condition found tbRes List
AntiAg, Antiplatelet aggregation: Click to Expand ⟱
Source:
Type:
Antiplatelet aggregation refers to the process by which platelets clump together to form a blood clot.
The plethora of evidence indicates that among multiple hemostasis components, platelets play major roles in cancer progression by providing surface and granular contents for several interactions as well as behaving like immune cells.On the other hand, there are suggestions that antiplatelet treatment may promote solid tumor development in a phenomenon described as “cancers follow bleeding.” The controversies around antiplatelet agents justify insight into the subject to establish what, if any, role platelet-directed therapy has in the continuum of anticancer management.
The interplay between antiplatelet aggregation and cancer is an area of active research, with potential implications for therapeutic strategies. Antiplatelet agents, such as aspirin, are being investigated for their role in cancer prevention and treatment, particularly in reducing metastasis and improving patient outcomes.
Scientific Papers found: Click to Expand⟱
2463- AL,    Garlic as an antithrombotic and antiplatelet aggregation agent
- Review, Nor, NA
AntiAg↑, other↑,
2462- AL,    Comparison of antiplatelet activity of garlic tablets with cardio-protective dose of aspirin in healthy volunteers: a randomized clinical trial
- Trial, Nor, NA
AntiAg∅,
2558- AL,    Allicin, an Antioxidant and Neuroprotective Agent, Ameliorates Cognitive Impairment
- Review, AD, NA
*AntiCan↑, *antiOx↑, *cardioP↑, *neuroP↑, cognitive↑, *ROS↓, *NOX↓, *TLR4↓, *NF-kB↓, *JNK↓, *AntiAg↑, *H2S↑, *BP↓, Telomerase↓, *Insulin↑, BioAv↝, *GSH↑, *Catalase↑,
2559- AL,    Effect of the Garlic Pill in comparison with Plavix on Platelet Aggregation and Bleeding Time
- Human, Nor, NA
AntiAg↑, COX2↓, cardioP↑,
2560- AL,    Effect of garlic on platelet aggregation in humans: a study in healthy subjects and patients with coronary artery disease
- ex-vivo, Nor, NA
*AntiAg↑, BioAv↝, Dose↝,
2658- AL,    The Toxic Effect Ways of Allicin on Different Cell Lines
- Review, Var, NA
*antiOx↑, *AntiAg↑, *cardioP↑, Ca+2↑, ROS↑, Casp↑, p38↑, MAPK↑, hepatoP↑, chemoP↑,
2640- Api,    Apigenin: A Promising Molecule for Cancer Prevention
- Review, Var, NA
chemoP↑, ITGB4↓, TumCI↓, TumMeta↓, Akt↓, ERK↓, p‑JNK↓, *Inflam↓, *PKCδ↓, *MAPK↓, EGFR↓, CK2↓, TumCCA↑, CDK1↓, P53↓, P21↑, Bax:Bcl2↑, Cyt‑c↑, APAF1↑, Casp↑, cl‑PARP↑, VEGF↓, Hif1a↓, IGF-1↓, IGFBP3↑, E-cadherin↑, β-catenin/ZEB1↓, HSPs↓, Telomerase↓, FASN↓, MMPs↓, HER2/EBBR2↓, CK2↓, eff↑, AntiAg↑, eff↑, FAK↓, ROS↑, Bcl-2↓, Cyt‑c↑, cl‑Casp3↑, cl‑Casp7↑, cl‑Casp8↑, cl‑Casp9↑, cl‑IAP2↑, AR↓, PSA↓, p‑pRB↓, p‑GSK‐3β↓, CDK4↓, ChemoSen↑, Ca+2↑, cal2↑,
