compIII Cancer Research Results

compIII, Mitochondrial complex III: Click to Expand ⟱
Source:
Type:
Complex III is part of the mitochondrial respiratory chain. It plays a key role in oxidative phosphorylation by transferring electrons from ubiquinol (coenzyme Q) to cytochrome c.
• The complex is made up of multiple subunits. In humans, some of the key proteins include:
-UQCRC1 (ubiquinol-cytochrome c reductase core protein I)
-UQCRC2 (core protein II)
-UQCRFS1 (the Rieske iron-sulfur protein)
-UQCRB (cytochrome b)

Complex III is a significant source of reactive oxygen species (ROS) when electron transport is inefficient. Increased ROS can promote DNA damage and genomic instability, factors known to drive cancer progression.
Expression levels of Complex III subunits, particularly UQCRFS1 and UQCRC1, have been evaluated as biomarkers. High expression may suggest a more aggressive tumor phenotype, thus linking mitochondrial respiratory chain activity with clinical outcomes.
Scientific Papers found: Click to Expand⟱
1355- Ash,    Withaferin A-Induced Apoptosis in Human Breast Cancer Cells Is Mediated by Reactive Oxygen Species
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, MCF7 - in-vitro, Nor, HMEC
eff↑, mt-ROS↑, mitResp↓, OXPHOS↓, compIII↑, BAX↑, Bak↑, other↓, ATP∅, selectivity∅,
9162- BITC,    Benzyl isothiocyanate targets mitochondrial respiratory chain to trigger reactive oxygen species-dependent apoptosis in human breast cancer cells
- in-vitro, BC, MDA-MB-231 - in-vitro, BC, MCF7
Apoptosis↑, ROS↑, compIII↓, eff↓, JNK↑, MAPK↑, selectivity↑,
9185- BITC,  PEITC,  AITC,  ITCs,    Effects of Brassicaceae Isothiocyanates on Prostate Cancer
- Review, Pca, NA
antiOx↑, Inflam↓, Bacteria↓, chemoPv↑, TumCCA↑, Apoptosis↑, ChemoSen↑, TumCP↓, TumCI↓, TumMeta↓, DNMTs↓, HDAC↓, HDAC6↓, AR↓, selectivity↑, CDK1↓, CycB/CCNB1↓, P53↑, WEE1↑, CDC25↓, cMyc↓, cycD1/CCND1↓, cycE/CCNE↓, CDK4↓, CDK6↓, XIAP↓, survivin↓, Bcl-2↓, compIII↓, APAF1↑, ROS↑, OXPHOS↓, MMP↓, Ca+2↑, CXCR4↓, IL6↓, JAK2↓, STAT3↓, mTOR↓, Synergy↑, CSCs↓, uPAR↓, NF-kB↓, TGF-β↓, angioG↓,
2014- CAP,    Role of Mitochondrial Electron Transport Chain Complexes in Capsaicin Mediated Oxidative Stress Leading to Apoptosis in Pancreatic Cancer Cells
