isoquercitrin / BioAv Cancer Research Results

ISQ, isoquercitrin: Click to Expand ⟱
Features:

Isoquercitrin - Quercetin-3-O-Glucoside

Alternative Names: Isoquercetin, quercetin-3-O-glucoside, quercetin-3-O-β-D-glucopyranoside, Q3G, IQ

Type: Flavonol glycoside / quercetin glycoside / natural phytochemical

Sources: Naturally present in numerous medicinal plants, fruits, vegetables, and plant-derived foods. Isoquercitrin can also be produced from rutin by enzymatic removal of the rhamnose residue.

Function: Isoquercitrin is a bioactive quercetin glycoside with antioxidant, anti-inflammatory, anticancer, metabolic, and neuroprotective effects. Reported mechanisms include modulation of Nrf2/ARE, NF-κB, JAK/STAT3, PI3K/AKT, MAPK, AMPK, Wnt signaling, oxidative stress, and programmed cell death.

Cancer: Preclinical studies demonstrate inhibition of cancer-cell proliferation, survival, migration, and tumor-associated signaling together with induction of apoptosis and modulation of oxidative stress. Anticancer mechanisms include regulation of Wnt, MAPK, JAK/STAT3, PI3K/AKT, NF-κB, and related signaling pathways.

Alzheimer's Disease: Preclinical studies indicate neuroprotective activity, including improved learning and memory in amyloid-β-induced models and reduction of oxidative and inflammatory neuronal injury.
BioAv, bioavailability: Click to Expand ⟱
Source:
Type: measurement
Bioavailability (usually in %) absorbed by the body.
Scientific Papers found: Click to Expand⟱
7559- ISQ,    Difference in absorption of the two structurally similar flavonoid glycosides, hyperoside and isoquercitrin, in rats
- in-vivo, Nor, NA
*Dose↝, *BioAv↑,

Showing Research Papers: 1 to 1 of 1

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Pathway results for Effect on Cancer / Diseased Cells:


Total Targets: 0

Pathway results for Effect on Normal Cells:


Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↑, 1,   Dose↝, 1,  
Total Targets: 2

Scientific Paper Hit Count for: BioAv, bioavailability
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:455  Target#:792  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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