Ginkgolic acids / HER2/EBBR2 Cancer Research Results

GAs, Ginkgolic acids: Click to Expand ⟱
Features:

Ginkgolic acids (GAs) are a group of naturally occurring 2-hydroxy-6-alkylsalicylic acids found in Ginkgo biloba leaves, seeds and especially the seed coat. Major congeners include ginkgolic acid C13:0, C15:1 and C17:1. Ginkgolic acids have demonstrated antimicrobial, antiviral, autophagy-modulating and anticancer activities in preclinical studies. In cancer models, GAs can suppress proliferation, migration and invasion and promote apoptosis through mechanisms including inhibition of SUMOylation, STAT3 signalling, Hsp90 activity and other oncogenic pathways. Individual congeners can differ substantially in potency and biological activity, so specific forms such as C15:1 or C17:1 should be recorded separately when identified. Ginkgolic acids are kept separate from standardized Ginkgo biloba extracts because they are considered potentially toxic constituents and are deliberately reduced to very low concentrations in purified medicinal ginkgo preparations. Current anticancer evidence is predominantly preclinical.



HER2/EBBR2, Human epidermal growth factor receptor 2: Click to Expand ⟱
Source:
Type:
Also called erbB-2 (or ERb-2) -Receptor tyrosine-protein kinase
HER2 is a protein that helps breast cancer cells grow quickly.
HER2/neu protein is a receptor tyrosine kinase that is normally involved in cell growth and division. However, in some cancers, the HER2/neu gene is overexpressed or mutated, leading to an overproduction of the protein. This can cause cells to grow and divide uncontrollably, leading to tumor formation.
Scientific Papers found: Click to Expand⟱
7213- GAs,    Anti-Cancer Properties of Ginkgolic Acids in Human Nasopharyngeal Carcinoma CNE-2Z Cells via Inhibition of Heat Shock Protein 90
- vitro+vivo, NPC, CNE2 - in-vitro, BC, MDA-MB-231 - in-vitro, BC, MCF7 - in-vitro, Lung, H1975
ATPase↓, HSP90↓, TumCP↓, *toxicity↝, MMP2↓, MMP9↓, HER2/EBBR2↓, c-Raf↓, Akt↓, Bcl-2↓, other↝,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Mitochondria & Bioenergetics(tgid=3) ⓘ

c-Raf↓, 1,  

Cell Death(tgid=5) ⓘ

Akt↓, 1,   Bcl-2↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

HER2/EBBR2↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

other↝, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

HSP90↓, 1,  

Migration(tgid=13) ⓘ

ATPase↓, 1,   MMP2↓, 1,   MMP9↓, 1,   TumCP↓, 1,  

Clinical Biomarkers(tgid=22) ⓘ

HER2/EBBR2↓, 1,  
Total Targets: 11

Pathway results for Effect on Normal Cells:


Functional Outcomes(tgid=23) ⓘ

toxicity↝, 1,  
Total Targets: 1

Scientific Paper Hit Count for: HER2/EBBR2, Human epidermal growth factor receptor 2
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:436  Target#:359  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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