC,    Vitamin K: Redox-modulation, prevention of mitochondrial dysfunction and anticancer effect
- Review, Var, NA
"highlight2" >ChemoSen↑, "highlight2" >ROS↑, "highlight2" >eff↑,
1835- VitK3,  VitC,    Potential therapeutic application of the association of vitamins C and K3 in cancer treatment
- Review, Var, NA
"highlight2" >ROS↑, "highlight2" >TumCD↑, "highlight2" >TumCG↓, "highlight2" >OS↑,
2428- VitK3,    Vitamin K3 and K5 are inhibitors of tumor pyruvate kinase M2
- Study, Var, NA
"highlight2" >PKM2↓, "highlight2" >ChemoSen↑,
2372- VitK3,    The role of pyruvate kinase M2 in anticancer therapeutic treatments
- Review, Var, NA
"highlight2" >PKM2↓, "highlight2" >eff↑, "highlight2" >AntiCan↑,
1839- VitK3,    Vitamin K3 derivative inhibits androgen receptor signaling in targeting aggressive prostate cancer cells
- in-vitro, Pca, NA
"highlight2" >TumCP↓, "highlight2" >Apoptosis↑, "highlight2" >TumCCA↑, "highlight2" >ROS↑, "highlight2" >eff↓, "highlight2" >AR↓, "highlight2" >Trx↓, "highlight2" >Bcl-2↓,
1838- VitK3,  PDT,    Photodynamic Effects of Vitamin K3 on Cervical Carcinoma Cells Activating Mitochondrial Apoptosis Pathways
- in-vitro, Cerv, NA
"highlight2" >eff↑, "highlight2" >ROS↑, "highlight2" >tumCV↓, "highlight2" >TumCG↓, "highlight2" >Apoptosis↑, "highlight2" >cl‑Casp3↑, "highlight2" >cl‑Casp9↑, "highlight2" >Bcl-xL↑, "highlight2" >Cyt‑c↑, "highlight2" >Bcl-2↓,
1837- VitK3,  VitC,    Alpha-Tocopheryl Succinate Inhibits Autophagic Survival of Prostate Cancer Cells Induced by Vitamin K3 and Ascorbate to Trigger Cell Death
- in-vivo, Pca, NA
"highlight2" >eff↑, "highlight2" >ROS↑, "highlight2" >TumAuto↑,
1815- VitK3,  VitK2,    Vitamin K
- Review, Nor, NA
"highlight2" >*Dose↝, "highlight2" >BMD↑,
1834- VitK3,  PDT,    Effects of Vitamin K3 Combined with UVB on the Proliferation and Apoptosis of Cutaneous Squamous Cell Carcinoma A431 Cells
- in-vitro, Melanoma, A431
"highlight2" >eff↑, "highlight2" >TumCG↓, "highlight2" >TumCP↓, "highlight2" >ROS↑, "highlight2" >MMP↓,
1832- VitK3,  VitC,    Vitamin K3 and vitamin C alone or in combination induced apoptosis in leukemia cells by a similar oxidative stress signalling mechanism
- in-vitro, AML, K562
"highlight2" >ROS↑, "highlight2" >H2O2↑, "highlight2" >NF-kB↑, "highlight2" >P53↑, "highlight2" >cJun↑, "highlight2" >Casp3↑, "highlight2" >MMP↓, "highlight2" >DNAdam↑, "highlight2" >Dose?,
1831- VitK3,  VitK2,    The anticancer effects of vitamin K
- Review, Var, NA
"highlight2" >AntiCan↑, "highlight2" >Dose∅,
1828- VitK3,  VitC,    Pankiller effect of prolonged exposure to menadione on glioma cells: potentiation by vitamin C
- in-vivo, GBM, NA
"highlight2" >eff↑, "highlight2" >ROS↑, "highlight2" >Dose∅,
1827- VitK3,    A biophysical approach to menadione membrane interactions: relevance for menadione-induced mitochondria dysfunction and related deleterious/therapeutic effects
- Analysis, Var, NA
"highlight2" >ROS↑, "highlight2" >ChemoSen↑,
1826- VitK3,    PRX1 knockdown potentiates vitamin K3 toxicity in cancer cells: a potential new therapeutic perspective for an old drug
- in-vitro, Cerv, HeLa - in-vitro, Lung, A549
"highlight2" >eff↑, "highlight2" >ROS↑,
1821- VitK3,    Menadione (Vitamin K3) induces apoptosis of human oral cancer cells and reduces their metastatic potential by modulating the expression of epithelial to mesenchymal transition markers and inhibiting migration
- in-vitro, Oral, NA - in-vitro, Nor, HEK293 - in-vitro, Nor, HaCaT
"highlight2" >selectivity↑, "highlight2" >TumCD↓, "highlight2" >BAX↑, "highlight2" >P53↑, "highlight2" >Bcl-2↓, "highlight2" >p65↓, "highlight2" >E-cadherin↑, "highlight2" >EMT↓, "highlight2" >Vim↓, "highlight2" >Fibronectin↓, "highlight2" >TumCG↓, "highlight2" >TumCMig↓,
1820- VitK3,    Vitamin K3 (menadione) suppresses epithelial-mesenchymal-transition and Wnt signaling pathway in human colorectal cancer cells
- in-vitro, CRC, SW480 - in-vitro, CRC, SW-620
"highlight2" >selectivity↑, "highlight2" >TumCI↓, "highlight2" >TumCMig↓, "highlight2" >EMT↓, "highlight2" >E-cadherin↑, "highlight2" >ZO-1↑, "highlight2" >N-cadherin↓, "highlight2" >Vim↓, "highlight2" >Zeb1↓, "highlight2" >MMP2↓, "highlight2" >MMP9↓, "highlight2" >TOPflash↓, "highlight2" >β-catenin/ZEB1↓, "highlight2" >p300↓, "highlight2" >cycD1/CCND1↓, "highlight2" >TumCCA↑,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 25

