Database Query Results : Mushroom Lion’s Mane, ,

mushLions, Mushroom Lion’s Mane: Click to Expand ⟱
Features:
Lion’s Mane Mushroom (Hericium erinaceus) is renowned for its potential health benefits, particularly in areas like neuroprotection, cognitive function, and immune support.

-Most commonly cited mechanisms of Lion’s Mane is its ability to stimulate the synthesis of Nerve Growth Factor (NGF)
-Specific compounds such as hericenones and erinacines present in the mushroom are thought to be responsible for this effect.
-May inhibit NF-κB Pathway
-May lower the production of pro-inflammatory cytokines (e.g., TNF-α, IL-6)
-Neutralize free radicals, reducing oxidative stress
-Lion’s Mane influences gut health and, in turn, the gut-brain axis
-Anti-inflammatory responses, antioxidant protection

-Mushrooms, including Lion’s Mane (Hericium erinaceus), contain ergosterol—a precursor to vitamin D. When exposed to ultraviolet (UV) light (such as sunlight), ergosterol is converted to vitamin D₂ (ergocalciferol).
Scientific Papers found: Click to Expand⟱
2484- mushLions,    Neurotrophic and Neuroprotective Effects of Hericium erinaceus
- Review, Stroke, NA - Review, AD, NA - Review, Park, NA
*eff↑, *BBB↑, *Dose↝, *neuroP↑, *cognitive↑, *toxicity∅,
3806- mushLions,    Dietary Supplementation of Lion's Mane Medicinal Mushroom, Hericium erinaceus (Agaricomycetes), and Spatial Memory in Wild-Type Mice
- in-vitro, NA, NA
*motorD↑, *memory↑,
3807- mushLions,    Searching for a Longevity Food, We Bump into Hericium erinaceus Primordium Rich in Ergothioneine: The “Longevity Vitamin” Improves Locomotor Performances during Aging
*AntiAge↑, *other↑, *NOS2↓, *COX2↓, *P53↑, *neuroP↑,
3808- mushLions,    Neuroprotective Metabolites of Hericium erinaceus Promote Neuro-Healthy Aging
- in-vitro, NA, NA
*Inflam↓, *ROS↓, *neuroP↑,
3809- mushLions,    The Monkey Head Mushroom and Memory Enhancement in Alzheimer's Disease
- Review, NA, NA
*cognitive↑, *Apoptosis↓, *Aβ↓, *AChE↓, *BACE↓,
3810- mushLions,    Key Mechanisms and Potential Implications of Hericium erinaceus in NLRP3 Inflammasome Activation by Reactive Oxygen Species during Alzheimer’s Disease
- Review, NA, NA
*neuroP↑, *p‑tau↓, *APP↓, *Aβ↓, *ROS↓, *Inflam↓, *NLRP3↓,
3811- mushLions,    Hericium erinaceus (Bull.) Pers. Ethanolic Extract with Antioxidant Properties on Scopolamine-Induced Memory Deficits in a Zebrafish Model of Cognitive Impairment
- in-vitro, NA, NA
*memory↑, *BBB↑, *GSH↑, *AChE↓, *MDA↓,
3812- mushLions,    Structural characterization of polysaccharide purified from Hericium erinaceus fermented mycelium and its pharmacological basis for application in Alzheimer's disease: Oxidative stress related calcium homeostasis
- in-vitro, AD, NA
*cognitive↑, *Aβ↓, *p‑tau↓, *ROS↓, *NRF2↓, *Ca+2↝,
3813- mushLions,    Erinacine A-enriched Hericium erinaceus mycelium ameliorates Alzheimer's disease-related pathologies in APPswe/PS1dE9 transgenic mice
- in-vitro, AD, NA
*Aβ↓, *cognitive↑, *neuroP↑,
3814- mushLions,    Lion's Mane (Hericium erinaceus) Exerts Anxiolytic Effects in the rTg4510 Tau Mouse Model
- in-vitro, AD, NA
*neuroP↑, *cognitive↑, *cognitive∅, *BBB↑, *NGF↑, *BDNF↑, *NO↓, *memory↑, *Aβ↓,
3815- mushLions,    Neurohealth Properties of Hericium erinaceus Mycelia Enriched with Erinacines
- Review, Stroke, NA - Review, Park, NA - Review, AD, NA
*eff↑, *cognitive↑,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 11