- in-vitro, PC, Bxpc-3 - in-vitro, Nor, HPDE-6 - in-vivo, PC, AsPC-1
ROS↑, *ROS∅, selectivity↑, compI↓, compIII↓, eff↑, selectivity↑, ATP↓, Cyt‑c↑, Casp9↑, Casp3↑, MMP↓, SOD↓, GSH/GSSG↓, Apoptosis↑, *toxicity∅, GSH↓, Catalase↓, GPx↓, Dose↝,
8998- Citicoline,  Rad,    The impact of citicoline on brain mitochondrial dysfunction induced in rats after head irradiation
- in-vivo, Nor, NA
*Dose↝, *ROS↓, *compI↑, *compIII↑, *ATP↑, *Ca+2↓, *Iron↓, *Casp3↓, *glucose↝, *ACE/ACE1↑, *AChE↓,
6699- DFC,    Mitochondrial H2O2 Is a Central Mediator of Diclofenac-Induced Hepatocellular Injury
- vitro+vivo, Nor, NA
*ROS↑, *hepatoP↓, *eff↑, *ATP↓, OXPHOS↓, *ETC↓, *compI↓, *compIII↓,
6698- DFC,    Diclofenac induces proteasome and mitochondrial dysfunction in murine cardiomyocytes and hearts
- in-vivo, Nor, NA
*cardioP↓, *ROS↑, MMP↓, compIII↓,
7282- Gins,    Ginsenoside Rh2 stimulates the production of mitochondrial reactive oxygen species and induces apoptosis of cervical cancer cells by inhibiting mitochondrial electron transfer chain complex
- in-vitro, Cerv, NA
compI↓, compIII↓, ETC↓, ROS↑, Apoptosis↑, tumCV↓, selectivity↑, MMP↓, ATP↓, OXPHOS↓, ECAR↓, Glycolysis↓,
7482- H2,    Molecular Hydrogen Therapy: Mechanisms, Delivery Methods, Preventive, and Therapeutic Application
- Review, Var, NA - Review, IBD, NA - Review, Stroke, NA - Review, Sepsis, NA - Review, AD, NA
Dose↝, *Inflam↓, *IL1β↓, *IL6↓, *TNF-α↓, *neuroP↑, *mTOR↓, *IL10↑, *TGF-β↑, *Sepsis↓, *NRF2↑, *antiOx↑, *Catalase↑, *SOD↑, *GPx↑, *ROS↓, *HO-1↑, *PI3K↑, *Akt↑, *hepatoP↑, *MPO↓, *cardioP↑, CDK4↓, CDK6↑, CD47↓, PI3K↓, Akt↓, Hif1a↓, selectivity↑, *MMP↑, *ATP↑, *ER Stress↓, *CHOP/DDIT3↓, *Casp12↓, *GRP78/BiP↓, *p38↓, *p‑JNK↓, *LC3‑Ⅱ/LC3‑Ⅰ↑, *p‑eIF2α↓, *ATF4↓, *XBP-1↓, *Imm↑, *IFN-γ↓, *IL4↓, *GranB/GZMB↓, NK cell↑, radioP↑, *CD4+↑, CD8+↑, *Dose↝, *other↑, *Dose↝, *antiPs↑, *BioAv↝, *GutMicro↑, Dose↝, *IBI↑, TumCP↓, TumCI↓, TumCMig↓, CD8+↑, PGC-1α↑, Akt↓, SCD1↓, *MDA↓, Synergy↑, *APP↓, *BACE/β-secretase↓, *Aβ↓, *cognitive↑, *neuroP↑, NP/CIPN↓, *Stroke↓, *NLRP3↓, *ALAT↓, *AST↓, *LPS↓, *hepatoP↑, chemoP↑, *creat↓, *Urea↓, *RenoP↑, *eff↑, Apoptosis↑, XIAP↓, IAP2/BIRC3↓, TumVol↓, MALAT1↓, EZH2↓, miR-124-3p↓, eff↑, ChemoSen↑, *compII↑, *compIII↑, *LDL↓, *Obesity↓, QoL↑, PFS↑, *antiAll↑,
