Database Query Results : diet FMD Fasting Mimicking Diet, ,

dietFMD, diet FMD Fasting Mimicking Diet: Click to Expand ⟱
Features:
5-day diet to mimic fasting without fasting.
FMDs are caloric-restricted plant–based diets containing low proteins, low sugar and high fats which represent a more feasible and safer option to water-only fasting.
Fasting modality                         Approx CRIS
--------------------------------------   ----------
Time-restricted eating (12–16 h)          –3 to –4
Early time-restricted eating (eTRE)        –4
Intermittent fasting (24 h 1–2x/week)     –4
Periodic fasting / FMD                    –4 to –5*
Calorie restriction (chronic)             –3 (risk tradeoffs)


Scientific Papers found: Click to Expand⟱
1853- dietFMD,    Impact of Fasting on Patients With Cancer: An Integrative Review
- Review, Var, NA
"highlight2" >*toxicity∅, "highlight2" >QoL∅, "highlight2" >eff↑, "highlight2" >eff↝, "highlight2" >ChemoSideEff↓, "highlight2" >TumCG↓, "highlight2" >Dose↑, "highlight2" >toxicity↝, "highlight2" >eff↑, "highlight2" >IGF-1↑, "highlight2" >*OXPHOS↑, "highlight2" >BG↓, "highlight2" >Insulin↓, "highlight2" >RadioS↑,
2352- dietFMD,    Glucose restriction reverses the Warburg effect and modulates PKM2 and mTOR expression in breast cancer cell lines
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, MCF-7
"highlight2" >Warburg↓, "highlight2" >mTOR↓, "highlight2" >PKM2↓,
2152- dietFMD,    Prolonged Nightly Fasting and Breast Cancer Prognosis
- Analysis, BC, NA
"highlight2" >eff↑, "highlight2" >Dose↓, "highlight2" >Risk↓,
1863- dietFMD,  Chemo,    Effect of fasting on cancer: A narrative review of scientific evidence
- Review, Var, NA
"highlight2" >eff↑, "highlight2" >ChemoSideEff↓, "highlight2" >ChemoSen↑, "highlight2" >Insulin↓, "highlight2" >HDAC↓, "highlight2" >IGF-1↓, "highlight2" >STAT5↓, "highlight2" >BG↓, "highlight2" >MAPK↓, "highlight2" >HO-1↓, "highlight2" >ATG3↑, "highlight2" >Beclin-1↑, "highlight2" >p62↑, "highlight2" >SIRT1↑, "highlight2" >LAMP2↑, "highlight2" >OXPHOS↑, "highlight2" >ROS↑, "highlight2" >P53↑, "highlight2" >DNAdam↑, "highlight2" >TumCD↑, "highlight2" >ATP↑, "highlight2" >Treg lymp↓, "highlight2" >M2 MC↓, "highlight2" >CD8+↑, "highlight2" >Glycolysis↓, "highlight2" >GutMicro↑, "highlight2" >GutMicro↑, "highlight2" >Warburg↓, "highlight2" >Dose↝,
1862- dietFMD,    Exceptional tumour responses to fasting-mimicking diet combined with standard anticancer therapies: A sub-analysis of the NCT03340935 trial
- Trial, Var, NA
"highlight2" >OS↑,
1861- dietFMD,  Chemo,    Fasting induces anti-Warburg effect that increases respiration but reduces ATP-synthesis to promote apoptosis in colon cancer models
- in-vitro, Colon, CT26 - in-vivo, NA, NA
"highlight2" >selectivity↑, "highlight2" >ChemoSen↑, "highlight2" >BG↓, "highlight2" >AminoA↓, "highlight2" >Warburg↓, "highlight2" >OCR↑, "highlight2" >ATP↓, "highlight2" >ROS↑, "highlight2" >Apoptosis↑, "highlight2" >GlucoseCon↓, "highlight2" >PI3K↓, "highlight2" >PTEN↑, "highlight2" >GLUT1↓, "highlight2" >GLUT2↓, "highlight2" >HK2↓, "highlight2" >PFK1↓, "highlight2" >PKA↓, "highlight2" >ATP:AMP↓, "highlight2" >Glycolysis↓, "highlight2" >lactateProd↓,
1860- dietFMD,  Chemo,    Fasting-mimicking diet blocks triple-negative breast cancer and cancer stem cell escape
- in-vitro, BC, SUM159 - in-vitro, BC, 4T1
