diet FMD Fasting Mimicking Diet / BG Cancer Research Results

dietFMD, diet FMD Fasting Mimicking Diet: Click to Expand ⟱
Features:
5-day diet to mimic fasting without fasting.
FMDs are caloric-restricted plant–based diets containing low proteins, low sugar and high fats which represent a more feasible and safer option to water-only fasting.
Fasting modality                         Approx CRIS
--------------------------------------   ----------
Time-restricted eating (12–16 h)          –3 to –4
Early time-restricted eating (eTRE)        –4
Intermittent fasting (24 h 1–2x/week)     –4
Periodic fasting / FMD                    –4 to –5*
Calorie restriction (chronic)             –3 (risk tradeoffs)

Compare STF(short term Fasting) to FMD
IGF-1 / insulin suppression (core driver)
| Aspect            | STF                 | FMD      |
| ----------------- | ------------------- | -------- |
| Depth             | **Very deep**       | Moderate |
| Speed             | **Rapid (24–48 h)** | Gradual  |
| Tumor stress      | **High**            | Medium   |
| Normal protection | High                | High     |
Fasting-Mimicking Diet (FMD; ~5-day low-protein, low-calorie cycle) Cancer vs Normal Cell Effects
Rank Pathway / Axis Cancer Cells Normal Cells Label Primary Interpretation Notes
1 Insulin / IGF-1 signaling ↓ IGF-1 signaling (chronic stress) ↓ IGF-1 with regenerative priming Driver Sustained growth factor suppression Repeated IGF-1 lowering impairs tumor growth programs
2 AMPK → mTOR nutrient sensing ↓ mTOR; ↑ AMPK (growth inhibition) ↓ mTOR; ↑ AMPK (maintenance mode) Driver Prolonged anabolic suppression More sustained but less acute than STF
3 Autophagy / mitophagy ↑ autophagy → loss of tumor robustness ↑ autophagy → rejuvenation Driver Cellular renewal vs destabilization Repeated cycles promote organelle quality control
4 Mitochondrial metabolism ↓ metabolic resilience ↑ mitochondrial fitness Secondary Energy efficiency divergence Normal cells adapt better across cycles
5 Inflammatory signaling (NF-κB / cytokines) ↓ pro-tumor inflammation ↓ systemic inflammation Secondary Anti-inflammatory milieu Inflammation reduction contributes to chemopreventive effects
6 Reactive oxygen species (ROS) ↑ ROS (secondary, context-dependent) ↓ ROS Secondary Metabolism-linked redox shift ROS effects are indirect and less pronounced than STF
7 NRF2 antioxidant response ↔ modest activation ↑ NRF2 (protective) Adaptive Stress adaptation NRF2 supports normal-cell recovery between cycles
8 Cell cycle / regeneration ↓ proliferation ↑ regeneration post-cycle Phenotypic Degrowth vs regeneration FMD uniquely promotes regeneration upon refeeding


BG, Blood Glucose: Click to Expand ⟱
Source:
Type:
Blood Glucose
Scientific Papers found: Click to Expand⟱
1863- dietFMD,  Chemo,    Effect of fasting on cancer: A narrative review of scientific evidence
- Review, Var, NA
eff↑, ChemoSideEff↓, ChemoSen↑, Insulin↓, HDAC↓, IGF-1↓, STAT5↓, BG↓, MAPK↓, HO-1↓, ATG3↑, Beclin-1↑, p62↑, SIRT1↑, LAMP2↑, OXPHOS↑, ROS↑, P53↑, DNAdam↑, TumCD↑, ATP↑, Treg lymp↓, M2 MC↓, CD8+↑, Glycolysis↓, GutMicro↑, GutMicro↑, Warburg↓, Dose↝,
1861- dietFMD,  Chemo,    Fasting induces anti-Warburg effect that increases respiration but reduces ATP-synthesis to promote apoptosis in colon cancer models
- in-vitro, Colon, CT26 - in-vivo, NA, NA
selectivity↑, ChemoSen↑, BG↓, AminoA↓, Warburg↓, OCR↑, ATP↓, ROS↑, Apoptosis↑, GlucoseCon↓, PI3K↓, PTEN↑, GLUT1↓, GLUT2↓, HK2↓, PFK1↓, PKA↓, ATP:AMP↓, Glycolysis↓, lactateProd↓,
1860- dietFMD,  Chemo,    Fasting-mimicking diet blocks triple-negative breast cancer and cancer stem cell escape
- in-vitro, BC, SUM159 - in-vitro, BC, 4T1
PI3K↑, Akt↑, mTOR↑, CDK4↑, CDK6↑, hyperG↓, TumCG↓, TumVol↓, Casp3↑, BG↓, eff↑, eff∅, PKA↓, KLF5↓, p‑GSK‐3β↑, Nanog↓, OCT4↓, KLF2↓, eff↑, ROS↑, BIM↑, ASK1↑, PI3K↑, Akt↑, mTOR↑, CDK1↓, CDK4↑, CDK6↑, eff↑,
1853- dietFMD,    Impact of Fasting on Patients With Cancer: An Integrative Review
- Review, Var, NA
*toxicity∅, QoL∅, eff↑, eff↝, ChemoSideEff↓, TumCG↓, Dose↑, toxicity↝, eff↑, IGF-1↑, *OXPHOS↑, BG↓, Insulin↓, RadioS↑,
1852- dietFMD,  Chemo,    Starvation Based Differential Chemotherapy: 
A Novel Approach for Cancer Treatment
- Review, Var, NA
ChemoSideEff↓, *toxicity↓, mTOR↓, IGF-1↓, IGFBP1↑, BG↓, ROS↑,
1851- dietFMD,  Chemo,    Starvation-dependent differential stress resistance protects normal but not cancer cells against high-dose chemotherapy
- in-vitro, GBM, LN229 - in-vitro, neuroblastoma, SH-SY5Y
selectivity↑, selectivity↑, ROS↑, DNAdam↑, BG↓,
1849- dietFMD,    The emerging role of fasting-mimicking diets in cancer treatment
- Review, Var, NA
TumCG↓, toxicity∅, BG↓, IGF-1↓, mTOR↓, M2 MC↓, eff↑, ChemoSen↑, QoL↑, RadioS↑, selectivity↑,
1841- dietFMD,    Fasting-Mimicking Diet Is Safe and Reshapes Metabolism and Antitumor Immunity in Patients with Cancer
- Trial, Var, NA
BG↓, AntiCan↑, IFN-γ↑, eff↑, Dose↝, CD14↓, IGF-1↓, IGFR↓, CD8+↑, NK cell↑,

