COL1 Cancer Research Results

COL1, Collagen I: Click to Expand ⟱
Source:
Type:
Collagen I, primarily composed of two chains encoded by the genes COL1A1 and COL1A2.
- Collagen I is the most abundant collagen in the human body and is a major component of the extracellular matrix (ECM), providing structural support to tissues.
- It is typically a heterotrimer composed of two α1(I) chains (COL1A1) and one α2(I) chain (COL1A2).

- Cancer progression is often accompanied by significant remodeling of the ECM.
- Collagen I deposition frequently increases in many solid tumors, contributing to a dense and fibrotic stroma (desmoplasia).
- Increased collagen I deposition can lead to higher ECM stiffness, which in turn modifies cell signaling and behavior.

Expression Patterns:
- Tumors such as breast, pancreatic, colorectal, and lung cancers often exhibit elevated levels of collagen I.
- High collagen I expression or deposition in the tumor stroma is frequently correlated with a more aggressive tumor phenotype.
Scientific Papers found: Click to Expand⟱
9223- AITC,    Allyl isothiocyanate inhibits invasion and angiogenesis in breast cancer via EGFR-mediated JAK-1/STAT-3 signaling pathway
- in-vivo, BC, NA
COL1↓, angioG↓, TumCI↓, STAT3↓, JAK1↓, Dose↝, TumNum↓, TumVol↓,
2662- AL,    Allicin inhibits tubular epithelial-myofibroblast transdifferentiation under high glucose conditions in vitro
- in-vitro, Nor, HK-2
*α-SMA↓, *Vim↓, *COL1↓, *E-cadherin↑, *TGF-β1↓, *p‑ERK↓, *EMT↓,
3516- Bor,    Boron in wound healing: a comprehensive investigation of its diverse mechanisms
- Review, Wounds, NA
*Inflam↓, *antiOx↑, *ROS↓, *angioG↑, *COL1↑, *α-SMA↑, *TGF-β↑, *BMD↑, *hepatoP↑, *TNF-α↑, *HSP70/HSPA5↑, *SOD↑, *Catalase↑, *GSH↑, *MDA↓, *TOS↓, *IL6↓, *JAK2↓, *STAT3↓, *AMPK↑, *lipid-P↓, *VEGF↑, *Half-Life↝,
1104- CAR,    Carvacrol Ameliorates Transforming Growth Factor-β1-Induced Extracellular Matrix Deposition and Reduces Epithelial-Mesenchymal Transition by Regulating The Phosphatidylinositol 3-Kinase/Protein Kinase B Pathway In Hk-2 Cells
- in-vitro, Kidney, HK-2
tumCV↓, COL4↓, COL1↓, Fibronectin↓, E-cadherin↑, Snail↑, Vim↑, α-SMA↑, PI3K↓, Akt↓,
7012- Fuc,    Fucoidan: A promising natural therapeutic agent for protecting human kidney health
- Review, EC, NA
*RenoP↑, *Inflam↓, *antiOx↑, *ROS↓, *BloodF↑, *diuretic↑, *BioAv↓, *BioAv↑, *MAPK↓, *ERK↑, *NLRP3↓, *NRF2↑, *MDA↓, *SOD↑, *GPx↑, *Catalase↑, *lipid-P↓, *DNAdam↓, *Fibrosis↓, *JAK2↓, *STAT3↓, *uricA↓, *COL1↓, *α-SMA↓, *SIRT1↑, *HO-1↑, *GLP-1R↑, *HMGB1↓, *RAGE↓, *NF-kB↓, *TGF-β1↓, *PI3K↓, *Akt↓, *GutMicro↑, *SCFAs↑, *Buty↑, *IBI↑, *TJ↑, *Dose↝,
