Database Query Results : Capsaicin, ,

CAP, Capsaicin: Click to Expand ⟱

Features:

Capsaicin is a chemical compound that gives chili peppers their spicy flavor and heat.

Biological activity, capsaicin has been reported to exhibit a range of effects, including:
Pain relief: 10-50 μM
Anti-inflammatory activity: 20-50 μM
Antioxidant activity: 10-100 μM
Anti-cancer activity: 50-100 μM
Cardiovascular health: 20-50 μM

Approximate μM concentrations of capsaicin, the active compound in chili peppers, that can be achieved with different amounts of chili peppers:
1 teaspoon of dried chili pepper flakes (5g):~10-50 μM of capsaicin
1 tablespoon of dried chili pepper flakes (15g): ~30-150 μM of capsaicin
1 cup of fresh chili peppers (100g): ~100-500 μM of capsaicin
1 teaspoon of chili pepper extract (5g): ~100-500 μM of capsaicin
1 tablespoon of chili pepper extract (15g): ~300-1500 μM of capsaicin

Approximate μM concentrations of capsaicin in various foods that contain capsaicin:
Jalapeño peppers: 1 pepper (20g): ~20-100 μM of capsaicin 2–8 mg/100g of fresh Jalapeño
Serrano peppers: 1 pepper (10g): ~10-50 μM of capsaicin 5–15 mg/100g
Cayenne peppers: 1 pepper (10g): ~50-200 μM of capsaicin
Habanero peppers: 1 pepper (20g): ~100-500 μM of capsaicin 15–30 mg/100g
Ghost peppers: 1 pepper (20g): ~200-1000 μM of capsaicin
Hot sauce: 1 teaspoon (5g): ~10-50 μM of capsaicin
Chili flakes: 1 teaspoon (5g): ~10-50 μM of capsaicin
Spicy sauces and marinades: 1 tablespoon (15g): ~10-50 μM of capsaicin

Cayenne Pepper Powder – Approximate capsaicin content: roughly 5–20 mg/g (15-30g human for 100uM?)

-IC50 in Cancer Cell Lines: Approximately 50–300 µM (consume 150mg of capsaican not possible?)
-IC50 in Normal Cell Lines: Generally higher—often 2–3 times greater

Pathways:
-disrupting mitochondrial membrane potential, leading to cytochrome c release and subsequent activation of caspases
-Activation of TRPV1: resulting in increased intracellular calcium levels
-capsaicin can lead to increased production of ROS within cancer cells
-Inhibition of NF-κB
-Inhibit PI3K/AKT/mTOR signaling
-STAT3 Inhibition
-Cell Cycle Arrest
-reduce the expression of vascular endothelial growth factor (VEGF)
-COX-2
-capsaicin is a natural ADAM10 activator and shows potential to attenuate amyloid pathology and protect against AD

Scientific Papers found: Click to Expand⟱

288-

ALA,

HCA,

CAP,

Octr,

Tumor regression with a combination of drugs interfering with the tumor metabolism: efficacy of hydroxycitrate, lipoic acid and capsaicin

"highlight2" >TumCG↓,

2015-

CAP,

CUR,

urea,

Anti-cancer Activity of Sustained Release Capsaicin Formulations

Review,

Var,

"highlight2" >AntiCan↑, "highlight2" >TumCG↓, "highlight2" >angioG↓, "highlight2" >TumMeta↓, "highlight2" >BioAv↓, "highlight2" >BioAv↓, "highlight2" >BioAv↑, "highlight2" >selectivity↑, "highlight2" >EPR↑, "highlight2" >eff↓, "highlight2" >ChemoSen↑, "highlight2" >Dose∅, "highlight2" >Half-Life∅, "highlight2" >eff↑,

