Polyphenols / Apoptosis Cancer Research Results

Poly, Polyphenols: Click to Expand ⟱
Features:

Polyphenols are a large and structurally diverse family of plant-derived phenolic compounds characterized by multiple phenolic hydroxyl groups and encompassing major subclasses including flavonoids, phenolic acids, stilbenes, lignans, and tannins. They occur widely in fruits, vegetables, herbs, tea, coffee, cocoa, and medicinal plant extracts. Polyphenols exhibit broad biological activity involving redox regulation, inflammatory signaling, kinase pathways, apoptosis, cell-cycle control, angiogenesis, metabolism, and epigenetic regulation. In cancer models, many polyphenols inhibit proliferation, promote apoptosis or senescence, suppress invasion and angiogenesis, and can alter sensitivity to chemotherapy or radiotherapy. Effects are highly compound-, dose-, and context-dependent; antioxidant activity in normal tissues may coexist with pro-oxidant ROS induction in cancer cells. Oral bioavailability is frequently limited by poor absorption and extensive intestinal, hepatic, and microbial metabolism, making high-concentration in-vitro findings difficult to extrapolate directly to human systemic exposure.

Polyphenols — broad umbrella class of plant-derived phenolic compounds.

  • Flavonoids
    • Flavones
      • Apigenin
      • Luteolin
    • Flavonols
      • Quercetin
      • Kaempferol
      • Fisetin
    • Flavan-3-ols
      • Catechin
      • Epicatechin
      • EGCG
    • Flavanones
      • Hesperetin
      • Naringenin
    • Isoflavones
      • Genistein
      • Daidzein
      • Formononetin
    • Anthocyanins
      • Cyanidin
      • Delphinidin
      • Pelargonidin
    • Chalcones
      • Isoliquiritigenin
      • Licochalcone A
      • Xanthohumol
      • Isobavachalcone
  • Phenolic acids
    • Hydroxybenzoic acids
      • Gallic acid
      • Protocatechuic acid
      • Ellagic acid
    • Hydroxycinnamic acids
      • Caffeic acid
      • Ferulic acid
      • p-Coumaric acid
      • Chlorogenic acid
      • Cynarin
  • Stilbenes
    • Resveratrol
    • Pterostilbene
  • Lignans
    • Secoisolariciresinol
    • Matairesinol
    • Enterolactone
    • Enterodiol
  • Tannins
    • Hydrolyzable tannins
      • Gallotannins
      • Ellagitannins
    • Condensed tannins
      • Proanthocyanidins
Apoptosis, Apoptosis: Click to Expand ⟱
Source:
Type: type of cell death
Situation in which a cell actively pursues a course toward death upon receiving certain stimuli.
Cancer is one of the scenarios where too little apoptosis occurs, resulting in malignant cells that will not die.
Scientific Papers found: Click to Expand⟱
7413- CS,  Poly,    Anticancer effects induced by artichoke extract in oral squamous carcinoma cell lines
- in-vitro, SCC, SCC25
AntiCan↑, tumCV↓, TumCG↓, Apoptosis↑, selectivity↑, BAX↑, Casp9↑, Bcl-2↓, TumCCA↑, other↝, hepatoP↑,
7416- CS,  Poly,    Phenolic-Rich Extracts from Artichoke By-Products Promote Apoptosis in Human Colorectal Cancer Cell Lines
- in-vitro, Colon, Caco-2 - in-vitro, Colon, HT29
tumCV↓, BAX↑, Casp9↑, Casp3↑, Bcl-2↓, Apoptosis↑, other↝, eff↑,

Showing Research Papers: 1 to 2 of 2

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 2

Pathway results for Effect on Cancer / Diseased Cells:


Cell Death(tgid=5) ⓘ

Apoptosis↑, 2,   BAX↑, 2,   Bcl-2↓, 2,   Casp3↑, 1,   Casp9↑, 2,  

Transcription & Epigenetics(tgid=7) ⓘ

other↝, 2,   tumCV↓, 2,  

Cell Cycle & Senescence(tgid=11) ⓘ

TumCCA↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

TumCG↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

eff↑, 1,   selectivity↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 1,   hepatoP↑, 1,  
Total Targets: 13

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: Apoptosis, Apoptosis
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:450  Target#:14  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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