Database Query Results : Huperzine A/Huperzia serrata, ,

Hup, Huperzine A/Huperzia serrata: Click to Expand ⟱
Features:
huperzine A is a natural product and has been studied for its potential benefits in Alzheimer's disease (AD).
-inhibits acetylcholinesterase(AChE), the enzyme that breaks down acetylcholine, a key neurotransmitter involved in memory and learning.
Scientific Papers found: Click to Expand⟱
3754- BBR,  CUR,  EGCG,  Hup,    Traditional Chinese medicinal herbs as potential AChE inhibitors for anti-Alzheimer’s disease: A review
*AChE↓, *Aβ↓, *LDL↓, *RenoP↑, *BChE↓, *eff↑, *BACE↓, *AChE↓, *eff↑,
3748- CUR,  RES,  Hup,  Riv,  Gala  Natural acetylcholinesterase inhibitors: A multi-targeted therapeutic potential in Alzheimer's disease
- Review, AD, NA
*AChE↓, *Inflam↓, *Aβ↓, *cognitive↑, *ROS↓,
3799- Hup,    The use of Huperzia species for the treatment of Alzheimer's disease
- NA, AD, NA
*antiOx↑, *Inflam↓, *AChE↓,
3800- Hup,    Role of huperzine a in the treatment of Alzheimer's disease
- Review, AD, NA
*AChE↓, *neuroP↑, *cognitive↑,
3801- Hup,    An update on huperzine A as a treatment for Alzheimer's disease
- Review, AD, NA
*AChE↓, *antiOx↑, *neuroP↑,
3802- Hup,    New insights into huperzine A for the treatment of Alzheimer's disease
- Review, AD, NA
*AChE↓, *neuroP↑,
3803- Hup,    Huperzine A and Its Neuroprotective Molecular Signaling in Alzheimer’s Disease
- Review, AD, NA
*AChE↓, *neuroP↑, *BBB↑, *Half-Life↑, *cognitive↑, *Dose↝, *BACE↓, *IronCh↑, *TfR1/CD71↓, *ROS↓,
3804- Hup,    Huperzine A for Alzheimer's disease: a systematic review and meta-analysis of randomized clinical trials
- Review, AD, NA
*cognitive↑, *cognitive∅, *AChE↓,
3805- Hup,    Isolation, diversity and acetylcholinesterase inhibitory activity of the culturable endophytic fungi harboured in Huperzia serrata from Jinggang Mountain, China
- Analysis, AD, NA
*AChE↓,
4209- Hup,    Huperzine A, reduces brain iron overload and alleviates cognitive deficit in mice exposed to chronic intermittent hypoxia
- in-vivo, NA, NA
*ROS↓, *cognitive↑, *neuroP↑, *Bax:Bcl2↓, *Casp3↑, *NADPH↓, *NOX↓, *TfR1/CD71↓, *Iron↓, *PSD95↑, *BDNF↑,
4210- Hup,    A Synopsis of Multitarget Potential Therapeutic Effects of Huperzine A in Diverse Pathologies–Emphasis on Alzheimer’s Disease Pathogenesis
- Review, AD, NA
*neuroP↑, *AChE↓, *Ach↑, *memory↑, *NGF↑, *BDNF↑,
4211- Hup,    Huperzine A ameliorates obesity-related cognitive performance impairments involving neuronal insulin signaling pathway in mice
- in-vitro, NA, NA
*memory↑, *p‑Akt↑, *BACE↓, *cognitive↑,
4212- Hup,    Huperzine A Alleviates Oxidative Glutamate Toxicity in Hippocampal HT22 Cells via Activating BDNF/TrkB-Dependent PI3K/Akt/mTOR Signaling Pathway
- in-vitro, Nor, HT22
*ROS↓, *p‑Akt↓, *p‑mTOR↓, *p‑p70S6↓, *BDNF↑, *Apoptosis↓, *Casp3↓, *Bcl-2↑,
4213- Hup,    Huperzine A-Liposomes Efficiently Improve Neural Injury in the Hippocampus of Mice with Chronic Intermittent Hypoxia
- in-vivo, NA, NA
*cognitive↑, *SOD↑, *GPx↑, *MDA↓, *ROS↓, *Iron↓, *TfR1/CD71↓, *FTL↓, *ERK↑, *PKA↑, *CREB↑, *BDNF↑, *PSD95↑, *neuroP↑,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 14

Results for Effect on Normal Cells:
Ach↑,1,   AChE↓,11,   p‑Akt↓,1,   p‑Akt↑,1,   antiOx↑,2,   Apoptosis↓,1,   Aβ↓,2,   BACE↓,3,   Bax:Bcl2↓,1,   BBB↑,1,   BChE↓,1,   Bcl-2↑,1,   BDNF↑,4,   Casp3↓,1,   Casp3↑,1,   cognitive↑,7,   cognitive∅,1,   CREB↑,1,   Dose↝,1,   eff↑,2,   ERK↑,1,   FTL↓,1,   GPx↑,1,   Half-Life↑,1,   Inflam↓,2,   Iron↓,2,   IronCh↑,1,   LDL↓,1,   MDA↓,1,   memory↑,2,   p‑mTOR↓,1,   NADPH↓,1,   neuroP↑,7,   NGF↑,1,   NOX↓,1,   p‑p70S6↓,1,   PKA↑,1,   PSD95↑,2,   RenoP↑,1,   ROS↓,5,   SOD↑,1,   TfR1/CD71↓,3,  
Total Targets: 42

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:343  Target#:%  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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