CYP1A2 Cancer Research Results

CYP1A2, CYP1A2: Click to Expand ⟱
Source:
Type:
CYP1A2, cytochrome P450 enzyme
– CYP1A2 contributes to the metabolism of xenobiotics and can bioactivate pro-carcinogens into DNA-damaging compounds.
Scientific Papers found: Click to Expand⟱
1152- Api,    Does Oral Apigenin Have Real Potential for a Therapeutic Effect in the Context of Human Gastrointestinal and Other Cancers?
- Analysis, Nor, NA
*BioAv↓, Half-Life∅, *BioAv↓, Dose∅, Synergy↑, CYP1A2↓, CYP2C9↓, CYP3A4↓,
8831- DIM,    3,3′-Diindolylmethane Exhibits Significant Metabolism after Oral Dosing in Humans
- Human, Nor, NA
*chemoPv↑, *Dose↝, *Half-Life?, *BioAv↝, NA↑, CYP1A2↑, 2/16-OHE1↑, AR↝, BioAv↑,
8845- DIM,  I3C,    3,3′-Diindolylmethane and indole-3-carbinol: potential therapeutic molecules for cancer chemoprevention and treatment via regulating cellular signaling pathways
- Review, Var, NA
*BioAv↝, *BioAv↓, *BioAv↓, *AntiAg↑, *ROS↓, *AntiThr↑, *Stroke↓, *CYP1A1↑, *CYP1A2↑, *GSTs↑, *NQO1↑, AntiTum↑, AntiCan↑, TumAuto↓, Let-7↑, miR-34a↑, TumCMig↓, Apoptosis↑, MMP↓, mtDam↑, ROS↑, TumCCA↑, other↝, PSA↓, Dose↝, MMP2↓, MMP3↓, MMP9↓, EGFR↓, RAS↓, PI3K↓, Akt↓, mTOR↓, CDK4↓, cycD1/CCND1↓, P21↑, MDM2↓, TumCP↓, NF-kB↓, RANKL↓, PUMA↓, Wnt↓, MTA2↓, EZH2↓, AhR↓, PTEN↑, NOTCH1↓, IRAK1↓, p27/CDKN1B↓, CDKN1C/p57↓, CDC25↓, EGFR↓, Zeb1↓, FOXM1↓, SOX4↓, E-cadherin↑, uPA↓, uPAR↓,
7581- I3C,    A phase I study of indole-3-carbinol in women: tolerability and effects
- Trial, Nor, NA
CYP1A2↑, Dose↝,
9173- ITCs,  SFN,    Dietary isothiocyanates and anticancer agents: exploring synergism for improved cancer management
- Review, Var, NA
Synergy↑, AntiCan↑, chemoP↑, ChemoSen?, toxicity↓, ROS↑, NRF2↑, NF-kB↓, CYP1A1↓, CYP1A2↓, CYP1B1↓, TumCCA↑, PI3K↓, Akt↓, mTOR↓, PTEN↑, BAX↑, ChemoSen↑, Synergy↑, Synergy↑, Synergy↑, Synergy↑, Synergy↑, Dose↝, Synergy↑,
2906- LT,    Luteolin, a flavonoid with potentials for cancer prevention and therapy
- Review, Var, NA
*Inflam↓, AntiCan↑, antiOx⇅, Apoptosis↑, TumCP↓, TumMeta↓, angioG↓, PI3K↓, Akt↓, NF-kB↓, XIAP↓, P53↑, *ROS↓, *GSTA1↑, *GSR↑, *SOD↑, *Catalase↑, *other↓, ROS↑, Dose↝, chemoP↑, NF-kB↓, JNK↑, p27/CDKN1B↑, P21↑, DR5↑, Casp↑, Fas↑, BAX↑, MAPK↓, CDK2↓, IGF-1↓, PDGF↓, EGFR↓, PKCδ↓, TOP1↓, TOP2↓, Bcl-xL↓, FASN↓, VEGF↓, VEGFR2/KDR/Flk1↓, MMP9↓, Hif1a↓, FAK↓, MMP1↓, Twist↓, ERK↓, P450↓, CYP1A1↓, CYP1A2↓, TumCCA↑,
4922- PEITC,    Phenethyl Isothiocyanate: A comprehensive review of anti-cancer mechanisms
- Review, Var, NA
Risk↓, AntiCan↑, TumCP↓, TumMeta↓, ChemoSen↑, *BioAv↑, *other↝, *Dose↝, Dose↓, *BioAv↑, *Dose↝, *Half-Life↝, *toxicity↝, GSH↓, ROS↑, CYP1A1↑, CYP1A2↑, P450↓, CYP2E1↑, CYP3A4↓, CYP2A3/CYP2A6↓, *ROS↓, *GPx1↑, *SOD1↑, *SOD2↑, Akt↓, EGFR↓, HER2/EBBR2↓, P53↑, Telomerase↓, selectivity↑, MMP↓, Cyt‑c↑, Apoptosis↑, DR4↑, Fas↑, XIAP↓, survivin↓, TumAuto↑, Hif1a↓, angioG↓, MMPs↓, ERK↓, NF-kB↓, EMT↓, TumCI↓, TumCMig↓, Glycolysis↓, ATP↓, selectivity↑, *antiOx↑, Dose↝, other↝, OCR↓, GSH↓, ITGB1↓, ITGB6↓, ChemoSen↑,
2216- SK,    Shikonin upregulates the expression of drug-metabolizing enzymes and drug transporters in primary rat hepatocytes
- in-vivo, Nor, NA
*NRF2↑, *AhR↑, *CYP1A1↑, *CYP1A2↑, *CYP2C6↑, *CYP2D1↑, *CYP3A2↑, *NQO1↑,