7817- ISQ,  MOR,    Morin and isoquercitrin protect against ischemic neuronal injury by modulating signaling pathways and stimulating mitochondrial biogenesis
- in-vitro, AD, NA
*neuroP?, *compI↑, *compIII↑, *compV↑, *p‑ERK↑,
9191- ITCs,  AITC,  BITC,  PEITC,  SFN  Molecular Targets of Isothiocyanates in Cancer: Recent Advances
- Review, Var, NA
Risk↓, TumCG↓, ROS↑, TumCCA↑, Apoptosis↑, Ingr?, chemoPv↑, P450↓, SXR↓, CYP3A4↓, NRF2↑, ARE↑, HO-1↑, p38↓, TrxR↑, Trx↑, NF-kB↓, AP-1↓, BioAv↑, Akt↓, STAT3↓, HDAC↓, VEGF↓, MMP2↓, Hif1a↓, CD31/PECAM-1↓, PI3K↓, PDK1 / PDPK1↓, mTOR↓, FOXO1↓, FOXO3↓, BIM↑, p27/CDKN1B↑, P21↑, HER2/EBBR2↓, EGFR↓, Bcl-xL↓, XIAP↓, ROS↓, Zeb1↓, Snail↓, E-cadherin↑, MMP2↓, MMP9↓, ROS↑, MMP↓, Casp↑, DNAdam↑, TumCCA↑, γH2AX↑, CSCs↓, OCT4↓, SOX2↓, Nanog↓, NOTCH2↑, selectivity↝, ETC↓, compI↓, compIII↓, OCR↓, Synergy↑, ChemoSen↑, RadioS↑, Synergy↑, Synergy↑, Synergy↑, Synergy↑, Synergy↑,
9193- ITCs,  PEITC,  BITC,  SFN,    Cancer chemoprevention with dietary isothiocyanates mature for clinical translational research
- Review, Var, NA
Risk↓, TumCCA↑, TumCD↑, selectivity↑, TumCP↓, angioG↓, EMT↓, CSCs↓, NF-kB↓, NOTCH↑, BioAv↑, AntiCan↑, Synergy↑, Polyps↓, ROS↑, compIII↓, ChemoSen↑, RadioS↑, *p‑4E-BP1↓,
8384- LT,    Current situation and research progress of luteolin in the treatment of gastrointestinal malignant tumors
- Review, GC, NA
Apoptosis↑, TumAuto↑, TumCCA↑, EMT↓, *ROS↓, *antiOx↑, ROS↑, P53↑, LC3II↑, Beclin-1/ATG6↑, p‑MAP2K1/MEK1↓, p‑ERK↓, BAX↑, cl‑Casp3↑, Bcl-2↓, p‑MAPK↓, DNArepair↓, HMGB1↓, XRCC1↓, ERCC3↑, CycB/CCNB1↓, CDC2↓, p‑CHK1↑, TumCCA↑, TumCP?, Wnt↓, β-catenin/ZEB1↓, miR-384↑, PTN↓, MMP2↓, MMP3↓, MMP9↓, MMP16↓, Ferroptosis↑, GPx4↓, Synergy↑, Ki-67↓, GSH↓, ChemoSen↑, TumCP↓, TumCMig↓, TumCI↓, PI3K↓, Akt↓, mTOR↓, NF-kB↓, NOTCH↓, miR-139-5p↑, miR-34a↑, miR-422a↑, miR-107↑, miR-21↓, miR-155↓, miR-224↓, miR-340↓, E-cadherin↑, N-cadherin↓, Vim↓, HK1↓, FOXO1↓, compI↓, compIII↓, compV↓, ETC↓, BioAv↝,
8733- M-Blu,    Mitochondria as a target for neuroprotection: role of methylene blue and photobiomodulation
- Review, AD, NA - Review, Stroke, NA
*ETC↑, *ROS↓, *Inflam↓, *memfluid↑, *BloodF↑, *BBB↑, *OCR↑, *ATP↑, *BioAv↑, *Aβ↓, *compIV↑, *Stroke↓, *compI↑, *compII↑, *compIII↑, *GlucoseCon↑, *neuroG↑,

