Caffeic Acid Phenethyl Ester (CAPE) Cancer Research Results

CAPE, Caffeic Acid Phenethyl Ester (CAPE): Click to Expand ⟱
Features:

Caffeic Acid Phenethyl Ester (CAPE) — CAPE is a propolis-derived phenolic ester and bioactive honeybee-hive constituent with pleiotropic anti-inflammatory and antineoplastic signaling effects. It is best classified as a natural polyphenolic small molecule and experimental adjunct candidate rather than an approved anticancer drug. Standard abbreviations include CAPE; common chemical naming includes caffeic acid phenethyl ester and phenethyl caffeate. CAPE is most strongly associated with poplar-type propolis chemistry, but it is also available as an ingredient in some dietary-supplement products. Current oncology relevance remains preclinical to early translational, with growing interest in chemosensitization and radiosensitization but no established cancer indication.

Primary mechanisms (ranked):

  1. NF-κB pathway inhibition with downstream suppression of pro-inflammatory and pro-survival transcription
  2. PI3K/Akt and p70S6K network suppression with reduced proliferation and survival signaling
  3. Wnt/β-catenin/TCF inhibition with reduced cyclin D1 and c-MYC signaling
  4. Anti-invasive / anti-metastatic modulation via reduced MMP expression and related motility programs
  5. Mitochondrial and metabolic stress reprogramming, including membrane depolarization and a shift toward glycolysis in some tumor models
  6. Chemo/radiosensitization in selected models, including autophagy inhibition and context-dependent enhancement of cytotoxic therapy
  7. Secondary redox and cytoprotective modulation, including ROS buffering or oxidative stress induction depending on model and exposure
  8. Secondary eicosanoid/inflammatory enzyme effects, including COX-2 and lipoxygenase-related signaling suppression

Bioavailability / PK relevance: Oral translation is constrained by poor aqueous solubility, limited absorption, esterase-sensitive disposition, and substantial hydrolysis to caffeic acid in vivo. Rat PK work supports measurable exposure after oral dosing, but CAPE analogues with improved permeability outperform parent CAPE. Formulation strategies are therefore mechanistically relevant for systemic use.

In-vitro vs systemic exposure relevance: Many direct anticancer studies use roughly 10–60 μM exposure, with some effects emerging near or above this range; those concentrations may exceed or stress the upper edge of practical systemic exposure with simple oral delivery. Tumor-directed claims should therefore be weighted more heavily when supported by in vivo xenograft, radiosensitization, or formulation-enabled data rather than cell culture alone.

Clinical evidence status: Predominantly preclinical with in vitro, xenograft, and ex vivo support; small translational signals exist for radiosensitization/radioprotection concepts, but there is no established oncology trial program or approved cancer use for CAPE itself.