1117- GBE,    Ginkgobiloba leaf extract mitigates cisplatin-induced chronic renal interstitial fibrosis by inhibiting the epithelial-mesenchymal transition of renal tubular epithelial cells mediated by the Smad3/TGF-β1 and Smad3/p38 MAPK pathways
- vitro+vivo, Kidney, HK-2
α-SMA↓, COL1↓, TGF-β↓, SMAD2↓, SMAD3↓, p‑SMAD2↓, p‑SMAD3↓, p38↓, p‑p38↓, Vim↓, TIMP1↓, CCN2/CTGF↓, E-cadherin↑, MMP1:TIMP1↑,
7492- H2,  Chemo,    Molecular Hydrogen Protects against Various Tissue Injuries from Side Effects of Anticancer Drugs by Reducing Oxidative Stress and Inflammation
- Review, Var, NA
*ROS↓, *antiOx↑, *Inflam↓, *chemoP↑, AntiCan↑, ChemoSen↑, chemoP↑, *BUN↓, *creat↓, *TUNEL↓, *MDA↓, *SOD↑, *Catalase↑, *NRF2↑, *BNP↓, *AST↓, *ALAT↓, *TNF-α↓, *IL1β↓, *IL6↓, *Casp3↓, *Casp9↓, *GPx↑, *E-cadherin↑, *Vim↓, *α-SMA↓, *COL1↓, *cardioP↑, *hepatoP↑, *p‑mTOR↓, *EMT↓, eff∅, *LPS↓, *TLR4↓, radioP↑,
8086- KAE,    Hepatoprotective Effect of Kaempferol: A Review of the Dietary Sources, Bioavailability, Mechanisms of Action, and Safety
- Review, Nor, NA
*hepatoP↑, *BioAv↝, *CYP2E1↓, *antiOx↑, *AST↓, *ALAT↓, *ROS↓, *lipid-P↓, *SIRT1↑, *GSH↑, *SOD↑, *p‑SMAD2↓, *p‑SMAD3↓, *COL1↓, *other↝,
8105- KAE,    Chemo-preventive and therapeutic effect of the dietary flavonoid kaempferol: A comprehensive review
- Review, Var, NA
Apoptosis↑, tumCV↓, TumCCA↑, PI3K↓, Akt↓, EMT↓, N-cadherin↓, E-cadherin↓, Slug?, Snail?, MMP2↓, MMP9↓, CTSB↓, CTSD↓, Casp3↑, Casp8↑, Casp9↑, TIMP2↓, Akt↓, TumCD↑, i-Ca+2↑, MMP↓, *ROS↓, *SOD↑, *Catalase↑, *GPx↑, *GSTs↑, *AST↓, *ALAT↓, *MDA↓, *CYP2E1↓, *NRF2↑, *AGEs↓, *IL6↓, *TNF-α↓, *NF-kB↓, *Casp3↓, *BAX↓, *antiAll↑, *COX2/PTGS2↓, *PGE2↓, *RUNX2↑, *BMP2↑, *COL1↑, *p62↑, *FASN↓, *DGAT1↓, FOXP3↑, DNAdam↑, ROS↑, Catalase↓, *ROS↓, *MMP↑, *Cyt‑c↓, *AntiDiabetic↑, *Obesity↓, *cardioP↑,
8080- KAE,    Hepatoprotective Effect of Kaempferol—A Review
- Review, Nor, NA
*hepatoP↑, *SIRT1↑, *AMPK↑, *TLR4↓, *NF-kB↓, *GutMicro↑, *Dose↝, *BioAv↓, *BioAv↑, *CYP2E1↓, *lipidLev↓, *COX2/PTGS2↓, *IL1β↓, *TNF-α↓, *IL6↓, *NO↓, *PGE2↓, *iNOS↓, *SOD↑, *MDA↓, *ROS↓, *AST↓, *ALAT↓, *GSH↑, *SOD↑, *Cyt‑c↓, *BAX↓, *Casp3↓, *Casp8↓, *Casp9↓, *COL1↓, *p‑SMAD2↓, *p‑SMAD3↑, *α-SMA↓, *TGF-β↓, *P450↝, *P-gp/ABCB1↓, *BioEnh↑,
9294- MF,    Pulsed electromagnetic fields in muscle and tendon injuries: a narrative review of preclinical and clinical evidence
- Review, Nor, NA
*VEGF↑, *COL1↑, *IL6↑, *IL10↑, *Fibronectin↑, *Pain↓, *other↑, *Inflam↓,