2461- ASA,    Aspirin and platelets: the antiplatelet action of aspirin and its role in thrombosis treatment and prophylaxis
- Review, NA, NA
AntiAg↑, COX1↓, eff↑,
2466- CUR,    Regulatory Effects of Curcumin on Platelets: An Update and Future Directions
- Review, Nor, NA
*AntiAg↑, *antiOx↑, *Inflam↓, *12LOX↑, COX1↓, COX2↓, MMP9↓, NF-kB↓,
2468- EGCG,    Green tea epigallocatechin-3-gallate inhibits platelet signalling pathways triggered by both proteolytic and non-proteolytic agonists
- in-vitro, Nor, NA
*AntiAg↑, *Ca+2↓,
2561- EGCG,  ASA,    Anti-platelet effects of epigallocatechin-3-gallate in addition to the concomitant aspirin, clopidogrel or ticagrelor treatment
- ex-vivo, Nor, NA
AntiAg↑, eff↑, Half-Life↝, other∅,
2562- EGCG,    Green Tea Epigallocatechin 3-Gallate Reduced Platelet Aggregation and Improved Anticoagulant Proteins in Patients with Transfusion-Dependent β-Thalassemia: A Randomized Placebo-Controlled Clinical Trial
- Trial, NA, NA
AntiAg↑, other↝,
2563- EGCG,    Cardioprotective effect of epigallocatechin gallate in myocardial ischemia/reperfusion injury and myocardial infarction: a meta-analysis in preclinical animal studies
- Review, NA, NA
cardioP↑, ROS↑, AntiAg↑, eff↑, COX1↓,
824- GAR,    Garcinol A Novel Inhibitor of Platelet Activation and Apoptosis
- in-vitro, NA, NA
AntiAg↓,
2464- GI,    The Effect of Ginger (Zingiber officinale) on Platelet Aggregation: A Systematic Literature Review
- Review, Nor, NA
*Inflam↓, *antiOx↑, *LDL↓, *AntiAg↑, *AntiAg∅,
2465- GI,    Effect of daily ginger consumption on platelet aggregation
- Trial, Nor, NA
AntiAg↝, Dose∅,
2894- HNK,    Pharmacological features, health benefits and clinical implications of honokiol
- Review, Var, NA - Review, AD, NA
*BioAv↓, *neuroP↑, *BBB↑, *ROS↓, *Keap1↑, *NRF2↑, *Casp3↓, *SIRT3↑, *Rho↓, *ERK↓, *NF-kB↓, angioG↓, RAS↓, PI3K↓, Akt↓, mTOR↓, *memory↑, *Aβ↓, *PPARγ↑, *PGC-1α↑, NF-kB↓, Hif1a↓, VEGF↓, HO-1↓, Foxm1↓, p27↑, P21↑, CDK2↓, CDK4↓, CDK6↓, cycD1↓, Twist↓, MMP2↓, Rho↑, ROCK1↑, TumCMig↓, cFLIP↓, BMPs↑, OCR↑, ECAR↓, *AntiAg↑, *cardioP↑, *antiOx↑, *ROS↓, P-gp↓,
3285- Lyco,    Comparative evaluation of antiplatelet effect of lycopene with aspirin and the effect of their combination on platelet aggregation: An in vitro study
- in-vitro, Nor, NA
*AntiAg↑, *eff↑,
3286- Lyco,    Inhibitory effects of lycopene on in vitro platelet activation and in vivo prevention of thrombus formation
- in-vitro, Nor, NA
*AntiAg↑,