CAPE — Cancer vs Normal Cell Pathway Map

Rank Pathway / Axis Cancer Cells Normal Cells TSF Primary Effect Notes / Interpretation
1 NF-κB inflammatory transcription NF-κB ↓; inflammatory/pro-survival gene programs ↓ Inflammatory stress ↓ P/R Anti-inflammatory and anti-survival signaling suppression Most canonical CAPE axis; supported by classic mechanistic work and newer radiosensitization studies. Central for cytokine, survival, and stress-response attenuation.
2 PI3K/Akt / p70S6K / c-MYC Akt ↓; p70S6K ↓; c-MYC ↓; proliferation ↓ ↔ / protective (context-dependent) R/G Cytostatic and pro-apoptotic pressure Strong relevance in prostate and NSCLC models; appears therapeutically leveraged in combination settings.
3 Wnt / β-catenin / TCF β-catenin ↓; nuclear β-catenin ↓; cyclin D1 ↓; c-MYC ↓ ↔ R/G Growth arrest and apoptosis support Well supported in colon cancer models; helps explain antiproliferative and differentiation-related effects.
4 MMP invasion / metastasis axis MMP-2 ↓; MMP-9 ↓; MT1-MMP ↓; invasion ↓ ECM injury/inflammation ↓ (context-dependent) R/G Anti-invasive and anti-metastatic effect Useful translational axis because it links inflammatory signaling to motility and matrix remodeling.
5 Mitochondria / metabolic reprogramming Mitochondrial membrane potential ↓; respiration shift toward glycolysis Potential radioprotective anti-inflammatory support in tissue slices P/R Stress amplification and therapeutic-window modulation Recent lung data suggest CAPE can destabilize tumor bioenergetics while dampening inflammatory injury signals in normal tissue contexts.
6 Autophagy / chemosensitization Autophagy ↓; oxaliplatin sensitivity ↑ ↔ R/G Adjunct sensitization to therapy Now a meaningful secondary axis; 2024 colon-cancer work supports autophagy inhibition as one mechanism of drug sensitization.
7 Radiosensitization RadioS ↑ (adenocarcinoma-selective in some models) Radiation-associated inflammatory injury ↓ (context-dependent) R/G Potential therapeutic-window expansion Important emerging translational niche rather than a universal CAPE effect; appears histology- and context-dependent.
8 ROS / NRF2 redox modulation (secondary) ROS ↔ / ↑ / ↓ (context-dependent); NRF2 ↔ / ↑ (secondary) ROS injury ↓; cytoprotective antioxidant tone ↑ (context-dependent) P/R/G Redox buffering or oxidative stress depending on setting CAPE is not best treated as a simple antioxidant. In tumors it may contribute to stress and death signaling, while in normal tissue it may support anti-inflammatory/radioprotective responses.
9 COX-2 / lipoxygenase inflammatory eicosanoids COX-2-related signaling ↓; LOX-related signaling ↓ Inflammatory eicosanoid tone ↓ P/R Inflammation and microenvironment restraint Mechanistically plausible and historically supported, but generally more secondary than NF-κB/Akt/β-catenin in oncology framing.
10 Clinical Translation Constraint Bioavailability ↓; exposure consistency ↓ Systemic delivery limitations ↑ — Formulation-limited translation Poor solubility, hydrolysis, and variable absorption limit confidence that common oral dosing reproduces stronger in vitro anticancer concentrations.