218- MFrot,  MF,    Extremely low frequency magnetic fields inhibit adipogenesis of human mesenchymal stem cells
- in-vitro, Nor, NA
*PPARγ↓, *p‑JNK↑, *Wnt↑, *ALP∅, *COL1∅, *RUNX2∅, *OCN∅, *FABP4↓, *p‑JNK↑, *Diff↓,
9011- Phyco,    Phycocyanin: A Potential Drug for Cancer Treatment
- Review, Var, NA
*antiOx↑, *Inflam↓, *AntiCan↑, *Imm↑, *RenoP↑, *hepatoP↑, Synergy↑, EMT↓, TumCCA↑, P21↑, cycE/CCNE↓, CDK2↓, Cyt‑c↑, Casp↑, cl‑PARP1↑, Bax:Bcl2↑, MMP↓, ROS↑, CD59↑, Fas?, IL1β↓, IL2↓, IFN-γ↓, TNF-α↓, JAK3↓, STAT3↓, IL4↑, COX2/PTGS2↓, PGE2↓, MMP9↓, MMP2↓, MMP9↓, TIMP2↓, Vim↓, COL1↓, E-cadherin↑, MDR1↓, AP-1↓, ChemoSen↑, chemoP↑, RadioS↑, TumAuto↑,
1257- PI,    Piperlongumine attenuates bile duct ligation-induced liver fibrosis in mice via inhibition of TGF-β1/Smad and EMT pathways
- ex-vivo, LiverDam, NA
*Fibronectin↓, *α-SMA↓, *COL1↓, *COL3A1↓, *TGF-β↓, *EMT↓, *MMP2↓, *α-SMA↓, *Smad7↑, *E-cadherin↑, *Vim↓, *hepatoP↑, *antiOx↑, *GSH↑, *ROS↓,
923- QC,    Quercetin as an innovative therapeutic tool for cancer chemoprevention: Molecular mechanisms and implications in human health
- Review, Var, NA
ROS↑, GSH↓, Ca+2↝, MMP↓, Casp3↑, Casp8↑, Casp9↑, other↓, *ROS↓, *NRF2↑, HO-1↑, TumCCA↑, Inflam↓, STAT3↓, DR5↑, P450↓, MMPs↓, IFN-γ↓, IL6↓, COX2/PTGS2↓, IL8↓, iNOS↓, TNF-α↓, cl‑PARP↑, Apoptosis↑, P53↑, Sp1/3/4↓, survivin↓, TRAILR↑, Casp10↑, DFF45↑, TNFR 1↑, Fas↑, NF-kB↓, IKKα↓, cycD1/CCND1↓, Bcl-2↓, BAX↑, PI3K↓, Akt↓, E-cadherin↓, Vim↓, β-catenin/ZEB1↓, cMyc↓, EMT↓, MMP2↓, NOTCH1↓, MMP7↓, angioG↓, TSP-1↑, CSCs↓, XIAP↓, Snail↓, Slug↓, LEF1↓, P-gp/ABCB1↓, EGFR↓, GSK‐3β↓, mTOR↓, RAGE↓, HSP27↓, VEGF↓, TGF-β↓, COL1↓, COL3A1↓,
9033- SP,    Spirulina and Its Bioactive Compounds as Multi-Target Anticancer Agents: Mechanisms, Immune Modulation, and Translational Potential
- Review, Var, NA
Apoptosis↑, TumCCA↑, angioG↓, VEGF↓, VEGFR1↓, EMT↓, Ingr↝, Imm↑, pol-M1↑, Th1 response↑, Th17↑, chemoP↑, BioAv↓, Synergy?, Ingr↝, Ingr↝, Ingr↝, ROS⇅, ROS↑, mtDam↑, DNAdam↑, SOD↓, Bcl-2↓, Casp3↑, MDA↓, Catalase↑, ROS↓, MOMP↑, Cyt‑c↑, Casp9↑, CellShr↑, ChrCon↑, Dose↝, TNFR 1↑, FADD↑, TRADD↑, Beclin-1/ATG6↑, PI3K↓, Akt↓, mTOR↓, TumAuto↑, TumCMig↓, TumCI↓, Vim↓, Fibronectin↓, COL1↓, MMP2↓, MMP9↓, COX2/PTGS2↓, MCP1/CCL2↓, ICAM-1↓, VCAM-1↓, Snail↓, Slug↓, Zeb1↓, Twist↓, E-cadherin↑, chemoP↑, *hepatoP↑, *lipid-P↓, *Casp3↓, *BAX↓, RenoP↑, *creat↓, *Urea↓, *SOD↑, *Catalase↑, *neuroP↑, *cognitive↑, *ROS↓, *NeuroI↓, *memory↑, *BDNF↑, *CREB↑, *toxicity↓, *toxicity↝, *BioAv↓, *BioAv↓, *Half-Life↝,

