Mucuna pruriens/Velvet Bean / ACE Cancer Research Results

MP, Mucuna pruriens/Velvet Bean: Click to Expand ⟱
Features:

Mucuna pruriens - Velvet Bean, Kapikacchu

Type: Botanical extract / L-DOPA-rich medicinal seed

Active Constituents: L-DOPA (levodopa), flavonoids, phenolic compounds, alkaloids, fatty acids, and other bioactive constituents.

Function: Mucuna pruriens is notable for its naturally high L-DOPA content and has dopaminergic, antioxidant, mitochondrial, anti-inflammatory, and neuroprotective effects. Whole-seed extracts also contain additional constituents that may modify the effects of L-DOPA.

Cancer: Emerging experimental evidence suggests antiproliferative, pro-apoptotic, and chemosensitizing effects in selected cancer models, although the cancer evidence is less extensive than its neurological literature.

Alzheimer's Disease: Preclinical evidence supports antioxidant, mitochondrial, anti-inflammatory, and neuroprotective effects relevant to neurodegeneration, although Mucuna pruriens is much more strongly established in Parkinson's disease research than in Alzheimer's disease.
ACE, Angiotensin-Converting Enzyme 1: Click to Expand ⟱
Source:
Type:

ACE - Angiotensin-Converting Enzyme 1

Abbreviation: ACE, ACE1, CD143

Type: Zinc metallopeptidase / renin-angiotensin system enzyme

Function: Converts angiotensin I to the biologically active vasoconstrictor angiotensin II and degrades bradykinin. ACE regulates blood pressure, vascular function, inflammation, oxidative stress, fibrosis, angiogenesis, and tissue remodeling through the classical renin-angiotensin system.

Cancer: ↑ Increased ACE/angiotensin II signaling can promote tumor-associated inflammation, angiogenesis, proliferation, fibrosis, invasion, and metastasis, particularly through downstream AT1R signaling. ACE inhibition can suppress tumor growth and angiogenic signaling in several experimental cancer models.

Alzheimer's Disease: ↕ Context-dependent. ACE participates in potentially harmful angiotensin II-mediated vascular, oxidative, and inflammatory signaling, but also directly degrades amyloid-β and can convert Aβ42 toward Aβ40. ACE levels and activity therefore show complex compartment-dependent relationships with Alzheimer's pathology.
Scientific Papers found: Click to Expand⟱
7368- RS,  Amla,  CS,  Pom,  MP  Natural angiotensin converting enzyme inhibitors: A safeguard against hypertension, respiratory distress syndrome, and chronic kidney diseases
- Study, Nor, NA
*ACE↓,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Total Targets: 0

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

ACE↓, 1,  
Total Targets: 1

Scientific Paper Hit Count for: ACE, Angiotensin-Converting Enzyme 1
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:445  Target#:1629  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

Home Page