condition found tbRes List
dietMet, diet Methionine-Restricted Diet: Click to Expand ⟱
Features:
Methionine (MET) restriction (MR) has been shown to arrest cancer growth and sensitizes tumors to chemotherapy.
-Many cancer cells rely heavily on exogenous methionine to sustain rapid growth and proliferation because they often have impaired methionine salvage pathways.
-Methionine contributes to the synthesis of glutathione, a key antioxidant. (Methionine is a precursor of glutathione, a tripeptide that reduces reactive oxygen species.)
-MR diets might influence the redox state of cancer cells, increasing oxidative stress and thereby leading to cell death in metabolically compromised tumor cells.
-Proliferation and growth of several types of cancer cells are inhibited by MR, while normal cells are unaffected by limiting methionine as long as homocysteine is present.
-Methionine restriction is effective when the non-essential amino acid, cysteine, is absent from the diet or media. methionine is the precursor for cysteine which is essential for the formation of GSH.
-Malignant cells lack the enzyme required to recycle homocysteine therefore giving methionine restriction the capacity to alter cancer cells while maintaining normal, healthy cells.

While vegan diets are typically low in methionine, some nuts and legumes (such as Brazil nuts and kidney beans) are rich in methionine.

Foods to avoid for MR diet:
Animal Proteins:
-Red Meat (Beef, Pork, Lamb):
-Poultry (Chicken, Turkey):
-Fish and Seafood:
-Eggs: Both the egg whites and yolks are protein rich.
-Dairy Products: Milk, cheese, and yogurt
Certain Plant Proteins:
-Soy Products:
-Legumes:
Protein Supplements:

Foods Lower in Methionine (Often Favorable on an MR Diet)
Fruits & Vegetables: leafy greens, berries, apples, and citrus fruits.
Grains & Cereals: rice, oats, and barley
Nuts and Seeds: can vary in methionine content.
Alternative Protein Sources: emphasize protein sources with a lower methionine-to-cysteine ratio.
ChemoSen, chemo-sensitization: Click to Expand ⟱
Source:
Type:
The effectiveness of chemotherapy by increasing cancer cell sensitivity to the drugs used to treat them, which is known as “chemo-sensitization”.

Chemo-Sensitizers:
-Curcumin
-Resveratrol
-EGCG
-Quercetin
-Genistein
-Berberine
-Piperine: alkaloid from black pepper
-Ginsenosides: active components of ginseng
-Silymarin
-Allicin
-Lycopene
-Ellagic acid
-caffeic acid phenethyl ester
-flavopiridol
-oleandrin
-ursolic acid
-butein
-betulinic acid
Scientific Papers found: Click to Expand⟱
2268- dietMet,    Methionine dependency and cancer treatment
- Review, Var, NA
ChemoSen↑, last three decades suggest that methionine restriction can become an additional cancer therapeutic strategy, notably in association with chemotherapy.
*eff↑, All normal human cell lines tested in culture, including fibroblasts and liver, kidney and epithelial cells, are methionine-independent
selectivity↑, Numerous malignant cell lines (breast, lung, colon, kidney, bladder, melanoma, glioblastoma, etc.) are methionine-dependent
eff↑, reclinical studies showed better antitumour activity using methionine-free diet plus 5-FU than either treatment administered separately

1893- dietMet,    Clinical Studies of Methionine-Restricted Diets for Cancer Patients
- Review, Var, NA
TumCG↓, Methionine (MET) restriction (MR) has been shown to arrest cancer growth and sensitizes tumors to chemotherapy
ChemoSen↑,
MATs↓, Plasma methionine levels fell from 21.6 to 9 μm within 2 weeks, a 58% decline.

2264- dietMet,    Methionine restriction for cancer therapy: From preclinical studies to clinical trials
- Review, Var, NA
TumCP↓, methionine restriction (MR) reduces cancer cell proliferation via different mechanisms
*ROS?, MR lowers sulfur-containing metabolite levels, reduces oxidative stress, and enhances the immune response
ChemoSen↑, may sensitize tumors to chemo/radiotherapy
RadioS↑,
eff↑, therapeutic potential of MR lies in its ability to synergize with other therapies, enhancing overall antitumor efficacy.
ROS↑, increases ROS, weaking cancer cell defense (from graphical abstract). In colon cancer, MR increases oxidative stress, induces cell cycle arrest, and promotes the apoptosis of p53(Tumor Protein 53)-deleted cells
selectivity↑, methionine-depleted media significantly impaired the growth of malignant cells while leaving normal cell growth unchanged.
TS↓, MR also targets thymidylate synthase (TS), a key enzyme in nucleotide synthesis, enhancing the chemotherapeutic efficacy of 5-FU by lowering TS activity and expression
eff↑, duration of methionine deprivation can significantly affect the tumor cell response. Intermittent methionine deprivation appears particularly beneficial, enhancing tumor cell sensitivity to CD8+ T cell-mediated cytotoxicity

