Ginkgo biloba-EGb 761 Cancer Research Results

EGb 761, Ginkgo biloba-EGb 761: Click to Expand ⟱

Features:

<p>
<strong>EGb 761</strong> is a standardized, purified extract of
<em>Ginkgo biloba</em> leaves developed for medicinal use. It is typically
standardized to approximately <strong>22–27% flavone glycosides</strong> and
<strong>5–7% terpene lactones</strong>, including ginkgolides A, B and C and
bilobalide, while potentially undesirable <strong>ginkgolic acids</strong> are
reduced to very low levels. EGb 761 has antioxidant, mitochondrial,
neuroprotective, vasoregulatory, anti-inflammatory and platelet-activating-factor
antagonist effects and has been studied extensively in cognitive impairment,
dementia and Alzheimer’s disease. Reported mechanisms include reduction of
oxidative stress, stabilization of mitochondrial function, modulation of
neurotransmitter signalling, protection against amyloid-β-associated toxicity,
improved cerebral microcirculation and modulation of inflammatory pathways.
EGb 761 is kept separate from generic <em>Ginkgo biloba</em> supplements
because commercial extracts vary substantially in flavonoid, terpene-lactone
and ginkgolic-acid content and are not necessarily pharmacologically equivalent
to the standardized EGb 761 preparation. EGb 761 is kept separate
from isolated ginkgolides, bilobalide and ginkgolic acids 
</p>

<a href="https://pmc.ncbi.nlm.nih.gov/articles/PMC12417213/">high PCA content in EGb 761 may contribute to cognitive benefits</a><br>
 bioactive compounds such as terpenoids (Ginkgolides A, B, and C), polyphenols, organic acids, and flavonoids (quercetin, kaempferol, and isorhamnetin). <br>

<a href="https://pubmed.ncbi.nlm.nih.gov/22784423/">EGb 761</a> 
is a dry extract from Ginkgo biloba leaves (35–67:1), extraction solvent acetone
60% (w/w). The extract is adjusted to 22.0–27.0% ginkgo flavonoids and 5.0–7.0% terpene lactones,
consisting of 2.8–3.4% ginkgolides A, B, and C and 2.6–3.2% bilobalide and contains less than 5 ppm
ginkgolic acids<br>

<pre>


Table 1. Protective capacity of individual compounds of EGb 761 in brain cells)
COMPOUNDMEAN (SEM) PROTECTION ( % )
(0.5 mg/ml) (percentage recovery after insult)
Ginkgolide A    8.0±1.9∗∗
Ginkgolide B    33.0±11.2∗
Ginkgolide C    8.5±1.6∗∗
Ginkgolide J    37.0±12.2∗
Bilobalide      36.3±7.7∗∗
Flavonoids      56.4±12.7∗∗∗
</pre>

Scientific Papers found: Click to Expand⟱

7220-

EGb 761,

Ginkgo Biloba Extract Inhibits Metastasis and ERK/Nuclear Factor kappa B (NF-κB) Signaling Pathway in Gastric Cancer

vitro+vivo,

GC,

SGC-7901

mouse model

TumCP↓, TumCMig↓, TumCI↓, p‑ERK↓, NF-kB↓, MMP2↓, eff↑, TumCG↓, TumMeta↓, Dose↝, TumVol↓,

7241-

EGb 761,

ASA,

Effect of Ginkgo biloba (EGb 761) and aspirin on platelet aggregation and platelet function analysis among older adults at risk of cardiovascular disease: a randomized clinical trial

Trial,

Nor,

*Dose↝, *AntiAg∅,

7240-

EGb 761,

EGb 761 protects liver mitochondria against injury induced by in vitro anoxia/reoxygenation

in-vitro,

Nor,

*ATP↑, *ROS↓, *hepatoP↑,

7239-

EGb 761,

Efficacy and adverse effects of ginkgo biloba for cognitive impairment and dementia: a systematic review and meta-analysis

Review,

AD,

*cognitive↑, *eff↑,

7237-

EGb 761,

Ginkgo biloba Extract Mechanism Inhibits Hepatocellular Carcinoma through the Nuclear Factor-κB/p53 Signaling Pathway

in-vitro,

HCC,

HepG2

TumCG↓, tumCV↓, Apoptosis↑, P53↑, NF-kB↓,

7236-

EGb 761,

Neuroprotective effects of bilobalide, a component of the Ginkgo biloba extract (EGb 761), in gerbil global brain ischemia

in-vivo,

Stroke,

gerbil

*Dose↑, *Stroke↓,

7235-

EGb 761,

Stabilization of Mitochondrial Membrane Potential and Improvement of Neuronal Energy Metabolism by Ginkgo Biloba Extract EGb 761

in-vitro,

AD,

*MMP↑, *ATP↑,

7232-

EGb 761,

Efficacy and safety of Ginkgo biloba extract EGb 761 in mild cognitive impairment with neuropsychiatric symptoms: a randomized, placebo-controlled, double-blind, multi-center trial

Trial,

AD,

240 mg EGb 761 daily or placebo for a period of 24 weeks, 37 patients taking EGb 761 and 36 patients receiving placebo.