Showing Research Papers: 1 to 8 of 8

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 8

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

HO-1↓, 1,   hyperG↓, 1,   OXPHOS↑, 1,   ROS↑, 5,  

Metal & Cofactor Biology ⓘ

KLF5↓, 1,  

Mitochondria & Bioenergetics ⓘ

ATP↓, 1,   ATP↑, 1,   Insulin↓, 2,   OCR↑, 1,  

Core Metabolism/Glycolysis ⓘ

AminoA↓, 1,   ATP:AMP↓, 1,   GlucoseCon↓, 1,   GLUT2↓, 1,   Glycolysis↓, 2,   HK2↓, 1,   lactateProd↓, 1,   PFK1↓, 1,   SIRT1↑, 1,   Warburg↓, 2,  

Cell Death ⓘ

Akt↑, 2,   Apoptosis↑, 1,   ASK1↑, 1,   BIM↑, 1,   Casp3↑, 1,   MAPK↓, 1,   TumCD↑, 1,  

Autophagy & Lysosomes ⓘ

ATG3↑, 1,   Beclin-1↑, 1,   LAMP2↑, 1,   p62↑, 1,  

DNA Damage & Repair ⓘ

DNAdam↑, 2,   P53↑, 1,  

Cell Cycle & Senescence ⓘ

CDK1↓, 1,   CDK4↑, 2,  

Proliferation, Differentiation & Cell State ⓘ

p‑GSK‐3β↑, 1,   HDAC↓, 1,   IGF-1↓, 4,   IGF-1↑, 1,   IGFBP1↑, 1,   IGFR↓, 1,   mTOR↓, 2,   mTOR↑, 2,   Nanog↓, 1,   OCT4↓, 1,   PI3K↓, 1,   PI3K↑, 2,   PTEN↑, 1,   STAT5↓, 1,   TumCG↓, 3,  

Migration ⓘ

KLF2↓, 1,   PKA↓, 2,   Treg lymp↓, 1,  

Barriers & Transport ⓘ

GLUT1↓, 1,  

Immune & Inflammatory Signaling ⓘ

CD14↓, 1,   IFN-γ↑, 1,   M2 MC↓, 2,   NK cell↑, 1,  

Hormonal & Nuclear Receptors ⓘ

CDK6↑, 2,  

Drug Metabolism & Resistance ⓘ

ChemoSen↑, 3,   Dose↑, 1,   Dose↝, 2,   eff↑, 8,   eff↝, 1,   eff∅, 1,   RadioS↑, 2,   selectivity↑, 4,  

Clinical Biomarkers ⓘ

BG↓, 8,   GutMicro↑, 2,  

Functional Outcomes ⓘ

AntiCan↑, 1,   ChemoSideEff↓, 3,   QoL↑, 1,   QoL∅, 1,   toxicity↝, 1,   toxicity∅, 1,   TumVol↓, 1,  

Infection & Microbiome ⓘ

CD8+↑, 2,  
Total Targets: 76

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

OXPHOS↑, 1,  

Functional Outcomes ⓘ

toxicity↓, 1,   toxicity∅, 1,  
Total Targets: 3

Scientific Paper Hit Count for: BG, Blood Glucose
8 diet FMD Fasting Mimicking Diet
5 Chemotherapy
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:79  Target#:1162  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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