Vitamin A, Retinoic Acid / IL1β Cancer Research Results

VitA,RetA, Vitamin A, Retinoic Acid: Click to Expand ⟱
Features:
Retinoic acid is a naturally occurring derivative of vitamin A (retinol).

Retinoic acid is produced in the body from dietary vitamin A. Vitamin A can be ingested in two primary forms:
• Preformed vitamin A (retinol and its esters) found in animal products like liver, dairy, and fish.
• Provitamin A carotenoids (such as beta-carotene) found in colorful fruits and vegetables. Once ingested, these compounds are converted into retinol, which can then be oxidized to retinal and further oxidized to retinoic acid.

All-trans retinoic acid (ATRA) is a key component in the treatment of acute promyelocytic leukemia (APL). In APL, ATRA induces the differentiation of malignant promyelocytes into mature granulocytes, leading to clinical remission.

-Retinoic acid can have antioxidant properties
-High levels of retinoic acid have been associated with increased ROS production and oxidative stress
-The potential prooxidant action may contribute to its anti-cancer effects by inducing oxidative damage in cancer cells, thereby enhancing apoptosis.
IL1β, interleukin-1 beta: Click to Expand ⟱
Source:
Type:
The term "IL-1" is often used as an umbrella term for the interleukin-1 family, which includes multiple cytokines. The two best-known members are IL-1α and IL-1β.
IL-1β is secreted from cells and plays a major systemic role in inflammation. It is a crucial mediator in the inflammatory response and is involved in the fever response, activation of endothelial cells, and leukocyte recruitment.
Its increased expression is commonly linked to:
  – Promotion of a pro-inflammatory microenvironment that supports tumor growth.
  – Enhanced angiogenesis, invasion, and metastasis.
  – Recruitment of myeloid cells that may further suppress antitumor immunity.

High expression of either tends to be associated with a more aggressive phenotype and worse prognosis in many cancer types.
Scientific Papers found: Click to Expand⟱
6329- DRE,  VitA,RetA,    Combined dandelion extract and all-trans retinoic acid induces cytotoxicity in human breast cancer cells
- in-vitro, BC, MCF-7 - in-vitro, BC, MDA-MB-231
MMP9↓, IL1β↓, P53↑, KAI1/CD82↑, eff↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned ⓘ

KAI1/CD82↑, 1,  

DNA Damage & Repair ⓘ

P53↑, 1,  

Migration ⓘ

MMP9↓, 1,  

Immune & Inflammatory Signaling ⓘ

IL1β↓, 1,  

Drug Metabolism & Resistance ⓘ

eff↑, 1,  
Total Targets: 5

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: IL1β, interleukin-1 beta
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:290  Target#:978  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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