Glutathione Cancer Research Results

GSH, Glutathione: Click to Expand ⟱

Features:

Glutathione = GSH (reduced form)
Oxidized glutathione = GSSG
GSH/GSSG ratio = key indicator of cellular redox state

-Neutralizes H₂O₂ and lipid peroxides
-Maintains redox homeostasis

Most cancers show:
-Elevated GSH levels
-Increased GSH synthesis and recycling
-High GSH/GSSG ratio

This supports:
-Survival under oxidative stress
-Resistance to chemotherapy and radiation
-Detoxification of drugs (e.g., irinotecan, cisplatin)
-Cancer cells often develop a “GSH addiction”.

Natural Products Affecting GSH
Compound	        Effect
Curcumin	        ↓ GSH in cancer cells
Sulforaphane	        Transient NRF2 activation → later depletion
Resveratrol	        Disrupts GSH recycling
Quercetin	        Consumes GSH during detox
Selenium compounds	Dose-dependent: support GPX or induce redox stress
High-dose Vitamin C	Depletes GSH via ROS overload

Scientific Papers found: Click to Expand⟱

5106-

SSE,

GSH,

Dual role of glutathione in selenite-induced oxidative stress and apoptosis in human hepatoma cells

in-vitro,

Liver,

HepG2

ROS↑, Apoptosis↑, eff↑, GSH↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:

Redox & Oxidative Stress ⓘ

GSH↓, 1, ROS↑, 1,

Cell Death ⓘ

Apoptosis↑, 1,

Drug Metabolism & Resistance ⓘ

eff↑, 1,
Total Targets: 4

Pathway results for Effect on Normal Cells:

Total Targets: 0

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells