Pomegranate/Punica granatum / ACE Cancer Research Results

Pom, Pomegranate/Punica granatum: Click to Expand ⟱
Features:

Punica granatum - Pomegranate

Type: Botanical extract / polyphenol- and ellagitannin-rich fruit

Active Constituents: Punicalagins, ellagic acid, ellagitannins, anthocyanins, flavonoids, and other polyphenols. Gut metabolism can generate urolithins from ellagitannins.

Function: Punica granatum extracts exhibit antioxidant, anti-inflammatory, antiproliferative, pro-apoptotic, antiangiogenic, and metabolic effects. Biological activity varies among juice, peel, seed, and standardized extract preparations.

Cancer: Experimental and clinical research has investigated pomegranate in prostate, breast, colorectal, and other cancers. Reported mechanisms include inhibition of proliferation, inflammation, angiogenesis, invasion, and metastasis and promotion of apoptosis.

Alzheimer's Disease: Experimental studies suggest neuroprotective activity through reduction of oxidative stress, neuroinflammation, amyloid-related pathology, and synaptic dysfunction. Pomegranate-derived polyphenols and their metabolites may contribute to these effects.
ACE, Angiotensin-Converting Enzyme 1: Click to Expand ⟱
Source:
Type:

ACE - Angiotensin-Converting Enzyme 1

Abbreviation: ACE, ACE1, CD143

Type: Zinc metallopeptidase / renin-angiotensin system enzyme

Function: Converts angiotensin I to the biologically active vasoconstrictor angiotensin II and degrades bradykinin. ACE regulates blood pressure, vascular function, inflammation, oxidative stress, fibrosis, angiogenesis, and tissue remodeling through the classical renin-angiotensin system.

Cancer: ↑ Increased ACE/angiotensin II signaling can promote tumor-associated inflammation, angiogenesis, proliferation, fibrosis, invasion, and metastasis, particularly through downstream AT1R signaling. ACE inhibition can suppress tumor growth and angiogenic signaling in several experimental cancer models.

Alzheimer's Disease: ↕ Context-dependent. ACE participates in potentially harmful angiotensin II-mediated vascular, oxidative, and inflammatory signaling, but also directly degrades amyloid-β and can convert Aβ42 toward Aβ40. ACE levels and activity therefore show complex compartment-dependent relationships with Alzheimer's pathology.
Scientific Papers found: Click to Expand⟱
7368- RS,  Amla,  CS,  Pom,  MP  Natural angiotensin converting enzyme inhibitors: A safeguard against hypertension, respiratory distress syndrome, and chronic kidney diseases
- Study, Nor, NA
*ACE↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Total Targets: 0

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

ACE↓, 1,  
Total Targets: 1

Scientific Paper Hit Count for: ACE, Angiotensin-Converting Enzyme 1
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:444  Target#:1629  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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