3261- Lyco,    Lycopene and Vascular Health
- Review, Stroke, NA
*Inflam↓, *antiOx↑, *AntiAg↑, *cardioP↑, *SOD↑, *Catalase↑, *ROS↓, *mtDam↓, *cardioP↑, *NF-kB↓, *NO↓, *COX2↓, *LDL↓, *eff↑, *ER Stress↓, *BioAv↑, *eff↑, *MMPs↓, *COX2↓, *RAGE↓,
1807- NarG,    A Systematic Review of the Preventive and Therapeutic Effects of Naringin Against Human Malignancies
- Review, NA, NA
AntiTum↑, TumCP↓, tumCV↓, TumCCA↑, Mcl-1↓, RAS↓, e-Raf↓, VEGF↓, AntiAg↑, MMP2↓, MMP9↓, TIMP2↑, TIMP1↑, p38↓, Wnt↓, β-catenin/ZEB1↑, Casp↑, P53↑, BAX↑, COX2↓, GLO-I↓, CYP1A1↑, lipid-P↓, p‑Akt↓, p‑mTOR↓, VCAM-1↓, P-gp↓, survivin↓, Bcl-2↓, ROS↑, ROS↑, MAPK↑, STAT3↓, chemoP↑,
2970- PL,    Piperlongumine induces apoptosis and autophagy in leukemic cells through targeting the PI3K/Akt/mTOR and p38 signaling pathways
- in-vitro, AML, NA
AntiAg↑, TumCG↓, Apoptosis↑, PI3K↓, Akt↓, mTOR↓, p38↑, Casp3↑,
2950- PL,    Overview of piperlongumine analogues and their therapeutic potential
- Review, Var, NA
AntiAg↑, neuroP↑, Inflam↓, NO↓, PGE2↓, MMP3↓, MMP13↓, TumCMig↓, TumCI↓, p38↑, JNK↑, NF-kB↑, ROS↑, Foxm1↓, TrxR1↓, GSH↓, Trx↓, cMyc↓, Casp3↑, Bcl-2↓, Mcl-1↓, STAT3↓, AR↓, DNAdam↑,
3354- QC,    Quercetin: Its Main Pharmacological Activity and Potential Application in Clinical Medicine
- Review, Var, NA
*ROS↓, *IronCh↓, *lipid-P↓, *GSH↑, *NRF2↑, TumCCA↑, ER Stress↑, P53↑, CDK2↓, cycA1↓, CycB↓, cycE↓, cycD1↓, PCNA↓, P21↑, p27↑, PI3K↓, Akt↓, mTOR↓, STAT3↓, cFLIP↓, cMyc↓, survivin↓, DR5↓, *Inflam↓, *IL6↓, *IL8↓, COX2↓, 5LO↓, *cardioP↑, *FASN↓, *AntiAg↑, *MDA↓,
3348- QC,    Quercetin and iron metabolism: What we know and what we need to know
- Review, NA, NA
*IronCh↑, *ROS↓, *AntiAg↑, *Fenton↓, *lipid-P↓, *hepatoP↑, *RenoP↑, HIF-1↑, ROS↑,
3368- QC,    The potential anti-cancer effects of quercetin on blood, prostate and lung cancers: An update
- Review, Var, NA
*Inflam↓, *antiOx↑, *AntiCan↑, Casp3↓, p‑Akt↓, p‑mTOR↓, p‑ERK↓, β-catenin/ZEB1↓, Hif1a↓, AntiAg↓, VEGFR2↓, EMT↓, EGFR↓, MMP2↓, MMP↓, TumMeta↓, MMPs↓, Akt↓, Snail↓, N-cadherin↓, Vim↓, E-cadherin↑, STAT3↓, TGF-β↓, ROS↓, P53↑, BAX↑, PKCδ↓, PI3K↓, COX2↓, cFLIP↓, cycD1↓, cMyc↓, IL6↓, IL10↓, Cyt‑c↑, TumCCA↑, DNMTs↓, HDAC↓, ac‑H3↑, ac‑H4↑, Diablo↑, Casp3↑, Casp9↑, PARP1↑, eff↑, PTEN↑, VEGF↓, NO↓, iNOS↓, ChemoSen↑, eff↑, eff↑, eff↑, uPA↓, CXCR4↓, CXCL12↓, CLDN2↓, CDK6↓, MMP9↓, TSP-1↑, Ki-67↓, PCNA↓, ROS↑, ER Stress↑,
2564- RES,    Effect of resveratrol on platelet aggregation by fibrinogen protection
- in-vitro, NA, NA
AntiAg↑, antiOx↓, COX2↓,
2565- RES,    https://onlinelibrary.wiley.com/doi/10.1111/j.1365-2141.2007.06788.x
- in-vitro, NA, NA - in-vivo, NA, NA
