ACC1 Cancer Research Results

ACC1, acetyl‐CoA carboxylase 1: Click to Expand ⟱
Source:
Type:
ACC1 (encoded by the ACACA gene) is a key enzyme in de novo lipogenesis. It catalyzes the carboxylation of acetyl‐CoA to malonyl‐CoA, a critical step in fatty acid synthesis. Because lipids are essential for membrane synthesis and energy storage, ACC1 plays a critical role in cell growth and metabolism.

ACC1 plays a central role in fatty acid synthesis, and its dysregulation is closely linked to cancer metabolism. In many cancer types, overexpression of ACC1 is associated with:
-Enhanced lipid production to support rapid proliferation,
-Aggressive tumor behavior and potentially poorer prognosis,
-Promotion of a vulnerable metabolic state that could be targeted therapeutically.

ACC1’s expression level may serve as a prognostic marker. Studies have suggested that patients with tumors showing high ACC1 expression may have decreased overall survival or may progress more rapidly.
Scientific Papers found: Click to Expand⟱
1172- Ash,    Withaferin A Inhibits Fatty Acid Synthesis in Rat Mammary Tumors
- in-vitro, BC, MCF7 - in-vitro, BC, MDA-MB-231 - in-vivo, NA, NA
FASN↓, ACLY↓, ACC1↓, CPT1A↓, SREBP1/SREBF1↓,
9177- ITCs,  SFN,    Dietary Isothiocyanates: Novel Insights into the Potential for Cancer Prevention and Therapy
- Review, Var, NA
CSCs↓, GutMicro↑, Bacteria↓, TumCCA↑, Apoptosis↑, TumAuto↑, angioG↓, TumCI↓, TumMeta↓, NRF2↑, Glycolysis↓, Wnt↓, β-catenin/ZEB1↓, HH↓, NOTCH↓, NK cell↑, EMT↓, angioG↓, BioAv↓, BioAv↑, AntiBio↑, Bacteria↓, HK2↓, PDH↓, OXPHOS↓, AKT1↓, ACC1↓, FASN↓, ACC-α↓, ACLY↓, SREBP1/SREBF1↓, OCT4↓, Nanog↓, YAP/TEAD↓, miR-21↓, miR-29b↓, ALDH1A1↓, miR-140↑, CD44↓, BMI1↓, miR-200c↑, TumCG↓, TumCI↓, TumCMig↓, E-cadherin↑, N-cadherin↓, Vim↓, α-SMA↓, Slug↓, Snail↓, Twist↓, DNAdam⇅, BioAv↓, ChemoSen↑,
2404- SFN,    Prostate cancer chemoprevention by sulforaphane in a preclinical mouse model is associated with inhibition of fatty acid metabolism
- in-vitro, Pca, LNCaP - in-vitro, Pca, 22Rv1 - in-vivo, NA, NA
ACC1↓, FASN↓, CPT1A↓, β-oxidation↓, SREBP1/SREBF1?, HK2↓, PKM2↓, LDHA↓, Glycolysis↓,
9291- TERPs,    Plant-derived terpenoids modulating cancer cell metabolism and cross-linked signaling pathways: an updated reviews
- Review, Var, NA
AntiCan?, *Inflam↓, *AntiBio↑, *AntiViral↑, Ingr↝, HK2↓, ACC1↓, PKM2↓, ENO1↓, GLUT1↓, PI3K↓, Akt↓, mTOR↓, FASN↓, Apoptosis↑, Bcl-2↓, NRF2↓,

Showing Research Papers: 1 to 4 of 4

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 4

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

NRF2↓, 1,   NRF2↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

OXPHOS↓, 1,   PDH↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ACC-α↓, 1,   ACC1↓, 4,   ACLY↓, 2,   CPT1A↓, 2,   ENO1↓, 1,   FASN↓, 4,   Glycolysis↓, 2,   HK2↓, 3,   LDHA↓, 1,   PKM2↓, 2,   SREBP1/SREBF1?, 1,   SREBP1/SREBF1↓, 2,   β-oxidation↓, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↑, 2,   Bcl-2↓, 1,   YAP/TEAD↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 1,   AKT1↓, 1,   mTOR↓, 1,   PI3K↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

miR-140↑, 1,   miR-200c↑, 1,   miR-21↓, 1,   miR-29b↓, 1,   OCT4↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

TumAuto↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam⇅, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

TumCCA↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ALDH1A1↓, 1,   BMI1↓, 1,   CSCs↓, 1,   HH↓, 1,   Nanog↓, 1,   NOTCH↓, 1,   TumCG↓, 1,   Wnt↓, 1,  

Migration(tgid=13) ⓘ

E-cadherin↑, 1,   EMT↓, 1,   N-cadherin↓, 1,   Slug↓, 1,   Snail↓, 1,   TumCI↓, 2,   TumCMig↓, 1,   TumMeta↓, 1,   Twist↓, 1,   Vim↓, 1,   α-SMA↓, 1,   β-catenin/ZEB1↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 2,  

Barriers & Transport(tgid=15) ⓘ

GLUT1↓, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD44↓, 1,   NK cell↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 2,   BioAv↑, 1,   ChemoSen↑, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan?, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 1,   Bacteria↓, 2,   GutMicro↑, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr↝, 1,  
Total Targets: 64

Pathway results for Effect on Normal Cells:


Immune & Inflammatory Signaling(tgid=16) ⓘ

Inflam↓, 1,  

Infection & Microbiome(tgid=24) ⓘ

AntiBio↑, 1,   AntiViral↑, 1,  
Total Targets: 3

Scientific Paper Hit Count for: ACC1, acetyl‐CoA carboxylase 1
2 Sulforaphane (mainly Broccoli)
1 Ashwagandha(Withaferin A)
1 Isothiocyanates
1 Terpenoids
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1033  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

Home Page