Radicicol/monorden / eff Cancer Research Results

Radic, Radicicol/monorden: Click to Expand ⟱
Features: HSP90 inhibitor

Radicicol, also known as monorden, is a fungal resorcylic acid lactone and natural-product HSP90 inhibitor. It binds the N-terminal ATP-binding pocket of HSP90 and inhibits its molecular-chaperone activity, resulting in destabilization and degradation of HSP90-dependent client proteins involved in tumour growth and survival. Reported effects include suppression of oncogenic kinase signalling, cell-cycle arrest, and apoptosis in experimental cancer models. Although radicicol is potent in biochemical and cell-based assays, the native compound has limited therapeutic utility because of chemical instability, rapid metabolism, and weak in-vivo activity. Reference.



eff, efficacy: Click to Expand ⟱
Source:
Type:
Power to enhance an anti cancer effect
Scientific Papers found: Click to Expand⟱
6918- FIS,  Geld,  Radic,    HSP90 Inhibitors, Geldanamycin and Radicicol, Enhance Fisetin-Induced Cytotoxicity via Induction of Apoptosis in Human Colonic Cancer Cells
- in-vitro, CRC, COLO205
eff↑, cl‑Casp3↑, PARP↑, MMPs↓, cl‑Casp9↑, other↝,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Cell Death(tgid=5) ⓘ

cl‑Casp3↑, 1,   cl‑Casp9↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

other↝, 1,  

DNA Damage & Repair(tgid=10) ⓘ

PARP↑, 1,  

Migration(tgid=13) ⓘ

MMPs↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

eff↑, 1,  
Total Targets: 6

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: eff, efficacy
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:423  Target#:961  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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