*cognitive↑, *toxicity↓,

7231-

EGb 761,

Efficacy and tolerability of Ginkgo biloba extract EGb 761® in dementia: a systematic review and meta-analysis of randomized placebo-controlled trials

Review,

AD,

 2,684 outpatients randomized to receive treatment for 22–26 weeks,

*toxicity↓, *eff↑, *cognitive↑, *other↑, *eff↑,

7230-

EGb 761,

Ginkgo biloba extract (EGb 761) promotes peripheral nerve regeneration and neovascularization after acellular nerve allografts in a rat model

in-vivo,

Nor,

Seventy-two Sprague–Dawley rats

*Dose↝, *NGF↑, *angioG↑, *VEGF↑, *SOX18↑, *CD133↑, *IL6↑,

7229-

EGb 761,

Meta-analysis of the efficacy and safety of Ginkgo biloba extract for the treatment of dementia

Review,

AD,

*toxicity↓, *Dose↝, *ROS↓, *PAF↓, *memory↑, *BloodF↑, *antiOx↑, *Inflam↓, *Tinn↓,

7228-

EGb 761,

Current Perspectives on the Beneficial Role of Ginkgo biloba in Neurological and Cerebrovascular Disorders

Review,

AD,

*Dose↝, *PAF↑, *AntiAg↑, *BloodF↑, *Inflam↓, *neuroP↑, *Stroke↓, *Dose↝, *Sepsis↓, *memory↑,

7225-

EGb 761,

Efficacy and safety of Ginkgo biloba standardized extract in the treatment of vascular cognitive impairment: a randomized, double-blind, placebo-controlled clinical trial

Trial,

AD,

 90 patients

*cognitive↑, *Dose↝, *Dose↝,

7222-

EGb 761,

Ginkgo biloba extract EGb 761® in the symptomatic treatment of mild-to-moderate dementia: a profile of its use

Review,

AD,

*cognitive↑, *toxicity↓, *Dose↝, *BioAv↑, *Half-Life↑, *neuroP↑, *Half-Life↝, *Dose↝, *other↝, *eff↑,

3721-

EGb 761,

Ginkgo biloba Extract in Alzheimer’s Disease: From Action Mechanisms to Medical Practice

Review,

AD,

*antiOx↑, *ROS↓, *SOD↑, *Catalase↑, *GSR↑, *MMP↑, *Inflam↓, *Aβ↓, *memory↑, *Dose↝, *BBB↑, *neuroP↑,

7219-

EGb 761,

Ginkgo biloba Prevents Oxidative Stress-Induced Apoptosis Blocking p53 Activation in Neuroblastoma Cells

in-vitro,

Nor,

SK-N-BE

H2O2 induced

*MMP↑, *Bax:Bcl2↓, *cl‑PARP↓, *i-antiOx↑, *mt-Apoptosis↓, *neuroP↑,

7209-

EGb 761,

Ginkgo biloba Extract EGb 761 in the Treatment of Patients with Mild Neurocognitive Impairment: A Systematic Review

Review,

AD,

*cognitive↑, *toxicity↓,

7208-

EGb 761,

EGb 761 reduces Ca2+ influx and apoptosis after pentylenetetrazole treatment in a neuroblastoma cell line

in-vitro,

Nor,

SH-SY5Y

pentylenetetrazole treatment in a neuroblastoma cell line

*Ca+2↑, *Apoptosis↓, *ROS↓, *MMP↑, *Casp3↓, *Casp9↓,

7203-

EGb 761,

Ginkgo biloba extract EGb 761 is safe and effective in the treatment of mild dementia - a meta-analysis of patient subgroups in randomised controlled trials

Review,

AD,

cognitive↑, QoL↑, Dose↝,

7202-

EGb 761,

Ginkgo biloba leaf extract EGb 761® for the treatment of various diseases: Overview of systematic reviews

Review,

AD,

*cognitive↑, *Tinn↓, *toxicity↓,

7200-

EGb 761,

PCA,

Optimized Ginkgo biloba extract EGb 761®: boosted therapeutic benefits with minimized CYP enzyme interference

*Dose↝, *AChE↓, *GSK‐3β↝, *eff↑, *cognitive↑, *toxicity↓,

7196-

EGb 761,

Ginkgo biloba extract EGb 761 in patients with dementia and a history of cerebral infarction-meta-analysis of pooled data from randomised clinical trials