"highlight2" >PI3K↑, "highlight2" >Akt↑, "highlight2" >mTOR↑, "highlight2" >CDK4↑, "highlight2" >CDK6↑, "highlight2" >hyperG↓, "highlight2" >TumCG↓, "highlight2" >TumVol↓, "highlight2" >Casp3↑, "highlight2" >BG↓, "highlight2" >eff↑, "highlight2" >eff∅, "highlight2" >PKA↓, "highlight2" >KLF5↓, "highlight2" >p‑GSK‐3β↑, "highlight2" >Nanog↓, "highlight2" >OCT4↓, "highlight2" >KLF2↓, "highlight2" >eff↑, "highlight2" >ROS↑, "highlight2" >BIM↑, "highlight2" >ASK1↑, "highlight2" >PI3K↑, "highlight2" >Akt↑, "highlight2" >mTOR↑, "highlight2" >CDK1↓, "highlight2" >CDK4↑, "highlight2" >CDK6↑, "highlight2" >eff↑,
1859- dietFMD,  Chemo,    Fasting-Mimicking Diet Reduces HO-1 to Promote T Cell-Mediated Tumor Cytotoxicity
- in-vitro, BC, 4T1 - in-vivo, Melanoma, B16-BL6
"highlight2" >CLP↑, "highlight2" >CD8+↑, "highlight2" >TumCG↓, "highlight2" >HO-1↓, "highlight2" >TILs↑,
1858- dietFMD,  Chemo,    Effect of short-term fasting on the cisplatin activity in human oral squamous cell carcinoma cell line HN5 and chemotherapy side effects
- in-vitro, HNSCC, HN5
"highlight2" >Apoptosis↑, "highlight2" >necrosis↑,
1857- dietFMD,    Fasting cycles retard growth of tumors and sensitize a range of cancer cell types to chemotherapy
- in-vitro, BC, 4T1 - in-vivo, NA, NA
"highlight2" >TumCG↓, "highlight2" >ChemoSen↑, "highlight2" >OS↑,
1856- dietFMD,  immuno,    Targeting the Gut Microbiome to Improve Immunotherapy Outcomes: A Review
- Review, Var, NA
"highlight2" >GutMicro↑,
1855- dietFMD,    Impact of modified short-term fasting and its combination with a fasting supportive diet during chemotherapy on the incidence and severity of chemotherapy-induced toxicities in cancer patients - a controlled cross-over pilot study
- Trial, NA, NA
"highlight2" >ChemoSideEff↓, "highlight2" >QoL↑, "highlight2" >IGF-1↓, "highlight2" >Insulin↓,
1854- dietFMD,    How Far Are We from Prescribing Fasting as Anticancer Medicine?
- Review, Var, NA
"highlight2" >ChemoSideEff↓, "highlight2" >ChemoSen↑, "highlight2" >IGF-1↓, "highlight2" >IGFBP1↑, "highlight2" >adiP↑, "highlight2" >glyC↓, "highlight2" >E-cadherin↑, "highlight2" >MMPs↓, "highlight2" >Casp3↑, "highlight2" >ROS↑, "highlight2" >ATP↓, "highlight2" >AMPK↑, "highlight2" >mTOR↓, "highlight2" >ROS↑, "highlight2" >Glycolysis↓, "highlight2" >NADPH↓, "highlight2" >OXPHOS↝, "highlight2" >eff↑, "highlight2" >eff↑, "highlight2" >*RAS↓, "highlight2" >*MAPK↓, "highlight2" >*PI3K↓, "highlight2" >*Akt↓, "highlight2" >eff↑, "highlight2" >ROS↑, "highlight2" >Akt↑, "highlight2" >Casp3↑,
1852- dietFMD,  Chemo,    Starvation Based Differential Chemotherapy: 
A Novel Approach for Cancer Treatment
- Review, Var, NA
"highlight2" >ChemoSideEff↓, "highlight2" >*toxicity↓, "highlight2" >mTOR↓, "highlight2" >IGF-1↓, "highlight2" >IGFBP1↑, "highlight2" >BG↓, "highlight2" >ROS↑,
1851- dietFMD,  Chemo,    Starvation-dependent differential stress resistance protects normal but not cancer cells against high-dose chemotherapy
- in-vitro, GBM, LN229 - in-vitro, neuroblastoma, SH-SY5Y
"highlight2" >selectivity↑, "highlight2" >selectivity↑, "highlight2" >ROS↑, "highlight2" >DNAdam↑, "highlight2" >BG↓,
1850- dietFMD,    Fasting-mimicking diet remodels gut microbiota and suppresses colorectal cancer progression
- in-vivo, CRC, NA
"highlight2" >TumCP↑, "highlight2" >angioG↓, "highlight2" >CD8+↑, "highlight2" >GutMicro↑, "highlight2" >eff↑,
1849- dietFMD,    The emerging role of fasting-mimicking diets in cancer treatment
- Review, Var, NA
