| Features: |
| Sonodynamic therapy (SDT) is an emerging, non-invasive treatment modality that employs ultrasound energy in conjunction with sonosensitizers to induce cytotoxicity in target tissues. A key mechanism by which SDT exerts its therapeutic effects is through the generation of reactive oxygen species (ROS). Also known as high-intensity focused ultrasound (HIFU) SDT relies on the ultrasound-triggered activation of sonosensitizers (similar in concept to photosensitizers used in photodynamic therapy). When activated by ultrasound, these compounds undergo energy transitions that lead to the production of ROS, such as singlet oxygen and free radicals. -Advantages of SDT include its non-invasive nature, deep tissue penetration of ultrasound, and the ability to target localized areas with high precision. -Challenges remain in precisely controlling ROS production and ensuring that the resulting oxidative stress is sufficient to induce cell death in tumor cells without overwhelming damage to surrounding normal tissues. Sonosensitizers: – Hematoporphyrin Derivative (HPD) and Photofrin – Protoporphyrin IX (PpIX) – Chlorin e6 (Ce6) – Phthalocyanine compounds – Titanium Dioxide (TiO2) Nanoparticles – Other metallic or semiconductor nanoparticles, sometimes functionalized or loaded with traditional sensitizer molecules (e.g., gold nanoparticles, copper-cysteamine), have been explored to enhance ROS production and improve tumor targeting. – Curcumin, derived from turmeric, has been shown in several studies to exhibit sonosensitizing properties. – Under ultrasound activation, quercetin may act as a sonosensitizer, increasing ROS generation and contributing to cancer cell apoptosis. US frequency range of 150 kHz–3 MHz, irradiation dose of 2–3 W cm−2, and the actuation duration range of 1–20 min are used for SDT research https://can-amhifu.com/ https://canadaclinicsupply.com/product/soundcare-plus-professional-dual-ultrasound-device-by-roscoe/ https://physiostore.ca/product-category/therapeutic-modalities/therapeutic-ultrasound/clinical-ultrasound-systems/ https://physiostore.ca/richmar-home-ultrasound-2000-2nd-edition/ |
| 1603- | Cu, | BP, | SDT, | Glutathione Depletion-Induced ROS/NO Generation for Cascade Breast Cancer Therapy and Enhanced Anti-Tumor Immune Response |
| - | in-vitro, | BC, | 4T1 | - | in-vivo, | NA, | NA |
| 2535- | M-Blu, | SDT, | Apoptosis of ovarian cancer cells induced by methylene blue-mediated sonodynamic action |
| - | in-vitro, | Ovarian, | HO-8910 |
| 2546- | M-Blu, | SDT, | The sonodynamic antitumor effect of methylene blue on sarcoma180 cells in vitro |
| - | in-vitro, | sarcoma, | S180 |
| 2547- | M-Blu, | SDT, | The effect of dual-frequency ultrasound waves on B16F10 melanoma cells: Sonodynamic therapy using nanoliposomes containing methylene blue |
| - | in-vitro, | Melanoma, | B16-BL6 |
| 1674- | PBG, | SDT, | HPT, | Study on the effect of a triple cancer treatment of propolis, thermal cycling-hyperthermia, and low-intensity ultrasound on PANC-1 cells |
| - | in-vitro, | PC, | PANC1 | - | in-vitro, | Nor, | H6c7 |
| 1403- | SDT, | BBR, | From 2D to 3D In Vitro World: Sonodynamically-Induced Prooxidant Proapoptotic Effects of C60-Berberine Nanocomplex on Cancer Cells |
| - | in-vitro, | Cerv, | HeLa | - | in-vitro, | Lung, | LLC1 |
| 2536- | SDT, | Sonodynamic Therapy: Rapid Progress and New Opportunities for Non-Invasive Tumor Cell Killing with Sound |
| - | Review, | Var, | NA |
| 2537- | SDT, | Design and Challenges of Sonodynamic Therapy System for Cancer Theranostics: From Equipment to Sensitizers |
| - | Review, | Var, | NA |
| 2548- | SDT, | Sonoporation, a Novel Frontier for Cancer Treatment: A Review of the Literature |
| - | Review, | Var, | NA |
| 2549- | SDT, | Landscape of Cellular Bioeffects Triggered by Ultrasound-Induced Sonoporation |
| - | Review, | Var, | NA |
| 2550- | SDT, | Intracellular Delivery and Calcium Transients Generated in Sonoporation Facilitated by Microbubbles |
| - | in-vitro, | Nor, | NA |
| 2551- | SDT, | Sonoporation: Past, Present, and Future |
| - | Review, | Var, | NA |
| 2538- | SNP, | SDT, | Z, | Dual-functional silver nanoparticle-enhanced ZnO nanorods for improved reactive oxygen species generation and cancer treatment |
| - | Study, | Var, | NA | - | vitro+vivo, | NA, | NA |
| 2539- | SNP, | SDT, | Combined effect of silver nanoparticles and therapeutical ultrasound on ovarian carcinoma cells A2780 |
| - | in-vitro, | Melanoma, | A2780S |
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