Vitamin B6,pyridoxine / cognitive Cancer Research Results

VitB6, Vitamin B6,pyridoxine: Click to Expand ⟱
Features:
Vitamin B6 (pyridoxine) has been studied in relation to Alzheimer’s disease (AD) due to its role in brain health, neurotransmitter synthesis, and homocysteine metabolism. 
Biological Role of Vitamin B6
-can act as a potent antioxidant 
-Essential for the production of serotonin, dopamine, GABA, and norepinephrine.
-Homocysteine regulation: B6 is a cofactor in the conversion of homocysteine to cysteine.
    Elevated homocysteine levels are linked to increased AD risk and brain atrophy.
-Anti-inflammatory effects: B6 may modulate inflammation, a key factor in neurodegeneration.
-Myelin and cognitive function: Involved in myelin formation and synaptic plasticity.
-higher vitamin B6 intakes have been associated with greater grey matter volume

Cognitive support / Homocysteine lowering	10–50 mg/day	Often combined with B12 and folate


cognitive, cognitive: Click to Expand ⟱
Source:
Type:
Cognitive


Scientific Papers found: Click to Expand⟱
4078- betaCar,  VitC,  VitB6,    Impact of Diet on Learning, Memory and Cognition
- Review, AD, NA
*neuroP↑, Carotenoids, vitamin C, and vitamin B6 were identified as the dietary nutrients with the highest protective capacity against MCI, potentially due to their antioxidant properties
*antiOx↑,
*cognitive↑,

4061- betaCar,  VitB12,  VitB6,  FA,  VitB3  Revisiting the Role of Vitamins and Minerals in Alzheimer’s Disease
- Review, AD, NA
*cognitive↑, vitamin A supplementation has been to be effective in lowering cognitive decline and AD pathology
*cognitive↑, Studies that involved B12 supplementation have shown beneficial effects on cognition and inflammatory status.
*Inflam↓,
*homoC↓, decreased serum homocysteine and TNF-α
*TNF-α↓,
*other↝, treatment with a high dose of B vitamins consisting of folic acid, B12, and B6 for 24 months was able to slow down the shrinkage of the whole brain volum
*memory↑, In line with the improved cognitive function, NAD+ treatment significantly alleviated neuroinflammation, impaired synaptic plasticity, DNA damage, and hippocampal neuronal loss in these mice.

4063- Flav,  VitB12,  VitB6,    Homocysteine and Dementia: An International Consensus Statement
- Review, AD, NA
*homoC↓, plasma total homocysteine, which reflects the functional status of three B vitamins (folate, vitamins B12, B6).
*cognitive↑, Intervention trials in elderly with cognitive impairment show that homocysteine-lowering treatment with B vitamins markedly slows the rate of whole and regional brain atrophy and also slows cognitive decline.

4053- VitB12,  VitB6,  FA,    Vitamins in Alzheimer’s Disease—Review of the Latest Reports
- Review, AD, NA
*cognitive↑, A diet rich in antioxidant vitamins can improve the cognitive functions of patients
*homoC↓, Vitamin B12 is involved in the transformation of homocysteine to methionine, and vitamin B6 and folic acid are cofactors for this reaction.
*SAM-e↓, This reduces the concentration of S-adenosylmethionine, which is a methyl donor.

4067- VitB12,  VitB6,  VitD3,    Plants, Plants, and More Plants: Plant-Derived Nutrients and Their Protective Roles in Cognitive Function, Alzheimer's Disease, and Other Dementias
- Review, AD, NA
*cognitive↑, A diet rich in vitamin B and antioxidants can benefit the cognitive functions of individuals as shown in randomized clinical trials

4058- VitB12,  VitB6,  FA,    The preventive efficacy of vitamin B supplements on the cognitive decline of elderly adults: a systematic review and meta-analysis
- Review, AD, NA
*homoC↓, Vitamin B supplements can lower the serum homocysteine (Hcy) level, but whether it can prevent cognitive decline or not remains unclear.
*cognitive↑, Vitamin B supplements might delay or maintain the cognitive decline of elderly adults. We can recommend that the vitamin B supplements should be considered as a preventive medication to MCI patients or elderly adults without cognitive impairment.

4056- VitB12,  VitB6,  FA,    Vitamin B12, B6, or Folate and Cognitive Function in Community-Dwelling Older Adults: A Systematic Review and Meta-Analysis
- Review, AD, NA
*Risk∅, High vitamin B6 concentrations showed no significant benefit on cognition and dementia risk.
*cognitive↑, Higher levels of vitamin B12 (OR = 0.77, 95% CI = 0.61-0.97) and folate concentration (OR = 0.68, 95% CI = 0.51-0.90) were associated with better cognition in cross-sectional studies
*cognitive∅, but not in sensitivity analyses or prospective studies

4054- VitB12,  VitB6,  FA,    Role of B vitamins in modulating homocysteine and metabolic pathways linked to brain atrophy: Metabolomics insights from the VITACOG trial
- Study, AD, NA
*homoC↓, B vitamins influence metabolic pathways beyond tHcy reduction, particularly the tricarboxylic acid cycle and glutamine–glutamate cycling, critical for brain energy homeostasis and neurotransmission.
*neuroP↑,
*cognitive↑, This metabolic signature supports B vitamin supplementation as a strategy for slowing MCI progression.

