Neem / VEGF Cancer Research Results

Neem, Neem: Click to Expand ⟱
Features:

Neem (Azadirachta indica) is a medicinal plant whose leaves, bark, seeds, and oil contain multiple bioactive compounds, including nimbolide, nimbidin, azadirachtin, gedunin, and quercetin. Reported activities include antimicrobial, antifungal, antiparasitic, anti-inflammatory, and anticancer effects. Neem is entered separately from nimbolide because neem extracts are complex mixtures, while nimbolide is a single isolated limonoid. Reference



VEGF, Vascular endothelial growth factor: Click to Expand ⟱
Source: HalifaxProj (inhibit)
Type:
A signal protein produced by many cells that stimulates the formation of blood vessels. Vascular endothelial growth factor (VEGF) is a signal protein that plays a crucial role in angiogenesis, the process by which new blood vessels form from existing ones. This process is vital for normal physiological functions, such as wound healing and the menstrual cycle, but it is also a key factor in the growth and spread of tumors in cancer.
Because of its significant role in tumor growth and progression, VEGF has become a target for cancer therapies. Anti-VEGF therapies, such as monoclonal antibodies (e.g., bevacizumab) and small molecule inhibitors, aim to inhibit the action of VEGF, thereby reducing blood supply to tumors and limiting their growth. These therapies have been used in various types of cancer, including colorectal, lung, and breast cancer.
Scientific Papers found: Click to Expand⟱
6775- Neem,  Nimb,    Therapeutics Role of Azadirachta indica (Neem) and Their Active Constituents in Diseases Prevention and Treatment
- Review, Nor, NA
*antiOx↑, P53↑, PTEN↑, NF-kB↓, PI3K↓, Akt↓, Bcl-2↓, VEGF↓, *Inflam↓, *COX2/PTGS2↓, *5LO↝, *Wound Healing↑, *Imm↑, *hepatoP↑, *AntiDiabetic↑, *neuroP↑, *AntiViral↑, *Bacteria↑, *AntiBio↑, *AntiFungal↑, cMyc↓, BAX↓, IAP1↓, IAP2/BIRC3↓, Bcl-xL↓, survivin↓, XIAP↓, angioG↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Mitochondria & Bioenergetics(tgid=3) ⓘ

XIAP↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

cMyc↓, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 1,   BAX↓, 1,   Bcl-2↓, 1,   Bcl-xL↓, 1,   IAP1↓, 1,   IAP2/BIRC3↓, 1,   survivin↓, 1,  

DNA Damage & Repair(tgid=10) ⓘ

P53↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

PI3K↓, 1,   PTEN↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1,   VEGF↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

NF-kB↓, 1,  
Total Targets: 15

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

AntiBio↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 1,  

Migration(tgid=13) ⓘ

5LO↝, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 1,   Imm↑, 1,   Inflam↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiDiabetic↑, 1,   hepatoP↑, 1,   neuroP↑, 1,   Wound Healing↑, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiFungal↑, 1,   AntiViral↑, 1,   Bacteria↑, 1,  
Total Targets: 13

Scientific Paper Hit Count for: VEGF, Vascular endothelial growth factor
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:420  Target#:334  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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