SOX4 Cancer Research Results

SOX4, SRY‐box transcription factor 4: Click to Expand ⟱
Source:
Type:
SOX4 belongs to the SOX (SRY-related HMG-box) family of transcription factors and plays a critical role in embryonic development, differentiation, and cell survival.
• In cancer, SOX4 has been implicated in processes such as epithelial-to-mesenchymal transition (EMT), invasion, metastasis, and resistance to apoptosis.

In many cancers—including breast, colorectal, lung, ovarian, and pancreatic cancers—high SOX4 expression is generally associated with a more aggressive tumor phenotype and poorer clinical outcomes.
Scientific Papers found: Click to Expand⟱
4406- AgNPs,    Silver nanoparticles achieve cytotoxicity against breast cancer by regulating long-chain noncoding RNA XLOC_006390-mediated pathway
- in-vitro, BC, MCF7 - in-vitro, BC, T47D - in-vitro, BC, MDA-MB-231
TumCD↑, other↓, P53↑, TumCCA↑, Apoptosis↑, ChemoSen↑, tumCV↓, γH2AX↑, SOX4↓,
8851- DIM,    3,3’-Diindolylmethane and its derivatives: nature-inspired strategies tackling drug resistant tumors by regulation of signal transduction, transcription factors and microRNAs
- Review, Var, NA
Apoptosis↑, NF-kB↓, Akt↓, Wnt↓, PI3K↓, mTOR↓, PSA↓, Let-7↓, miR-34a↓, EZH2↓, NOTCH1↓, AR↓, E-cadherin↑, Zeb1↓, Vim↓, Slug↓, EMT↓, MTA2↓, NF-kB↓, IRAK1↓, EGFR↓, SOX4↓, FOXM1↓, p27/CDKN1B↓, AhR↓, EZH2↓, Wnt↓, PUMA↓, AEG1↑, ROS↑, PPARα↑, CycB/CCNB1↑,
8845- DIM,  I3C,    3,3′-Diindolylmethane and indole-3-carbinol: potential therapeutic molecules for cancer chemoprevention and treatment via regulating cellular signaling pathways
- Review, Var, NA
*BioAv↝, *BioAv↓, *BioAv↓, *AntiAg↑, *ROS↓, *AntiThr↑, *Stroke↓, *CYP1A1↑, *CYP1A2↑, *GSTs↑, *NQO1↑, AntiTum↑, AntiCan↑, TumAuto↓, Let-7↑, miR-34a↑, TumCMig↓, Apoptosis↑, MMP↓, mtDam↑, ROS↑, TumCCA↑, other↝, PSA↓, Dose↝, MMP2↓, MMP3↓, MMP9↓, EGFR↓, RAS↓, PI3K↓, Akt↓, mTOR↓, CDK4↓, cycD1/CCND1↓, P21↑, MDM2↓, TumCP↓, NF-kB↓, RANKL↓, PUMA↓, Wnt↓, MTA2↓, EZH2↓, AhR↓, PTEN↑, NOTCH1↓, IRAK1↓, p27/CDKN1B↓, CDKN1C/p57↓, CDC25↓, EGFR↓, Zeb1↓, FOXM1↓, SOX4↓, E-cadherin↑, uPA↓, uPAR↓,
2864- HNK,    Honokiol: A Review of Its Anticancer Potential and Mechanisms
- Review, Var, NA
TumCCA↑, CDK2↓, EMT↓, MMPs↓, AMPK↑, TumCI↓, TumCMig↓, TumMeta↓, VEGFR2/KDR/Flk1↓, *antiOx↑, *Inflam↓, *BBB↑, *neuroP↑, *ROS↓, Dose↝, selectivity↑, Casp3↑, Casp9↑, NOTCH1↓, cycD1/CCND1↓, cMyc↓, P21?, DR5↑, cl‑PARP↑, P53↑, Mcl-1↑, p65↓, NF-kB↓, ROS↑, JNK↑, NRF2↑, cJun↑, EF-1α↓, MAPK↓, PI3K↓, mTORC1↓, CSCs↓, OCT4↓, Nanog↓, SOX4↓, STAT3↓, CDK4↓, p‑RB1↓, PGE2↓, COX2/PTGS2↓, β-catenin/ZEB1↑, IKKα↓, HDAC↓, HATs↑, H3↑, H4↑, LC3II↑, c-Raf↓, SIRT3↑, Hif1a↓, ER Stress↑, GRP78/BiP↑, cl‑CHOP/DDIT3↑, MMP↓, PCNA↓, Zeb1↓, NOTCH3↓, CD133↓, Nestin↓, ATG5↑, ATG7↑, survivin↓, ChemoSen↑, SOX2↓, OS↑, P-gp/ABCB1↓, Half-Life↓, Half-Life↝, Synergy↑, BioAv↓,
8055- KAE,    Molecular Mechanisms of the Anticancer Activity of the Flavonoid Kaempferol: A Comprehensive Review
- Review, Var, NA
antiNeop↑, *toxicity↓, TumCCA↑, ROS↑, ER Stress↑, TumAuto↑, Pyro↑, Ferroptosis↑, angioG↓, Imm↝, Synergy↑, ChemoSen↑, MPT↑, MMP↓, mtDam↑, Cyt‑c↑, Bax:Bcl2↑, Fas↑, DR4↑, DR5↑, JNK↑, ERK↑, CHOP/DDIT3↑, ER Stress↑, UPR↑, Ca+2↑, PI3K↓, Akt↓, mTOR↓, AMPK↑, *Ferroptosis↓, *antiOx↑, *NRF2↑, *GPx4↑, *ROS↓, *MDA↓, *i-Iron↓, *xCT/SLC7A11↑, VEGF↓, Wnt↓, β-catenin/ZEB1↓, EMT↓, STAT3↓, M2 MC↓, MCP1/CCL2↓, MMP9↓, MMP2↓, TIMP2↓, ChemoSen↑, PKM2↑, Glycolysis↓, CSCs↓, SOX4↓, OCT4↓, CD44↓, Nanog↓, MDR1↓, *GutMicro↑,
1275- LT,    Mechanism of luteolin induces ferroptosis in nasopharyngeal carcinoma cells
- in-vitro, Laryn, NA
Ferroptosis↑, MDA↑, Iron↑, SOD↓, GSH↓, GPx4↓, SOX4↓, GDF15↓,
4630- OLE,    Targeting resistant breast cancer stem cells in a three-dimensional culture model with oleuropein encapsulated in methacrylated alginate microparticles
- in-vitro, BC, NA
Bcl-2↓, BAX↑, Casp3↑, Casp9↑, Vim↓, Slug↓, E-cadherin↑, CSCs↓, P21↑, survivin↝, OCT4↑, Nanog↑, SOX4↑,
2946- PL,    Piperlongumine, a potent anticancer phytotherapeutic: Perspectives on contemporary status and future possibilities as an anticancer agent
- Review, Var, NA
ROS↑, GSH↓, DNAdam↑, ChemoSen↑, RadioS↑, BioEnh↑, selectivity↑, BioAv↓, eff↑, p‑Akt↓, mTOR↓, GSK‐3β↓, β-catenin/ZEB1↓, HK2↓, Glycolysis↓, Cyt‑c↑, Casp9↑, Casp3↑, Casp7↑, cl‑PARP↑, TrxR↓, ER Stress↑, ATF4↝, CHOP/DDIT3↑, Prx4↑, NF-kB↓, cycD1/CCND1↓, CDK4↓, CDK6↓, p‑RB1↓, RAS↓, cMyc↓, TumCCA↑, selectivity↑, STAT3↓, NRF2↑, HO-1↑, PTEN↑, P-gp/ABCB1↓, MDR1↓, MRP1/ABCC1↓, survivin↓, Twist↓, AP-1↓, Sp1/3/4↓, STAT1↓, STAT6↓, SOX4↑, XBP-1↑, P21↑, eff↑, Inflam↓, COX2/PTGS2↓, IL6↓, MMP9↓, TumMeta↓, TumCI↓, ICAM-1↓, CXCR4↓, VEGF↓, angioG↓, Half-Life↝, BioAv↑,
4663- RES,    Exploring resveratrol’s inhibitory potential on lung cancer stem cells: a scoping review of mechanistic pathways across cancer models
- Review, Var, NA
*antiOx↑, *Inflam↓, *chemoPv↑, CSCs↓, Wnt↓, β-catenin/ZEB1↓, NOTCH↓, PI3K↓, Akt↓, mTOR↓, GSK‐3β↝, Snail↓, HH↓, p‑GSK‐3β↓, N-cadherin↓, EMT↓, CD133↓, CD44↓, ALDH1A1↓, OCT4↓, SOX4↓, Shh↓, Smo↓, Gli1↓, GLI2↓,

