Database Query Results : Vitamin E, ,

VitE, Vitamin E: Click to Expand ⟱
Features:
Vitamin E is a fat‐soluble antioxidant
It primarily comprises two families:
Tocopherols
  α-Tocopherol (most active and abundant form found in human tissues)
  β-Tocopherol
  γ-Tocopherol
  δ-Tocopherol
Tocotrienols
  α-Tocotrienol
  β-Tocotrienol
 γ-Tocotrienol
  δ-Tocotrienol


-Vitamin E can neutralize free radicals, which are reactive molecules that may damage cells and potentially contribute to cancer development. This antioxidant property has led researchers to explore whether vitamin E could help protect cells from damage during cancer treatment.
-Cancer Prevention: Some epidemiological studies suggested that higher intake of vitamin E (usually through diet rather than supplements) might be associated with a lower risk of certain cancers.


Scientific Papers found: Click to Expand⟱
4764- CoQ10,  VitE,    Auxiliary effect of trolox on coenzyme Q10 restricts angiogenesis and proliferation of retinoblastoma cells via the ERK/Akt pathway
- in-vitro, RPE, Y79 - in-vitro, Nor, ARPE-19 - in-vivo, NA, NA
tumCV↓, CoQ10, alone and with trolox, reduced Y79 cell viability, induced apoptosis through excess ROS generation, and decreased MMP significantly.
Apoptosis↑,
ROS↑,
MMP↓,
TumCCA↑, Both treatments caused G2/M phase cell arrest.
VEGF↓, The combination of CoQ10 and trolox significantly reduced VEGF-A, ERK, and Akt receptor levels, while CoQ10 alone significantly inhibited ERK and Akt phosphorylation.
ERK↓,
Akt↓,
ChemoSen↑, Several studies thereafter reported a higher therapeutic response rate of CoQ10 when used with other chemotherapeutic agents13, 14 while also improving the tolerability of cancer treatments15,16,17.
chemoP↑,
toxicity↓, CoQ10 + trolox have no adverse effect on ARPE-19 cells
angioG↓, Co-culture of Y79 with human umbilical vein endothelial cells (HUVECs) and the CAM assay results prove that both CoQ10 alone and CoQ10 + trolox are effective in mitigating angiogenic proliferation of cells both in vitro and in vivo

3628- Croc,  VitE,  CUR,    Vitamin E, Turmeric and Saffron in Treatment of Alzheimer’s Disease
- Review, AD, NA
*antiOx↑, Vitamin E is a potent antioxidant that may have beneficial effects in Alzheimer’s in dealing with oxidative stress
*ROS↓,
*lipid-P↓, Alpha-tocopherol was found as protective against lipid peroxidation
*Aβ↓, Researchers found that all forms of tocopherol enhanced the Aβ production and decreased the Aβ degradation. T
*AChE↓, vitamin E treatment significantly restored acetylcholinesterase activity and increased the Na+/K+ ATPase activity.
*cognitive↑, Although high plasma vitamin E is linked to better cognitive performance [
*Inflam↓, curcumin is effective in AD as an antioxidant, anti-inflammatory therapeutic agent that improves the cognitive functions

4076- FA,  VitE,  VitB6,    Reduced risk of Alzheimer’s disease with high folate intake: The Baltimore Longitudinal Study of Aging
- Study, AD, NA
*Risk↓, Higher intake of folate (RR, 0.41; 95% confidence interval [CI], 0.22 to 0.76), vitamin E (RR, 0.56; 95% CI, 0.30 to 1.06), and vitamin B6 (RR, 0.41; 95% CI, 0.20 to 0.84) were associated individually with a decreased risk of AD
*other↝, When these 3 vitamins were analyzed together, only total intake of folate at or above the RDA (RR, 0.45; 95% CI, 0.21 to 0.97) was associated with a significant decreased risk of AD
*Risk∅, No association was found between total intake of vitamins C, carotenoids, or vitamin B12 and risk of AD.