4266-

CAP,

Capsaicin effects on brain-derived neurotrophic factor in rat dorsal root ganglia and spinal cord

in-vivo,

NA,

rat

"highlight2" >*BDNF↑,

3855-

CAP,

Capsaicin consumption reduces brain amyloid-beta generation and attenuates Alzheimer’s disease-type pathology and cognitive deficits in APP/PS1 mice

in-vivo,

AD,

30 mg/kg

APP/PS1 mice

"highlight2" >*Risk↓, "highlight2" >*Aβ↓, "highlight2" >*p‑tau↓, "highlight2" >*Inflam↓, "highlight2" >*neuroP↑, "highlight2" >*cognitive↑, "highlight2" >*ADAM10↑, "highlight2" >*PPARα↑,

3854-

CAP,

Capsaicin consumption reduces brain amyloid-beta generation and attenuates Alzheimer’s disease-type pathology and cognitive deficits in APP/PS1 mice

in-vivo,

AD,

mice

"highlight2" >*Aβ↓, "highlight2" >*cognitive↑, "highlight2" >*APP↓, "highlight2" >*MMP-10↝, "highlight2" >*p‑tau↓, "highlight2" >*Inflam↓, "highlight2" >*neuroP↑, "highlight2" >*Risk↓, "highlight2" >*TNF-α↓, "highlight2" >*IFN-γ↓, "highlight2" >*IL6↓, "highlight2" >*PPARα↑,

2652-

CAP,

Oxidative Stress Inducers in Cancer Therapy: Preclinical and Clinical Evidence

Review,

Var,

"highlight2" >chemoPv↑, "highlight2" >AntiCan↑, "highlight2" >ROS↑, "highlight2" >TumCG↓, "highlight2" >ROS↑, "highlight2" >MMP↑, "highlight2" >Apoptosis↑, "highlight2" >TumCCA↑, "highlight2" >JNK↑, "highlight2" >SOD↓, "highlight2" >Catalase↓, "highlight2" >GPx↓, "highlight2" >other↓, "highlight2" >SIRT1↓, "highlight2" >NADPH↑, "highlight2" >FOXO3↑,

2394-

CAP,

Capsaicin acts as a novel NRF2 agonist to suppress ethanol induced gastric mucosa oxidative damage by directly disrupting the KEAP1-NRF2 interaction

in-vitro,

Nor,

GES-1

(0, 2, and 8 μM)

"highlight2" >*mtDam↓, "highlight2" >*NRF2↑, "highlight2" >*HO-1↑, "highlight2" >*Trx↑, "highlight2" >*GSS↑, "highlight2" >*NQO1↑, "highlight2" >*Keap1↓, "highlight2" >*ROS↓, "highlight2" >*PKM2↓, "highlight2" >*LDHA↓, "highlight2" >*Inflam↓,

2349-

CAP,

The TRPV1-PKM2-SREBP1 axis maintains microglial lipid homeostasis in Alzheimer’s disease

in-vivo,

AD,

mouse brain

"highlight2" >*TRPV1↑, "highlight2" >*PKM2↓, "highlight2" >*SREBP2↑, "highlight2" >*memory↑,

2348-

CAP,

Recent advances in analysis of capsaicin and its effects on metabolic pathways by mass spectrometry

Analysis,

Nor,

"highlight2" >Warburg↓, "highlight2" >*PKM2↓, "highlight2" >*COX2↓, "highlight2" >*Inflam↓, "highlight2" >*Sepsis↓, "highlight2" >*AMPK↑, "highlight2" >*PKA↑, "highlight2" >*mitResp↑, "highlight2" >*FAO↑, "highlight2" >*FASN↓, "highlight2" >*PGM1?, "highlight2" >*ATP↑, "highlight2" >*ROS↓,

2347-

CAP,

Capsaicin ameliorates inflammation in a TRPV1-independent mechanism by inhibiting PKM2-LDHA-mediated Warburg effect in sepsis

in-vivo,

Nor,

in-vitro,

Nor,

RAW264.7

"highlight2" >*PKM2↓, "highlight2" >*LDHA↓, "highlight2" >*Warburg↓, "highlight2" >*COX2↓, "highlight2" >*Sepsis↓, "highlight2" >*Inflam↓, "highlight2" >*ECAR↓, "highlight2" >*OCR↑,