Showing Research Papers: 1 to 9 of 9

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 9

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

GPx4↓, 1,   GSH↓, 2,   HO-1↑, 1,   Iron↑, 1,   MDA↑, 1,   NRF2↑, 2,   Prx4↑, 1,   ROS↑, 5,   SOD↓, 1,   TrxR↓, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

CDC25↓, 1,   mtDam↑, 2,   SIRT3↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

AMPK↑, 2,   Glycolysis↓, 2,   GSK‐3β↓, 1,   GSK‐3β↝, 1,   p‑GSK‐3β↓, 1,   HK2↓, 1,   PKM2↑, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↑, 3,   BAX↑, 1,   Bax:Bcl2↑, 1,   Bcl-2↓, 1,   Casp3↑, 3,   Casp7↑, 1,   Casp9↑, 3,   Cyt‑c↑, 2,   DR5↑, 2,   Fas↑, 1,   Ferroptosis↑, 2,   Mcl-1↑, 1,   MDM2↓, 1,   PUMA↓, 2,   Pyro↑, 1,   survivin↓, 2,   survivin↝, 1,   TumCD↑, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 4,   p‑Akt↓, 1,   EF-1α↓, 1,   EGFR↓, 3,   ERK↑, 1,   IKKα↓, 1,   JNK↑, 2,   MAPK↓, 1,   mTOR↓, 5,   PI3K↓, 5,   PTEN↑, 2,   c-Raf↓, 1,   RAS↓, 2,   Sp1/3/4↓, 1,   STAT3↓, 3,   STAT6↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF4↝, 1,   cJun↑, 1,   cMyc↓, 2,   EZH2↓, 3,   FOXM1↓, 2,   H3↑, 1,   H4↑, 1,   HATs↑, 1,   HDAC↓, 1,   miR-34a↓, 1,   miR-34a↑, 1,   MTA2↓, 2,   OCT4↓, 3,   OCT4↑, 1,   other↓, 1,   other↝, 1,   SOX2↓, 1,   SOX4↓, 7,   SOX4↑, 2,   tumCV↓, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↑, 2,   cl‑CHOP/DDIT3↑, 1,   ER Stress↑, 4,   GRP78/BiP↑, 1,   UPR↑, 1,   XBP-1↑, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

ATG5↑, 1,   ATG7↑, 1,   LC3II↑, 1,   TumAuto↓, 1,   TumAuto↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↑, 1,   P53↑, 2,   cl‑PARP↑, 2,   PCNA↓, 1,   γH2AX↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK2↓, 1,   CDK4↓, 3,   CDK6↓, 1,   CDKN1C/p57↓, 1,   CycB/CCNB1↑, 1,   cycD1/CCND1↓, 3,   P21?, 1,   P21↑, 3,   p27/CDKN1B↓, 2,   p‑RB1↓, 2,   TumCCA↑, 5,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