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

GPx↓, 1,   GSH↓, 1,   H2O2↑, 3,   lipid-P↑, 1,   ROS↑, 12,   Trx↓, 1,   Trx1↓, 1,  

Mitochondria & Bioenergetics ⓘ

AIF↑, 1,   MMP↓, 2,  

Core Metabolism/Glycolysis ⓘ

Glycolysis↓, 1,   PKM2↓, 3,   RNR↓, 1,  

Cell Death ⓘ

Apoptosis↑, 3,   autoS↑, 1,   BAX↑, 1,   Bcl-2↓, 3,   Bcl-xL↑, 1,   Casp3↑, 2,   cl‑Casp3↑, 1,   cl‑Casp9↑, 1,   Cyt‑c↑, 1,   TumCD↓, 1,   TumCD↑, 3,  

Transcription & Epigenetics ⓘ

cJun↑, 1,   tumCV↓, 2,  

Autophagy & Lysosomes ⓘ

TumAuto↑, 1,  

DNA Damage & Repair ⓘ

DNAdam↑, 2,   P53↑, 2,  

Cell Cycle & Senescence ⓘ

cycD1/CCND1↓, 1,   TumCCA↑, 3,  

Proliferation, Differentiation & Cell State ⓘ

EMT↓, 2,   p300↓, 1,   TOPflash↓, 1,   TumCG↓, 4,  

Migration ⓘ

E-cadherin↑, 2,   Fibronectin↓, 1,   MMP2↓, 1,   MMP9↓, 1,   N-cadherin↓, 1,   TumCI↓, 1,   TumCMig↓, 2,   TumCP↓, 3,   Vim↓, 2,   Zeb1↓, 1,   ZO-1↑, 1,   β-catenin/ZEB1↓, 1,  

Immune & Inflammatory Signaling ⓘ

NF-kB↑, 1,   p65↓, 1,  

Hormonal & Nuclear Receptors ⓘ

AR↓, 1,  

Drug Metabolism & Resistance ⓘ

ChemoSen↑, 4,   Dose?, 2,   Dose∅, 2,   eff↓, 2,   eff↑, 8,   selectivity↑, 4,  

Clinical Biomarkers ⓘ

AR↓, 1,   BMD↑, 1,  

Functional Outcomes ⓘ

AntiCan↑, 2,   OS↑, 2,  
Total Targets: 59

Pathway results for Effect on Normal Cells:


Drug Metabolism & Resistance ⓘ

Dose↝, 1,  
Total Targets: 1

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:230  Target#:%  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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