2020-

CAP,

Capsaicinoids and Their Effects on Cancer: The “Double-Edged Sword” Postulate from the Molecular Scale

Review,

Var,

"highlight2" >AntiTum↑, "highlight2" >selectivity↑, "highlight2" >TRPV1↑, "highlight2" >MMP↓, "highlight2" >Ca+2↑, "highlight2" >ER Stress↑, "highlight2" >angioG↓, "highlight2" >Casp3?, "highlight2" >cl‑PARP↑, "highlight2" >selectivity↑, "highlight2" >ROS↑, "highlight2" >*ROS∅, "highlight2" >selectivity↑,

2019-

CAP,

Capsaicin: A Two-Decade Systematic Review of Global Research Output and Recent Advances Against Human Cancer

Review,

Var,

"highlight2" >chemoPv↑, "highlight2" >Ca+2↑, "highlight2" >antiOx↑, "highlight2" >*ROS↓, "highlight2" >*MMP∅, "highlight2" >*Cyt‑c∅, "highlight2" >*Casp3∅, "highlight2" >*eff↑, "highlight2" >*Inflam↓, "highlight2" >*NF-kB↓, "highlight2" >*COX2↓, "highlight2" >iNOS↓, "highlight2" >TRPV1↑, "highlight2" >i-Ca+2?, "highlight2" >MMP↓, "highlight2" >Cyt‑c↑, "highlight2" >Bax:Bcl2↑, "highlight2" >P53↑, "highlight2" >JNK↑, "highlight2" >PI3K↓, "highlight2" >Akt↓, "highlight2" >mTOR↓, "highlight2" >LC3II↑, "highlight2" >ATG5↑, "highlight2" >p62↑, "highlight2" >Fap1↓, "highlight2" >Casp3↑, "highlight2" >Apoptosis↑, "highlight2" >ROS↑, "highlight2" >MMP9↓, "highlight2" >eff↑, "highlight2" >eff↓, "highlight2" >eff↑, "highlight2" >selectivity↑, "highlight2" >eff↑, "highlight2" >ChemoSen↑,

2018-

CAP,

MF,

Capsaicin: Effects on the Pathogenesis of Hepatocellular Carcinoma

Review,

HCC,

"highlight2" >TRPV1↑, "highlight2" >eff↑, "highlight2" >Akt↓, "highlight2" >mTOR↓, "highlight2" >p‑STAT3↑, "highlight2" >MMP2↑, "highlight2" >ER Stress↑, "highlight2" >Ca+2↑, "highlight2" >ROS↑, "highlight2" >selectivity↑, "highlight2" >MMP↓, "highlight2" >eff↑,

2017-

CAP,

Spice Up Your Kidney: A Review on the Effects of Capsaicin in Renal Physiology and Disease

Review,

Var,

"highlight2" >RenoP↑, "highlight2" >AntiTum↑, "highlight2" >AMPK↑, "highlight2" >mTOR↑, "highlight2" >PD-1↓, "highlight2" >PD-L1↓,

2016-

CAP,

Capsaicin binds the N-terminus of Hsp90, induces lysosomal degradation of Hsp70, and enhances the anti-tumor effects of 17-AAG (Tanespimycin)

"highlight2" >HSP90↓, "highlight2" >ATPase↓, "highlight2" >eff↑, "highlight2" >HSP70/HSPA5↓, "highlight2" >other↝, "highlight2" >NF-kB↓, "highlight2" >EGFR↓, "highlight2" >CDK4↓, "highlight2" >Src↓, "highlight2" >VEGF↓, "highlight2" >PI3K↓, "highlight2" >Akt↓,

2014-

CAP,

Role of Mitochondrial Electron Transport Chain Complexes in Capsaicin Mediated Oxidative Stress Leading to Apoptosis in Pancreatic Cancer Cells

in-vitro,

PC,

Bxpc-3

150uM

in-vitro,

Nor,

HPDE-6

150uM

normal pancreatic epithelial cells were resistant to the effects of capsaicin.