2263- dietMet,    Methionine Restriction and Cancer Biology
- Review, Var, NA
AntiCan↑, dependence of many tumor cells on an exogenous source of the sulfur amino acid, methionine, [9,10,11] makes dietary methionine restriction (MR) an exciting potential tool in the treatment of cancer.
TumCP↓, Proliferation and growth of several types of cancer cells are inhibited by MR,
TumCG↓,
selectivity↑, while normal cells are unaffected by limiting methionine as long as homocysteine is present
ChemoSen↓, MR has been shown to enhance efficacy of chemotherapy and radiation therapy in animal models
RadioS↑,
Insulin↓, MR may work by inhibiting prostate cancer cell proliferation, inhibiting the insulin/IGF-1 axis
*GlucoseCon↑, increase in tissue-specific glucose uptake measured during a hyperinsulinemic-euglycemic clamp
*ROS↓, MR does not increase oxidative stress, in part because MR enhances antioxidant capacity and increases proton leak in the liver, likely decreasing ROS production
*antiOx↑,
*GSH↑, ability of MR to increase GSH levels in red blood cells. Surprisingly, when methionine was restricted by 80% in the diet of rats, the level of GSH in the blood actually increased due to adaptations in sulfur-amino acid metabolism
GSH↑, However, GSH concentrations were reduced in the liver
eff↑, Of note, methionine restriction is effective when the non-essential amino acid, cysteine, is absent from the diet or media.
polyA↓, MR may work by inhibiting prostate cancer cell proliferation, inhibiting the insulin/IGF-1 axis, or by reducing polyamine synthesis. MR-induced depletion of polyamines
TS↓, MR selectively reduces TS activity in prostate cancer cells by ~80% within 48 h, but does not affect TS activity in normal prostate epithelial cells
Raf↓, MR inhibits Raf and Akt oncogenic pathways, while increasing caspase-9 and the mitochondrial pro-apoptotic protein, Bak
Akt↓,
Casp9↑,
Bak↑,
P21↑, MR upregulating p21 and p27 (cell cycle inhibitors that halt cell cycle progression) in LNCaP cells
p27↑,
Insulin↓, MR-induced reduction in circulating insulin and IGF1, which have both been linked to tumor growth
IGF-1↓,

1897- dietMet,    Methionine metabolism in health and cancer: a nexus of diet and precision medicine
- Review, Var, NA
OS↑, dietary MR, which reduces but does not completely eliminate methionine, and improvement of health as well as reversal of pathology, by means including lifespan extension, attenuation of high fat diet-induced obesity and prevention of diabetes
TumCG↓, where animals were fed diets lacking individual amino acids and were subsequently shown to exhibit significantly reduced tumour growth under a methionine-deprived diet
TumCCA↑, MR was shown to effectively induce a cell cycle blockade and overall tumour regression
ChemoSen↑, MR significantly increased the efficacy of 5-FU treatment when 5-FU was given at a chemoresistant dose
RadioS↑, MR also showed synergistic effects when combined with radiation, which as a monotherapy had previously been shown to exert only a modest effect

1895- dietMet,    Altering Diet Enhances Response to Cancer Treatments in Mice
- Review, Var, NA
ChemoSen↑, diet very low in the nutrient methionine improved the ability of chemotherapy and radiation therapy to shrink tumors.


* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 6

Results for Effect on Cancer/Diseased Cells:
Akt↓,1,   AntiCan↑,1,   Bak↑,1,   Casp9↑,1,   ChemoSen↓,1,   ChemoSen↑,5,   eff↑,4,   GSH↑,1,   IGF-1↓,1,   Insulin↓,2,   MATs↓,1,   OS↑,1,   P21↑,1,   p27↑,1,   polyA↓,1,   RadioS↑,3,   Raf↓,1,   ROS↑,1,   selectivity↑,3,   TS↓,2,   TumCCA↑,1,   TumCG↓,3,   TumCP↓,2,  
Total Targets: 23

Results for Effect on Normal Cells:
antiOx↑,1,   eff↑,1,   GlucoseCon↑,1,   GSH↑,1,   ROS?,1,   ROS↓,1,  
Total Targets: 6

Scientific Paper Hit Count for: ChemoSen, chemo-sensitization
6 diet Methionine-Restricted Diet
Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:292  Target#:1106  State#:%  Dir#:%
  wNotes=on  sortOrder:rid,rpid

 

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