TSF legend: P: 0–30 min; R: 30 min–3 hr; G: >3 hr
Scientific Papers found: Click to Expand⟱
5774- CA,  CAPE,    Caffeic Acid Versus Caffeic Acid Phenethyl Ester in the Treatment of Breast Cancer MCF-7 Cells: Migration Rate Inhibition
- NA, BC, MCF-7
TumCMig↓, Wound Healing↑, eff↑, tumCV↓,
5765- CAPE,    Absorption properties and effects of caffeic acid phenethyl ester and its p-nitro-derivative on P-glycoprotein in Caco-2 cells and rats
- vitro+vivo, Colon, Caco-2
P-gp↓,
5773- CAPE,    Caffeic acid phenethyl ester inhibits invasion and expression of matrix metalloproteinase in SK-Hep1 human hepatocellular carcinoma cells by targeting nuclear factor kappa B
- NA, HCC, SK-HEP-1
TumCI↓, MMP2↓, MMP9↓, NF-kB↓, TumMeta↓,
5772- CAPE,    The Pluripotent Activities of Caffeic Acid Phenethyl Ester
- Review, Var, NA
*Bacteria↓, *AntiCan↑, *Imm↑, *Wound Healing↑, *NF-kB↓, *5LO↓, *AntiDiabetic↑, ChemoSen↑, selectivity↑, chemoPv↑,
5771- CAPE,  PBG,    Caffeic acid phenethyl ester: Unveiling its potential as a potent apoptosis inducer for combating hypopharyngeal squamous cell carcinoma
- in-vitro, HNSCC, NA
MMP↓, Casp3↑, survivin↓, XIAP↓,
5770- CAPE,    Caffeic acid phenethyl ester is a potent and specific inhibitor of activation of nuclear transcription factor NF-kappa B
- in-vitro, Nor, NA
*NF-kB↓, *Imm↑, *Inflam↓,
5769- CAPE,    Caffeic Acid Phenethyl Ester Inhibits the Proliferation of HEp2 Cells by Regulating Stat3/Plk1 Pathway and Inducing S Phase Arrest
- in-vitro, Laryn, HEp2
tumCV↓, STAT3↓, TumCCA↑,
5768- CAPE,    Neuroprotective Potential of Caffeic Acid Phenethyl Ester (CAPE) in CNS Disorders: Mechanistic and Therapeutic Insights
- Review, AD, NA - Review, Park, NA - Review, Stroke, NA
*antiOx↑, *Inflam↑, *AntiCan↑, *NRF2↑, *GSK‐3β↑, *Akt↑, *PI3K↑, *ROS↓, *SOD↑, *GSH↑, *MDA↓, *tau↓, *neuroP↑, *memory↑, *AChE↓, *other↝, *lipid-P↓,
5767- CAPE,    Caffeic Acid Phenethyl Ester Is a Potential Therapeutic Agent for Oral Cancer
- Review, Oral, NA
TumCP↓, tumCV↓, TumMeta↓, Akt↓, NF-kB↓, MMPs↓, EGFR↓, COX2↓, TumCCA?,
5766- CAPE,    A Nano-Liposomal Formulation of Caffeic Acid Phenethyl Ester Modulates Nrf2 and NF-κβ Signaling and Alleviates Experimentally Induced Acute Pancreatitis in a Rat Model
- in-vivo, Nor, NA
*MDA↓, *NF-kB↓, *p65↓, *TNF-α↓, *cl‑Casp3↓, *GSR↑, *GSH↑, *NRF2↑, *HO-1↑, *Bax:Bcl2↓, *antiOx↑, *Inflam↓,
5754- CAPE,  Rad,    The radiosensitizing effect of Caffeic Acid Phenethyl Ester in breast cancer is dependent on p53 status
- in-vivo, BC, MDA-MB-231
tumCV↓, eff⇅, RadioS↑, OS↑,
5764- CAPE,    Caffeic Acid Phenethyl Ester (CAPE), Derived from a Honeybee Product Propolis, Exhibits a Diversity of Anti-tumor Effects in Preclinical Models of Human Breast Cancer
- vitro+vivo, BC, MCF-7 - NA, BC, MDA-MB-231
TumCG↓, TumCCA↑, Apoptosis↑, NF-kB↓, MDR1↓, VEGF↓, angioG↓,
5763- CAPE,    Synthesis and Biological Evaluation of a Caffeic Acid Phenethyl Ester Derivatives as Anti-Hepatocellular Carcinoma Agents via Inhibition of Mitochondrial Respiration and Disruption of Cellular Metabolism
- NA, HCC, NA
*antiOx↑, *neuroP↑, NF-kB↓, TumCG↓, TumMeta↓, MMPs↓, P53↑, ChemoSen↑,
5762- CAPE,    Caffeic acid phenethyl ester promotes oxaliplatin sensitization in colon cancer by inhibiting autophagy
- in-vitro, CRC, SW480 - in-vitro, CRC, HCT116
ChemoSen↓, Apoptosis↑,
5761- CAPE,    Caffeic acid phenethyl ester suppresses the proliferation of human prostate cancer cells through inhibition of AMPK and Akt signaling networks
- in-vitro, Pca, LNCaP - in-vitro, Pca, DU145 - in-vitro, Pca, PC3
TumCP↓, TumCG↓, TumCCA↑, AMPK↓, NF-kB↓, β-catenin/ZEB1↓, CREB↓, cycD1/CCND1↓, cycE/CCNE↓, CDK2↓, CDK4↓,
5760- CAPE,    Caffeic acid phenethyl ester induces growth arrest and apoptosis of colon cancer cells via the beta-catenin/T-cell factor signaling
- in-vitro, CRC, HCT116 - in-vitro, CRC, SW480
TumCG↓, TumCCA↑,
5759- CAPE,    CAPE is a potent and a specific inhibitor of NF-kappa B activation and this may provide the molecular basis for its multiple immunomodulatory and antiinflammatory activities.
- Study, Nor, NA
*NF-kB↓,
5758- CAPE,  PBG,    Caffeic acid phenethyl ester and therapeutic potentials
- Review, Var, NA
*antiOx↑, *Inflam↓, ChemoSen↑, chemoP↑, COX1↓, COX2↓, selectivity↑, NF-kB↓, RadioS↑, *ROS↓, *lipid-P↓,
5757- CAPE,    Caffeic acid phenethyl ester (CAPE): pharmacodynamics and potential for therapeutic application
- Review, Nor, NA
*NF-kB↓, NF-kB↓, P53↑, FOXO↑, Wnt↓, TumCI↓, *HO-1↑, MMP9↓, MMP2↓, COX1↓, COX2↓, 5LO↓,

