condition found tbRes List
Part, Parthenolide: Click to Expand ⟱
Features:
Parthenolide is a naturally occurring sesquiterpene lactone derived from the medicinal plant feverfew (Tanacetum parthenium).
-Micheliolide (MCL) is converted readily from parthenolide (PTL), and has better stability and solubility than PTL
-Parthenolide is a natural compound used to treat migraines and arthritis and found to act as a potent NF-κB signaling inhibitor.

Main activities include:
-Inhibition of NF-κB Signaling:
-Induction of Oxidative Stress (ROS): oxidative stress can overwhelm the antioxidant defenses of the cancer cells, leading to cellular damage and death
-Parthenolide can interfere with STAT3 signaling, inhibiting the transcription of genes that favor tumor growth and resistance to apoptosis.
-Modulation of the MAPK/ERK Pathway:
-Impact on the JNK Pathway:
-Parthenolide has been shown to target cancer stem cells
TrxR2, thioredoxin reductase-mitochondrial: Click to Expand ⟱
Source:
Type:
TrxR2 is a mitochondrial selenoprotein that reduces oxidized Trx2, thereby preserving a reduced environment within the mitochondria.
• By maintaining mitochondrial redox homeostasis, TrxR2 contributes to cell survival, protects against oxidative stress, and helps regulate apoptosis.
• Its activity is especially critical in rapidly proliferating cells, such as cancer cells, which often experience elevated levels of reactive oxygen species (ROS).

-In various cancers—such as breast, lung, and colorectal cancers—upregulation of TrxR2 has been linked to enhanced cell survival, resistance to oxidative stress, and, in some studies, poorer clinical outcomes.
Scientific Papers found: Click to Expand⟱
1984- Part,    Targeting Thioredoxin Reductase by Parthenolide Contributes to Inducing Apoptosis of HeLa Cells
- in-vitro, Cerv, HeLa
AntiCan↑, PTL demonstrates potent anticancer efficacy in numerous types of malignant cells,
TrxR1↓, PTL interacts with both cytosolic thioredoxin reductase (TrxR1) and mitochondrial thioredoxin reductase (TrxR2)
TrxR2↓,
ROS↑, elicit reactive oxygen species-mediated apoptosis in HeLa cells
Apoptosis↑,
eff↓, blocked by pretreatment of the cells with NAC
eff↑, depletion of cellular GSH by pretreatment of the cells with BSO enhances the cytotoxicity of PTL


* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 1

Results for Effect on Cancer/Diseased Cells:
AntiCan↑,1,   Apoptosis↑,1,   eff↓,1,   eff↑,1,   ROS↑,1,   TrxR1↓,1,   TrxR2↓,1,  
Total Targets: 7

Results for Effect on Normal Cells:

Total Targets: 0

Scientific Paper Hit Count for: TrxR2, thioredoxin reductase-mitochondrial
Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:8  Target#:1222  State#:%  Dir#:%
  wNotes=on  sortOrder:rid,rpid

 

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