Showing Research Papers: 1 to 16 of 16

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 16

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

Catalase↓, 1,   Catalase↑, 1,   GSH↓, 1,   HO-1↑, 1,   MDA↓, 1,   ROS↓, 1,   ROS↑, 4,   ROS⇅, 1,   SOD↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

mtDam↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

GSK‐3β↓, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↑, 3,   BAX↑, 1,   Bax:Bcl2↑, 1,   Bcl-2↓, 2,   Casp↑, 1,   Casp10↑, 1,   Casp3↑, 3,   Casp8↑, 2,   Casp9↑, 3,   CellShr↑, 1,   Cyt‑c↑, 2,   DR5↑, 1,   FADD↑, 1,   Fas?, 1,   Fas↑, 1,   iNOS↓, 1,   MOMP↑, 1,   p38↓, 1,   p‑p38↓, 1,   survivin↓, 1,   TNFR 1↑, 2,   TRAILR↑, 1,   TumCD↑, 1,   XIAP↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 5,   EGFR↓, 1,   IKKα↓, 1,   JAK1↓, 1,   JAK3↓, 1,   mTOR↓, 2,   PI3K↓, 4,   Sp1/3/4↓, 1,   STAT3↓, 3,  

Transcription & Epigenetics(tgid=7) ⓘ

cMyc↓, 1,   other↓, 1,   tumCV↓, 2,  

Protein Folding & ER Stress(tgid=8) ⓘ

HSP27↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↑, 1,   CTSB↓, 1,   CTSD↓, 1,   TumAuto↑, 2,  

DNA Damage & Repair(tgid=10) ⓘ

DFF45↑, 1,   DNAdam↑, 2,   P53↑, 1,   cl‑PARP↑, 1,   cl‑PARP1↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK2↓, 1,   ChrCon↑, 1,   cycD1/CCND1↓, 1,   cycE/CCNE↓, 1,   P21↑, 1,   TumCCA↑, 4,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

CSCs↓, 1,   NOTCH1↓, 1,  

Migration(tgid=13) ⓘ

AP-1↓, 1,   Ca+2↝, 1,   i-Ca+2↑, 1,   CCN2/CTGF↓, 1,   COL1↓, 6,   COL3A1↓, 1,   COL4↓, 1,   E-cadherin↓, 2,   E-cadherin↑, 4,   EMT↓, 4,   Fibronectin↓, 2,   LEF1↓, 1,   MMP1:TIMP1↑, 1,   MMP2↓, 4,   MMP7↓, 1,   MMP9↓, 4,   MMPs↓, 1,   N-cadherin↓, 1,   Slug?, 1,   Slug↓, 2,   SMAD2↓, 1,   p‑SMAD2↓, 1,   SMAD3↓, 1,   p‑SMAD3↓, 1,   Snail?, 1,   Snail↓, 2,   Snail↑, 1,   TGF-β↓, 2,   TIMP1↓, 1,   TIMP2↓, 2,   TSP-1↑, 1,   TumCI↓, 2,   TumCMig↓, 1,   Twist↓, 1,   Vim↓, 4,   Vim↑, 1,   Zeb1↓, 1,   α-SMA↓, 1,   α-SMA↑, 1,   β-catenin/ZEB1↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 3,   VCAM-1↓, 1,   VEGF↓, 2,   VEGFR1↓, 1,  

Barriers & Transport(tgid=15) ⓘ

MMP↓, 3,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD59↑, 1,   COX2/PTGS2↓, 3,   FOXP3↑, 1,   ICAM-1↓, 1,   IFN-γ↓, 2,   IL1β↓, 1,   IL2↓, 1,   IL4↑, 1,   IL6↓, 1,   IL8↓, 1,   Imm↑, 1,   Inflam↓, 1,   pol-M1↑, 1,   MCP1/CCL2↓, 1,   NF-kB↓, 1,   PGE2↓, 1,   RAGE↓, 1,   Th1 response↑, 1,   Th17↑, 1,   TNF-α↓, 2,   TRADD↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 1,   ChemoSen↑, 2,   Dose↝, 2,   eff∅, 1,   MDR1↓, 1,   P-gp/ABCB1↓, 1,   P450↓, 1,   RadioS↑, 1,   Synergy?, 1,   Synergy↑, 1,  

Clinical Biomarkers(tgid=22) ⓘ

EGFR↓, 1,   IL6↓, 1,   RAGE↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 1,   chemoP↑, 4,   radioP↑, 1,   RenoP↑, 1,   TumNum↓, 1,   TumVol↓, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↝, 4,  
Total Targets: 151