in-vivo,

PC,

AsPC-1

mice orally fed with 2.5 mg/kg capsaicin

mice, 2.5 mg/kg capsaicin was given to mice by oral gavage, which is 0.202 mg/kg when converted to human equivalent dose (HED) and equates to 13.2 mg dose of capsaicin for a 60 kg person

"highlight2" >ROS↑, "highlight2" >*ROS∅, "highlight2" >selectivity↑, "highlight2" >compI↓, "highlight2" >compIII↓, "highlight2" >eff↑, "highlight2" >selectivity↑, "highlight2" >ATP↓, "highlight2" >Cyt‑c↑, "highlight2" >Casp9↑, "highlight2" >Casp3↑, "highlight2" >MMP↓, "highlight2" >SOD↓, "highlight2" >GSH/GSSG↓, "highlight2" >Apoptosis↑, "highlight2" >*toxicity∅, "highlight2" >GSH↓, "highlight2" >Catalase↓, "highlight2" >GPx↓, "highlight2" >Dose↝,

2013-

CAP,

Capsaicin, a component of red peppers, inhibits the growth of androgen-independent, p53 mutant prostate cancer cells

in-vitro,

Pca,

PC3

0-5 x 10-4 mol/L

in-vitro,

Pca,

LNCaP

in-vitro,

Pca,

DU145

in-vivo,

NA,

5 mg/kg/d;

mice

"highlight2" >TumCP↓, "highlight2" >P53↑, "highlight2" >P21↑, "highlight2" >BAX↑, "highlight2" >PSA↓, "highlight2" >AR↓, "highlight2" >NF-kB↓, "highlight2" >Proteasome↓, "highlight2" >TumVol↓, "highlight2" >eff∅,

2012-

CAP,

Capsaicin induces cytotoxicity in human osteosarcoma MG63 cells through TRPV1-dependent and -independent pathways

NA,

OS,

MG63

0-40 μM

20 μM

"highlight2" >AntiTum↑, "highlight2" >Apoptosis↑, "highlight2" >TRPV1↑, "highlight2" >ROS↑, "highlight2" >SOD↓, "highlight2" >AMPK↑, "highlight2" >P53↑, "highlight2" >JNK↑, "highlight2" >Bcl-2↓, "highlight2" >Cyt‑c↑, "highlight2" >cl‑Casp3↑, "highlight2" >cl‑PARP↑, "highlight2" >Ca+2↑, "highlight2" >MMP↓,

1518-

CAP,

Capsaicin-mediated tNOX (ENOX2) up-regulation enhances cell proliferation and migration in vitro and in vivo

in-vitro,

CRC,

HCT116

"highlight2" >ENOX2↑, "highlight2" >TumCP↑, "highlight2" >TumCMig↑, "highlight2" >Dose?, "highlight2" >eff↑,

1517-

CAP,

Capsaicin Inhibits Multiple Bladder Cancer Cell Phenotypes by Inhibiting Tumor-Associated NADH Oxidase (tNOX) and Sirtuin1 (SIRT1)

in-vitro,

Bladder,

TSGH8301

in-vitro,

CRC,

T24

"highlight2" >ENOX2↓, "highlight2" >TumCCA↑, "highlight2" >ERK↓, "highlight2" >p‑FAK↓, "highlight2" >p‑pax↓, "highlight2" >TumCMig↓, "highlight2" >EMT↓, "highlight2" >SIRT1↓, "highlight2" >Dose∅, "highlight2" >ROS↑, "highlight2" >MMP↓, "highlight2" >Bcl-2↓, "highlight2" >Bak↑, "highlight2" >cl‑PARP↑, "highlight2" >Casp3↑, "highlight2" >SIRT1↓, "highlight2" >ac‑P53↑, "highlight2" >BIM↑, "highlight2" >p‑RB1↓, "highlight2" >cycD1/CCND1↓, "highlight2" >Dose∅, "highlight2" >β-catenin/ZEB1↓, "highlight2" >N-cadherin↓, "highlight2" >E-cadherin↑,