"highlight2" >TumCG↓, "highlight2" >toxicity∅, "highlight2" >BG↓, "highlight2" >IGF-1↓, "highlight2" >mTOR↓, "highlight2" >M2 MC↓, "highlight2" >eff↑, "highlight2" >ChemoSen↑, "highlight2" >QoL↑, "highlight2" >RadioS↑, "highlight2" >selectivity↑,
1848- dietFMD,  Chemo,    Fasting mimicking diet as an adjunct to neoadjuvant chemotherapy for breast cancer in the multicentre randomized phase 2 DIRECT trial
- Trial, BC, NA
"highlight2" >ChemoSideEff↓, "highlight2" >ChemoSen↑, "highlight2" >eff↑,
1847- dietFMD,  VitC,    Synergistic effect of fasting-mimicking diet and vitamin C against KRAS mutated cancers
- in-vitro, PC, PANC1
"highlight2" >TumCG↓, "highlight2" >ChemoSen↑, "highlight2" >eff↑, "highlight2" >HO-1↓, "highlight2" >Ferritin↓, "highlight2" >Iron↑, "highlight2" >ROS↑, "highlight2" >TumCD↑, "highlight2" >IGF-1↓, "highlight2" >eff↓, "highlight2" >eff↓,
1846- dietFMD,  VitC,    A fasting-mimicking diet and vitamin C: turning anti-aging strategies against cancer
- Study, Var, NA
"highlight2" >TumCG↓, "highlight2" >ChemoSen↑, "highlight2" >ChemoSideEff↓, "highlight2" >ROS↑, "highlight2" >Fenton↑, "highlight2" >H2O2↑, "highlight2" >eff↑, "highlight2" >HO-1↓, "highlight2" >DNAdam↑, "highlight2" >eff↑,
1845- dietFMD,    Fasting and fasting mimicking diets in cancer prevention and therapy
- Review, Var, NA
"highlight2" >eff↑, "highlight2" >selectivity↑, "highlight2" >ChemoSen↑,
1844- dietFMD,    Unlocking the Potential: Caloric Restriction, Caloric Restriction Mimetics, and Their Impact on Cancer Prevention and Treatment
- Review, NA, NA
"highlight2" >Risk↓, "highlight2" >AMPK↑, "highlight2" >Akt↓, "highlight2" >mTOR↓, "highlight2" >SIRT1↑, "highlight2" >Hif1a↓, "highlight2" >NRF2↓, "highlight2" >SOD↑, "highlight2" >ROS↑, "highlight2" >IGF-1↓, "highlight2" >p‑Akt↓, "highlight2" >PI3K↑, "highlight2" >GutMicro↑, "highlight2" >OS↑, "highlight2" >eff↝, "highlight2" >ROS↑, "highlight2" >TumCCA↑, "highlight2" >*DNArepair↑, "highlight2" >DNAdam↑,
1843- dietFMD,  BTZ,    Cyclic Fasting–Mimicking Diet Plus Bortezomib and Rituximab Is an Effective Treatment for Chronic Lymphocytic Leukemia
- in-vivo, CLL, NA
"highlight2" >AntiTum↓, "highlight2" >Apoptosis↑, "highlight2" >IGF-1↓, "highlight2" >eff↑, "highlight2" >OS↑, "highlight2" >eff↑,
1842- dietFMD,    Safety and Feasibility of Fasting-Mimicking Diet and Effects on Nutritional Status and Circulating Metabolic and Inflammatory Factors in Cancer Patients Undergoing Active Treatment
- Trial, Var, NA
"highlight2" >Strength∅, "highlight2" >Weight∅, "highlight2" >IGF-1↓, "highlight2" >IGFBP3↑, "highlight2" >IGFBP1↑, "highlight2" >eff↑,
1841- dietFMD,    Fasting-Mimicking Diet Is Safe and Reshapes Metabolism and Antitumor Immunity in Patients with Cancer
- Trial, Var, NA
"highlight2" >BG↓, "highlight2" >AntiCan↑, "highlight2" >IFN-γ↑, "highlight2" >eff↑, "highlight2" >Dose↝, "highlight2" >CD14↓, "highlight2" >IGF-1↓, "highlight2" >IGFR↓, "highlight2" >CD8+↑, "highlight2" >NK cell↑,
1626- dietSTF,  dietFMD,    When less may be more: calorie restriction and response to cancer therapy
- Review, Var, NA
"highlight2" >CRM↑, "highlight2" >ChemoSen↑, "highlight2" >RadioS↑, "highlight2" >eff↑, "highlight2" >eff↑, "highlight2" >IGF-1↓, "highlight2" >TumCG↓, "highlight2" >AMPK↑, "highlight2" >eff↑, "highlight2" >ChemoSen↑, "highlight2" >RadioS↑, "highlight2" >ROS↑, "highlight2" >DNAdam↑, "highlight2" >eff↑, "highlight2" >HO-1↓,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 26