Showing Research Papers: 1 to 14 of 14

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 14

Pathway results for Effect on Cancer / Diseased Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 1,   ARE↑, 1,   Catalase↓, 1,   GPx↓, 1,   GPx4↓, 1,   GSH↓, 2,   GSH/GSSG↓, 1,   HO-1↑, 1,   NRF2↑, 1,   ROS↓, 1,   ROS↑, 8,   mt-ROS↑, 1,   SOD↓, 1,   Trx↑, 1,   TrxR↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

CDC2↓, 1,   CDC25↓, 1,   compI↓, 4,   compIII↓, 8,   compIII↑, 1,   compV↓, 1,   ETC↓, 3,   mitResp↓, 1,   OCR↓, 1,   OXPHOS↓, 4,   PGC-1α↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ATP↓, 2,   ATP∅, 1,   ECAR↓, 1,   Glycolysis↓, 1,   HK1↓, 1,   PDK1 / PDPK1↓, 1,   SCD1↓, 1,  

Cell Death(tgid=5) ⓘ

APAF1↑, 1,   Apoptosis↑, 7,   Bak↑, 1,   BAX↑, 2,   Bcl-2↓, 2,   Bcl-xL↓, 1,   BIM↑, 1,   Casp↑, 1,   Casp3↑, 1,   cl‑Casp3↑, 1,   Casp9↑, 1,   Cyt‑c↑, 1,   Ferroptosis↑, 1,   IAP2/BIRC3↓, 1,   p38↓, 1,   survivin↓, 1,   TumCD↑, 1,   XIAP↓, 3,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 4,   EGFR↓, 1,   p‑ERK↓, 1,   HER2/EBBR2↓, 1,   JAK2↓, 1,   JNK↑, 1,   p‑MAP2K1/MEK1↓, 1,   MAPK↑, 1,   p‑MAPK↓, 1,   mTOR↓, 3,   PI3K↓, 3,   STAT3↓, 2,  

Transcription & Epigenetics(tgid=7) ⓘ

cMyc↓, 1,   DNMTs↓, 1,   EZH2↓, 1,   FOXO1↓, 2,   FOXO3↓, 1,   HDAC↓, 2,   HDAC6↓, 1,   miR-107↑, 1,   miR-124-3p↓, 1,   miR-139-5p↑, 1,   miR-155↓, 1,   miR-21↓, 1,   miR-224↓, 1,   miR-340↓, 1,   miR-34a↑, 1,   miR-384↑, 1,   miR-422a↑, 1,   OCT4↓, 1,   other↓, 1,   SOX2↓, 1,   tumCV↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

Beclin-1/ATG6↑, 1,   LC3II↑, 1,   TumAuto↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

DNAdam↑, 1,   DNArepair↓, 1,   ERCC3↑, 1,   P53↑, 2,   XRCC1↓, 1,   γH2AX↑, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK1↓, 1,   CDK4↓, 2,   CDK6↓, 1,   CDK6↑, 1,   p‑CHK1↑, 1,   CycB/CCNB1↓, 2,   cycD1/CCND1↓, 1,   cycE/CCNE↓, 1,   Ki-67↓, 1,   P21↑, 1,   p27/CDKN1B↑, 1,   TumCCA↑, 6,   WEE1↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

CSCs↓, 3,   Ki-67↓, 1,   Nanog↓, 1,   NOTCH↓, 1,   NOTCH↑, 1,   NOTCH2↑, 1,   TumCG↓, 1,   TumCP?, 1,   TumCP↓, 4,   Wnt↓, 1,  

Migration(tgid=13) ⓘ

AP-1↓, 1,   Ca+2↑, 1,   E-cadherin↑, 2,   EMT↓, 2,   MALAT1↓, 1,   MMP16↓, 1,   MMP2↓, 3,   MMP3↓, 1,   MMP9↓, 2,   N-cadherin↓, 1,   Snail↓, 1,   TGF-β↓, 1,   TumCI↓, 3,   TumCMig↓, 2,   TumMeta↓, 1,   uPAR↓, 1,   Vim↓, 1,   Zeb1↓, 1,   β-catenin/ZEB1↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 2,   CD31/PECAM-1↓, 1,   Hif1a↓, 2,   VEGF↓, 1,  

Barriers & Transport(tgid=15) ⓘ

MMP↓, 5,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD47↓, 1,   CD8+↑, 2,   CXCR4↓, 1,   HMGB1↓, 1,   IL6↓, 1,   Inflam↓, 1,   NF-kB↓, 4,   NK cell↑, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

PTN↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AR↓, 1,   SXR↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↑, 2,   BioAv↝, 1,   ChemoSen↑, 5,   CYP3A4↓, 1,   Dose↝, 3,   eff↓, 1,   eff↑, 3,   P450↓, 1,   RadioS↑, 2,   selectivity↑, 7,   selectivity↝, 1,   selectivity∅, 1,   Synergy↑, 10,  

Clinical Biomarkers(tgid=22) ⓘ

AR↓, 1,   EGFR↓, 1,   EZH2↓, 1,   HER2/EBBR2↓, 1,   IL6↓, 1,   Polyps↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 1,   chemoP↑, 1,   chemoPv↑, 2,   NP/CIPN↓, 1,   PFS↑, 1,   QoL↑, 1,   radioP↑, 1,   Risk↓, 2,   TumVol↓, 1,  