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 6,   Catalase↑, 5,   GPx↑, 3,   GSH↑, 4,   GSTs↑, 1,   HO-1↑, 1,   lipid-P↓, 4,   MDA↓, 5,   NRF2↑, 4,   ROS↓, 10,   SOD↑, 8,   TOS↓, 1,   uricA↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ALAT↓, 4,   AMPK↑, 2,   Buty↑, 1,   DGAT1↓, 1,   FABP4↓, 1,   FASN↓, 1,   lipidLev↓, 1,   SCFAs↑, 1,   SIRT1↑, 3,  

Cell Death(tgid=5) ⓘ

BAX↓, 3,   Casp3↓, 4,   Casp8↓, 1,   Casp9↓, 2,   Cyt‑c↓, 2,   iNOS↓, 1,   TUNEL↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 1,   CREB↑, 1,   ERK↑, 1,   p‑ERK↓, 1,   JAK2↓, 2,   p‑JNK↑, 2,   MAPK↓, 1,   p‑mTOR↓, 1,   PI3K↓, 1,   STAT3↓, 2,  

Transcription & Epigenetics(tgid=7) ⓘ

other↑, 1,   other↝, 1,   RUNX2↑, 1,   RUNX2∅, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

HSP70/HSPA5↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

p62↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↓, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

BMP2↑, 1,   Diff↓, 1,   Wnt↑, 1,  

Migration(tgid=13) ⓘ

COL1↓, 6,   COL1↑, 3,   COL1∅, 1,   COL3A1↓, 1,   E-cadherin↑, 3,   EMT↓, 3,   Fibronectin↓, 1,   Fibronectin↑, 1,   Fibrosis↓, 1,   MMP2↓, 1,   p‑SMAD2↓, 2,   p‑SMAD3↓, 1,   p‑SMAD3↑, 1,   Smad7↑, 1,   TGF-β↓, 2,   TGF-β↑, 1,   TGF-β1↓, 2,   Vim↓, 3,   α-SMA↓, 6,   α-SMA↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↑, 1,   NO↓, 1,   VEGF↑, 2,  

Barriers & Transport(tgid=15) ⓘ

IBI↑, 1,   MMP↑, 1,   TJ↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

COX2/PTGS2↓, 2,   HMGB1↓, 1,   IL10↑, 1,   IL1β↓, 2,   IL6↓, 4,   IL6↑, 1,   Imm↑, 1,   Inflam↓, 5,   LPS↓, 1,   NeuroI↓, 1,   NF-kB↓, 3,   NLRP3↓, 1,   PGE2↓, 2,   RAGE↓, 1,   TLR4↓, 2,   TNF-α↓, 3,   TNF-α↑, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

BDNF↑, 1,  

Protein Aggregation(tgid=19) ⓘ

AGEs↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

BNP↓, 1,   GLP-1R↑, 1,   PPARγ↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 4,   BioAv↑, 2,   BioAv↝, 1,   BioEnh↑, 1,   CYP2E1↓, 3,   Dose↝, 2,   Half-Life↝, 2,   P-gp/ABCB1↓, 1,   P450↝, 1,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 4,   ALP∅, 1,   AST↓, 4,   BloodF↑, 1,   BMD↑, 1,   BUN↓, 1,   creat↓, 2,   IL6↓, 4,   IL6↑, 1,   OCN∅, 1,   RAGE↓, 1,   Urea↓, 1,  

Functional Outcomes(tgid=23) ⓘ

antiAll↑, 1,   AntiCan↑, 1,   AntiDiabetic↑, 1,   cardioP↑, 2,   chemoP↑, 1,   cognitive↑, 1,   diuretic↑, 1,   hepatoP↑, 7,   memory↑, 1,   neuroP↑, 1,   Obesity↓, 1,   Pain↓, 1,   RenoP↑, 2,   toxicity↓, 1,   toxicity↝, 1,  

Infection & Microbiome(tgid=24) ⓘ

GutMicro↑, 2,  
Total Targets: 134

Scientific Paper Hit Count for: COL1, Collagen I
3 Kaempferol
2 Magnetic Fields
1 Allyl isothiocyanate
1 Allicin (mainly Garlic)
1 Boron
1 Carvacrol
1 Fucoidan
1 Ginkgo biloba
1 Hydrogen Gas
1 Chemotherapy
1 Magnetic Field Rotating
1 Phycocyanin
1 Piperine
1 Quercetin
1 Spirulina(Arthrospira/Limnospira)
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1004  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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