AntiAg↑, TXA2↑, PKCδ↑, Dose↝,
2566- RES,    A comprehensive review on the neuroprotective potential of resveratrol in ischemic stroke
- Review, Stroke, NA
*neuroP↑, *NRF2↑, *SIRT1↑, *PGC-1α↑, *FOXO↑, *HO-1↑, *NQO1↑, *ROS↓, *BP↓, *BioAv↓, *Half-Life↝, *AMPK↑, *GSK‐3β↓, *eff↑, *AntiAg↑, *BBB↓, *Inflam↓, *MPO↓, *TLR4↓, *NF-kB↓, *p65↓, *MMP9↓, *TNF-α↓, *IL1β↓, *PPARγ↑, *MMP↑, *ATP↑, *Cyt‑c∅, *mt-lipid-P↓, *H2O2↓, *HSP70/HSPA5↝, *Mets↝, *eff↑, *eff↑, *motorD↑, *MDA↓, *NADH:NAD↑, eff↑, eff↑,
2567- RES,    Neuroprotective Effects of Resveratrol in Ischemic Brain Injury
- Review, Stroke, NA
*eff↑, *neuroP↑, *antiOx↑, *Inflam↓, *cardioP↑, *AntiAg↑,
2441- RES,    Anti-Cancer Properties of Resveratrol: A Focus on Its Impact on Mitochondrial Functions
- Review, Var, NA
*toxicity↓, *BioAv↝, *Dose↝, *hepatoP↑, *neuroP↑, *AntiAg↑, *COX2↓, *antiOx↑, *ROS↓, *ROS↑, PI3K↓, Akt↓, NF-kB↓, Wnt↓, β-catenin/ZEB1↓, NRF2↑, GPx↑, HO-1↑, BioEnh?, PTEN↑, ChemoSen↑, eff↑, mt-ROS↑, Warburg↓, Glycolysis↓, GlucoseCon↓, GLUT1↓, lactateProd↓, HK2↓, EGFR↓, cMyc↓, ROS↝, MMPs↓, MMP7↓, survivin↓, TumCP↓, TumCMig↓, TumCI↓,
2467- RES,    Resveratrol inhibits Ca2+ signals and aggregation of platelets
- in-vitro, Nor, NA
*AntiAg↑, Ca+2↓,
3063- RES,    Resveratrol: A Review of Pre-clinical Studies for Human Cancer Prevention
- Review, Var, NA
*Inflam↓, *antiOx↑, *AntiAg↑, *chemoP↑, ChemoSen↑, BioAv↑, Half-Life↝, COX2↓, cycD1↓, CDK2↓, CDK4↓, CDK6↓, P21↑, MMP9↓, NF-kB↓, Telomerase↓, PSA↓, MAPK↑, P53↑,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 33

Results for Effect on Cancer/Diseased Cells:
5LO↓,1,   Akt↓,6,   p‑Akt↓,2,   angioG↓,1,   AntiAg↓,2,   AntiAg↑,12,   AntiAg↝,1,   AntiAg∅,1,   antiOx↓,1,   AntiTum↑,1,   APAF1↑,1,   Apoptosis↑,1,   AR↓,2,   BAX↑,2,   Bax:Bcl2↑,1,   Bcl-2↓,3,   BioAv↑,1,   BioAv↝,2,   BioEnh?,1,   BMPs↑,1,   Ca+2↓,1,   Ca+2↑,2,   cal2↑,1,   cardioP↑,2,   Casp↑,3,   Casp3↓,1,   Casp3↑,3,   cl‑Casp3↑,1,   cl‑Casp7↑,1,   cl‑Casp8↑,1,   Casp9↑,1,   cl‑Casp9↑,1,   CDK1↓,1,   CDK2↓,3,   CDK4↓,3,   CDK6↓,3,   cFLIP↓,3,   chemoP↑,3,   ChemoSen↑,4,   CK2↓,2,   CLDN2↓,1,   cMyc↓,4,   cognitive↑,1,   COX1↓,3,   COX2↓,7,   CXCL12↓,1,   CXCR4↓,1,   cycA1↓,1,   CycB↓,1,   cycD1↓,4,   cycE↓,1,   CYP1A1↑,1,   Cyt‑c↑,3,   Diablo↑,1,   DNAdam↑,1,   DNMTs↓,1,   Dose↝,2,   Dose∅,1,   DR5↓,1,   E-cadherin↑,2,   ECAR↓,1,   eff↑,12,   EGFR↓,3,   EMT↓,1,   ER Stress↑,2,   ERK↓,1,   p‑ERK↓,1,   FAK↓,1,   FASN↓,1,   Foxm1↓,2,   GLO-I↓,1,   GlucoseCon↓,1,   GLUT1↓,1,   Glycolysis↓,1,   GPx↑,1,   GSH↓,1,   p‑GSK‐3β↓,1,   ac‑H3↑,1,   ac‑H4↑,1,   Half-Life↝,2,   HDAC↓,1,   hepatoP↑,1,   HER2/EBBR2↓,1,   