Infection & Microbiome(tgid=24) ⓘ

Bacteria↓, 1,  

Ingredients & Constituents(tgid=25) ⓘ

Ingr?, 1,  
Total Targets: 181

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 2,   Catalase↑, 1,   GPx↑, 1,   HO-1↑, 1,   Iron↓, 1,   MDA↓, 1,   MPO↓, 1,   NRF2↑, 1,   ROS↓, 4,   ROS↑, 2,   ROS∅, 1,   SOD↑, 1,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

compI↓, 1,   compI↑, 3,   compII↑, 2,   compIII↓, 1,   compIII↑, 4,   compIV↑, 1,   compV↑, 1,   ETC↓, 1,   ETC↑, 1,   OCR↑, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ALAT↓, 1,   ATP↓, 1,   ATP↑, 3,   glucose↝, 1,   GlucoseCon↑, 1,   LDL↓, 1,  

Cell Death(tgid=5) ⓘ

Casp12↓, 1,   Casp3↓, 1,   GranB/GZMB↓, 1,   p38↓, 1,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↑, 1,   p‑ERK↑, 1,   p‑JNK↓, 1,   mTOR↓, 1,   PI3K↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

ATF4↓, 1,   other↑, 1,  

Protein Folding & ER Stress(tgid=8) ⓘ

CHOP/DDIT3↓, 1,   p‑eIF2α↓, 1,   ER Stress↓, 1,   GRP78/BiP↓, 1,   XBP-1↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

LC3‑Ⅱ/LC3‑Ⅰ↑, 1,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

p‑4E-BP1↓, 1,   neuroG↑, 1,  

Migration(tgid=13) ⓘ

Ca+2↓, 1,   TGF-β↑, 1,  

Barriers & Transport(tgid=15) ⓘ

BBB↑, 1,   IBI↑, 1,   memfluid↑, 1,   MMP↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

CD4+↑, 1,   IFN-γ↓, 1,   IL10↑, 1,   IL1β↓, 1,   IL4↓, 1,   IL6↓, 1,   Imm↑, 1,   Inflam↓, 2,   LPS↓, 1,   NLRP3↓, 1,   TNF-α↓, 1,  

Synaptic & Neurotransmission(tgid=18) ⓘ

AChE↓, 1,  

Protein Aggregation(tgid=19) ⓘ

APP↓, 1,   Aβ↓, 2,   BACE/β-secretase↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

ACE/ACE1↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↑, 1,   BioAv↝, 1,   Dose↝, 3,   eff↑, 2,  

Clinical Biomarkers(tgid=22) ⓘ

ALAT↓, 1,   AST↓, 1,   BloodF↑, 1,   creat↓, 1,   IL6↓, 1,   Urea↓, 1,  

Functional Outcomes(tgid=23) ⓘ

antiAll↑, 1,   antiPs↑, 1,   cardioP↓, 1,   cardioP↑, 1,   cognitive↑, 1,   hepatoP↓, 1,   hepatoP↑, 2,   neuroP?, 1,   neuroP↑, 2,   Obesity↓, 1,   RenoP↑, 1,   Stroke↓, 2,   toxicity∅, 1,  

Infection & Microbiome(tgid=24) ⓘ

GutMicro↑, 1,   Sepsis↓, 1,  
Total Targets: 94

Scientific Paper Hit Count for: compIII, Mitochondrial complex III
4 Benzyl isothiocyanate
3 Phenethyl isothiocyanate
3 Isothiocyanates
2 Allyl isothiocyanate
2 Diclofenac
2 Sulforaphane (mainly Broccoli)
1 Ashwagandha(Withaferin A)
1 Capsaicin
1 Citicoline, CDP-Choline
1 Radiotherapy/Radiation
1 Ginseng
1 Hydrogen Gas
1 isoquercitrin
1 Morin
1 Luteolin
1 Methylene blue
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1070  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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