Flaxseed/Linseed Cancer Research Results

FS, Flaxseed/Linseed: Click to Expand ⟱
Features:

Flaxseed, Flaxseed refers to flax that is consumed by humans, while linseed is used when it is used for commercial purposes.
-Buy whole raw flaxseed → grind it finely shortly before use. Whole seeds have their natural protective coat and therefore have better storage stability. Grinding disrupts that protection and improves bioavailability but simultaneously exposes ALA to oxygen.
-even 10 g/day milled flaxseed significantly increased circulating total enterolignans and ALA in one randomized study
-sprouts: At day 8, SDG was 6.3-fold higher and SECO 4.5-fold higher than in ungerminated seed. By day 10, total phenolics were ~5.6-fold higher and total flavonoids ~55-fold higher, with the highest measured antioxidant and antiproliferative activities. -One study of 15 flax sprout varieties found SDG ranging from only 13.3 µg/g to 8,987 µg/g dry weight—a ~676-fold range.
Scientific Papers found: Click to Expand⟱
8300- FS,    Flaxseed supplementation (not dietary fat restriction) reduces prostate cancer proliferation rates in men presurgery
- Trial, Pca, NA
Dose↝, TumCP↓, Ki-67↓, *toxicity↓, Ingr↑, testos↓, DHT↓, Risk↓, Dose↝,
8303- FS,    The relative bioavailability of enterolignans in humans is enhanced by milling and crushing of flaxseed
- Trial, Nor, NA
*Dose?, *BioAv↑,
8304- FS,    Flaxseed-derived enterolactone is inversely associated with tumor cell proliferation in men with localized prostate cancer
- Trial, Pca, NA
NF-kB↓, VEGF↓, Ki-67↓, TumCP↓,
8306- FS,  lign,    Flax Lignans: From Biosynthetic Regulation to Biological Activities
- Review, NA, NA
*BioAv↝, *antiOx↑, *ROS↓, *Inflam↓, *cardioP↑,
8307- FS,  lign,    Efficacy and safety of a flaxseed hull extract in the symptomatic management of benign prostatic hyperplasia: a parallel, randomized, double-blind, placebo-controlled, pilot study
- Trial, BPH, NA
*Dose↝, *IPSS↓, *toxicity↓, *QoL↑, *other↝,
8308- FS,  lign,    The treatment effects of flaxseed-derived secoisolariciresinol diglycoside and its metabolite enterolactone on benign prostatic hyperplasia involve the G protein-coupled estrogen receptor 1
- in-vivo, BPH, NA
*eff↑, *other↝, *GPER↑, *TumCCA↑, *P53↑, *P21↑, *cycD1/CCND1↓,
8310- FS,    Can flaxseed “milk” prevent anthracycline mediated cardiotoxicity in women with breast cancer (CANFLAX-BC)?
- Trial, BC, NA
cardioP↑,
8313- FS,    Flaxseed and its lignan and oil components: can they play a role in reducing the risk of and improving the treatment of breast cancer?
- Review, BC, NA
TumCG↓, ChemoSen↑, Risk↓, OS↑, TumCP↓, Apoptosis↑,
8315- FS,    Pilot study to explore effects of low-fat, flaxseed-supplemented diet on proliferation of benign prostatic epithelium and prostate-specific antigen
- Trial, Pca, NA
PSA↓,
8293- lign,  FS,    Flaxseed and its lignans inhibit estradiol-induced growth, angiogenesis, and secretion of vascular endothelial growth factor in human breast cancer xenografts in vivo
- in-vivo, BC, MCF7
TumCG↓, angioG↓, VEGF↓, Dose↝,
8305- lign,  FS,    Effects of dietary flaxseed lignan extract on symptoms of benign prostatic hyperplasia
- Trial, BPH, NA
Dose↝, IAP1↓, UFR↑,

Showing Research Papers: 1 to 11 of 11

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 11

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

Ingr↑, 1,   UFR↑, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↑, 1,   IAP1↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

TumCG↓, 2,  

Migration(tgid=13) ⓘ

Ki-67↓, 2,   TumCP↓, 3,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 1,   VEGF↓, 2,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

NF-kB↓, 1,   PSA↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

DHT↓, 1,   testos↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

ChemoSen↑, 1,   Dose↝, 4,  

Clinical Biomarkers(tgid=22) ⓘ

Ki-67↓, 2,   PSA↓, 1,  

Functional Outcomes(tgid=23) ⓘ

cardioP↑, 1,   OS↑, 1,   Risk↓, 2,  
Total Targets: 20

Pathway results for Effect on Normal Cells:


NA, unassigned(tgid=0) ⓘ

GPER↑, 1,   IPSS↓, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 1,   ROS↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

other↝, 2,  

DNA Damage & Repair(tgid=10) ⓘ

P53↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

cycD1/CCND1↓, 1,   P21↑, 1,   TumCCA↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

Inflam↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↑, 1,   BioAv↝, 1,   Dose?, 1,   Dose↝, 1,   eff↑, 1,  

Functional Outcomes(tgid=23) ⓘ

cardioP↑, 1,   QoL↑, 1,   toxicity↓, 2,  
Total Targets: 18

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:484  Target#:%  State#:%  Dir#:%
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