Review,

AD,

Review,

Stroke,

*neuroP↑, *cognitive↑, *Stroke↓, *toxicity↓, Dose↝,

7194-

EGb 761,

Kaempferol and quercetin, components of Ginkgo biloba extract (EGb 761), induce caspase-3-dependent apoptosis in oral cavity cancer cells

in-vitro,

Oral,

Casp3↑, Apoptosis↑, Dose↝, TumCP↓, cl‑PARP↑, AntiCan↑,

7193-

EGb 761,

5-FU,

Ginkgo biloba extract 761 enhances 5-fluorouracil chemosensitivity in colorectal cancer cells through regulation of high mobility group-box 3 expression

in-vitro,

CRC,

SW480

in-vitro,

CRC,

SW-620

*antiOx↑, AntiCan↑, ChemoSen↑, selectivity↑, EMT↓, E-cadherin↑, Vim↓, HMGB1↓, other↝, chemoPv↑,

7192-

EGb 761,

Ginkgo biloba extract EGb 761 exerts anti-angiogenic effects via activation of tyrosine phosphatases

in-vitro,

Nor,

HMEC

Risk↓, *TumCP↓, *TumCMig↓, *angioG↓,

7191-

EGb 761,

Pharmacokinetic drug interactions involving Ginkgo biloba

NA,

Nor,

*other∅, *Dose↝,

7206-

GBE,

EGb 761,

Ginkgo biloba: A Leaf of Hope in the Fight against Alzheimer's Dementia: Clinical Trial Systematic Review

Review,

AD,

*Dose↝, *Inflam↓, *antiOx↑, *neuroP↑, *cognitive↑,

Showing Research Papers: 1 to 27 of 27

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 27

Pathway results for Effect on Cancer / Diseased Cells:

Pathway results for Effect on Normal Cells:

NA, unassigned(tgid=0) ⓘ

PAF↓, 1, PAF↑, 1, Stroke↓, 3, Tinn↓, 2,

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 4, i-antiOx↑, 1, Catalase↑, 1, GSR↑, 1, ROS↓, 4, SOD↑, 1,

Mitochondria & Bioenergetics(tgid=3) ⓘ

ATP↑, 2, MMP↑, 4,

Cell Death(tgid=5) ⓘ

Apoptosis↓, 1, mt-Apoptosis↓, 1, Bax:Bcl2↓, 1, Casp3↓, 1, Casp9↓, 1,

Transcription & Epigenetics(tgid=7) ⓘ

other↑, 1, other↝, 1, other∅, 1,

DNA Damage & Repair(tgid=10) ⓘ

cl‑PARP↓, 1,

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

CD133↑, 1, GSK‐3β↝, 1,

Migration(tgid=13) ⓘ

AntiAg↑, 1, AntiAg∅, 1, Ca+2↑, 1, TumCMig↓, 1, TumCP↓, 1,

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1, angioG↑, 1, SOX18↑, 1, VEGF↑, 1,

Barriers & Transport(tgid=15) ⓘ

BBB↑, 1,

Immune & Inflammatory Signaling(tgid=16) ⓘ

IL6↑, 1, Inflam↓, 4,

Synaptic & Neurotransmission(tgid=18) ⓘ

AChE↓, 1, NGF↑, 1,

Protein Aggregation(tgid=19) ⓘ

Aβ↓, 1,

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↑, 1, Dose↑, 1, Dose↝, 13, eff↑, 5, Half-Life↑, 1, Half-Life↝, 1,

Clinical Biomarkers(tgid=22) ⓘ

BloodF↑, 2, IL6↑, 1,

Functional Outcomes(tgid=23) ⓘ

cognitive↑, 10, hepatoP↑, 1, memory↑, 3, neuroP↑, 6, toxicity↓, 8,

Infection & Microbiome(tgid=24) ⓘ

Sepsis↓, 1,
Total Targets: 52

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:438  Target#:%  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

Ginkgo biloba-EGb 761 Cancer Research Results

Pathway results for Effect on Cancer / Diseased Cells:

Cell Death(tgid=5) ⓘ

Transcription & Epigenetics(tgid=7) ⓘ

DNA Damage & Repair(tgid=10) ⓘ

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

Migration(tgid=13) ⓘ

Immune & Inflammatory Signaling(tgid=16) ⓘ

Drug Metabolism & Resistance(tgid=21) ⓘ

Functional Outcomes(tgid=23) ⓘ

Pathway results for Effect on Normal Cells:

NA, unassigned(tgid=0) ⓘ

Redox & Oxidative Stress(tgid=1) ⓘ

Mitochondria & Bioenergetics(tgid=3) ⓘ

Cell Death(tgid=5) ⓘ

Transcription & Epigenetics(tgid=7) ⓘ

DNA Damage & Repair(tgid=10) ⓘ

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

Migration(tgid=13) ⓘ

Angiogenesis & Vasculature(tgid=14) ⓘ

Barriers & Transport(tgid=15) ⓘ

Immune & Inflammatory Signaling(tgid=16) ⓘ

Synaptic & Neurotransmission(tgid=18) ⓘ

Protein Aggregation(tgid=19) ⓘ

Drug Metabolism & Resistance(tgid=21) ⓘ

Clinical Biomarkers(tgid=22) ⓘ

Functional Outcomes(tgid=23) ⓘ

Infection & Microbiome(tgid=24) ⓘ

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