| Features: |
| Polyphenols are a large and structurally diverse family of plant-derived phenolic compounds characterized by multiple phenolic hydroxyl groups and encompassing major subclasses including flavonoids, phenolic acids, stilbenes, lignans, and tannins. They occur widely in fruits, vegetables, herbs, tea, coffee, cocoa, and medicinal plant extracts. Polyphenols exhibit broad biological activity involving redox regulation, inflammatory signaling, kinase pathways, apoptosis, cell-cycle control, angiogenesis, metabolism, and epigenetic regulation. In cancer models, many polyphenols inhibit proliferation, promote apoptosis or senescence, suppress invasion and angiogenesis, and can alter sensitivity to chemotherapy or radiotherapy. Effects are highly compound-, dose-, and context-dependent; antioxidant activity in normal tissues may coexist with pro-oxidant ROS induction in cancer cells. Oral bioavailability is frequently limited by poor absorption and extensive intestinal, hepatic, and microbial metabolism, making high-concentration in-vitro findings difficult to extrapolate directly to human systemic exposure. Polyphenols — broad umbrella class of plant-derived phenolic compounds.
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| Hepatoprotective is the ability of a chemical substance to prevent damage to the liver. Grapefruit: -hepatoprotective potential has emerged from the study of naringenin and naringin. Blueberries/cranberries: -proanthocyanidins Grape: Nopal (Cactus pear) and tuna (Cactus pear fruit) “Opuntia ficus-indica”: Chamomile (Matricaria chamomilla or Chamomilla recutita): Silymarin (Silybum marianum): Blue green algae spirulina : Propolis (bee glue): POLYSACCHARIDES β-glucans |
| 7413- | CS, | Poly, | Anticancer effects induced by artichoke extract in oral squamous carcinoma cell lines |
| - | in-vitro, | SCC, | SCC25 |
| 7431- | Poly, | Garlic peel extract as an antioxidant inhibits triple‐negative breast tumor growth and angiogenesis by inhibiting cyclooxygenase‐2 expression |
| - | vitro+vivo, | BC, | 4T1 |
Query results interpretion may depend on "conditions" listed in the research papers. Such Conditions may include : -low or high Dose -format for product, such as nano of lipid formations -different cell line effects -synergies with other products -if effect was for normal or cancerous cells
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