Showing Research Papers: 1 to 19 of 19

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 19

Pathway results for Effect on Cancer / Diseased Cells:


Mitochondria & Bioenergetics ⓘ

MMP↓, 1,   XIAP↓, 1,  

Core Metabolism/Glycolysis ⓘ

AMPK↓, 1,   CREB↓, 1,  

Cell Death ⓘ

Akt↓, 1,   Apoptosis↑, 2,   Casp3↑, 1,   survivin↓, 1,  

Transcription & Epigenetics ⓘ

tumCV↓, 4,  

DNA Damage & Repair ⓘ

P53↑, 2,  

Cell Cycle & Senescence ⓘ

CDK2↓, 1,   CDK4↓, 1,   cycD1/CCND1↓, 1,   cycE/CCNE↓, 1,   TumCCA?, 1,   TumCCA↑, 4,  

Proliferation, Differentiation & Cell State ⓘ

FOXO↑, 1,   STAT3↓, 1,   TumCG↓, 4,   Wnt↓, 1,  

Migration ⓘ

5LO↓, 1,   MMP2↓, 2,   MMP9↓, 2,   MMPs↓, 2,   TumCI↓, 2,   TumCMig↓, 1,   TumCP↓, 2,   TumMeta↓, 3,   β-catenin/ZEB1↓, 1,  

Angiogenesis & Vasculature ⓘ

angioG↓, 1,   EGFR↓, 1,   VEGF↓, 1,  

Barriers & Transport ⓘ

P-gp↓, 1,  

Immune & Inflammatory Signaling ⓘ

COX1↓, 2,   COX2↓, 3,   NF-kB↓, 7,  

Drug Metabolism & Resistance ⓘ

ChemoSen↓, 1,   ChemoSen↑, 3,   eff↑, 1,   eff⇅, 1,   MDR1↓, 1,   RadioS↑, 2,   selectivity↑, 2,  

Clinical Biomarkers ⓘ

EGFR↓, 1,  

Functional Outcomes ⓘ

chemoP↑, 1,   chemoPv↑, 1,   OS↑, 1,   Wound Healing↑, 1,  
Total Targets: 48

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 4,   GSH↑, 2,   GSR↑, 1,   HO-1↑, 2,   lipid-P↓, 2,   MDA↓, 2,   NRF2↑, 2,   ROS↓, 2,   SOD↑, 1,  

Cell Death ⓘ

Akt↑, 1,   Bax:Bcl2↓, 1,   cl‑Casp3↓, 1,  

Transcription & Epigenetics ⓘ

other↝, 1,  

Proliferation, Differentiation & Cell State ⓘ

GSK‐3β↑, 1,   PI3K↑, 1,  

Migration ⓘ

5LO↓, 1,  

Immune & Inflammatory Signaling ⓘ

Imm↑, 2,   Inflam↓, 3,   Inflam↑, 1,   NF-kB↓, 5,   p65↓, 1,   TNF-α↓, 1,  

Synaptic & Neurotransmission ⓘ

AChE↓, 1,   tau↓, 1,  

Functional Outcomes ⓘ

AntiCan↑, 2,   AntiDiabetic↑, 1,   memory↑, 1,   neuroP↑, 2,   Wound Healing↑, 1,  

Infection & Microbiome ⓘ

Bacteria↓, 1,  
Total Targets: 30

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:395  Target#:%  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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