Database Query Results : Cinnamon, ,

Cin, Cinnamon: Click to Expand ⟱
Features:
Cinnamon is a spice from inner bark from several tree species.

Biological activity, cinnamaldehyde from Ceylon cinnamon:
Antimicrobial activity: 10-50 μM
Antioxidant activity: 10-100 μM
Anti-inflammatory activity: 20-50 μM
Anticancer activity: 50-100 μM
Cardiovascular health: 20-50 μM

5 g of Ceylon cinnamon might contain roughly between 30 mg and 150 mg of cinnamaldehyde, with an approximate mid-range estimate of about 70 mg.
Assuming a moderate supplemental intake 50–200 mg of cinnamaldehyde, peak plasma levels might be anticipated in the vicinity of 1–10 μM.
Scientific Papers found: Click to Expand⟱
952- Cin,    Cinnamon Extract Reduces VEGF Expression Via Suppressing HIF-1α Gene Expression and Inhibits Tumor Growth in Mice
- in-vitro, BC, MDA-MB-231 - in-vitro, GBM, U251 - in-vivo, Ovarian, SKOV3
VEGF↓, Hif1a↓, p‑STAT3↓, p‑Akt↓, angioG↓, TumCG↓, TumW↓, ascitic↓,
1055- Cin,    Cinnamon extract induces tumor cell death through inhibition of NFκB and AP1
- vitro+vivo, Melanoma, NA - vitro+vivo, CRC, NA - vitro+vivo, lymphoma, NA
TumCP↓, NF-kB↓, AP-1↓, Bcl-2↓, Bcl-xL↓, survivin↓,
1274- Cin,    Cinnamon bark extract suppresses metastatic dissemination of cancer cells through inhibition of glycolytic metabolism
- vitro+vivo, BC, MDA-MB-231
TumCI↓, G6PD↓, HK2↓, Glycolysis↓,
1567- Cin,    Cinnamon: Mystic powers of a minute ingredient
- Review, Var, NA
other∅, cognitive↑, antiOx↑, lipid-P↓, Apoptosis↑, NF-kB↓,
1568- Cin,    Can Cinnamon be the Silver Bullet for Cancer?
- Review, NA, NA
VEGF↓, Hif1a↓,
3888- Cin,    Cinnamon, a promising prospect towards Alzheimer's disease
- NA, AD, NA
*tau↓, *Aβ↓, *neuroP↑, *ROS↓, *Inflam↓, *cardioP↑, *antiOx↑, *cognitive↑, *BBB↑, *p‑GSK‐3β↑, *AChE↓,
3889- Cin,    Orally administrated cinnamon extract reduces β-amyloid oligomerization and corrects cognitive impairment in Alzheimer's disease animal models
- in-vivo, AD, NA
*Aβ↓, *cognitive↑, *tau↓,
3890- Cin,    The Therapeutic Roles of Cinnamaldehyde against Cardiovascular Diseases
- Review, NA, NA
*cardioP↑, *Inflam↓, *ROS↓, *lipid-P↓, *AntiAg↑, *angioG↑, *GutMicro↑, *ER Stress↓,
3891- Cin,    Identification of potential targets of cinnamon for treatment against Alzheimer's disease-related GABAergic synaptic dysfunction using network pharmacology
- Analysis, AD, NA
*BBB↑, *GABA↑, *eff↑, *antiOx↑, *Inflam↑, *Mood↑,
3892- Cin,    Cinnamon from the selection of traditional applications to its novel effects on the inhibition of angiogenesis in cancer cells and prevention of Alzheimer's disease, and a series of functions such as antioxidant, anticholesterol, antidiabetes, antibacterial, antifungal, nematicidal, acaracidal, and repellent activities
- Review, AD, NA - Review, Var, NA
*antiOx↑, *Inflam↓, *cardioP↑, angioG↓, VEGF↓, *LDL↓, COX2↓, Hif1a↓, *Aβ↓, *tau↓, *toxicity↓,
3893- Cin,    Cinnamon extract inhibits tau aggregation associated with Alzheimer's disease in vitro
- Review, AD, NA
*tau↓, *toxicity↓,
3894- Cin,    Interaction of cinnamaldehyde and epicatechin with tau: implications of beneficial effects in modulating Alzheimer's disease pathogenesis
- in-vitro, AD, NA
*tau↓, *ROS↓,
4259- Cin,    The Potential of Cinnamon as Anti-Depressant
- Review, NA, NA
*Inflam↓, *BDNF↑, *TNF-α↓, *lipid-P↓, *Mood↑,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 13

