Database Query Results : Coenzyme Q10, ,

CoQ10, Coenzyme Q10: Click to Expand ⟱
Features:
Coenzyme Q10 (CoQ10), also known as ubiquinone, is a fat-soluble antioxidant and a critical component of the mitochondrial electron transport chain, essential for ATP production. Its potential role in Alzheimer’s disease (AD) and cancer has been increasingly studied, mainly due to its effects on oxidative stress, mitochondrial function, and cellular energy metabolism.

Two types: ubiquinone(standard) vs ubiquinol(more bioavailable)

-high content in beef heart -Acts as an antioxidant, reducing ROS
-Some preclinical studies suggest CoQ10 may reduce Aβ-induced neurotoxicity
-CoQ10 is sometimes used with chemotherapy to reduce cardiotoxicity (especially with doxorubicin).
-Essential for ATP (energy) production.

-CoQ10 levels may drop by 25–40% in people taking statins.
-May support mitochondrial function in neurodegenerative diseases, including Alzheimer’s and Parkinson’s
Scientific Papers found: Click to Expand⟱
3990- CoQ10,    Serum levels of coenzyme Q10 in patients with Alzheimer's disease
- Study, AD, NA
*other∅,
3991- CoQ10,    Evaluation of Coenzyme Q as an Antioxidant Strategy for Alzheimer’s Disease
- in-vivo, AD, NA
*ROS↓, *antiOx↑,
3992- CoQ10,    Coenzyme Q10
- Review, AD, NA
*antiOx↑, *SOD↑, *lipid-P↓, *ROS↓, *other?,
3993- CoQ10,    Coenzyme Q10 Decreases Amyloid Pathology and Improves Behavior in a Transgenic Mouse Model of Alzheimer’s Disease
- Review, Park, NA - Review, AD, NA
*neuroP↑, *Aβ↓, *ROS↓, *cognitive↑, *antiOx↑,
3994- CoQ10,  Se,    Coenzyme Q10 Supplementation in Aging and Disease
- Review, AD, NA - Review, Park, NA
*AntiAge↑, *cardioP↑, *Inflam↓, *antiOx↑, *lipid-P↓, *QoL↑, *neuroP↑, *Dose↝, *BP↓, *IGF-1↑, *IGFBP1↑, *eff↑, *LDL↓, *HDL↑, *eff↑, *other↑, *RenoP↑, *ROS↓, *TNF-α↓, *IL6↓, *other↝, *other∅,
3995- CoQ10,    Effects of Coenzyme Q10 on TNF-alpha secretion in human and murine monocytic cell lines
- in-vitro, NA, NA
*TNF-α↓, *antiOx↑, *Inflam↓,
3996- CoQ10,    Coenzyme Q10 decreases TNF-alpha and IL-2 secretion by human peripheral blood mononuclear cells
- in-vitro, Nor, NA
*TNF-α↓,
3997- CoQ10,    Coenzyme Q and Its Role in the Dietary Therapy against Aging
- Review, AD, NA
*AntiAge↑, *Inflam↓, *antiOx↑, *Apoptosis↓, *BioAv↑, *other↝, *cognitive↑, *DNAdam↓, *ER Stress↓,
4257- CoQ10,    Dietary intake of coenzyme Q10 reduces oxidative stress in patients with acute ischemic stroke: a double-blind, randomized placebo-controlled study
- Trial, Stroke, NA
*MDA↓, *IL6↓, *SOD↑, *BDNF↑, *ROS↓, *Inflam↓, *neuroP↑,
4258- CoQ10,    Neuroprotective effects of coenzyme Q10-loaded exosomes obtained from adipose-derived stem cells in a rat model of Alzheimer's disease
- in-vivo, AD, NA
*memory↑, *BDNF↑, *cognitive↑, *SOX2↑,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 10

Results for Effect on Normal Cells:
AntiAge↑,2,   antiOx↑,6,   Apoptosis↓,1,   Aβ↓,1,   BDNF↑,2,   BioAv↑,1,   BP↓,1,   cardioP↑,1,   cognitive↑,3,   DNAdam↓,1,   Dose↝,1,   eff↑,2,   ER Stress↓,1,   HDL↑,1,   IGF-1↑,1,   IGFBP1↑,1,   IL6↓,2,   Inflam↓,4,   LDL↓,1,   lipid-P↓,2,   MDA↓,1,   memory↑,1,   neuroP↑,3,   other?,1,   other↑,1,   other↝,2,   other∅,2,   QoL↑,1,   RenoP↑,1,   ROS↓,5,   SOD↑,2,   SOX2↑,1,   TNF-α↓,3,  
Total Targets: 33

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:356  Target#:%  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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