2499- Fenb,  VitE,    Effects of fenbendazole and vitamin E succinate on the growth and survival of prostate cancer cells
- in-vitro, Pca, PC3
TumCP∅, After testing E8 cell line singly with FBZ then VES, we determined that neither FBZ at 22.5 ng/ml nor VES at 25 μg/ml had any significant inhibitory effect on proliferation, at least during the four days of exposure
TumCP↓, However, when we used a lower concentration of FBZ (14 ng/ml) together with VES (25 μg/ml), beginning at the third day, a synergistic inhibitory effect on proliferation was observed that became robust in the subsequent days
toxicity↓, FBZ, VES, or a VES+FBZ combination administered in the feed for 206 days at which point they were humanely euthanized ... no abnormalities were observed
eff↑, In summary, combination therapy with VES and FBZ deserves further investigation as a possible treatment modality for prostate cancer

3981- Lut,  Zeax,  VitE,    Omega-3 fatty acid, carotenoid and vitamin E supplementation improves working memory in older adults: A randomised clinical trial
- Trial, AD, NA
*memory↑, Following 24-month supplementation, individuals in the active group (n = 30; aged 69.03 ± 4.41 years; 56.7% female) recorded significantly fewer errors in working memory tasks than individuals receiving placebo
*other↑, Statistically significant improvements in tissue carotenoid concentrations, serum xanthophyll carotenoid concentrations and plasma ω-3FA concentrations were also observed in the active group versus placebo
*cognitive↑, Increasing nutritional intake of carotenoids and ω-3FAs may prove beneficial in reducing cognitive decline and dementia risk in later life.

3984- Lut,  VitE,    Serum concentrations of vitamin E and carotenoids are altered in Alzheimer's disease: A case-control study
- Study, AD, NA
*other↓, Serum levels of α-tocopherol and all six carotenoids were significantly lower in patients with AD compared with cognitively intact controls (P < .001). In contrast, γ-tocopherol was significantly higher in the serum of patients with AD

3911- PS,  VitE,    Cognitive effects of a dietary supplement made from extract of Bacopa monnieri, astaxanthin, phosphatidylserine, and vitamin E in subjects with mild cognitive impairment: a noncomparative, exploratory clinical study
- Human, AD, NA
*cognitive↑, In 102 assessable subjects, total ADAS-cog scores improved from 13.7±5.8 at baseline to 9.7±4.9 on day 60, and the clock drawing test scores improved from 8.5±2.3 to 9.1±1.9.
*other↑, dietary supplementation with the tested compound shows potential for counteracting cognitive impairment in subjects with mild cognitive impairment and warrants further investigation in adequately controlled, longer-term studies.

4616- VitA,RetA,  VitC,  VitD3,  VitE,  Rad  Vitamins and Radioprotective Effect: A Review
- Review, NA, NA
*radioP↑, Only four (A, C, D and E) out of thirteen vitamins have been detected with radioprotective properties being mainly vitamin E followed by vitamin C, A and D.
*ROS↓, mainly based on their mechanism of action in the suppression of the formation of reactive species and detoxification of radiation-induced species.

4050- VitB12,  VitD3,  VitE,    Nutrient intake, nutritional status, and cognitive function with aging
- Review, AD, NA
neuroP↑, evidence to support the critical role of several B vitamins in particular, but also of vitamin D, antioxidant vitamins (including vitamin E), and omega-3 fatty acids, which are preferentially taken up by brain tissue.

4077- VitB6,  FA,  VitB12,  VitD3,  VitE  Vitamin Supplementation as an Adjuvant Treatment for Alzheimer’s Disease
- Review, AD, NA
*antiOx↑, Vitamins are potent antioxidants and therefore can be used as an adjuvant therapy for the treatment of AD.
*cognitive↑, Among B vitamins, pyridoxine (B6), folic acid (B9), and cobalamin (B12) have shown to have potential in managing symptoms of AD.
*homoC↓, vitamin B6, B9 and B12 have shown to decrease the level of homocysteine, thereby helping in the control of this modifiable risk-factor for AD
*Risk↓, Low levels of vitamin B6 have been implicated in the pathogenesis of AD.
*Risk↓, Low level of serum folate is another predictor for AD
*Risk↓, The plasma levels of vitamin B12 were also found to be deficient in cases of AD
*other↝, Elevated plasma level of homocysteine is an important risk factor for gray matter atrophy
*Dose↝, 0.8mg B9, 20mg B6 and 0.5mg B12, over a period of 2 years has been demonstrated to decrease homocysteine induced gray matter atrophy
*Risk↓, The analysis of current literature on the relationship between vitamin D deficiency and AD revealed a direct relation between decreased serum level of vitamin D and AD
*Risk↓, decreased levels of plasma vitamin E is associated with increased risk of neurodegenerative disorders like AD and Mild Cognitive Impairment (MCI)

4079- VitE,  VitC,    Effects of fruits and vegetables on levels of vitamins E and C in the brain and their association with cognitive performance
- Review, AD, NA
*neuroP↑, Diets rich in fruits and vegetables have been shown to improve human well-being and to significantly delay the development of pathologic processes, including neurodegenerative disorders.
*antiOx↑, Both E and C are involved in the antioxidant defense of cells and actively contribute to the redox status of the cell.
*Dose↝, Vegetable oils, nuts and seeds are the main dietary sources of vitamin E, whereas fruits and vegetable are the primary sources of vitamin C
*cognitive↑, An optimal intake of these nutrients has been associated with decreased risk of developing cognitive impairments associated with aging.