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

antiOx↑, 3,   lipid-P↓, 2,   ROS↓, 3,  

Core Metabolism/Glycolysis ⓘ

LDL↓, 1,  

Protein Folding & ER Stress ⓘ

ER Stress↓, 1,  

Proliferation, Differentiation & Cell State ⓘ

p‑GSK‐3β↑, 1,  

Migration ⓘ

AntiAg↑, 1,  

Angiogenesis & Vasculature ⓘ

angioG↑, 1,  

Barriers & Transport BBB, epithelial layers), membrane transporters, ion channels, and water channels. It governs permeability, cellular uptake/efflux, tissue protection, and drug access to target compartments." style="cursor:help;color:#555;font-weight:normal;">ⓘ

BBB↑, 2,  

Immune & Inflammatory Signaling Inflammation group includes innate and adaptive immune pathways, cytokines, chemokines, pattern-recognition receptors, complement, and inflammasomes. It regulates host defense, tumor immunity, neuroinflammation, and chronic inflammatory disease processes." style="cursor:help;color:#555;font-weight:normal;">ⓘ

Inflam↓, 4,   Inflam↑, 1,   TNF-α↓, 1,  

Synaptic & Neurotransmission memory, and neuronal survival, and is especially relevant to Alzheimer’s and other neurodegenerative diseases." style="cursor:help;color:#555;font-weight:normal;">ⓘ

AChE↓, 1,   BDNF↑, 1,   GABA↑, 1,   tau↓, 5,  

Protein Aggregation tau biology, proteolytic processing, and aggregate toxicity. It captures molecular features specific to neurodegenerative pathology but remains extensible to other aggregation disorders." style="cursor:help;color:#555;font-weight:normal;">ⓘ

Aβ↓, 3,  

Drug Metabolism & Resistance ⓘ

eff↑, 1,  

Clinical Biomarkers Inflammation state | Microenvironment | Research-stage | | 28 | XIST | Epigenetic instability | Aggressiveness | Not yet clinical | | 29 | FOXM1 | High-risk biology | Aggressiveness | No routine testing | | 30 | TRIB3 | Stress adaptation | Aggressiveness | Mechanistic, not clinical | Core Liver & Systemic Biomarkers in Oncology | Marker | What It Reflects | Main Use in Cancer | Decision Impact | | --------- | ----------------------------------- | ----------------------------------------- | ----------- | | ALT | Hepatocellular injury | Baseline eligibility, toxicity monitoring | High | | AST | Liver + systemic injury | Detect liver injury, muscle involvement | High | | ALP | Cholestasis, bone turnover | Liver mets vs bone mets | High | | bilirubin | Hepatic clearance | Chemotherapy dosing | Critical | | albumin | Synthetic liver function, nutrition | Prognosis, frailty | High | | LDH | Tumor burden, hypoxia | Aggressiveness, prognosis | High | | INR | Liver synthetic failure | Treatment safety | High | Key Inflammatory / Host-Response Biomarkers Used in Oncology | Biomarker | What It Reflects | Main Use in Cancer | Clinical Decision Impact | | ------------------ | -------------------------------- | ---------------------------- | -------------------- | | C-reactive protein | Systemic inflammation | Prognosis, therapy tolerance | High | | ESR | Chronic inflammation | Disease activity trend | Moderate | | ferritin | Inflammation + iron status | Cachexia, cytokine load | High | | IL-6 | Cytokine signaling | Aggressiveness, cachexia | High (specialty use) | | LDH | Tumor burden + hypoxia | Risk stratification | Very high | | albumin | Nutritional & inflammatory state | Frailty, survival | Very high | </pre> " style="cursor:help;color:#555;font-weight:normal;">ⓘ

GutMicro↑, 1,  

Functional Outcomes cognitive performance, toxicity, and organism-level effects. It is intentionally mechanism-agnostic and anchors molecular data to real-world biological impact." style="cursor:help;color:#555;font-weight:normal;">ⓘ

cardioP↑, 3,   cognitive↑, 2,   Mood↑, 2,   neuroP↑, 1,   toxicity↓, 2,  
Total Targets: 24

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:62  Target#:%  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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