1265-

CAP,

Capsaicin shapes gut microbiota and pre-metastatic niche to facilitate cancer metastasis to liver

in-vivo,

CRC,

300 mg/kg

mice

"highlight2" >GutMicro↓, "highlight2" >Risk↑,

1264-

CAP,

Capsaicin modulates proliferation, migration, and activation of hepatic stellate cells

in-vitro,

HCC,

100 lM

"highlight2" >TumCP↓, "highlight2" >TumCMig↓, "highlight2" >TumCCA↑, "highlight2" >MMP∅, "highlight2" >MMP2↓, "highlight2" >MMP9↓, "highlight2" >α-SMA↓, "highlight2" >COL1A1↓, "highlight2" >COL3A1↓, "highlight2" >TIMP1↓,

1263-

CAP,

Capsaicin inhibits the migration and invasion via the AMPK/NF-κB signaling pathway in esophagus sequamous cell carcinoma by decreasing matrix metalloproteinase-9 expression

in-vitro,

ESCC,

Eca109

"highlight2" >TumCMig↓, "highlight2" >TumCI↓, "highlight2" >MMP9↓, "highlight2" >p‑AMPK↑, "highlight2" >SIRT1↑, "highlight2" >NF-kB↓, "highlight2" >p‑IκB↑,

1262-

CAP,

Capsaicin Inhibits Proliferation and Induces Apoptosis in Breast Cancer by Down-Regulating FBI-1-Mediated NF-κB Pathway

vitro+vivo,

BC,

"highlight2" >FBI-1↓, "highlight2" >Ki-67↓, "highlight2" >Bcl-2↓, "highlight2" >survivin↓, "highlight2" >BAX↑, "highlight2" >Casp3↑, "highlight2" >TumCP↓, "highlight2" >Apoptosis↑,

1261-

CAP,

Capsaicin inhibits glycolysis in esophageal squamous cell carcinoma by regulating hexokinase‑2 expression

in-vitro,

ESCC,

KYSE150

"highlight2" >GlucoseCon↓, "highlight2" >lactateProd↓, "highlight2" >HK2↓, "highlight2" >Glycolysis↓, "highlight2" >PTEN↑, "highlight2" >AKT1↓,

1260-

CAP,

Capsaicin inhibits in vitro and in vivo angiogenesis

vitro+vivo,

NA,

"highlight2" >VEGF↓, "highlight2" >angioG↓, "highlight2" >TumCCA↑, "highlight2" >cycD1/CCND1↓, "highlight2" >Akt↓,

1259-

CAP,

Capsaicin inhibits HIF-1α accumulation through suppression of mitochondrial respiration in lung cancer cells

in-vitro,

Lung,

H1299

in-vitro,

Lung,

A549

in-vitro,

Lung,

H23

in-vitro,

Lung,

H2009

"highlight2" >Hif1a↓, "highlight2" >PDK1↓, "highlight2" >GLUT1↓, "highlight2" >ROS↑, "highlight2" >mitResp↓, "highlight2" >ATP↓,

3760-

CUR,

GI,

CAP,

RosA,

Extending the lore of curcumin as dipteran Butyrylcholine esterase (BChE) inhibitor: A holistic molecular interplay assessment

"highlight2" >*AChE↓, "highlight2" >*other↓, "highlight2" >*other↓, "highlight2" >*other↓, "highlight2" >*other↓, "highlight2" >*other↓, "highlight2" >*other↓,

693-

EGCG,

CAP,

Phen,

Metabolite modulation of HeLa cell response to ENOX2 inhibitors EGCG and phenoxodiol

in-vitro,

Cerv,

HeLa

"highlight2" >ENOX2↓, "highlight2" >TumCG↓,

637-

EGCG,

CAP,

Cancer prevention trial of a synergistic mixture of green tea concentrate plus Capsicum (CAPSOL-T) in a random population of subjects ages 40-84