Showing Research Papers: 1 to 8 of 8

* indicates research on normal cells as opposed to diseased cells
Total Research Paper Matches: 8

Pathway results for Effect on Cancer / Diseased Cells:


NA, unassigned(tgid=0) ⓘ

NA↑, 1,  

Redox & Oxidative Stress(tgid=1) ⓘ

antiOx⇅, 1,   GSH↓, 2,   NRF2↑, 1,   ROS↑, 4,  

Mitochondria & Bioenergetics(tgid=3) ⓘ

CDC25↓, 1,   mtDam↑, 1,   OCR↓, 1,  

Core Metabolism/Glycolysis(tgid=4) ⓘ

ATP↓, 1,   FASN↓, 1,   Glycolysis↓, 1,  

Cell Death(tgid=5) ⓘ

Apoptosis↑, 3,   BAX↑, 2,   Bcl-xL↓, 1,   Casp↑, 1,   Cyt‑c↑, 1,   DR5↑, 1,   Fas↑, 2,   MDM2↓, 1,   PUMA↓, 1,   survivin↓, 1,   XIAP↓, 2,  

Kinase & Signal Transduction(tgid=6) ⓘ

Akt↓, 4,   EGFR↓, 4,   ERK↓, 2,   HER2/EBBR2↓, 1,   JNK↑, 1,   MAPK↓, 1,   mTOR↓, 2,   PI3K↓, 3,   PKCδ↓, 1,   PTEN↑, 2,   RAS↓, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

EZH2↓, 1,   FOXM1↓, 1,   miR-34a↑, 1,   MTA2↓, 1,   other↝, 2,   SOX4↓, 1,  

Autophagy & Lysosomes(tgid=9) ⓘ

TumAuto↓, 1,   TumAuto↑, 1,  

DNA Damage & Repair(tgid=10) ⓘ

P53↑, 2,   Telomerase↓, 1,   TOP1↓, 1,   TOP2↓, 1,  

Cell Cycle & Senescence(tgid=11) ⓘ

CDK2↓, 1,   CDK4↓, 1,   CDKN1C/p57↓, 1,   cycD1/CCND1↓, 1,   P21↑, 2,   p27/CDKN1B↓, 1,   p27/CDKN1B↑, 1,   TumCCA↑, 3,  