4062- VitB6,  FA,  VitB12,    Vitamin B6, B9, and B12 Intakes and Cognitive Performance in Elders: National Health and Nutrition Examination Survey, 2011–2014
- Study, AD, NA
*Risk↓, Compared with low vitamin B6 intake (<1.7 mg/day), adequate vitamin B6 intake (≥1.7 mg/day) corresponded to a 31.7% decrease in LCP odds in the DSST tests.
*Risk↓, Participants who consumed adequate B9 (≥400 mcg/day) were associated with 31.2%, 33.8%, and 46.5% declines in the risk of LCP in the CERAD, AF, and DSST tests in contrast to those having low B9 intake (<400 mcg/day)
*Risk↓, Adequate vitamin B12 intake (≥2.4 mcg/day) correlated with a lower LCP occurrence in the CERAD, AF, and DSST tests, with 30.5%, 21.5%, and 33.3% reductions, respectively
*cognitive↑, Adequate dietary vitamin B9 and B12 intakes are significantly associated with a better cognitive performance in immediate and delayed memory recall

4065- VitB6,  VitB12,  FA,    Vitamin B6, B12, and Folic Acid Supplementation and Cognitive Function
- Review, AD, NA
*cognitive∅, Three trials of vitamin B6 and 6 of vitamin B12 found no effect overall in a variety of doses, routes of administration, and populations.
*cognitive↑, One of 3 trials of folic acid found a benefit in cognitive function in people with cognitive impairment and low baseline serum folate levels.

4055- VitB6,  VitD3,    Vitamin B6 and vitamin D deficiency co-occurrence in geriatric memory patients
- Study, AD, NA
*Risk↓, Vitamin B6 deficiency was the most common (37.5%), followed by vitamin D deficiency (36.8%).
*cognitive↑, The coexistence of these vitamin deficiencies has a significant association with cognitive performance, indicating the clinical importance of monitoring and supplementation.

4077- VitB6,  FA,  VitB12,  VitD3,  VitE  Vitamin Supplementation as an Adjuvant Treatment for Alzheimer’s Disease
- Review, AD, NA
*antiOx↑, Vitamins are potent antioxidants and therefore can be used as an adjuvant therapy for the treatment of AD.
*cognitive↑, Among B vitamins, pyridoxine (B6), folic acid (B9), and cobalamin (B12) have shown to have potential in managing symptoms of AD.
*homoC↓, vitamin B6, B9 and B12 have shown to decrease the level of homocysteine, thereby helping in the control of this modifiable risk-factor for AD
*Risk↓, Low levels of vitamin B6 have been implicated in the pathogenesis of AD.
*Risk↓, Low level of serum folate is another predictor for AD
*Risk↓, The plasma levels of vitamin B12 were also found to be deficient in cases of AD
*other↝, Elevated plasma level of homocysteine is an important risk factor for gray matter atrophy
*Dose↝, 0.8mg B9, 20mg B6 and 0.5mg B12, over a period of 2 years has been demonstrated to decrease homocysteine induced gray matter atrophy
*Risk↓, The analysis of current literature on the relationship between vitamin D deficiency and AD revealed a direct relation between decreased serum level of vitamin D and AD
*Risk↓, decreased levels of plasma vitamin E is associated with increased risk of neurodegenerative disorders like AD and Mild Cognitive Impairment (MCI)

4052- VitB6,    B-Vitamin Intake and Biomarker Status in Relation to Cognitive Decline in Healthy Older Adults in a 4-Year Follow-Up Study
- Study, AD, NA
*neuroP↑, Lower vitamin B6 status, as measured using pyridoxal-5-phosphate (PLP; <43 nmol/L) was associated with a 3.5 times higher risk of accelerated cognitive decline,
*other↑, More importantly, it also demonstrated that B-vitamin supplementation reduced the rate of brain atrophy by 30% as measured using MRI
*other↑, This study showed that combined B-vitamin supplementation for two years had beneficial effects on cognitive performance in participants with MCI and elevated plasma homocysteine concentrations
*cognitive↑, Lower dietary intake and biomarker status of vitamin B6 were associated with a greater rate of cognitive decline over a subsequent 4 years follow-up period. (PLP < 30 nmol/L)
*eff↝, No significant association of dietary intake or biomarker status with cognitive decline were observed for the other B-vitamins (folate, vitamin B12 and riboflavin).
*Risk↑, Consistent with the biomarker data, those with lower dietary intakes of vitamin B6 at baseline were 4 times more likely to have a greater rate of cognitive decline over the 4 years time period.
*other↑, higher vitamin B6 intakes have been associated with greater grey matter volume


Showing Research Papers: 1 to 13 of 13

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 13

Pathway results for Effect on Cancer / Diseased Cells:


Total Targets: 0

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 2,   SAM-e↓, 1,  

Core Metabolism/Glycolysis ⓘ

homoC↓, 6,  

Transcription & Epigenetics ⓘ

other↑, 3,   other↝, 2,  

Immune & Inflammatory Signaling ⓘ

Inflam↓, 1,   TNF-α↓, 1,  

Drug Metabolism & Resistance ⓘ

Dose↝, 1,   eff↝, 1,  

Functional Outcomes ⓘ

cognitive↑, 14,   cognitive∅, 2,   memory↑, 1,   neuroP↑, 3,   Risk↓, 9,   Risk↑, 1,   Risk∅, 1,  
Total Targets: 16

Scientific Paper Hit Count for: cognitive, cognitive
13 Vitamin B6,pyridoxine
10 Vitamin B12
8 Folic Acid, Vit B9
3 Vitamin D3
2 beta-carotene(VitA)
1 Vitamin C (Ascorbic Acid)
1 Vitamin B3,Niacin
1 flavonoids
1 Vitamin E
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:360  Target#:557  State#:%  Dir#:2
  wNotes=on  sortOrder:rid,rpid

 

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