Oleocanthal / mTOR Cancer Research Results

OLEC, Oleocanthal: Click to Expand ⟱
Features:
Oleocanthal is a phenolic compound found ONLY in extra-virgin olive oil (EVOO).
It has strong anti-inflammatory activity (similar to ibuprofen-like COX inhibition).
In multiple cell and animal studies, it:
-selectively induces lysosomal membrane permeabilization in cancer cells, leading to rapid cell death
-inhibits tumor proliferation and metastasis pathways
-reduces HER2 signaling
-slows colorectal, breast, and prostate cancer progression in models

It has indirect CSC targeting

Not available as a supplement
-it is unstable outside the oil.
-some companies sell high-oleocanthal EVOO


mTOR, mammalian target of rapamycin: Click to Expand ⟱
Source: HalifaxProj (inhibit)
Type:
mTOR (mechanistic target of rapamycin) is a central regulator of cell growth, proliferation, metabolism, and survival. It is a serine/threonine kinase that integrates signals from nutrients, growth factors, and cellular energy status.
mTOR promotes protein synthesis and cell growth by activating downstream targets such as S6 kinase and 4E-BP1. In cancer, this pathway can become hyperactivated, leading to uncontrolled cell proliferation.

mTor Inhibitors:
-rapamycin (Sirolimus): classic natural product mTOR inhibitor
-Curcumin
-Resveratrol
-Epigallocatechin Gallate (EGCG)
-Honokiol
Scientific Papers found: Click to Expand⟱
4647- OLEC,    Oleocanthal, an Antioxidant Phenolic Compound in Extra Virgin Olive Oil (EVOO): A Comprehensive Systematic Review of Its Potential in Inflammation and Cancer
- Review, Var, NA
*Inflam↓, OC exhibits promising therapeutic potential against both inflammation and cancer.
AntiCan↑,
*COX2/PTGS2↓, OC was able to inhibit the enzymaticactivity of cyclooxigenease-2 (COX-1) and cyclooxigenease-2 (COX-2) with greater potencycompared to ibuprofen
*ROS↓, figure 3
*TNF-α↓,
*IL1β↓,
*iNOS↓,
TumCP↓, OC also effectively reduces cell proliferation and limits the production of the extracellular matrix in LX2 cells, suggesting its antifibrotic properties
*AntiAg↑, Healthy men: Anti-platelet effects
mTOR↓, Oleocanthalhas exhibited robust anti-proliferative effects in multiple breast cancer cell lines, accompanied by the downregulation of phosphorylated mTOR
STAT3↓, OC was shown to suppress STAT3 activity
ERK↓, OC was able to inhibit ERK1/2 and AKT phosphorylation and downregulate Bcl-2expression
p‑Akt↓,
Bcl-2↓,
ROS↑, OC effectively impeded the formation of cell colonies, triggered apoptosis, and incited the generation of intracellular ROS within cancer cells.
PSA↓, ↓PSA levels in mouse model


Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

ROS↑, 1,  

Cell Death(tgid=5) ⓘ

Bcl-2↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

p‑Akt↓, 1,   ERK↓, 1,   mTOR↓, 1,   STAT3↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

TumCP↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

PSA↓, 1,  

Clinical Biomarkers(tgid=22) ⓘ

PSA↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 1,  
Total Targets: 10

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

ROS↓, 1,  

Cell Death(tgid=5) ⓘ

iNOS↓, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 1,   IL1β↓, 1,   Inflam↓, 1,   TNF-α↓, 1,  
Total Targets: 7

Scientific Paper Hit Count for: mTOR, mammalian target of rapamycin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:377  Target#:209  State#:%  Dir#:1
  wNotes=on  sortOrder:rid,rpid

 

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