Human,

NA,

"highlight2" >ENOX2↓,

2446-

SFN,

CAP,

The Molecular Effects of Sulforaphane and Capsaicin on Metabolism upon Androgen and Tip60 Activation of Androgen Receptor

in-vitro,

Pca,

LNCaP

10uM

"highlight2" >AR↓, "highlight2" >Bcl-xL↓, "highlight2" >TumCP↓, "highlight2" >Glycolysis↓, "highlight2" >HK2↓, "highlight2" >PKA↓, "highlight2" >Hif1a↓, "highlight2" >PSA↓, "highlight2" >ECAR↓, "highlight2" >BioAv↑, "highlight2" >BioAv↓, "highlight2" >*toxicity↓,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 31

Pathway results for Effect on Cancer / Diseased Cells:

Pathway results for Effect on Normal Cells:

Redox & Oxidative Stress ⓘ

GSS↑, 1, HO-1↑, 1, Keap1↓, 1, NQO1↑, 1, NRF2↑, 1, ROS↓, 3, ROS∅, 2, Trx↑, 1,

Mitochondria & Bioenergetics ⓘ

ATP↑, 1, mitResp↑, 1, MMP∅, 1, mtDam↓, 1, OCR↑, 1,

Core Metabolism/Glycolysis ⓘ

AMPK↑, 1, ECAR↓, 1, FAO↑, 1, FASN↓, 1, LDHA↓, 2, PGM1?, 1, PKM2↓, 4, PPARα↑, 2, SREBP2↑, 1, Warburg↓, 1,

Cell Death ⓘ

Casp3∅, 1, Cyt‑c∅, 1, TRPV1↑, 1,

Transcription & Epigenetics ⓘ

other↓, 6,

Migration ⓘ

APP↓, 1, MMP-10↝, 1, PKA↑, 1,

Immune & Inflammatory Signaling ⓘ

COX2↓, 3, IFN-γ↓, 1, IL6↓, 1, Inflam↓, 6, NF-kB↓, 1, TNF-α↓, 1,

Synaptic & Neurotransmission ⓘ

AChE↓, 1, ADAM10↑, 1, BDNF↑, 1, p‑tau↓, 2,

Protein Aggregation ⓘ

Aβ↓, 2,

Drug Metabolism & Resistance ⓘ

eff↑, 1,

Clinical Biomarkers ⓘ

IL6↓, 1,

Functional Outcomes ⓘ

cognitive↑, 2, memory↑, 1, neuroP↑, 2, Risk↓, 2, toxicity↓, 1, toxicity∅, 1,

Infection & Microbiome ⓘ

Sepsis↓, 2,
Total Targets: 50

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:55  Target#:%  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

Database Query Results : Capsaicin, ,

Pathway results for Effect on Cancer / Diseased Cells:

NA, unassigned ⓘ

Redox & Oxidative Stress ⓘ

Mitochondria & Bioenergetics ⓘ

Core Metabolism/Glycolysis ⓘ

Cell Death ⓘ

Transcription & Epigenetics ⓘ

Protein Folding & ER Stress ⓘ

Autophagy & Lysosomes ⓘ

DNA Damage & Repair ⓘ

Cell Cycle & Senescence ⓘ

Proliferation, Differentiation & Cell State ⓘ

Migration ⓘ

Angiogenesis & Vasculature ⓘ

Barriers & Transport ⓘ

Immune & Inflammatory Signaling ⓘ

Hormonal & Nuclear Receptors ⓘ

Drug Metabolism & Resistance ⓘ

Clinical Biomarkers ⓘ

Functional Outcomes ⓘ

Pathway results for Effect on Normal Cells:

Redox & Oxidative Stress ⓘ

Mitochondria & Bioenergetics ⓘ

Core Metabolism/Glycolysis ⓘ

Cell Death ⓘ

Transcription & Epigenetics ⓘ

Migration ⓘ

Immune & Inflammatory Signaling ⓘ

Synaptic & Neurotransmission ⓘ

Protein Aggregation ⓘ

Drug Metabolism & Resistance ⓘ

Clinical Biomarkers ⓘ

Functional Outcomes ⓘ

Infection & Microbiome ⓘ

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