Database Query Results : , , TXA2

TXA2, thromboxane A2: Click to Expand ⟱
Source:
Type:
TXA2 is a bioactive lipid mediator primarily produced via the action of cyclooxygenases (COX-1/COX-2) and thromboxane synthase (TXA2S, gene TBXAS1), and it plays a role in regulating platelet aggregation, vasoconstriction, and cellular signaling that may contribute to tumor progression.

TXA2 is a bioactive lipid mediator that, beyond its role in platelet aggregation and vascular regulation, is involved in several tumor-promoting processes such as inflammation, angiogenesis, and metastasis. In various cancers—such as breast, prostate, colorectal, lung, ovarian, and head and neck cancers—elevated TXA2 levels or enhanced signaling have been associated with more aggressive disease and poorer clinical outcomes.
Scientific Papers found: Click to Expand⟱
5415- ASA,    The Anti-Metastatic Role of Aspirin in Cancer: A Systematic Review
- Review, Var, NA
TumMeta↓, COX1↓, TXA2↓, AntiAg↑, EMT↓, TumCMig↓, TumCI↓, AMPK↑, cMyc↓, PGE2↓, Dose↑, RadioS↑, PD-L1↓, E-cadherin↑, EMT↓, Slug↓, Vim↓, Twist↓, MMP2↓, MMP9↓, other↑,
5413- ASA,    Drug Resistance and Pseudoresistance: An Unintended Consequence of Enteric Coating Aspirin
- Trial, Nor, NA
*cardioP↑, *other↝, *COX1↓, *TXA2↓,
5408- ASA,    An aspirin a day keeps cancer at bay
- Review, Var, NA
TumMeta↓, TXA2↓, *AntiAg↑, COX1↓,
5402- ASA,    Aspirin prevents metastasis by limiting platelet TXA2 suppression of T cell immunity
- Review, Var, NA
COX1↓, TumMeta↓, *Half-Life↓, *COX2↓, *TXA2↓,
4342- CA,    Antiplatelet effects of caffeic acid due to Ca(2＋) mobilizationinhibition via cAMP-dependent inositol-1, 4, 5-trisphosphate receptor phosphorylation
- in-vitro, NA, NA
*AntiAg↑, *TXA2↓, *COX1↓,
4337- CUR,    Inhibitory effect of curcumin, a food spice from turmeric, on platelet-activating factor- and arachidonic acid-mediated platelet aggregation through inhibition of thromboxane formation and Ca2+ signaling
- in-vitro, NA, NA
*AntiAg↑, *TXA2↓,
1162- PI,    Piperine Inhibits the Activities of Platelet Cytosolic Phospholipase A2 and Thromboxane A2 Synthase without Affecting Cyclooxygenase-1 Activity: Different Mechanisms of Action Are Involved in the Inhibition of Platelet Aggregation and Macrophage Inflammatory Response
- in-vitro, NA, NA
*cPLA2↓, TXA2↓, COX2↓, PGE2↓, PGD2↓,
2565- RES,    https://onlinelibrary.wiley.com/doi/10.1111/j.1365-2141.2007.06788.x
- in-vitro, NA, NA - in-vivo, NA, NA
AntiAg↑, TXA2↑, PKCδ↑, Dose↝,

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 8

Pathway results for Effect on Cancer / Diseased Cells:


Core Metabolism/Glycolysis ⓘ

AMPK↑, 1,   cMyc↓, 1,  

Transcription & Epigenetics ⓘ

other↑, 1,  

Proliferation, Differentiation & Cell State ⓘ

EMT↓, 2,  

Migration ⓘ

AntiAg↑, 2,   E-cadherin↑, 1,   MMP2↓, 1,   MMP9↓, 1,   PKCδ↑, 1,   Slug↓, 1,   TumCI↓, 1,   TumCMig↓, 1,   TumMeta↓, 3,   Twist↓, 1,   Vim↓, 1,  

Angiogenesis & Vasculature ⓘ

TXA2↓, 3,   TXA2↑, 1,  

Immune & Inflammatory Signaling ⓘ

COX1↓, 3,   COX2↓, 1,   PD-L1↓, 1,   PGD2↓, 1,   PGE2↓, 2,  

Drug Metabolism & Resistance ⓘ

Dose↑, 1,   Dose↝, 1,   RadioS↑, 1,  

Clinical Biomarkers ⓘ

PD-L1↓, 1,  
Total Targets: 26

Pathway results for Effect on Normal Cells:


Core Metabolism/Glycolysis ⓘ

cPLA2↓, 1,  

Transcription & Epigenetics ⓘ

other↝, 1,  

Migration ⓘ

AntiAg↑, 3,  

Angiogenesis & Vasculature ⓘ

TXA2↓, 4,  

Immune & Inflammatory Signaling ⓘ

COX1↓, 2,   COX2↓, 1,  

Drug Metabolism & Resistance ⓘ

Half-Life↓, 1,  

Functional Outcomes ⓘ

cardioP↑, 1,  
Total Targets: 8

Scientific Paper Hit Count for: TXA2, thromboxane A2
4 Aspirin -acetylsalicylic acid
1 Caffeic acid
1 Curcumin
1 Piperine
1 Resveratrol
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1028  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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