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress ⓘ

Fenton↑, 1,   H2O2↑, 1,   HO-1↓, 5,   hyperG↓, 1,   Iron↑, 1,   NRF2↓, 1,   OXPHOS↑, 1,   OXPHOS↝, 1,   ROS↑, 13,   SOD↑, 1,  

Metal & Cofactor Biology ⓘ

Ferritin↓, 1,   KLF5↓, 1,  

Mitochondria & Bioenergetics ⓘ

ATP↓, 2,   ATP↑, 1,   Insulin↓, 3,   OCR↑, 1,  

Core Metabolism/Glycolysis ⓘ

adiP↑, 1,   AminoA↓, 1,   AMPK↑, 3,   ATP:AMP↓, 1,   CRM↑, 1,   GlucoseCon↓, 1,   GLUT2↓, 1,   glyC↓, 1,   Glycolysis↓, 3,   HK2↓, 1,   lactateProd↓, 1,   NADPH↓, 1,   PFK1↓, 1,   PKM2↓, 1,   SIRT1↑, 2,   Warburg↓, 3,  

Cell Death ⓘ

Akt↓, 1,   Akt↑, 3,   p‑Akt↓, 1,   Apoptosis↑, 3,   ASK1↑, 1,   BIM↑, 1,   Casp3↑, 3,   MAPK↓, 1,   necrosis↑, 1,   TumCD↑, 2,  

Autophagy & Lysosomes ⓘ

ATG3↑, 1,   Beclin-1↑, 1,   LAMP2↑, 1,   p62↑, 1,  

DNA Damage & Repair ⓘ

DNAdam↑, 5,   P53↑, 1,  

Cell Cycle & Senescence ⓘ

CDK1↓, 1,   CDK4↑, 2,   TumCCA↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

p‑GSK‐3β↑, 1,   HDAC↓, 1,   IGF-1↓, 11,   IGF-1↑, 1,   IGFBP1↑, 3,   IGFBP3↑, 1,   IGFR↓, 1,   mTOR↓, 5,   mTOR↑, 2,   Nanog↓, 1,   OCT4↓, 1,   PI3K↓, 1,   PI3K↑, 3,   PTEN↑, 1,   STAT5↓, 1,   TumCG↓, 8,  

Migration ⓘ

E-cadherin↑, 1,   KLF2↓, 1,   MMPs↓, 1,   PKA↓, 2,   Treg lymp↓, 1,   TumCP↑, 1,  

Angiogenesis & Vasculature ⓘ

angioG↓, 1,   Hif1a↓, 1,  

Barriers & Transport ⓘ

GLUT1↓, 1,  

Immune & Inflammatory Signaling ⓘ

CD14↓, 1,   CLP↑, 1,   IFN-γ↑, 1,   M2 MC↓, 2,   NK cell↑, 1,   TILs↑, 1,  

Hormonal & Nuclear Receptors ⓘ

CDK6↑, 2,  

Drug Metabolism & Resistance ⓘ

ChemoSen↑, 11,   Dose↓, 1,   Dose↑, 1,   Dose↝, 2,   eff↓, 2,   eff↑, 25,   eff↝, 2,   eff∅, 1,   RadioS↑, 4,   selectivity↑, 5,  

Clinical Biomarkers ⓘ

BG↓, 8,   Ferritin↓, 1,   GutMicro↑, 5,  

Functional Outcomes ⓘ

AntiCan↑, 1,   AntiTum↓, 1,   ChemoSideEff↓, 7,   OS↑, 4,   QoL↑, 2,   QoL∅, 1,   Risk↓, 2,   Strength∅, 1,   toxicity↝, 1,   toxicity∅, 1,   TumVol↓, 1,   Weight∅, 1,  

Infection & Microbiome ⓘ

CD8+↑, 4,  
Total Targets: 109

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress ⓘ

OXPHOS↑, 1,  

Cell Death ⓘ

Akt↓, 1,   MAPK↓, 1,  

DNA Damage & Repair ⓘ

DNArepair↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

PI3K↓, 1,   RAS↓, 1,  

Functional Outcomes ⓘ

toxicity↓, 1,   toxicity∅, 1,  
Total Targets: 8

Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:79  Target#:%  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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