4087- VitE,    Vitamin E and Alzheimer's disease: what do we know so far?
- Review, AD, NA
*Risk↑, Diminished circulating concentrations of vitamin E have been demonstrated in individuals with AD. Reduced plasma levels have furthermore been associated with an increased risk of AD
*Half-Life↑, The plasma half-life of α-tocopherol is estimated at 20 hrs, which is considerably longer than that of other isoforms, particularly the tocotrienol congeners
*antiOx↑, potent antioxidant capabilities of vitamin E are well known
*BioAv↑, α-tocopherol retains a superior in vivo role in neuroprotection due to its relatively greater bioavailability and preferential retention by tissues.
*neuroP↑, includes other neuro-protective, anti-inflammatory and cholesterol-reducing properties, in addition to influencing gene expression and potentially ensuing AD pathology.
*Inflam↑,
*LDL↓,
*cognitive↑, vitamin E supplementation was associated with decreased risk of cognitive decline in a cohort of 560 AD patients from the Canadian Study of Health and Aging

4088- VitE,    Vitamin E and Alzheimer’s Disease—Is It Time for Personalized Medicine?
- Review, AD, NA
*antiOx↑, major lipid-soluble antioxidant, which functions to maintain neurological integrity
*neuroP↑,
*Dose↓, Alarmingly, 90% of the population does not consume the RDA of 15 mg/day but average closer to half that value—around 7 mg/day [17]
*cognitive↑, individuals who consumed higher vitamin E-containing foods exhibited reduced cognitive decline per an adaptation of the Mini Mental State Examination (MMSE)
*other↝, benefit of vitamin E is skewed towards a pre-emptive measure to attenuate cognitive decline.

4089- VitE,    Cognitive function in elderly people is influenced by vitamin E status
- Study, AD, NA
*cognitive↑, Subjects who made no errors in the PMSQ test had significantly higher serum alpha-tocopherol concentrations

4179- VitE,    Vitamin E protects against oxidative damage and learning disability after mild traumatic brain injury in rats
- in-vivo, NA, NA
*BDNF↑, vitamin E dietary supplementation can protect the brain against the effects of mild TBI on synaptic plasticity and cognition, using molecular systems associated with the maintenance of long-term plasticity, such as BDNF and Sir2.

4321- VitE,    Unraveling the molecular mechanisms of vitamin deficiency in Alzheimer's disease pathophysiology
- Review, AD, NA
*ROS↓, Vitamin E (Tocotrienols and alpha-tocopherol), is a fat-soluble vitamin that protects neural cells from oxidative stress
*cardioP↑, promotes cardiovascular health by preventing clotting
*lipid-P↓, It prevents lipid peroxidation, supports docosahexaenoic acid (DHA) transport, and enhances cognition, reduces AD progression, highlighting its importance in maintaining cognitive function and preventing neurodegeneration
*cognitive↑,
*neuroP↑,
*Aβ↓, vitamin E influences gene expression by upregulating genes involved in Aβ clearance, a key factor in AD
*NGF↑, Vitamin E deficiency downregulates nerve growth factor (NGF) and sodium-dependent dopamine transporter, both essential for neuroprotection, neuronal survival, and neurotransmission


* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 16

Results for Effect on Cancer/Diseased Cells:
Akt↓,1,   angioG↓,1,   Apoptosis↑,1,   chemoP↑,1,   ChemoSen↑,1,   eff↑,1,   ERK↓,1,   MMP↓,1,   neuroP↑,1,   ROS↑,1,   toxicity↓,2,   TumCCA↑,1,   TumCP↓,1,   TumCP∅,1,   tumCV↓,1,   VEGF↓,1,  
Total Targets: 16

Results for Effect on Normal Cells:
AChE↓,1,   antiOx↑,5,   Aβ↓,2,   BDNF↑,1,   BioAv↑,1,   cardioP↑,1,   cognitive↑,9,   Dose↓,1,   Dose↝,2,   Half-Life↑,1,   homoC↓,1,   Inflam↓,1,   Inflam↑,1,   LDL↓,1,   lipid-P↓,2,   memory↑,1,   neuroP↑,4,   NGF↑,1,   other↓,1,   other↑,2,   other↝,3,   radioP↑,1,   Risk↓,6,   Risk↑,1,   Risk∅,1,   ROS↓,3,  
Total Targets: 26

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