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

GSH↑, 1,   MDA↓, 1,   NRF2↓, 1,   ROS↓, 3,  

Cell Death ⓘ

Apoptosis↓, 1,  

Transcription & Epigenetics ⓘ

other↑, 1,  

DNA Damage & Repair ⓘ

P53↑, 1,  

Migration ⓘ

APP↓, 1,   Ca+2↝, 1,  

Angiogenesis & Vasculature ⓘ

NO↓, 1,  

Barriers & Transport BBB, epithelial layers), membrane transporters, ion channels, and water channels. It governs permeability, cellular uptake/efflux, tissue protection, and drug access to target compartments." style="cursor:help;color:#555;font-weight:normal;">ⓘ

BBB↑, 3,  

Immune & Inflammatory Signaling Inflammation group includes innate and adaptive immune pathways, cytokines, chemokines, pattern-recognition receptors, complement, and inflammasomes. It regulates host defense, tumor immunity, neuroinflammation, and chronic inflammatory disease processes." style="cursor:help;color:#555;font-weight:normal;">ⓘ

COX2↓, 1,   Inflam↓, 2,  

Synaptic & Neurotransmission memory, and neuronal survival, and is especially relevant to Alzheimer’s and other neurodegenerative diseases." style="cursor:help;color:#555;font-weight:normal;">ⓘ

AChE↓, 2,   BDNF↑, 1,   NGF↑, 1,   p‑tau↓, 2,  

Protein Aggregation tau biology, proteolytic processing, and aggregate toxicity. It captures molecular features specific to neurodegenerative pathology but remains extensible to other aggregation disorders." style="cursor:help;color:#555;font-weight:normal;">ⓘ

Aβ↓, 5,   BACE↓, 1,   NLRP3↓, 1,  

Drug Metabolism & Resistance ⓘ

Dose↝, 1,   eff↑, 2,  

Clinical Biomarkers Inflammation state | Microenvironment | Research-stage | | 28 | XIST | Epigenetic instability | Aggressiveness | Not yet clinical | | 29 | FOXM1 | High-risk biology | Aggressiveness | No routine testing | | 30 | TRIB3 | Stress adaptation | Aggressiveness | Mechanistic, not clinical | Core Liver & Systemic Biomarkers in Oncology | Marker | What It Reflects | Main Use in Cancer | Decision Impact | | --------- | ----------------------------------- | ----------------------------------------- | ----------- | | ALT | Hepatocellular injury | Baseline eligibility, toxicity monitoring | High | | AST | Liver + systemic injury | Detect liver injury, muscle involvement | High | | ALP | Cholestasis, bone turnover | Liver mets vs bone mets | High | | bilirubin | Hepatic clearance | Chemotherapy dosing | Critical | | albumin | Synthetic liver function, nutrition | Prognosis, frailty | High | | LDH | Tumor burden, hypoxia | Aggressiveness, prognosis | High | | INR | Liver synthetic failure | Treatment safety | High | Key Inflammatory / Host-Response Biomarkers Used in Oncology | Biomarker | What It Reflects | Main Use in Cancer | Clinical Decision Impact | | ------------------ | -------------------------------- | ---------------------------- | -------------------- | | C-reactive protein | Systemic inflammation | Prognosis, therapy tolerance | High | | ESR | Chronic inflammation | Disease activity trend | Moderate | | ferritin | Inflammation + iron status | Cachexia, cytokine load | High | | IL-6 | Cytokine signaling | Aggressiveness, cachexia | High (specialty use) | | LDH | Tumor burden + hypoxia | Risk stratification | Very high | | albumin | Nutritional & inflammatory state | Frailty, survival | Very high | </pre> " style="cursor:help;color:#555;font-weight:normal;">ⓘ

NOS2↓, 1,  

Functional Outcomes cognitive performance, toxicity, and organism-level effects. It is intentionally mechanism-agnostic and anchors molecular data to real-world biological impact." style="cursor:help;color:#555;font-weight:normal;">ⓘ

AntiAge↑, 1,   cognitive↑, 6,   cognitive∅, 1,   memory↑, 3,   motorD↑, 1,   neuroP↑, 6,   toxicity∅, 1,  
Total Targets: 30

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:325  Target#:%  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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