ABL1 Cancer Research Results

ABL1, Tyrosine-protein kinase ABL1: Click to Expand ⟱
Source: CGL-Driver Genes
Type: Oncogene
ABL1 is a protein tyrosine kinase involved in cell differentiation, division and stress response.
ABL1 (Abelson murine leukemia viral oncogene homolog 1) is a gene that encodes a protein tyrosine kinase, which plays a crucial role in various cellular processes, including cell division, differentiation, and response to stress.
ABL1, its role as an oncogene is most prominently illustrated by the BCR-ABL fusion protein, which is formed through a chromosomal translocation between the ABL1 gene and the BCR gene.
High ABL1 Expression: In some cancers, high levels of ABL1 expression may correlate with poor prognosis, while in others, it may not have a significant impact.
Scientific Papers found: Click to Expand⟱
6588- DAS,    Dasatinib (BMS-354825), a dual SRC/ABL kinase inhibitor, inhibits the kinase activity of wild-type, juxtamembrane, and activation loop mutant KIT isoforms associated with human malignancies
Src↓, ABL1↓,
6589- DAS,    Effects of dasatinib on SRC kinase activity and downstream intracellular signaling in primitive chronic myelogenous leukemia hematopoietic cells
- in-vitro, CLL, NA
Src↓, ABL1↓,
6590- DAS,    Action of the Src family kinase inhibitor, dasatinib (BMS-354825), on human prostate cancer cells
- in-vitro, Pca, NA
Src↓, ABL1↓, BioAv↑, TumCG↓, Dose↓, TumCA↓, TumCMig↓, TumCI↓,
6591- DAS,    Dasatinib in solid tumors
- Review, Var, NA
Src↓, PDGF↓, ABL1↓, BioAv↝, Half-Life↝, Dose↝, eff↑,

Showing Research Papers: 1 to 4 of 4

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 4

Pathway results for Effect on Cancer / Diseased Cells:


Mitochondria & Bioenergetics ⓘ

ABL1↓, 4,  

Proliferation, Differentiation & Cell State ⓘ

Src↓, 4,   TumCG↓, 1,  

Migration ⓘ

PDGF↓, 1,   TumCA↓, 1,   TumCI↓, 1,   TumCMig↓, 1,  

Drug Metabolism & Resistance ⓘ

BioAv↑, 1,   BioAv↝, 1,   Dose↓, 1,   Dose↝, 1,   eff↑, 1,   Half-Life↝, 1,  
Total Targets: 13

Pathway results for Effect on Normal Cells:


Total Targets: 0

Scientific Paper Hit Count for: ABL1, Tyrosine-protein kinase ABL1
4 Dasatinib/Phyrago
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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