Proliferation, Differentiation & Cell State(tgid=12) ⓘ

IGF-1↓, 1,   Let-7↑, 1,   NOTCH1↓, 1,   TumCP↓, 3,   Wnt↓, 1,  

Migration(tgid=13) ⓘ

E-cadherin↑, 1,   EMT↓, 1,   FAK↓, 1,   ITGB1↓, 1,   ITGB6↓, 1,   MMP1↓, 1,   MMP2↓, 1,   MMP3↓, 1,   MMP9↓, 2,   MMPs↓, 1,   PDGF↓, 1,   TumCI↓, 1,   TumCMig↓, 2,   TumMeta↓, 2,   Twist↓, 1,   uPA↓, 1,   uPAR↓, 1,   Zeb1↓, 1,  

Angiogenesis & Vasculature(tgid=14) ⓘ

angioG↓, 2,   Hif1a↓, 2,   VEGF↓, 1,   VEGFR2/KDR/Flk1↓, 1,  

Barriers & Transport(tgid=15) ⓘ

MMP↓, 2,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

DR4↑, 1,   IRAK1↓, 1,   NF-kB↓, 5,   PSA↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

2/16-OHE1↑, 1,   AhR↓, 1,   AR↝, 1,   RANKL↓, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↑, 1,   ChemoSen?, 1,   ChemoSen↑, 3,   CYP1A1↓, 2,   CYP1A1↑, 1,   CYP1A2↓, 3,   CYP1A2↑, 3,   CYP1B1↓, 1,   CYP2A3/CYP2A6↓, 1,   CYP2C9↓, 1,   CYP2E1↑, 1,   CYP3A4↓, 2,   Dose↓, 1,   Dose↝, 5,   Dose∅, 1,   Half-Life∅, 1,   P450↓, 2,   selectivity↑, 2,   Synergy↑, 8,  

Clinical Biomarkers(tgid=22) ⓘ

AR↝, 1,   EGFR↓, 4,   EZH2↓, 1,   FOXM1↓, 1,   HER2/EBBR2↓, 1,   PSA↓, 1,  

Functional Outcomes(tgid=23) ⓘ

AntiCan↑, 4,   AntiTum↑, 1,   chemoP↑, 2,   Risk↓, 1,   toxicity↓, 1,  
Total Targets: 119

Pathway results for Effect on Normal Cells:


Redox & Oxidative Stress(tgid=1) ⓘ

antiOx↑, 1,   Catalase↑, 1,   GPx1↑, 1,   GSR↑, 1,   GSTs↑, 1,   NQO1↑, 2,   NRF2↑, 1,   ROS↓, 3,   SOD↑, 1,   SOD1↑, 1,   SOD2↑, 1,  

Transcription & Epigenetics(tgid=7) ⓘ

AntiThr↑, 1,   other↓, 1,   other↝, 1,  

Migration(tgid=13) ⓘ

AntiAg↑, 1,  

Immune & Inflammatory Signaling(tgid=16) ⓘ

Inflam↓, 1,  

Hormonal & Nuclear Receptors(tgid=20) ⓘ

AhR↑, 1,  

Drug Metabolism & Resistance(tgid=21) ⓘ

BioAv↓, 4,   BioAv↑, 2,   BioAv↝, 2,   CYP1A1↑, 2,   CYP1A2↑, 2,   CYP2C6↑, 1,   CYP2D1↑, 1,   CYP3A2↑, 1,   Dose↝, 3,   GSTA1↑, 1,   Half-Life?, 1,   Half-Life↝, 1,  

Functional Outcomes(tgid=23) ⓘ

chemoPv↑, 1,   Stroke↓, 1,   toxicity↝, 1,  
Total Targets: 32

Scientific Paper Hit Count for: CYP1A2, CYP1A2
2 Diindolylmethane
2 Indole-3-carbinol
1 Apigenin (mainly Parsley)
1 Isothiocyanates
1 Sulforaphane (mainly Broccoli)
1 Luteolin
1 Phenethyl isothiocyanate
1 Shikonin
Query results interpretion may depend on "conditions" listed in the research papers.
Such Conditions may include : 
  -low or high Dose
  -format for product, such as nano of lipid formations
  -different cell line effects
  -synergies with other products 
  -if effect was for normal or cancerous cells

Filter Conditions: Pro/AntiFlg:%  IllCat:%  CanType:%  Cells:%  prod#:%  Target#:1129  State#:%  Dir#:%
  wNotes=0  sortOrder:rid,rpid

 

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