Database Query Results : Lutein, , IL1β

Lut, Lutein: Click to Expand ⟱
Features:
Lutein
-Kale, spinach, parsley, corn, egg yolks, peas
-Breast cancer: Inverse correlation with dietary intake
- Potent antioxidant, scavenges ROS (reactive oxygen species)
-Downregulates NF-κB and other inflammatory pathways
-Promotes apoptosis in cancer cells
-inhibits angiogenesis
IL1β, interleukin-1 beta: Click to Expand ⟱
Source:
Type:
The term "IL-1" is often used as an umbrella term for the interleukin-1 family, which includes multiple cytokines. The two best-known members are IL-1α and IL-1β.
IL-1β is secreted from cells and plays a major systemic role in inflammation. It is a crucial mediator in the inflammatory response and is involved in the fever response, activation of endothelial cells, and leukocyte recruitment.
Its increased expression is commonly linked to:
  – Promotion of a pro-inflammatory microenvironment that supports tumor growth.
  – Enhanced angiogenesis, invasion, and metastasis.
  – Recruitment of myeloid cells that may further suppress antitumor immunity.

High expression of either tends to be associated with a more aggressive phenotype and worse prognosis in many cancer types.
Scientific Papers found: Click to Expand⟱
4191- Zeax,  Lut,    Effects of macular xanthophyll supplementation on brain-derived neurotrophic factor, pro-inflammatory cytokines, and cognitive performance
- Trial, AD, NA
*BDNF↑, BDNF, MPOD, serum MXans, and AOC all increased significantly versus placebo in both treatment groups over the 6-month study period (p < .05 for all).
*IL1β↓, IL-1β decreased significantly versus placebo in both treatment groups (p = .0036 and p = .006, respectively).
*cognitive↑, For cognitive measures, scores for composite memory, verbal memory, sustained attention, psychomotor speed, and processing speed all improved significantly in treatment groups
*memory↑, For cognitive scores, change in BDNF was correlated to change in composite memory (r = 0.32; p = .014) and verbal memory


* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Results for Effect on Cancer/Diseased Cells:

Total Targets: 0

Results for Effect on Normal Cells:
BDNF↑,1,   cognitive↑,1,   IL1β↓,1,   memory↑,1,  
Total Targets: 4

Scientific Paper Hit Count for: IL1β, interleukin-1 beta
Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:1  prod#:349  Target#:978  State#:0  Dir#:1
  wNotes=on  sortOrder:rid,rpid

 

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