HIF-1↑,1,   Hif1a↓,3,   HK2↓,1,   HO-1↓,1,   HO-1↑,1,   HSPs↓,1,   cl‑IAP2↑,1,   IGF-1↓,1,   IGFBP3↑,1,   IL10↓,1,   IL6↓,1,   Inflam↓,1,   iNOS↓,1,   ITGB4↓,1,   JNK↑,1,   p‑JNK↓,1,   Ki-67↓,1,   lactateProd↓,1,   lipid-P↓,1,   MAPK↑,3,   Mcl-1↓,2,   MMP↓,1,   MMP13↓,1,   MMP2↓,3,   MMP3↓,1,   MMP7↓,1,   MMP9↓,4,   MMPs↓,3,   mTOR↓,3,   p‑mTOR↓,2,   N-cadherin↓,1,   neuroP↑,1,   NF-kB↓,4,   NF-kB↑,1,   NO↓,2,   NRF2↑,1,   OCR↑,1,   other↑,1,   other↝,1,   other∅,1,   P-gp↓,2,   P21↑,4,   p27↑,2,   p38↓,1,   p38↑,3,   P53↓,1,   P53↑,4,   cl‑PARP↑,1,   PARP1↑,1,   PCNA↓,2,   PGE2↓,1,   PI3K↓,5,   PKCδ↓,1,   PKCδ↑,1,   p‑pRB↓,1,   PSA↓,2,   PTEN↑,2,   e-Raf↓,1,   RAS↓,2,   Rho↑,1,   ROCK1↑,1,   ROS↓,1,   ROS↑,8,   ROS↝,1,   mt-ROS↑,1,   Snail↓,1,   STAT3↓,4,   survivin↓,3,   Telomerase↓,3,   TGF-β↓,1,   TIMP1↑,1,   TIMP2↑,1,   Trx↓,1,   TrxR1↓,1,   TSP-1↑,1,   TumCCA↑,4,   TumCG↓,1,   TumCI↓,3,   TumCMig↓,3,   TumCP↓,2,   tumCV↓,1,   TumMeta↓,2,   Twist↓,1,   TXA2↑,1,   uPA↓,1,   VCAM-1↓,1,   VEGF↓,4,   VEGFR2↓,1,   Vim↓,1,   Warburg↓,1,   Wnt↓,2,   β-catenin/ZEB1↓,3,   β-catenin/ZEB1↑,1,  
Total Targets: 176

Results for Effect on Normal Cells:
12LOX↑,1,   AMPK↑,1,   AntiAg↑,17,   AntiAg∅,1,   AntiCan↑,2,   antiOx↑,10,   ATP↑,1,   Aβ↓,1,   BBB↓,1,   BBB↑,1,   BioAv↓,2,   BioAv↑,1,   BioAv↝,1,   BP↓,2,   Ca+2↓,1,   cardioP↑,7,   Casp3↓,1,   Catalase↑,2,   chemoP↑,1,   COX2↓,3,   Cyt‑c∅,1,   Dose↝,1,   eff↑,7,   ER Stress↓,1,   ERK↓,1,   FASN↓,1,   Fenton↓,1,   FOXO↑,1,   GSH↑,2,   GSK‐3β↓,1,   H2O2↓,1,   H2S↑,1,   Half-Life↝,1,   hepatoP↑,2,   HO-1↑,1,   HSP70/HSPA5↝,1,   IL1β↓,1,   IL6↓,1,   IL8↓,1,   Inflam↓,9,   Insulin↑,1,   IronCh↓,1,   IronCh↑,1,   JNK↓,1,   Keap1↑,1,   LDL↓,2,   lipid-P↓,2,   mt-lipid-P↓,1,   MAPK↓,1,   MDA↓,2,   memory↑,1,   Mets↝,1,   MMP↑,1,   MMP9↓,1,   MMPs↓,1,   motorD↑,1,   MPO↓,1,   mtDam↓,1,   NADH:NAD↑,1,   neuroP↑,5,   NF-kB↓,4,   NO↓,1,   NOX↓,1,   NQO1↑,1,   NRF2↑,3,   p65↓,1,   PGC-1α↑,2,   PKCδ↓,1,   PPARγ↑,2,   RAGE↓,1,   RenoP↑,1,   Rho↓,1,   ROS↓,8,   ROS↑,1,   SIRT1↑,1,   SIRT3↑,1,   SOD↑,1,   TLR4↓,2,   TNF-α↓,1,   toxicity↓,1,  
Total Targets: 80

Scientific Paper Hit Count for: AntiAg, Antiplatelet aggregation
7 Resveratrol
6 Allicin (mainly Garlic)
4 EGCG (Epigallocatechin Gallate)
3 Lycopene
3 Quercetin
2 Aspirin -acetylsalicylic acid
2 Ginger/6-Shogaol/Gingerol
2 Piperlongumine
1 Apigenin (mainly Parsley)
1 Curcumin
1 Garcinol
1 Honokiol
1 Naringin
Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:10  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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