ALDH1A1↓, 1,   CD133↓, 2,   CSCs↓, 4,   GDF15↓, 1,   Gli1↓, 1,   HH↓, 1,   Let-7↓, 1,   Let-7↑, 1,   mTORC1↓, 1,   Nanog↓, 2,   Nanog↑, 1,   Nestin↓, 1,   NOTCH↓, 1,   NOTCH1↓, 3,   NOTCH3↓, 1,   Shh↓, 1,   Smo↓, 1,   STAT1↓, 1,   TumCP↓, 1,   Wnt↓, 5,  

Migration(tgid=13) ⓘ

AEG1↑, 1,   AP-1↓, 1,   Ca+2↑, 1,   E-cadherin↑, 3,   EMT↓, 4,   GLI2↓, 1,   MMP2↓, 2,   MMP3↓, 1,   MMP9↓, 3,   MMPs↓, 1,   N-cadherin↓, 1,   Slug↓, 2,   Snail↓, 1,   TIMP2↓, 1,   TumCI↓, 2,   TumCMig↓, 2,   TumMeta↓, 2,   Twist↓, 1,   uPA↓, 1,   uPAR↓, 1,   Vim↓, 2,   Zeb1↓, 3,   β-catenin/ZEB1↓, 3,   β-catenin/ZEB1↑, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 2,   Hif1a↓, 1,   VEGF↓, 2,   VEGFR2/KDR/Flk1↓, 1,  

Barriers & Transport(tgid=15) ⓘ

MMP↓, 3,   MPT↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD44↓, 2,   COX2/PTGS2↓, 2,   CXCR4↓, 1,   DR4↑, 1,   ICAM-1↓, 1,   IL6↓, 1,   Imm↝, 1,   Inflam↓, 1,   IRAK1↓, 2,   M2 MC↓, 1,   MCP1/CCL2↓, 1,   NF-kB↓, 5,   p65↓, 1,   PGE2↓, 1,   PSA↓, 2,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AhR↓, 1,   AhR↓, 1,   AR↓, 1,   PPARα↑, 1,   RANKL↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 2,   BioAv↑, 1,   BioEnh↑, 1,   ChemoSen↑, 5,   Dose↝, 2,   eff↑, 2,   Half-Life↓, 1,   Half-Life↝, 2,   MDR1↓, 2,   MRP1/ABCC1↓, 1,   P-gp/ABCB1↓, 2,   RadioS↑, 1,   selectivity↑, 3,   Synergy↑, 2,  

Clinical Biomarkers(tgid=22) ⓘ

AR↓, 1,   EGFR↓, 3,   EZH2↓, 3,   FOXM1↓, 2,   IL6↓, 1,   PSA↓, 2,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 1,   antiNeop↑, 1,   AntiTum↑, 1,   OS↑, 1,  
Total Targets: 195

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 3,   GPx4↑, 1,   GSTs↑, 1,   i-Iron↓, 1,   MDA↓, 1,   NQO1↑, 1,   NRF2↑, 1,   ROS↓, 3,   xCT/SLC7A11↑, 1,  

Cell Death(tgid=5) ⓘ

Ferroptosis↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

Inflam↓, 2,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 2,   BioAv↝, 1,   CYP1A1↑, 1,   CYP1A2↑, 1,  

Functional Outcomes(tgid=23) ⓘ

chemoPv↑, 1,   neuroP↑, 1,   Stroke↓, 1,   toxicity↓, 1,  

Infection & Microbiome(tgid=24) ⓘ

GutMicro↑, 1,  
Total Targets: 23

Scientific Paper Hit Count for: SOX4, SRY‐box transcription factor 4
2 Diindolylmethane
1 Silver-NanoParticles
1 Indole-3-carbinol
1 Honokiol
1 Kaempferol
1 Luteolin
1 Oleuropein
1 Piperlongumine
1 Resveratrol
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1060  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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